检索结果-南通市图书馆

Controversies in the management of primary sclerosingcholangitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第5期8卷 265-272页

作者： jeremy S Nayagam Stephen P Pereira John Devlin Phillip m Harrison Deepak Joshi Institute of Liver Studies King’s College HospitalLondon SE5 9RSUnited Kingdom Institute of Liver and Digestive Health University College LondonLondon NW3 2PFUnited Kingdom

Primary sclerosing cholangitis(PSC) remains a rare but significant disease, which affects mainly young males in association with inflammatory bowel disease. There have been few advances in the understanding of the pathogenesis of the condition and no therapeutics with proven mortality benefit aside from liver transplantation. There remain areas of controversy in the management of PSC which include the differentiation from other cholangiopathies, in particular immunoglobulin G4 related sclerosing cholangitis, the management of dominant biliary strictures, and the role of ursodeoxycholic acid. In addition, the timing of liver transplantation in PSC remains difficult to predict with standard liver severity scores. In this review, we address these controversies and highlight the latest evidence base in the management of PSC.

关键词： Immunoglobulin G4 related sclerosingcholangitis Cholangiocarcinoma Primary sclerosingcholangitis Liver transplantation Dominant strictures

molecular Investigation of Genetic Signatures of Selection in <i>Plasmodium falciparum</i>Actin-Binding Protein Coronin, Cysteine Desulfurase, and Plasmepsin 2 Gene in mbita Field Isolates, Western Kenya

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Genetics 2021年第4期11卷 120-144页

作者： Houdou Diarra Edward E. makhulu Peter O. Odhiambo Robinson m. Irekwa Johnson Kinyua jeremy K. Herren Victor A. mobegi Department of molecular Biology and Biotechnology Institute of Basic Sciences Technology and Innovation Pan African University (PAUSTI) Nairobi Kenya International Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya Nagasaki University Institute of Tropical medicine-Kenya medical Research Institute Project (NUITm-KEmRI-Project) Nairobi Ken-ya Department of Biochemistry Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya Department of Biochemistry School of Medicine University of Nairobi Nairobi Kenya

Background: Plasmodium falciparum (Pf) resistance to antimalarial drugs is a major impediment to malaria control. The Pf.Kelch 13 (PfK13) gene has been largely reported to be associated with artemisinin resistance. However, recent studies have shown artemisinin resistance without Kech13 mutations suggesting the implication of others genes in artemisinin resistance. In this current study, we focused on mutations in Pf.actin-binding protein coronin, Pf.cysteine desulfurase and Pf.plasmepsin 2 gene, three putative candidates recently were reported to be involved in artemisinin, lumefantrine and piperaquine resistance respectively. Method: Archived blood samples previously collected from asymptomatic school children from December 2016 to October 2018 were used in this study. Genomic DNA was extracted using ISOL

关键词： Plasmodium falciparum mutations Artemisinin Lumefantrine Piperaquine

myofascial Foot Pain Following Uneventful Epidural Analgesia for Labor and Delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2012年第1期2卷 11-13页

作者： Badie S. mansour Gretchen m. Wienecke Jorge A. Cure jeremy T. Almon Alberto J. de Armendi 不详

Following an uneventful delivery under epidural analgesia, a 17 year old female patient was referred to the Pain Clinic because of numbness and pain of the left big toe for 2 and a half months. An Orthopedic consultation had ruled out foot injury and concluded that the pain was radicular and secondary to nerve damage from the epidural analgesia. A Pain Clinic evaluation made the diagnosis of myofascial pain which was successfully treated with trigger pint block using normal saline.

关键词： myofascial Pain Trigger Point Epidural Analgesia Delivery in Adolescent Local Infiltration Chronic Foot Pain

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids mechanism-based inactivation Dronedarone

mechanical Properties, metallurgical Characteristics and Anisotropy of Additive manufacturing of 316L

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of minerals and materials Characterization and Engineering 2022年第2期10卷 209-223页

作者： D. moreno Y. Nahmana O. Nafman O. Kam B. Wolfman A. Y. cohen m. Shapira Bet Shemesh Engines LTD FAA & EASA Bet Shemesh Israel

Additive manufacturing (Am), while enabling the production of parts with complex geometries, presents new challenges. In particular, the achievement of the basic mechanical properties of the alloy must be ensured. In general, the strength-ductility properties of metals depend strongly on their microstructure, and controlling these properties requires paying attention to the alloy composition, processing technique and heat treatments. Austenite 316L stainless steel parts produced by Am demonstrate good ductility and high yield strength—higher than that obtained with annealed 316L. Some preferred orientation of the mechanical properties was found as a function of the laser path, namely, the Young’s modulus varied with respect to the angle between the build direction and the normal to the build direction. In the present study, samples of Am 316L in three orientations relative to the print direction (0˚, 45˚and 90˚) are compared to a forged sample. mechanical properties, scanning electron microscopy-SEm fractography, energy dispersive X-ray spectroscope-EDS analysis of the fracture and optical cross section images of the samples along the stress tension after the failure are presented.

关键词： SS316L Additive manufacturing (Am) Preferred Orientation mechanical Properties Young’s modulus

Low-Load Bench Press Training to Fatigue Results in muscle Hypertrophy Similar to High-Load Bench Press Training

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical medicine 2013年第2期4卷 114-121页

作者： Riki Ogasawara jeremy P. Loenneke Robert S. Thiebaud Takashi Abe Department of Health and Exercise Science University of Oklahoma Norman USA Graduate School of Frontier Sciences University of Tokyo Kashiwa Japan College of Sport and Health Science Ritsumeikan University of Tokyo Kusatsu Japan Graduate School of Frontier Sciences University of Tokyo Kashiwa Japan Department of Health Exercise Science & Recreation Management University of Mississippi Oxford USA

The purpose of this study was to determine whether the training responses observed with low-load resistance exercise to volitional fatigue translates into significant muscle hypertrophy, and compare that response to high-load resistance training. Nine previously untrained men (aged 25 [SD 3] years at the beginning of the study, standing height 1.73 [SD 0.07] m, body mass 68.9 [SD 8.1] kg) completed 6-week of high load-resistance training (HL-RT) (75% of one repeti-tion maximal [1Rm], 3-sets, 3x/wk) followed by 12 months of detraining. Following this, subjects completed 6 weeks of low load-resistance training (LL-RT) to volitional fatigue (30% 1 Rm, 4 sets, 3x/wk). Increases (p 0.05) in magnetic resonance imaging-measured triceps brachii and pectorals major muscle cross-sectional areas were similar for both HL-RT (11.9% and 17.6%, respectively) and LL-RT (9.8% and 21.1%, respectively). In addition, both groups increased (p 0.05) 1Rm and maximal elbow extension strength following training;however, the percent increases in 1Rm (8.6% vs. 21.0%) and elbow extension strength (6.5% vs. 13.9%) were significantly (p 0.05) lower with LL-RT. Both protocols elicited similar increases in muscle cross-sectional area, however differences were observed in strength. An explanation of the smaller relative increases in strength may be due to the fact that detraining after HL-RT did not cause strength values to return to baseline levels thereby producing smaller changes in strength. In addition, the results may also suggest that the consistent practice of lifting a heavy load is necessary to maximize gains in muscular strength of the trained movement. These results demonstrate that significant muscle hypertrophy can occur without high-load resistance training and suggests that the focus on percentage of external load as the important deciding factor on muscle hypertrophy is too simplistic and inappropriate.

关键词： Bench Press Training Intensity muscle CSA mRI Strength

数值模式不同分辨率和地形对东亚降水模拟影响的试验

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大气科学 2006年第2期30卷 185-192页

作者：高学杰徐影赵宗慈 jeremy S.PAL Filippo GIORGI 中国气象局气候研究开放实验室国家气候中心北京100081 The Abdus Salam International Centre for Theoretical Physics Trieste

为探讨东亚地区降水数值模拟中水平分辨率和地形的作用,使用RegCm2区域气候模式,采用不同的模式分辨率和地形,对东亚降水进行对比模拟试验。结果表明,东亚地区降水的模拟效果取决于模式的水平分辨率,模式分辨率越高,模拟的效果越好。使... 详细信息

为探讨东亚地区降水数值模拟中水平分辨率和地形的作用,使用RegCm2区域气候模式,采用不同的模式分辨率和地形,对东亚降水进行对比模拟试验。结果表明,东亚地区降水的模拟效果取决于模式的水平分辨率,模式分辨率越高,模拟的效果越好。使用实际地形的模拟效果好于使用平滑地形的。但同时,使用较高分辨率的平滑地形的模拟,效果好于使用次高分辨率的实际地形的模拟。这表明在东亚地区降水模拟中,分辨率与地形相比,起着至少同样重要的作用。结果指出,对东亚地区降水的模拟而言,使用60 km及以上分辨率可能是必需的。

关键词：东亚降水区域气候模式分辨率地形

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

内毒素腹腔内注射诱发小鼠肠套叠的实验研究

华夏医学 1999年第1期12卷 12-14页

作者：林中 m.HANANI P.cohen 桂林医学院附属医院消化内科以色列希伯来大学医学院HADASSAH医院

报告了一种新型的内毒素肠套叠动物模型，并对其发病机理进行了初步探索。结果发现：给小鼠腹腔内注射内毒素，肠套叠诱发率为２３．８％，内毒素最佳剂量是１２ｍｇ／ｋｇ，肠套叠形成高峰时间在６～１２ｈ。内毒素使肠传递时间延长，... 详细信息

报告了一种新型的内毒素肠套叠动物模型，并对其发病机理进行了初步探索。结果发现：给小鼠腹腔内注射内毒素，肠套叠诱发率为２３．８％，内毒素最佳剂量是１２ｍｇ／ｋｇ，肠套叠形成高峰时间在６～１２ｈ。内毒素使肠传递时间延长，一氧化氮合成酶抑制剂Ｌ－ＮＡＭＥ降低肠套叠诱发率。实验结果提示：内毒素可诱发肠套叠，其发病机理与肠动力紊乱有关。该动物模型可为研究肠套叠的病因，发病机理及治疗提供帮助。

关键词：肠套叠内毒素一氧化氮小鼠

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

罗伯特·达德利首席执行宫英国石油公司

商业周刊（中文版） 2013年第17期 98-99页

作者： Paul m. Barrett jeremy Liebman(摄影) 杨飞(译)

罗伯特·达德利（RobertDudley）谈英国石油在墨西哥湾陷入的法律纠纷以及美国人对石油公司的厌恶

关键词：英国石油公司罗伯特达德行宫法律纠纷墨西哥湾美国人