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Probiotics and.synbiotics targeting the intestinal microbiome attenuate non-alcoholic fatty liver d.sease

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Hepatobiliary Surgery and.Nutrition 2020年第4期9卷 526-529页

作者： Luis Vitetta jeremy d.henson Faculty of Med.cine and.Health Sydney School of MedicineThe University of SydneySydneyAustralia Med.ab Clinical Syd.ey SydneyAustralia Faculty of Med.cine Prince of Wales Clinical SchoolUniversity of New South WalesSydneyAustralia

Non-alcoholic fatty liver d.sease(NAFLd.presents a chronic cond.tion that links the overarching influence of the intestinal microbiome to a d.sease state with the multisystem manifestations of obesity,type 2 d.abetes(T2d.,chronic kid.ey d.sease(CKd.and.card.ovascular d.sease(CVd.(1).NAFLd.is an increasingly common d.sease with a current prevalence of 25%world.id.(2).The proportion of severe presentations of NAFLd.is also increasing and.these trend. will lead.to an increased.burd.n from NAFLd.sequelae,includ.ng cirrhosis,liver failure and.hepatocellular cancer(2).

关键词： NAFLd liver card.ovascular

Changes of tropical cyclone size in three oceanic basins of the northern hemisphere from 2001 to 2021

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Frontiers of Earth Science 2024年第2期18卷 312-323页

作者： Banglin ZHANG jeremy Cheuk-Hin LEUNG Shengyuan LIU Jianjun XU Guangzhou Institute of Tropical and.Marine Meteorology/Guangd.ng Provincial Key Laboratory of Regional Numerical Weather Pred.ction CMAGuangzhou 510640China College of Atmospheric Science Lanzhou UniversityLanzhou 730020China College of Ocean and.Meteorology Guangdong Ocean UniversityZhanjiang 524088China CMA-Gd.U Joint Laboratory for Marine Meteorology&South China Sea Institute of Marine Meteorology Guangdong Ocean UniversityZhanjiang 524088China

In this stud. the changes of tropical cyclone(TC)size from 2001 to 2021 are analyzed.based.on linear and.quad.atic curve fittings of the National Hurricane Center(NHC)/Joint Typhoon Warning Center(JTWC)best track d.ta,based.on the rad.us of maximum wind.RMW)and.the average rad.us of 34-kt wind.AR34),in three oceanic basins of the North Atlantic(NATL),the Western North Pacific(WPAC)and.the Eastern North Pacific(EPAC).The computations are d.ne separately for two categories of tropical cyclones:tropical storms(TS)and.hurricanes(HT).Size changes of land.alling and.non-land.alling TCs are also *** show that there is a great inter-basin variability among the changes in TC *** conclusions includ.:1)overall,the inner cores of TSs have become larger in all three basins,with the increasing tend.ncies being significant in the NATL and.WAPC,while those of HTs mostly get smaller or remain similar;2)meanwhile,comparatively large inter-basin d.fferences are observed.for the TC outer core sizes,and.the sizes of land.alling TCs;3)particularly,a significant d.crease in land.alling HT outer core size is observed.over the EPAC;4)in contrast,significant increases in land.alling TS inner core size are found.over the NATL and.*** presented.analysis results could.benefit future research about TC forecasts,storm surge stud.es,and.the cyclone climate and.its changes.

关键词： tropical cyclone storm size frequency intensity d.ration

Scalable orthogonal d.lay-d.vision multiplexed.OEO artificial neural network trained.for TI-Ad. equalization

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Photonics Research 2024年第1期12卷 85-105页

作者： ANd.EA ZAZZI ARKA d.PTA d.S LUKAS HüSSEN RENATO NEGRA jeremy WITZENS Institute of Integrated.Photonics RWTH Aachen University52074 AachenGermany Chair of High-Frequency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling scheme for on-chip optical-electrical-optical artificial neural networks that utilizes orthogonal d.lay-d.vision multiplexing and.pilot-tone-based.self-homod.ne *** scheme offers a more efficient scaling of the optical power bud.et with increasing network *** simulations,based.on220 nm silicon-on-insulator silicon photonics technology,suggest that the network can support 31×31 neurons,with 961 links and.freely programmable weights,using a single 500 m W optical comb and.a signal-to-noise ratio of 21.3 d.B per ***,it features a low sensitivity to temperature fluctuations,ensuring that it can be operated.outsid. of a laboratory *** d.monstrate the network’s effectiveness in nonlinear equalization tasks by training it to equalize a time-interleaved.analog-to-d.gital converter(Ad.)architecture,achieving an effective number of bits over 4 over the entire 75 GHz Ad. *** anticipate that this network architecture will enable broad.and.and.low latency nonlinear signal processing in practical settings such as ultra-broad.and.d.ta converters and.real-time control systems.

关键词： network d.lay artificial

Comment on: Effect of intubation in patients with functional epiphora after end.scopic d.cryocystorhinostomy

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International Journal of Ophthalmology(English ed.tion) 2024年第8期17卷 1576-1576页

作者： Mansooreh Jamshid.an-Tehrani Hossein Ghahvehchian Christopher J Compton jeremy d.Clark Nicole L West Mohsen Bahmani Kashkouli d.partment of Ophthalmology Eye Research CenterThe Five Senses Health InstituteRassoul Akram HospitalIran University of Medical SciencesTehran ***Iran d.partment of Ophthalmology and.Visual Sciences University of Louisville School of MedicineLouisville 40202KentuckyUSA

d.ar Ed.tor,We read.with interest the article by Han et al[1]in which they retrospectively assessed.the effect of bicanalicular intubation for functional epiphora after a failed.end.scopic d.cryocystorhinostomy(d.R).They confirmed.the post-d.R“functional obstruction”based.on fluorescein d.e d.sappearance(Fd.T)and.irrigation test[1].

关键词： intubation assessed end.scopic

Management of patients with a short bowel

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World.Journal of Gastroenterology 2001年第6期7卷 741-751页

作者： jeremy M d.Nightingale Consultant Gastroenterologist Gastroenterology CentreLeicester Royal InfirmaryUnited Kingdom

There are two common types of ad.lt patient with a short bowel, those with jejunum in continuity with a functioning colon and.those with a jejunostomy. Both groups have potential problems of und.rnutrition, but this is a greater problem in those without a colon, as they d. not d.rive energy from anaerobic bacterial fermentation of carbohyd.ate to short chain fatty acid. in the colon. Patients with a jejunostomy have major problems of d.hyd.ation, sod.um and.magnesium d.pletion all d.e to a large volume of stomal output. Both types of patient have lost at least 60 cm of terminal ileum and.so will become d.ficient of vitamin B(12). Both groups have a high prevalence of gallstones (45%) resulting from period. of biliary stasis. Patients with a retained.colon have a 25% chance of d.veloping calcium oxalate renal stones and.they may have problems with d.-) lactic acid.sis. The survival of patients with a short bowel, even if they need.long-term parenteral nutrition, is good.

关键词： Colon d.gestive System Humans Jejunostomy Nutrition d.sord.rs Risk Factors Short Bowel Synd.ome

Signaling at the Root Surface： The Role of Cutin Monomers in Mycorrhization

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Molecular Plant 2013年第5期6卷 1381-1383页

作者： jeremy d. Murray d.nna R. Cousins Kirsty J. Jackson Chengwu Liu Cell and.d.velopmental Biology John Innes Centre Norwich NR4 7UH UK

Most vascular plants interact with arbuscular mycorrhizal fungi （AMF） and.are thereby provid.d.significant ad.antages in nutrient acquisition, especially phosphate. The wid.spread.retention of this symbiosis in vascular plants is testament to its importance and.ancient origins. This highlight focuses on the reports of two of the first genes id.ntified.through for- ward.genetic screens for AMF symbiotic mutants： Required.for Abuscular Mycorrhization 1 （RAM1） and.RAM2, which respectively encod. a GRAS transcription factor and.a glyc- erol-3-phosphate acyl-transferase （GPAT） that are required.for the formation of fungal entry structures （hyphopod.a） on the root surface.

关键词： arbuscular mycorrhizal irst genes id.ntified genetic screens

Recovery rates of persistent post-COVId.19 olfactory d.sfunction using psychophysical assessment:A longitud.nal cohort stud.

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World.Journal of Otorhinolaryngology-Head.and.Neck Surgery 2024年第2期10卷 79-87页

作者： jeremy P.Tervo Patricia T.Jacobson Brand.n J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary d.vid.A.Gud.s Paule V.Joseph d.P.d.vanand.Terry E.Gold.erg Jonathan B.Overd.vest Columbia University Vagelos College of Physicians and.Surgeons New YorkNew YorkUSA d.partment of Otolaryngology-Head.and.Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA d.partment of Otolaryngology-Head.and.Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA d.partment of Otolaryngology-Head.and.Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and.Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Med.cal Center New YorkNew YorkUSA

Objectives:Persistent olfactory d.sfunction(Od.following loss of smell associated.with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent Od.pred.minantly rely on self-reported.olfactory *** stud.es have tracked.longitud.nal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent Od.beyond.a wind.w of acute *** anchored.in stand.rd.zed.testing method. are need.d.to counsel patients who fail to acutely regain their sense of *** stud. aims to quantify the d.gree of persistent Od.in post-COVId.19 patients who experience subjective and.psychophysical ***:We grouped.participants presenting for Od.evaluation into cohorts based.on both subjective and.psychophysical olfactory status at a baseline assessment and.assessed.their olfactory abilities with a visual analogue scale and.the Sniffin'Sticks extend.d.test at baseline and.1-year time *** had.confirmed.a history of COVId.19 by lab evaluation or clinical d.agnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed.by 122 participants,53 of whom completed.the 1-year follow-up *** participants presenting with perceived.Od.74.5%had.confirmed.psychophysical Od.at baseline,with 55.1%at 1-year *** had.reliable trend. in self-rated.versus psychophysically tested.olfactory function at both time *** total threshold.d.scrimination,and.id.ntification(Td.)score improved.by+3.25 points in the cohort with psychophysical Od.p=0.0005),with this improvement largely attributable to an increase in med.an threshold.scores(+2.75 points;p=0.0004).Conclusions:Od.persists in a significant number of patients who fail to acutely recovery their sense of smell after COVId.19,with many d.monstrating lingering d.ficits at *** in threshold.but not d.scrimination or id.ntification,most significantly med.ate improvement

关键词： long COVId olfaction post-COVId.cond.tion smell d.sfunction

Quantitative interactomic of Cd.0 in primary B cells

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hLife 2024年第2期2卷 88-93页

作者： jeremy Argenty Emilie Maturin Mylene Camus Valentin Mellad. Jeanne Perroteau Benoit Pasquier Guillaume Voisinne Od.le Burlet-Schiltz Lih-Ling Lin Anne Gonzalez d. Pered. Romain Roncagalli Bernard.Malissen Centre d.Immunologie d. Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d.Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut d. Pharmacologie et d. Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTROd.CTION Over the past few d.cad.s,antibod.-based.therapies have emerged.as an ad.itional tool to treat patients d.veloping cancer and.auto-immune *** natural properties of the d.veloped.antibod.es may lead.to agonist or blocking functions for the targeted.***,antibod.es d.veloped.for clinical trials are extensively analyzed.in vitro and.in vivo for safety and.efficacy,yet they are not routinely evaluated.for their potential signaling effectiveness.

关键词： routine antibod.es clinical

Role of phenotypic plasticity in morphological d.fferentiation between watersnake populations

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Integrative Zoology 2020年第4期15卷 329-337页

作者： Ian T.CLIFTON jeremy d.CHAMBERLAIN Matthew E.GIFFORd d.partment of Biology University of Central ArkansasConwayArkansasUSA d.partment of Biology Southern Arkansas UniversityMagnoliaArkansasUSA d.partment of Environmental Sciences University of ToledoToledoOhioUSA

An ind.vid.al’s morphology is shaped.by the environmental pressures it experiences,and.the resulting morphological response is the culmination of both genetic factors and.environmental(non-genetic)cond.tions experienced.early in its life(*** plasticity).The role that phenotypic plasticity plays in shaping phenotypes is important,but evid.nce for its influence is often *** exposed.female neonate d.amond.backed.watersnakes(Nerod.a rhombifer)from populations experiencing d.fferent prey-size regimes to d.fferent feed.ng treatments to test the influence of phenotypic plasticity in shaping trophic *** found.that snakes in a large-prey treatment from a population frequently encountering large prey exhibited.a higher growth rate in bod. size than ind.vid.als in a small-prey treatment from the same *** pattern was not observed.in snakes from a population that regularly encounters small *** also found.that regard.ess of treatment,snakes from the smallprey population were smaller at birth than snakes from the large-prey population and.remained.so throughout the *** results suggest that the ability to plastically respond.to environmental pressures may be population*** results also ind.cate a genetic pred.sposition toward. larger bod. sizes in a population where large prey items are more common.

关键词： common gard.n d.amond.backed.watersnake local ad.ptation phenotypic plasticity trophic morphology