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Omental infarction diagnosed by computed tomography,missed with ultrasonography:A case report

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World Journal of Clinical Cases 2023年第4期11卷 972-978页

作者： Jae Kyoon Hwang Yu jeong cho Bo Seung Kang Kyueng-Whan Min Young Seo cho Yong Joo Kim Kyung Suk Lee Department of Pediatrics Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Surgery Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Emergency Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pathology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pediatrics Hanyang University HospitalHanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Omental infarction(OI)is a surgical abdominal disease that is not common in adults and is very rare in *** to various acute abdominal pain diseases including appendicitis,diagnosis was previously achieved by diagnostic laparotomy but more recently,ultrasonography or computed tomography(CT)examination has been *** SUMMARY A 6-year-old healthy boy with no specific medical history visited the emergency room with right lower abdominal *** underwent abdominal ultrasonography by a radiologist to rule out acute *** was discharged with no significant sonographic finding and symptom ***,the symptoms persisted for 2 more days and an outpatient visit was *** outpatient abdominal CT was used to make a diagnosis of *** laparoscopic operation,his symptoms *** In children’s acute abdominal pain,imaging studies should be performed for appendicitis and OI.

关键词： Omental infarction Children Ultrasonography Computed tomography Case report

Wrinkle-free graphene with spatially uniform electrical properties grown on hot-pressed copper

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Nano Research 2015年第4期8卷 1075-1080页

作者： jeong Hun Mun Joong Gun Oh Jae Hoon Bong Hai Xu Kian Ping Loh Byung Jin cho Departmen t of Electrical Engineering KAIST Daejeon 305-701 Republic of Korea Department of Chemistry National University of Singapore Singapore 117543 Singapore

The chemical vapor deposition （CVD） of graphene on Cu substrates enables the fabrication of large-area monolayer graphene on desired substrates. However, during the transfer of the synthesized graphene, topographic defects are unavoidably formed along the Cu grain boundaries, degrading the electrical properties of graphene and increasing the device-to-device variability. Here, we introduce a method of hot-pressing as a surface pre-treatment to improve the thermal stability of Cu thin film for the suppression of grain boundary grooving. The flattened Cu thin film maintains its smooth surface even after the subsequent high temperature CVD process necessary for graphene growth, and the formation of graphene without wrinkles is realized. Graphene field effect transistors （FETs） fabricated using the graphene synthesized on hot-pressed Cu thin film exhibit superior field effect mobility and significantly reduced device-to-device variation.

关键词： CVD graphene graphene synthesis graphene wrinkle graphene field effecttransistor

Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung Lee Jun Hyuk Kang Seon-Myeong Kim jeong-Ryeol Gong Kwang-Hyun cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

Liver function alterations after laparoscopy-assisted gastrectomy for gastric cancer and its clinical significance

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World Journal of Gastroenterology 2011年第3期17卷 372-378页

作者： Gui-Ae jeong Gyu-seok cho Eung-Jin Shin Moon-Soo Lee Hyung-Chul Kim Ok-Pyung Song Department of Surgery Soonchunhyang University College of Medicine

AIM: To evaluate the factors associated with liver function alterations after laparoscopy-assisted gastrectomy (LAG) for gastric cancer. METHODS: We collected the data of gastrectomy patients with gastric cancer and divided them into 2 groups: open gastrectomy (OG) and LAG. We also collected the data of patients with colon cancer to evaluate the effect of liver manipulations during surgery on liver function alterations. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and alkaline phosphatase were measured on the preoperative day and postoperative day 1 (POD1), POD3, POD5, and POD7. RESULTS: No changes in liver function were observed after the operation in patients with colon cancer (n = 121). However, in gastric cancer patients (n = 215), AST and ALT levels increased until POD5 compared to those in colon cancer patients and these findings were observed both in the LAG and OG without a significant difference except at POD1. The mean hepatic enzyme levels at POD1 in the LAG group were significantly higher than those in the OG group (P = 0.047 for AST and P = 0.039 for ALT). The factors associated with elevated ALT on POD1 in patients with gastric cancer were body mass index (P < 0.001), operation time (P < 0.001), intraoperative hepatic injury (P = 0.048), and ligation of an aberrant left hepatic artery (P = 0.052) but not type of operation (OG vs LAG, P = 0.094). CONCLUSION: We conclude that the liver function alteration after LAG may have been caused by direct liver manipulation or aberrant hepatic artery ligation rather than the CO2 pneumoperitoneum.

关键词： Gastric cancer Liver function Pneumoperitoneum Laparoscopy-assisted gastrectomy

Microstructure investigation and multicolor upconversion in Yb3+/Ln3+(Ln=Er/Tm/Ho) ions doped α-Sialon

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Progress in Natural Science:Materials International 2019年第5期29卷 549-555页

作者： Sang Hoon jeong Yuwaraj K.Kshetri Seung Ho Kim Sung Hun cho Soo W.Lee Department of Environment and Bio-Chemical Engineering Sun Moon University Research Center for Eco Multi-Functional Nano Materials Sun Moon University The Institute of Scientific and Industrial Research (ISIR) Osaka University

Yb3+/Ln3+(Ln=Er/Tm/Ho)-α-sialon ceramics were fabricated by hot press sintering *** microstructure and luminescent properties were studied by XRD,EDS,HRTEM and photoluminescence *** results showed that the sintered ceramics consisted ofα-Sialon with a trace amount ofβ-Sialon *** frequency upconversion and downconversion properties of Yb3+/Ln3+(Ln=Er/Tm/Ho)-α-Sialon ceramics were investigated under 980 nm low-power *** different concentrations of Yb3+/Ln3+(Ln=Er/Tm/Ho)produced multicolor emissions characteristics of each Ln3+ion as a result of the energy transfer from Yb3+to Er3+,Tm3+and Ho3+*** EDS spectra measurements and mappings showed that the Ln3+ions were well incorporated in theα-Sialon *** evolution of the emission decay behavior has been investigated to understand the energy transfer mechanism.

关键词： α-Sialon Hot press sintering Upconversion Energy transfer

Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： Seung-Hyun jeong Ji-Hun Jang Guk-Yeo Lee Seung-Jung Yang Hea-Young cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

Deep-learning-based gas identification by timevariant illumination of a single micro-LEDembedded gas sensor

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Light(Science & Applications) 2023年第5期12卷 826-837页

作者： Incheol cho Kichul Lee Young Chul Sim Jae-seok jeong Minkyu cho Heechan Jung Mingu Kang Yong-Hoon cho Seung Chul Ha Kuk-Jin Yoon Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea SENKO Co. Ltd.485Oesammi-DongOsan-SiGyeonggil-Do 18111Republic of Korea

Electronic nose(e-nose)technology for selectively identifying a target gas through chemoresistive sensors has gained much attention for various applications,such as smart factory and personal health *** overcome the crossreactivity problem of chemoresistive sensors to various gas species,herein,we propose a novel sensing strategy based on a single micro-LED(μLED)-embedded photoactivated(μLP)gas sensor,utilizing the time-variant illumination for identifying the species and concentrations of various target gases.A fast-changing pseudorandom voltage input is applied to the μLED to generate forced transient sensor responses.A deep neural network is employed to analyze the obtained complex transient signals for gas detection and concentration *** proposed sensor system achieves high classification(~96.99%)and quantification(mean absolute percentage error~31.99%)accuracies for various toxic gases(methanol,ethanol,acetone,and nitrogen dioxide)with a single gas sensor consuming 0.53 *** proposed method may significantly improve the efficiency of e-nose technology in terms of cost,space,and power consumption.

关键词： Deep illumination transient

Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

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World Journal of Gastroenterology 2015年第5期21卷 1457-1467页

作者： jeong Mo Bae Tae Hun Lee Nam-Yun cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 110-799South Korea

AIM:To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers(CRCs).METHODS:We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each *** included cytokeratin 7 and CK20 expression,microsatellite instability,Cp G island methylator phenotype,and KRAS and BRAF mutation *** and multivariate survival analysis was performed to reveal the prognostic value of CDX2 ***:CDX2 expression was lost in 42(5.9%) ***,loss of CDX2 expression was associated with proximal location,infiltrative growth,advanced T,N,M and overall *** microscopic examination,loss of CDX2 expression was associated with poor differentiation,increased number of tumor-infiltrating lymphocytes,luminal serration and mucin *** of CDX2 expression was also associated with increased CK7 expression,decreased CK20 expression,Cp G island methylator phenotype,microsatellite instability and BRAF *** a univariate survival analysis,patients with loss of CDX2 expression showed worse overall survival(P < 0.001) and progression-free survival(P < 0.001).In a multivariate survival analysis,loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio(HR) = 1.72,95%CI:1.04-2.85,P = 0.034] and progression-free survival(HR = 1.94,95%CI:1.22-3.07,P = 0.005).CONCLUSION:Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs.

关键词： CDX2 CpG island methylator phenotype Microsatellit

Prediction of effluent concentration in a wastewater treatment plant using machine learning models

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Journal of Environmental Sciences 2015年第6期27卷 90-101页

作者： Hong Guo Kwanho jeong Jiyeon Lim jeongwon Jo Young Mo Kim Jong-pyo Park Joon Ha Kim Kyung Hwa cho School of Environmental Science and Engineering Gwangju Institute of Science and Technology (GIST) School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology HECOREA. INC

Of growing amount of food waste, the integrated food waste and waste water treatment was regarded as one of the efficient modeling method. However, the load of food waste to the conventional waste treatment process might lead to the high concentration of total nitrogen（T-N） impact on the effluent water quality. The objective of this study is to establish two machine learning models-artificial neural networks（ANNs） and support vector machines（SVMs）, in order to predict 1-day interval T-N concentration of effluent from a wastewater treatment plant in Ulsan, Korea. Daily water quality data and meteorological data were used and the performance of both models was evaluated in terms of the coefficient of determination（R^2）, Nash-Sutcliff efficiency（NSE）, relative efficiency criteria（d rel）. Additionally, Latin-Hypercube one-factor-at-a-time（LH-OAT） and a pattern search algorithm were applied to sensitivity analysis and model parameter optimization, respectively. Results showed that both models could be effectively applied to the 1-day interval prediction of T-N concentration of effluent. SVM model showed a higher prediction accuracy in the training stage and similar result in the validation ***, the sensitivity analysis demonstrated that the ANN model was a superior model for 1-day interval T-N concentration prediction in terms of the cause-and-effect relationship between T-N concentration and modeling input values to integrated food waste and waste water treatment. This study suggested the efficient and robust nonlinear time-series modeling method for an early prediction of the water quality of integrated food waste and waste water treatment process.

关键词： Artificial neural network Support vector machine Effluent concentration Prediction accuracy Sensitivity analysis