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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III jeremy l.Barth Rodney J.Schlosser Thomas S.Edwards Timothy l.smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pld change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pluding Il-4 and Il-13 signaling,Il-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of Il-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt jeremy l.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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购买安全管理服务的五个技巧——包括五项中小企业必需的管理服务

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Windows IT Pro Magazine（国际中文版） 2008年第4期 63-65页

作者： jeremy l.smith 肖欣(译)

在购买补丁管理软件之前，评估一下补丁服务是否更适合你们的情况。同样，中小企业在恶意软件防护、防垃圾邮件、备份／恢复以及一致性扫描等管理服务方面都可以进行类似的评估。

关键词：安全管理中小企业服务备份/恢复管理软件软件防护垃圾邮件一致性

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脑缺血与缺血耐受

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国际脑血管病杂志 2006年第3期14卷 190+195-196页

作者： Daniel Zemke jeremy l.smith Mathew J.Reeves Arshad Majid 孙明徐超 Fromthe Department of Neurology and Ophthalmology Michigan State UniversityEastLansingMI48824USA Neuroscience Program Michigan State UniversityEastLan-singMI48824USA Department of Epidemiology Michigan State UniversityEast LansingMI48824USA 北京市神经外科研究所

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有... 详细信息

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有害效应。深入了解卒中后导致细胞死亡的过程和诸如缺血耐受之类的内源性神经保护机制,有助于为这种破坏性神经疾病找到新的治疗策略。

关键词：卒中缺血耐受预处理

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Metal to insulator transition for conducting polymers in plasmonic nanogaps

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light(Science & Applications) 2024年第1期13卷 23-32页

作者： Yuling Xiong Rohit Chikkaraddy Charlie Readman Shu Hu Kunli Xiong Jialong Peng Qianqi lin jeremy J.Baumberg NanoPhotonics Centre Cavendish LaboratoryDepartment of PhysicsUniversity of CambridgeCambridgeCB30HEUK School of Physics&Astronomy University of BirminghamEdgbastonBirminghamUK College of Advanced Interdisciplinary Studies and Hunan Provincial Key laboratory of Novel Nano-Optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaChina Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of TwenteEnschedeNetherlands

Conjugated polymers are promising material candidates for many future applications in flexible displays, organic circuits, and sensors. Their performance is strongly affected by their structural conformation including both electrical and optical anisotropy. Particularly for thin layers or close to crucial interfaces, there are few methods to track their organization and functional behaviors. Here we present a platform based on plasmonic nanogaps that can assess the chemical structure and orientation of conjugated polymers down to sub-10 nm thickness using light. We focus on a representative conjugated polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), of varying thickness (2-20 nm) while it undergoes redox in situ. This allows dynamic switching of the plasmonic gap spacer through a metal-insulator transition. Both dark-field (DF) and surface-enhanced Raman scattering (SERS) spectra track the optical anisotropy and orientation of polymer chains close to a metallic interface. Moreover, we demonstrate how this influences both optical and redox switching for nanothick PEDOT devices.

关键词： transition insulator conjugated

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Comment on: Effect of intubation in patients with functional epiphora after endoscopic dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1576-1576页

作者： Mansooreh Jamshidian-Tehrani Hossein Ghahvehchian Christopher J Compton jeremy D Clark Nicole l West Mohsen Bahmani Kashkouli Department of Ophthalmology Eye Research CenterThe Five Senses Health InstituteRassoul Akram HospitalIran University of Medical SciencesTehran ***Iran Department of Ophthalmology and Visual Sciences University of Louisville School of MedicineLouisville 40202KentuckyUSA

Dear Editor,We read with interest the article by Han et al[1]in which they retrospectively assessed the effect of bicanalicular intubation for functional epiphora after a failed endoscopic dacryocystorhinostomy(DCR).They confirmed the post-DCR“functional obstruction”based on fluorescein dye disappearance(FDDT)and irrigation test[1].

关键词： intubation assessed endoscopic

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A General Algorithm for Calculating Irreducible Brillouin Zones

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Communications in Computational Physics 2022年第2期31卷 495-515页

作者： jeremy J.Jorgensen John E.Christensen Tyler J.Jarvis Gus l.W.Hart Department of Physics and Astronomy Brigham Young UniversityProvoUtah84602USA Department ofMathematics BrighamYoungUniversityProvoUtah84602USA

Calculations of properties of materials require performing numerical integrals over the Brillouin zone(BZ).Integration points in density functional theory codes are uniformly spread over the BZ(despite integration error being concentrated in small regions of the BZ)and preserve symmetry to improve computational *** points over an irreducible Brillouin zone(IBZ),a rotationally distinct region of the BZ,do not have to preserve crystal symmetry for greater *** freedom allows the use of adaptive meshes with higher concentrations of points at locations of large error,resulting in improved algorithmic *** have created an algorithm for constructing an IBZ of any crystal structure in 2D and *** algorithmuses convex hull and half-space representations for the BZ and IBZ to make many aspects of construction and symmetry reduction of the BZ *** algorithm is simple,general,and available as open-source software.

关键词： Brillouin zone irreducible Brillouin zone

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Recent Unusual Consecutive Spring Tropical Cyclones in North Atlantic and Winter Oceanic Precursor Signals

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Journal of Meteorological Research 2023年第2期37卷 208-217页

作者： Hong HUANG jeremy Cheuk-Hin lEUNG Johnny ClCHAN Jimin lIU Weihong QIAN Banglin ZHANG College of Meteorology and Oceanography National University of Defense TechnologyChangsha410015 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key laboratory of Regional Numerical Weather Prediction China Meteorological AdministrationGuangzhou510640 School of Energy and Environment City University of Hong KongHong Kong999077 Southern Marine Science and Engineering Guangdong laboratory(Zhuhai) Zhuhai519082 College of Atmospheric Sciences Lanzhou UniversityLanzhou730000 Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030 Asia-Pacific Typhoon Collaborative Research Center Shanghai201306 Department of Atmospheric and Oceanic Sciences Peking UniversityBeijing100871

Although the North Atlantic(NA)hurricane season has been reported to start increasingly early,historical longterm changes in NA spring tropical cyclone(TC)activity have not been examined in previous *** find that spring TCs have become more frequent and intense,and they have more closely approached the US coastline over the past four decades,thus increasing the probability of landfall.A long-term increase in the NA sea surface temperature(SST)and northward incursion of warm water may be responsible for the increasing number,intensity,and northward shift of spring *** addition,the interdecadal winter NA SST tripole mode may induce a North Atlantic Oscillation(NAO)-like atmospheric response in the following spring,which controls spring TC tracks via modulating the strength and position of the NA subtropical high(or the Bermuda high).The superposition of the interdecadal positive winter SST tripole on the NA warming trend has contributed to the anomalous enhancement and northward shift of spring TC activity,increasing the spring TC risks in the US in the past six years.

关键词： hurricane climate change spring tropical cyclone preseason storm

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Deep learning for the detection of semantic features in tree X-ray CT scans

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Artificial Intelligence in Agriculture 2023年第1期7卷 13-26页

作者： Salim Khazem Antoine Richard jeremy Fix Cédric Pradalier GeorgiaTech-CNRS IRl 2958 MetzFrance CentraleSupélec MetzFrance GeorgiaTech lorraine MetzFrance lORIA CNRS UMR 7503MetzFrance University of luxembourg Campus Kirchberg6rue Richard Coudenhove-Kalergi L-1359 Luxembourg

According to the industry,the value of wood logs is heavily influenced by their internal structure,particularly the distribution of knots within the ***,CT scanners combined with classical computer vision approach are the most common tool for obtaining reliable and accurate images of the interior structure of *** where the tree semantic features,especially knots,contours and centers are within a tree could improve the efficiency of the overall tree industry by minimizing waste and enhancing the quality of wood-log ***,this requires to automatically process the CT-scanner images so as to extract the different elements such as tree centerline,knot localization and log contour,in a robust and efficient *** this paper,we propose an effective methodology based on deep learning for performing these different tasks by processing CTscanner images with deep convolutional neural *** meet this objective,three end-to-end trainable pipelines are *** first pipeline is focused on centers detection using CNNs architecture with a regression head,the second and the third one address contour estimation and knot detection as a binary segmentation task based on an Encoder-Decoder *** different architectures are tested on several tree *** these experiments,we demonstrate that our approaches can be used to extract the different elements of trees in a precise manner while preserving good performances of *** main objective was to demonstrate that methods based on deep learning might be used and have a relevant potential for segmentation and regression on CT-scans of tree trunks.

关键词： X-rays images Deep learning Convolutional neural networks Image segmentation Wood knots Coordinates detection Contour estimation

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In-vivo evaluation of molybdenum as bioabsorbable stent candidate

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Bioactive Materials 2022年第8期7卷 262-271页

作者： Malgorzata Sikora-Jasinska lea M.Morath Maria P.Kwesiga Margaret E.Plank Alexia l.Nelson Alexander A.Oliver Martin l.Bocks Roger J.Guillory II jeremy Goldman Department of Biomedical Engineering Michigan Technological UniversityUSA Department of Biomedical Engineering and Physiology Mayo Clinic Graduate School of Biomedical SciencesUSA Case Western Reserve University School of Medicine UH Rainbow Babies&Children’s HospitalClevelandOHUSA

Biodegradable stents have tremendous theoretical potential as an alternative to bare metal stents and drug-eluting stents for the treatment of obstructive coronary artery *** bioresorbable or biodegradable scaffold material needs to possess optimal mechanical properties and uniform degradation behavior that avoids local and systemic ***,molybdenum(Mo)has been investigated as a potential novel biodegradable material for this *** its proven moderate degradation rate and excellent mechanical properties,Mo may represent an ideal source material for clinical cardiac and vascular *** present study was performed to evaluate the mechanical performance of metallic Mo in vitro and the biodegradation properties in *** results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradable endovascular stent ***,Mo implants in mouse arteries avoided the typical cellular response that contributes to *** was minimal neointimal hyperplasia over 6 months,an absence of excessive smooth muscle cell(SMC)proliferation or inflammation near the implant,and avoidance of significant harm to regenerating endothelial cells(EC).Qualitative inspection of kidney sections showed a potentially pathological remodeling of kidney Bowman’s capsule and glomeruli,indicative of impaired filtering function and development of kidney disease,although quantifications of these morphological changes were not statistically ***,the results suggest that the products of Mo corrosion may exert beneficial or inert effects on the activities of inflammatory and arterial cells,while exerting potentially toxic effects in the kidneys that warrant further investigation.

关键词： Biodegradable stent Molybdenum Biocompatibility Degradation

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