检索结果-南通市图书馆

Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice

引用

Bone Research 2023年第4期11卷 772-783页

作者： Zhousheng Xiao Li cao Micholas Dean smith Hanxuan Li Wei Li jeremy c.smith Leigh Darryl Quarles Department of Medicine University of Tennessee Health Science CenterMemphisTN 38163USA UT/ORNL center for Molecular Biophysics Oak Ridge National LaboratoryOak RidgeTN 37830USA Department of Biochemistry and cellular and Molecular Biology The University of Tennessee-KnoxvilleKnoxvilleTN 37996-1939USA Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTN 38163USA

Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly ***,we used mouse genetics,mechanical loading,and pharmacological approaches to test the possibility that polycystin-1 and Wwtr1 have interdependent mechanosensing functions in *** created and compared the skeletal phenotypes of control Pkd1^(flox/)+;Wwtr1^(flox/)+,Pkd1^(Oc-cKO),Wwtr1^(Oc-cKO),and Pkd1/Wwtr1^(Oc-cKO)mice to investigate genetic *** with an interaction between polycystins and Wwtr1 in bone in vivo,Pkd1/Wwtr1^(Oc-cKO)mice exhibited greater reductions of BMD and periosteal MAR than either Wwtr1Oc-cKOor Pkd1^(Oc-cKO)***-cT 3D image analysis indicated that the reduction in bone mass was due to greater loss in both trabecular bone volume and cortical bone thickness in Pkd1/Wwtr1Oc-cKO mice compared to either Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***1/Wwtr1^(Oc-cKO)mice also displayed additive reductions in mechanosensing and osteogenic gene expression profiles in bone compared to Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***,we found that Pkd1/Wwtr1^(Oc-cKO)mice exhibited impaired responses to tibia mechanical loading in vivo and attenuation of loadinduced mechanosensing gene expression compared to control ***,control mice treated with a small molecule mechanomimetic,MS2 that activates the polycystin complex resulted in marked increases in femoral BMD and periosteal MAR compared to vehicle *** contrast,Pkd1/Wwtr1^(Oc-cKO)mice were resistant to the anabolic effects of *** findings suggest that Pc1 and Wwtr1 form an anabolic mechanotransduction signaling complex that mediates mechanical loading responses and serves as a potential novel therapeutic target for treating osteoporosis.

关键词： mec impaired additive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Free-electron crystals for enhanced X-ray radiation

引用

Light(Science & Applications) 2024年第7期13卷 1299-1309页

作者： Lee Wei Wesley Wong Xihang Shi Aviv Karnieli jeremy Lim Suraj Kumar Sergio carbajo Ido Kaminer Liang Jie Wong School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore. Solid State Institute and Faculty of Electrical and computer Engineering Technion–Israel Institute of TechnologyHaifa 3200003Israel. School of Electrical Engineering Fleischman Faculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel Department of Applied Physics Stanford UniversityStanfordCA 94305USA. Science Mathematics and TechnologySingapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore. Electrical and computer Engineering Department UCLA420 WestwoodLos AngelesCA 90095USA. Physics and Astronomy Department UCLA475 Portola PlazaLos AngelesCA 90095USA. SLAc National Accelerator Laboratory Stanford University2575 Sand Hill RoadMenlo ParkCA 94025USA

Bremsstrahlung—the spontaneous emission of broadband radiation from free electrons that are deflected by atomic nuclei—contributes to the majority of X-rays emitted from X-ray tubes and used in applications ranging from medical imaging to semiconductor chip ***,we show that the bremsstrahlung intensity can be enhanced significantly—by more than three orders of magnitude—through shaping the electron wavefunction to periodically overlap with atoms in crystalline ***,we show how to shape the bremsstrahlung X-ray emission pattern into arbitrary angular emission profiles for purposes such as unidirectionality and ***,we find that these enhancements and shaped emission profiles cannot be attributed solely to the spatial overlap between the electron probability distribution and the atomic centers,as predicted by the paraxial and nonrecoil theory for free electron light *** work highlights an unprecedented regime of free electron light emission where electron waveshaping provides multi-dimensional control over practical radiation processes like *** results pave the way towards greater versatility in table-top X-ray sources and improved fundamental understanding of quantum electron-light interactions.

关键词： overlap attributed arbitrary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

引用

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III jeremy L.Barth Rodney J.Schlosser Thomas S.Edwards Timothy L.smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(cRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic cRS patients without polyps(cRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with cRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic cRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pchange 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pcorrection)including IL-4 and IL-13 signaling,IL-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with cRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal to insulator transition for conducting polymers in plasmonic nanogaps

引用

Light(Science & Applications) 2024年第1期13卷 23-32页

作者： Yuling Xiong Rohit chikkaraddy charlie Readman Shu Hu Kunli Xiong Jialong Peng Qianqi Lin jeremy J.Baumberg NanoPhotonics centre Cavendish LaboratoryDepartment of PhysicsUniversity of CambridgeCambridgeCB30HEUK School of Physics&Astronomy University of BirminghamEdgbastonBirminghamUK college of Advanced Interdisciplinary Studies and Hunan Provincial Key Laboratory of Novel Nano-Optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaChina Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of TwenteEnschedeNetherlands

conjugated polymers are promising material candidates for many future applications in flexible displays, organic circuits, and sensors. Their performance is strongly affected by their structural conformation including both electrical and optical anisotropy. Particularly for thin layers or close to crucial interfaces, there are few methods to track their organization and functional behaviors. Here we present a platform based on plasmonic nanogaps that can assess the chemical structure and orientation of conjugated polymers down to sub-10 nm thickness using light. We focus on a representative conjugated polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), of varying thickness (2-20 nm) while it undergoes redox in situ. This allows dynamic switching of the plasmonic gap spacer through a metal-insulator transition. Both dark-field (DF) and surface-enhanced Raman scattering (SERS) spectra track the optical anisotropy and orientation of polymer chains close to a metallic interface. Moreover, we demonstrate how this influences both optical and redox switching for nanothick PEDOT devices.

关键词： transition insulator conjugated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

capturing cO2 Emissions in the George c. Wallace Tunnel: A case Study

引用

Intelligent control and Automation 2024年第3期15卷 83-94页

作者： Gabe canitz cole ciesta Klint Green Justin Sanders Jason Valencia jeremy Willingham Daniel Fonseca Department of Mechanical Engineering The University of Alabama Tuscaloosa AL USA

This paper describes the design of a ventilation system to be paired with a carbon capture system. The ventilation system utilizes the geometry of the George c. Wallace tunnel, located in the city of Mobile, Alabama, USA to capture and redirect emissions to a direct air capture (DAc) device to sequester 25% of the total cO2 mass generated from inside the tunnel. The total cO2 mass rate for the westbound traffic between the week-day hours of 7 a.m. and 6 p.m. has been estimated between 2,300 to 3,000 lbs./hr. By sequestering these emissions, the overall surrounding air quality was shown to be improved to a level that mirrors that from the pre-US industrial era of 270 ppm.

关键词： cO2 capture Tunnel Ventilation Air Flow Analysis Jet Fan Sizing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

challenging the assumption about a direct relationship between historic preservation and architecture in the United States

引用

Frontiers of Architectural Research 2018年第4期7卷 455-464页

作者： jeremy c.Wells School of Architecture Planning and PreservationUniversity of MarylandMD 20742United States

A close relationship is assumed to exist between historic preservation and architectural practice. This study explores the nature of this relationship by using evidence from scholarly literature, the job market, and architectural education. The examined literature contains many examples showing that the architecture field views historic preservation as an external interest. Evidence from the job market indicates that architecture employers are uninterested in historic preservation skills, and historic preservation employers are not looking for architecture skills. Architecture schools and accrediting organizations either disregard historic preservation or minimize its importance. Moreover, historic preservation is more closely related to environmental and behavioral studies than it is to the architectural field. The relationship between architecture and historic preservation is tenuous, strained, and based more on stereotypes than on actual evidence.

关键词： Historic preservation Architecture Heritage conservation Education Job market Employers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kernel-based consensus clustering for Ontology-embedded Document Repository of Power Substations

引用

cSEE Journal of Power and Energy Systems 2017年第2期3卷 212-221页

作者： Long Yan Wenhu Tang Q.H.Wu jeremy Simon smith Department of Electrical Engineering and Electronic The University of LiverpoolLiverpoolL693GJU.K. School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

This paper presents a novel consensus clustering(cc)approach for a document repository concerning power substations(PSD)and contributes to the intangible asset management of power systems.A domain ontology model,i.e.,substation ontology(SONT),is applied to modify the traditional vector space model(VSM)for document representation,which is concerned with the semantic relationship between terms.A new document representation is generated using a term mutual information matrix with the aid of *** addition,compared with two other novel cc algorithms,i.e.,non-negative matrix factorisation-based cc(NNMF-cc)and information theory-based cc(INT-cc),weighted partition via kernel-based cc algorithm(WPK-cc)is utilised to solve the cc issue for ***,genetic algorithms(GA)were applied to WPK-cc for PSD,as there are limitations in the original WPK-cc for document ***,selected mechanisms in each GA’s procedure are compared and improved,resulting in comprehensive parameter settings for the PSD *** simulation studies have been designed,in which the results are evaluated by purity validation method and show that the SONT-based document representation and improved WPK-cc,via modified GA,significantly improve the performance of the PSD cc.

关键词： power system asset management document clustering consensus clustering ontology kernel method GA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

引用

Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri jeremy Yuen-chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho Urologycentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,Pcontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning for the detection of semantic features in tree X-ray cT scans

引用

Artificial Intelligence in Agriculture 2023年第1期7卷 13-26页

作者： Salim Khazem Antoine Richard jeremy Fix cédric Pradalier GeorgiaTech-cNRS IRL 2958 MetzFrance centraleSupélec MetzFrance GeorgiaTech Lorraine MetzFrance LORIA CNRS UMR 7503MetzFrance University of Luxembourg Campus Kirchberg6rue Richard Coudenhove-Kalergi L-1359 Luxembourg

According to the industry,the value of wood logs is heavily influenced by their internal structure,particularly the distribution of knots within the ***,cT scanners combined with classical computer vision approach are the most common tool for obtaining reliable and accurate images of the interior structure of *** where the tree semantic features,especially knots,contours and centers are within a tree could improve the efficiency of the overall tree industry by minimizing waste and enhancing the quality of wood-log ***,this requires to automatically process the cT-scanner images so as to extract the different elements such as tree centerline,knot localization and log contour,in a robust and efficient *** this paper,we propose an effective methodology based on deep learning for performing these different tasks by processing cTscanner images with deep convolutional neural *** meet this objective,three end-to-end trainable pipelines are *** first pipeline is focused on centers detection using cNNs architecture with a regression head,the second and the third one address contour estimation and knot detection as a binary segmentation task based on an Encoder-Decoder *** different architectures are tested on several tree *** these experiments,we demonstrate that our approaches can be used to extract the different elements of trees in a precise manner while preserving good performances of *** main objective was to demonstrate that methods based on deep learning might be used and have a relevant potential for segmentation and regression on cT-scans of tree trunks.

关键词： X-rays images Deep learning convolutional neural networks Image segmentation Wood knots coordinates detection contour estimation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Designing a locating-routing three-echelon supply chain network under uncertainty

引用

International Journal of Intelligent computing and cybernetics 2022年第4期15卷 562-588页

作者： Leila Hashemi Armin Mahmoodi Milad Jasemi Richard c.Millar jeremy Laliberte Department of Industrial Management Islamic Azad University South Tehran BranchTehranIslamic Republic of Iran Department of Industrial Management Islamic Azad University ofMasjid-i-SoliemanMasjid-i-SoliemanIslamic Republic of Iran Stephens college of Business University of MontevalloMontevalloAlabamaUSA Department of Engineering Management and Systems Engineering The George Washington UniversityWashingtonDistrict of ColumbiaUSA Department of Mechanical and Aerospace Engineering Carleton UniversityOttawaCanada

Purpose-In the present research,location and routing problems,as well as the supply chain,which includes manufacturers,distributor candidate sites and retailers,are *** goal of addressing the issue is to reduce delivery times and systemcosts for retailers so that routing and distributor locationmay be ***/methodology/approach-By adding certain unique criteria and limits,the issue becomes more *** expect simultaneous deliveries and pickups,and retail service start times have soft and hard time *** expenses,noncompliance with the soft time window,distributor construction,vehicle purchase or leasing,andmanufacturing costs are all part of the system *** problem’s conceptual model is developed and modeled first,and then General Algebraic Modeling System software(GAMS)and Multiple Objective Particle Swarm Optimization(MOPSO)and non-dominated sorting genetic algorithm II(NSGAII)algorithms are used to solve it in small ***-According to the mathematical model’s solution,the average error of the two suggested methods,in contrast to the exact answer,is less than 0.7%.In addition,the performance of algorithms in terms of deviation from the GAMS exact solution is pretty satisfactory,with a divergence of 0.4%for the biggest problem(N 5100).As a result,NSGAII is shown to be superior to *** limitations/implications-Since this paper deals with two bi-objective models,the priorities of decision-makers in selecting the best solution were not taken into account,and each of the objective functions was given an equal weight based on the weighting *** model has not been compared or studied in both robust and deterministic *** is because,with the exception of the variable that indicates traffic mode uncertainty,all variables are deterministic,and the uncertainty character of demand in each level of the supply chain is *** implications-The suggested model’s conclusions

关键词： Metaheuristic algorithms Time windows Supply chain management Robust optimization Location-routing problems

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：