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Attitudes of General Hospital Staff towards Persons with Mental Illness: Associations between Place of Training, Ethnicity, and Type of Profession

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Open Journal of Psychiatry 2020年第2期10卷 53-63页

作者： Leslie Lim jeremy Heng Yiong-Huak Chan Department of Psychiatry Singapore General Hospital Singapore Biostatistics Unit Yong Loo Lin School of Medicine National University of Singapore Singapore

Objective: Persons with mental illnesses (PMI) commonly report encountering discriminatory attitudes and behaviours by Health Care Professionals (HCPs) involved in their care. Such stigmatising attitudes and behaviours may affect recovery rates and erode quality of care provided by these HCPs. We assess attitudes of HCPs towards PMI in a tertiary general hospital in Singapore. Methods: An anonymised online questionnaire was sent to HCPs working in the hospital. Attitudes were assessed using the Opening Minds Stigma Scale for Healthcare Professionals (OMS-HC), with responses rated on a 3-point Likert scale. Results: Doctors and Chinese staff trained locally were significantly more likely to feel more comfortable treating persons with physical than psychiatric problems, whereas Indian staff were less likely to express such reservations. HCPs generally accepted physical complaints at face value, while nurses tended to adopt critical attitudes toward patients and negatively perceived the utility of psychiatric treatment. For instance, nurses were more likely to judge persons with mental illness as not trying hard enough to get better, while admitting to having difficulty feeling compassion for those with psychiatric problems. Staff who received undergraduate and postgraduate training overseas were more likely to develop favourable attitudes toward PMI. Conclusions: The study has uncovered gaps in the understanding of mental disorders and their treatment. These knowledge deficits should be rectified so as to reduce negative attitudes toward PMI.

关键词： Attitudes Healthcare Professionals General Hospital

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Physics and astrophysics of strong magnetic field systems with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 74-96页

作者： Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li lin lin Roberto Mignani Nanda Rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit Paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang Institut für Astronomie und Astrophysik Eberhard Karls Universität Key Laboratory for Particle Astrophysics Institute of High Energy Physics Mullard Space Science Laboratory University College LondonHolmbury St Mary Department of Engineering Physics and Center for Astrophysics Tsinghua University School of Physics Peking University Department of Astronomy University of Geneva Department of Physics and Astronomy University of British Columbia Universitädell’Insubria Anton Pannekoek Institute for Astronomy University of Amsterdam INAF-Osservatorio Astronomico di Brera Center for Data Science New York University INAF-Osservatorio Astronomico di Roma Department of Physics Xiangtan University Department of Astronomy Beijing Normal University INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano Janusz Gil Institute of Astronomy University of Zielona Góra Instituto de Ciencias del Espacio(ICE) CSIC-IEEC INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Bologna Department of Physics and Astronomy University of Padova School of Physics and Electronic Engineering Guangzhou University NYU Abu Dhabi Saadiyat Campus P.O. NAF Osservatorio di Arcetri Largo Enrico Fermi 5 INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata European Space Astronomy Centre(ESA/ESAC) Science Operations Department Sabanci University Faculty of Engineering and Natural Sciences Centrum Astronomiczne im.M.Kopernika Department of Physics Sultan Qaboos University Institute of Theoretical Physics Faculty of Mathematics and PhysicsCharles University in Prague Raman Research Institute Sadashivanagar Department of Astronomy University of Washington The George Washington University Physics department 725 21st St NW Scuola Universitaria Superiore IUSS Pavia Palazzo del Broletto

In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s.

关键词： neutron stars QED magnetars accreting pulsars eXTP

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Tension estimation for no infill HDPE sheathing stayed-cable at XinBei bridge cable by ambient vibration method and EM tension sensor

Tension estimation for no infill HDPE sheathing stayed-cable...

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2012年海峡两岸破坏科学/材料试验学术会议

作者： Chih Kun Chu Qi-Wei Zhang Min-Jian Huang Che-Way Chang Jin-Hua Huang Chen-Hua lin jeremy Alva Graduate Institute of Civil Engineering ChungHua University

In this research we are investigating the Xinbei Bridge which is a cable stayed bridge with one pylon symmetric cable configuration with total span of 400 meters,200 meters at each side of the pylon,along the dike / embankment of SanChong area. The no infill HDPE sheathed stayed-cables in this cable-stayed bridge carry the deck of the bridge, which make them important for the *** make sure about structural health of these cables so that they can work properly and won’t fail due to overload,measurement of the load working the cable should be carried out,and due to the nature of the cable-stayed bridge,the force inside the cable will be axial force. In this paper we will compare the field observation result conducted using FBG based accelerometer,cable tension sensor instrument,all for no infill HDPE sheathed based stayed cable, which is different from traditional stayed cable in which the inside cable and the sheathing are not in contact with each *** will check the correlation of the data obtained,which is the actual force working on the structural *** hope that the result can be useful in the cable stayed bridge design and analysis,as well as structural health monitoring system for cable stayed bridge.

关键词： Cable Stayed Bbridge Stayed Cable Tension No Infill No Infill HDPE Sheathed Stayed Cable Fiber Bragg Grating Sensors Ambient Vibration Model

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Comparison of Stayed-Cable Tension of XinBei Bridge by FBG Strain Gauge installed using Adhesive and EM tension sensor

Comparison of Stayed-Cable Tension of XinBei Bridge by FBG S...

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2012年海峡两岸破坏科学/材料试验学术会议

作者： Chih-Kun Chu Qi-Wei Zhang Min-Jian Huang Che-Way Chang Jin-Hua Huang Chen-Hua lin jeremy Alva Graduate Institute of Civil Engineering ChungHua University

In this research we are investigating the tension in stayed cable of XinBei bridge,which located at Highway No.64 of SanZhong district,this cable stayed bridge has one pylon and symmetrically spreading cable stayed bridge which support bridge deck totaling 400 meters,200 meters at each side of the pylon,along the dike / embankment of SanZhong area. In this research we record and measure stayed-cable tension force by means of adhesive (instead of traditional method by welding) installed FBG(Fiber Bragg Grating) strain gauge as well as EM tension *** also take into account the temperature effect on the measurement. We compared the result from experiment using these two different methods,and provide conclusion on each method about their how they perform as well as their *** hope that our experiment work can be beneficial for future adhesive installed strain gauge reading and tension monitoring work.

关键词： Fiber Bragg Grating Adhesive Installed Strain Gauge Adhesive Reagents UV Light Hot Point

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An Evaluation of Tropical Cyclone Genesis Forecast over the Western North Pacific and the South China Sea from the CMA-TRAMS

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Journal of Tropical Meteorology 2024年第1期30卷 20-28页

作者：李梦婕陈子通戴光丰田群梁卓轩林青张艳霞 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMAGuangzhou 510641 China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 China Guangdong Meteorological Observatory Guangzhou 510641 China

Tropical cyclone(TC) genesis forecasting is essential for daily operational practices during the typhoon *** updated version of the Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS) offers forecasters reliable numerical weather prediction(NWP) products with improved configurations and fine resolution. While traditional evaluation of typhoon forecasts has focused on track and intensity, the increasing accuracy of TC genesis forecasts calls for more comprehensive evaluation methods to assess the reliability of these predictions. This study aims to evaluate the effectiveness of the CMA-TRAMS for cyclogenesis forecasts over the western North Pacific and South China Sea. Based on previous research and typhoon observation data over five years, a set of localized, objective criteria has been proposed. The analysis results indicate that the CMA-TRAMS demonstrated superiority in cyclogenesis forecasts, predicting 6 out of 22 TCs with a forecast lead time of up to 144 h. Additionally, over 80% of the total could be predicted 72 h in advance. The model also showed an average TC genesis position error of 218.3 km, comparable to the track errors of operational models according to the annual evaluation. The study also briefly investigated the forecast of Noul(2011). The forecast field of the CMA-TRAMS depicted thermal and dynamical conditions that could trigger typhoon genesis, consistent with the analysis field. The 96-hour forecast field of the CMA-TRAMS displayed a relatively organized threedimensional structure of the typhoon. These results can enhance understanding of the mechanism behind typhoon genesis,fine-tune model configurations and dynamical frameworks, and provide reliable forecasts for forecasters.

关键词： CMA-TRAMS cyclogenesis numerical weather prediction tropical cyclone

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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation Dronedarone

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LIM-domain-only 4(LMO4)enhances CD8^(+)T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling

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Signal Transduction and Targeted Therapy 2024年第9期9卷 4066-4078页

作者： Roland C.Schelker Jessica Fioravanti Fabio Mastrogiovanni jeremy G.Baldwin Nisha Rana Peng Li Ping Chen Timea Vadász Rosanne Spolski Christoph Heuser-Loy Dragana Slavkovic-Lukic Pedro Noronha Giuseppe Damiano Laura Raccosta Daniela Maggioni Sree Pullugula Jian-Xin lin Jangsuk Oh Patrick Grandinetti Mario Lecce Leo Hesse Emilia Kocks Azucena Martín-Santos Claudia Gebhard William G.Telford Yun Ji Nicholas P.Restifo Vincenzo Russo Michael Rehli Wolfgang Herr Warren J.Leonard Luca Gattinoni Division of Functional Immune Cell Modulation Leibniz Institute for ImmunotherapyRegensburgGermany Center for Cancer Research National Cancer InstituteNational Institutes of HealthBethesdaMDUSA Laboratory of Molecular Immunology and the Immunology Center National HeartLung and Blood InstituteNational Institutes of HealthBethesdaMDUSA Department of Internal MedicineⅢ University Hospital RegensburgRegensburgGermany Next Generation Sequencing Core Leibniz Institute for ImmunotherapyRegensburgGermany Immuno-Biotherapy of Melanoma and Solid Tumors Unit Division of Experimental OncologyIRCCS Scientific Institute San RaffaeleMilanItaly Vita-Salute San Raffaele University MilanItaly University of Regensburg RegensburgGermany National Center for Tumor Diseases WERA SiteWürzburg-Erlangen-Regensburg-AugsburgGermany Center for Immunomedicine in Transplantation and Oncology University Hospital RegensburgRegensburgGermany

High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy ***,we analyzed a published CRISPR activation screening to identify transcriptional regulators that could be harnessed to augment stem-like behavior in CD8^(+)T *** IFN-γproduction as a proxy for CD8^(+)T cell terminal differentiation,LMO4 emerged among the top hits inhibiting the development of effectors ***,we found that Lmo4 was downregulated upon CD8^(+)T cell activation but maintained under culture conditions facilitating the formation of stem-like T *** employing a synthetic biology approach to ectopically express LMO4 in antitumor CD8^(+)T cells,we enabled selective expansion and enhanced persistence of transduced cells,while limiting their terminal differentiation and ***4 overexpression promoted transcriptional programs regulating stemness,increasing the numbers of stem-like CD8^(+)memory T cells and enhancing their polyfunctionality and recall *** tested in syngeneic and xenograft tumor models,LMO4 overexpression boosted CD8^(+)T cell antitumor immunity,resulting in enhanced tumor *** than directly modulating gene transcription,LMO4 bound to JAK1 and potentiated STAT3 signaling in response to IL-21,inducing the expression of target genes(Tcf7,Socs3,Junb,and Zfp36)crucial for memory ***/Cas9-deletion of Stat3 nullified the enhanced memory signature conferred by LMO4,thereby abrogating the therapeutic benefit of LMO4 *** results establish LMO4 overexpression as an effective strategy to boost CD8^(+)T cell stemness,providing a new synthetic biology tool to bolster the efficacy of T cell-based immunotherapies.

关键词： STAT3 immunity LMO4

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Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-Yin Chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael Wong Anthony Chi-Fai Ng Yong Loo lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： The Fundamentals of Laparoscopic Surgery Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

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设计和开展随机实施试验:研究者指南

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英国医学杂志中文版 2021年第11期24卷 646-655页

作者： Luke Wolfenden Robbie Foy Justin Presseau jeremy M Grimshaw Noah M Ivers Byron J Powell Monica Taljaard John Wiggers Rachel Sutherland Nicole Nathan Christopher M Williams Melanie Kingsland Andrew Milat Rebecca K Hodder Sze lin Yoong 玉炫(译) 吴守媛(译) 兰慧(译) 张静怡(译) 李沁原(校) 陈耀龙(校) School of Medicine and Public Health Faculty of Health and MedicineUniversity of NewcastleCallaghanNSWAustralia Hunter New England Population Health Locked Bag 10WallsendNSW 2287Australia Leeds Institute of Health Sciences University of LeedsLeedsUK Clinical Epidemiology Program Ottawa Hospital Research InstituteOttawaONCanada School of Epidemiology and Public Health University of OttawaOttawaONCanada Department of Medicine University of OttawaOttawaONCanada Women′s College Research Institute Women′s College HospitalTorontoONCanada Institute for Health Systems Solutions and Virtual Care Women′s College HospitalTorontoONCanada Department of Family Medicine and Community Medicine Faculty of MedicineUniversity of TorontoTorontoONCanada Institute of Health Policy Management and EvaluationUniversity of TorontoTorontoONCanada Brown School and School of Medicine Washington University in St LouisSt LouisMIUSA School of Public Health Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Swinburne University of Technology School of Health SciencesFaculty HealthArts and DesignHawthornVICAustralia 兰州大学循证医学中心世界卫生组织指南实施与知识转化合作中心

实施科学是一门研究方法的学科,旨在实践和政策中促进循证干预措施的系统实施,进而改善健康。尽管实施研究需要高质量的证据,但实施策略的随机试验往往存在较为严重的局限性。这些局限性包括存在偏倚风险、缺乏理论运用、缺乏描述实施... 详细信息

实施科学是一门研究方法的学科,旨在实践和政策中促进循证干预措施的系统实施,进而改善健康。尽管实施研究需要高质量的证据,但实施策略的随机试验往往存在较为严重的局限性。这些局限性包括存在偏倚风险、缺乏理论运用、缺乏描述实施策略标准术语、局限于实施结局以及不充分报告。本文旨在对实施策略随机试验的设计、实施和报告提供指导,以提升循证实施科学。由研究人员、卫生政策制订者和实践者组成的国际小组整合了构建随机试验方法的重要文献和实施科学的最新进展。本文为实施策略随机试验的主要内容提供指导,包括试验目的阐明、试验中人员招募和保留策略、随机设计的选择、实施科学理论和框架的使用、测量(结局指标)、样本量计算、伦理审查和试验报告。本文也关注了实施试验中需要特别重视或调整的主题。为了推进实施策略随机试验的严格开展和报告,我们建议将本指南作为研究人员、卫生保健和公共卫生政策制订者或实践者、研究资助者和期刊编辑的参考资料。

关键词：实施策略参考资料期刊编辑随机试验卫生保健伦理审查公共卫生试验报告

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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri jeremy Yuen-Chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,P<0.001).After 3 months,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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