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Journal of Geriatric Cardiology 2019年第11期16卷 800-805页

作者： David Leibowitz Irit Stessman-Lande Hend Sliman jeremy M Jacobs Jochanan Stessman Dan Gilon Jerusalem Institute of Aging Research Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael Coronary Care Unit Hadassah–Hebrew University Medical CenterMount-ScopusJerusalemIsrael Department of Geriatrics and Rehabilitation Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael

Background People over the age of 85 are a rapidly growing age group with a high incidence of congestive heart failure(CHF),in particular heart failure with preserved ejection fraction(HFp EF).The diagnosis of CHF is challenging and longitudinal data assessing cardiac structure and function are necessary to distinguish physiologic from pathologic cardiac *** objective of the study was to determine longitudinal changes in cardiac struture and function from ages 85 to 94 years using home *** Subjects were recruited from the Jerusalem Longitudinal Cohort *** three members of the initial cohort(32 F,31 M)who underwent home echocardiography at age 85 were the subjects of the current study and underwent repeat home 2-D and Doppler echocardiographic assessment at age *** There were no significant longitudinal changes in left ventricular mass index(LVMI),however LV end-diastolic volume significantly decreased from 113.4±30 to 103.6±35.5 m L(P<0.02).Ejection fraction(EF)remained stable,however longitudinal systolic function significantly decreased with age from 7.9±1.8 to 6.6±1.4 cm/s2(P<0.0001).Diastolic function as assessed by increased E:e’(11.2±3.4 to 16±7.5,P<0.0001)and increased left atrial volume index(34.1±11.3 to 42.4±13.7 m L/m^2,P<0.0001)was reduced with *** This study demonstrated preserved EF with decreased longitudinal systolic function and diastolic function without significant change in LV *** in LV function in the very elderly may be independent of changes in LV geometry.

关键词： Echocardiography The elderly Ventricular function

Print companion for earth matters:environmental geology CD-ROM

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Designing a locating-routing three-echelon supply chain network under uncertainty

1998年

作者： jeremy Dunning Larry Onesti

来源：畅想之星图书光盘版（南... 评论

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 562-588页

作者： Leila Hashemi Armin Mahmoodi Milad Jasemi Richard C.Millar jeremy Laliberte Department of Industrial Management Islamic Azad University South Tehran BranchTehranIslamic Republic of Iran Department of Industrial Management Islamic Azad University ofMasjid-i-SoliemanMasjid-i-SoliemanIslamic Republic of Iran Stephens College of Business University of MontevalloMontevalloAlabamaUSA Department of Engineering Management and Systems Engineering The George Washington UniversityWashingtonDistrict of ColumbiaUSA Department of Mechanical and Aerospace Engineering Carleton UniversityOttawaCanada

Purpose-In the present research,location and routing problems,as well as the supply chain,which includes manufacturers,distributor candidate sites and retailers,are *** goal of addressing the issue is to reduce delivery times and systemcosts for retailers so that routing and distributor locationmay be ***/methodology/approach-By adding certain unique criteria and limits,the issue becomes more *** expect simultaneous deliveries and pickups,and retail service start times have soft and hard time *** expenses,noncompliance with the soft time window,distributor construction,vehicle purchase or leasing,andmanufacturing costs are all part of the system *** problem’s conceptual model is developed and modeled first,and then General Algebraic Modeling System software(GAMS)and Multiple Objective Particle Swarm Optimization(MOPSO)and non-dominated sorting genetic algorithm II(NSGAII)algorithms are used to solve it in small ***-According to the mathematical model’s solution,the average error of the two suggested methods,in contrast to the exact answer,is less than 0.7%.In addition,the performance of algorithms in terms of deviation from the GAMS exact solution is pretty satisfactory,with a divergence of 0.4%for the biggest problem(N 5100).As a result,NSGAII is shown to be superior to *** limitations/implications-Since this paper deals with two bi-objective models,the priorities of decision-makers in selecting the best solution were not taken into account,and each of the objective functions was given an equal weight based on the weighting *** model has not been compared or studied in both robust and deterministic *** is because,with the exception of the variable that indicates traffic mode uncertainty,all variables are deterministic,and the uncertainty character of demand in each level of the supply chain is *** implications-The suggested model’s conclusions

关键词： Metaheuristic algorithms Time windows Supply chain management Robust optimization Location-routing problems

A comparison of cyanoacrylate to sutures for wound closure following acoustic transmitter insertion in rainbow trout

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Aquaculture and Fisheries 2021年第5期6卷 513-518页

作者： jeremy Kientz Nathan Huysman Michael E.Barnes South Dakota Department of Game Fish and Parks4130 Adventure TrailRapid CitySD57702USA South Dakota Department of Game Fish and ParksMcNenny State Fish Hatchery19619 Trout LoopSpearfishSD57783USA

Tag retention,wound healing,wound closure,and tagged fish survival are critically important after surgical implantation of acoustic transmitters in *** study compared the use of sutures to cyanoacrylate adhesives and bandages for post-surgery wound *** rainbow trout Oncorhynchus mykiss were assigned to one of seven treatments:a control group where fish were only handled,two suture groups(tagged with dummy acoustic transmitters or non-tagged),and four cyanoacrylate adhesive groups(non-tagged,tagged with adipose fin applied as a biological bandage,tagged with anal fin applied,and non-tagged with water-proof bandage).Tag retention was significantly improved in adhesive with anal fin(89%)and tagged suture(78%)treatments when compared to only 11%tag retention in the adhesive with adipose fin *** redness severity increased over the 14 weeks of the study in the tagged and sutured fish,and in those receiving the waterproof *** redness severity was also significantly higher in the waterproof bandage and tagged and sutured treatments than both tagged adhesive treatments at the end of the *** gape was significantly more severe in the adhesive with adipose treatment than in the control,suture,tagged suture,and adhesive treatments,but no significant differences were observed between the adhesive with adipose treatment and the adhesive with anal fin or bandage *** gape never completely closed in the adhesive with adipose group,while both the tagged suture treatment and tagged adhesive with anal treatment wounds completely closed between four-and six-weeks *** results of this study indicate that cyanoacrylate adhesive used in conjunction with anal fin tissue is a suitable post-surgical treatment.

关键词： Surgery Acoustic transmitter Cyanoacrylate Rainbow trout Oncorhynchus mykiss

Plasmon-directed polymerization:Regulating polymer growth with light

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Nano Research 2018年第12期11卷 6384-6390页

作者： Yunxia Wang Shuangshuang Wang Shunping Zhang Oren A.Scherman jeremy J.Baumberg Tao Ding Hongxing Xu Key Laboratory of Artificial Micro-and Nano-structures Of Ministry of Education of China School of Physics and Technologywuhan UniversityWuhan 430072China Nanophotonics Centre Cavendish LaboratoryUniversity of CambridgeCambridgeCB30HEUK Department of Chemistry University of CambridgeLensfield RoadCambridgeCB2I EWUK

Plasmon-induced polymerization can facilitate the site-selectivity and orientation of polymer growth, which enriches the toolbox of polymerization and nanofabrication. Here, we demonstrate plasmon-induced polymerization, accomplished by low-power laser excitation of gold nanoparticles (NPs). We selectively control the growth of polymers around single plasmonic NPs while monitoring the polymerization using dark field spectroscopy and subsequent scanning electron microscopy. This plasmon-induced polymerization, generated by hot electron initiation, not only precisely controls the thickness and composition of the polymer coatings but also regulates the location and orientation of the growth, which are strongly influenced by the laser polarization and near-field distribution around the plasmonic NPs. A saturation increase in the polymer thickness provides a strong support for our mechanism. This facile approach of nanoscale polymerization directed by light not only provides new opportunities in nanosynthesis and nanofabrication for functional devices, but also opens many routes for polymer physics and chemistry at the nanoscale level.

关键词： hot electrons plasmons polarization selective growth

Management of patients with a short bowel

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World Journal of Gastroenterology 2001年第6期7卷 741-751页

作者： jeremy M D Nightingale Consultant Gastroenterologist Gastroenterology CentreLeicester Royal InfirmaryUnited Kingdom

There are two common types of adult patient with a short bowel, those with jejunum in continuity with a functioning colon and those with a jejunostomy. Both groups have potential problems of undernutrition, but this is a greater problem in those without a colon, as they do not derive energy from anaerobic bacterial fermentation of carbohydrate to short chain fatty acids in the colon. Patients with a jejunostomy have major problems of dehydration, sodium and magnesium depletion all due to a large volume of stomal output. Both types of patient have lost at least 60 cm of terminal ileum and so will become deficient of vitamin B(12). Both groups have a high prevalence of gallstones (45%) resulting from periods of biliary stasis. Patients with a retained colon have a 25% chance of developing calcium oxalate renal stones and they may have problems with D(-) lactic acidosis. The survival of patients with a short bowel, even if they need long-term parenteral nutrition, is good.

关键词： Colon Digestive System Humans Jejunostomy Nutrition Disorders Risk Factors Short Bowel Syndrome

Coastal protection using building with nature concept:A case study from Chongming Dongtan Shoal,China

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Acta Oceanologica Sinica 2021年第10期40卷 152-166页

作者： Zhentao Chong Min Zhang Jiahong Wen Luyang Wang Jie Mi jeremy Bricker Stanley Nmor Zhijun Dai School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of Estuarine and Coastal Research(East China Normal University) Shanghai 200241China Department of Hydraulic Engineering Delft University of Technology2628 CN DelftThe Netherlands Department of Civil&Environmental Engineering University of MichiganAnn ArborMI 48109USA Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research4400 AC YersekeThe Netherlands

With climate change and rising sea levels,the coastal zone’s flood risk is *** researches have shown a gradually degrading capacity of traditional hard engineering structures(e.g.,seawall,dikes)on flood mitigation due to problems such as land subsidence and insufficient *** remedy the defects,the"building with nature concept"for coastal protection with saltmarshes was examined by combining field measurements and numerical *** advantages of saltmarsh over traditional seawall on flood protection was demonstrated from the perspective of both flood area mitigation and economic gain,based on scenario *** show that tidal wetlands are essential in mitigating significant wave heights(Hs)and current velocities even during storm *** storm wave and current velocity reduction ratio(RRw and RRc)by saltmarshes on Chongming Dongtan Shoal(CMDS)during Typhoon 9711 is approximately 11%and 51%,*** wave and current mitigation by Scirpus mariqueter are more efficient than Spartina alterniflora and Phragmites australis during measurements in 2010,which were approximately 0.3 m and 0.2 m/s,0.125 m and 0.155 m/s,0.086 m and 0.128 m/s per kilometer width,*** summer saltmarsh area 54.2 km2 on CMDS protects approximately 32 km^(2)land area behind the seawall from being flooded,equivalent to the seawall heightening of approximately 0.42 m on equivalent flood *** performance of cost-and-benefit analysis shows a relatively higher(by 3%–7%)net present value(NPV)and a higher(by 1.5 times)benefit-cost ratio(BC)of nature-based solution(i.e.,saltmarsh restoration)compared with traditional hard engineering solution(i.e.,seawall construction).Thus,building seawall with nature,such as a hybrid flood protection measure,should be implemented in the future coastal redesign and maintenance.

关键词： nature-based flood protection storm wave mitigation numerical simulation cost-benefit analysis Chongming Dongtan Shoal

Signaling at the Root Surface： The Role of Cutin Monomers in Mycorrhization

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Molecular Plant 2013年第5期6卷 1381-1383页

作者： jeremy D. Murray Donna R. Cousins Kirsty J. Jackson Chengwu Liu Cell and Developmental Biology John Innes Centre Norwich NR4 7UH UK

Most vascular plants interact with arbuscular mycorrhizal fungi （AMF） and are thereby provided significant advantages in nutrient acquisition, especially phosphate. The widespread retention of this symbiosis in vascular plants is testament to its importance and ancient origins. This highlight focuses on the reports of two of the first genes identified through for- ward genetic screens for AMF symbiotic mutants： Required for Abuscular Mycorrhization 1 （RAM1） and RAM2, which respectively encode a GRAS transcription factor and a glyc- erol-3-phosphate acyl-transferase （GPAT） that are required for the formation of fungal entry structures （hyphopodia） on the root surface.

关键词： Rhizoplane MYCORRHIZAS Crucial components Signal Transduction monomers cutin Oomycetes signals butter oil Glycerol-3-Phosphate O-Acyltransferase

Cell-free DNA liquid biopsy for early detection of gastrointestinal cancers:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1799-1812页

作者： Isabelle Uhe Monika Elisabeth Hagen Frederic Ris jeremy Meyer Christian Toso Jonathan Douissard Abdominal Surgery Division Geneva University HospitalsGeneva 1211Switzerland

BACKGROUND Gastrointestinal tumors are among the most common cancer types,and early detection is paramount to improve their ***-free DNA(cfDNA)liquid biopsy raises significant hopes for non-invasive early *** To describe current applications of this technology for gastrointestinal cancer detection and *** A systematic review of the literature was performed across the PubMed *** reporting the use of cfDNA liquid biopsy in the screening or diagnosis of gastrointestinal cancers were included in the *** A total of 263 articles were screened for eligibility,of which 13 articles were *** investigated colorectal cancer(5 studies),pancreatic cancer(2 studies),hepatocellular carcinoma(3 studies),and multi-cancer detection(3 studies),including gastric,oesophageal,or bile duct cancer,representing a total of 4824 *** sensitivities ranged from 71% to 100%,and specificities ranged from 67.4% to 100%.Pre-cancerous lesions detection was less performant with a sensitivity of 16.9% and a 100% specificity in one *** study using a large biobank demonstrated a 94.9% sensitivity in detecting cancer up to 4 years before clinical symptoms,with a 61% accuracy in tissue-of-origin *** cfDNA liquid biopsy seems capable of detecting gastrointestinal cancers at an early stage of development in a non-invasive and repeatable manner and screening simultaneously for multiple cancer types in a single blood *** trials in clinically relevant settings are required to determine the exact place of this technology in gastrointestinal cancer screening and diagnosis strategies.

关键词： Cell-free DNA Tumor DNA Liquid biopsy Next-generation sequencing Cancer genomics Pancreatic cancer Colorectal cancer Hepatocellular carcinoma Multicancer detection Cancer screening Public health Precision oncology