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Improving toughness of medium-Mn steels after friction stir welding through grain morphology tuning

Journal of Materials Science & Technology 2022年第23期118卷 243-254页

作者： Mun Sik jeong Tak Min Park Dong-Il kim Hidetoshi Fujii Hye Ji Im Pyuck-Pa Choi Seung-Joon Lee jeongho Han Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung 15073Republic of Korea Joining and Welding Research Institute Osaka UniversityOsaka 567-0047Japan Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA

This work demonstrated the viability of friction stir welding for the welding of medium-Mn steels when used as cryogenic vessel materials for liquefied gas *** used an intercritically annealed Fe-7 Mn-0.2 C-3 Al(wt.%)steel with a dual-phase(α'martensite andγ_(R) retained austenite)nanolaminate structure as a base material and systematically compared its microstructure and impact toughness after friction stir and tungsten inert gas *** friction stir welded specimen exhibited a large amount ofγ_(R) phase owing to a relatively low temperature during welding,whereas the tungsten inert gas welded specimen comprised only theα'***,the friction stir welded steel exhibited a tuned morphology of nanoscale globular microstructure at the weld zone and did not exhibit any prior austenite grain boundary due to active recrystallization caused by deformation during *** preserved fraction ofγ_(R) and morphological tuning in the weldment improved the impact toughness of the friction stir welded steel at low *** the steel processed by tungsten inert gas welding,the notch crack propagated rapidly along the prior austenite grain boundaries-weakened by Mn and P segregations-resulting in poor impact ***,the friction stir welded steel exhibited a higher resistance against notch crack propagation due to the slow crack propagation along the ultrafine ferrite/ferrite(α/α)interfaces,damage tolerance by the active transformation-induced plasticity from the large amount ofγR,and enhanced boundary cohesion by suppressed Mn and P segregations.

关键词： Charpy impact test Transformation-induced plasticity Friction stir welding Phase stability Medium-Mn steel

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New insights in the pathogenesis of alcohol-related liver disease:The metabolic,immunologic,and neurologic pathways

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Liver Research 2023年第1期7卷 1-8页

作者： Tom Ryu Kyurae kim Sung Eun Choi Katherine Po Sin Chung Won-Il jeong Laboratory of Liver Research Graduate School of Medical Science and EngineeringKAISTDaejeonRepublic of Korea

Alcohol-related liver disease(ALD)became an important health issue *** chronic alcohol consumption,the development of ALD might be caused by metabolic and immunologic factors,such as reactive oxygen species(ROS)and pro-inflammatory *** example,hepatic cytochrome P4502E1 enzyme increases ROS production and stimulates de novo lipogenesis after alcohol *** addition,damage-and pathogen-associated molecular patterns stimulate their specific receptors in nonparenchymal cells,including Kupffer cells,hepatic stellate cells(HSCs),and lymphocytes,which result in hepatocyte death and infiltration of pro-inflammatory cells(e.g.,neutrophils and macrophages)in the ***,our studies have suggested the novel involvement of neurologic signaling pathways(e.g.,endocannabinoid and glutamate)through the metabolic synapse between hepatocytes and HSCs in the development of alcohol-related hepatic ***,agouti-related protein and beta2-adrenergic receptors aggravate hepatic ***,organ-crosstalk has emerged as a critical issue in *** alcohol consumption induces dysbiosis and barrier disruption in the gut,leading to endotoxin leakage into the portal circulation,or lipolysis-mediated transport of triglycerides from the adipose tissue to the *** summary,this review addresses multiple pathogeneses of ALD,provides novel neurologic signaling pathways,and emphasizes the importance of organ-crosstalk in the development of ALD.

关键词： Alcohol-related liver disease(ALD) Cannabinoid receptor Steatohepatitis Lipopolysaccharide(LPS) Metabotropic glutamate receptor(mGluR) Toll-like receptor 4(TLR4)

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T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

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Cellular & Molecular Immunology 2022年第3期19卷 447-448页

作者： Seong Jin Choi Dong-Uk kim Ji Yun Noh Sangwoo kim Su-Hyung Park Hye Won jeong Eui-Cheol Shin Division of Infectious Disease Department of Internal MedicineSeoul National University HospitalSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)DaejeonRepublic of Korea

In November 2021,the Omicron variant(B.1.1.529)emerged and was designated a variant of concern(VOC)by the World Health ***,Omicron was reported to extensively escape neutralizing antibodies elicited by COVID-19 vaccination or natural infection[1,2,3].However,whether Omicron evades the T cell immunity elicited by COVID-19 vaccination or natural infection remains to be *** address this issue,we analyzed the amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain(Wuhan-Hu-1)in the Omicron variant(hCoV-19/South Africa/CERI-KRISP-K032284/2021).

关键词： neutral conserved elucidated

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Optical Vernier sampling using a dual-comb-swept laser to solve distance aliasing

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Photonics Research 2021年第5期9卷 657-667页

作者： SEONGJIN BAK GYEONG hun kim HANSOL JANG CHANG-SEOK kim Department of Cogno-Mechatronics Engineering Pusan National UniversityBusan 46241Republic of Korea

Optical interferometry using comb-swept lasers has the advantage of efficiently reducing the acquisition bandwidth for high-speed and long-range detection. However, in general, the use of a comb-swept laser involves a critical limitation in that the absolute distance cannot be measured, and, thus, multiple layers cannot be distinguished when measuring each position. This is because of the distance ambiguity induced by optical aliasing, in which there is periodic repetition of the frequency of an interferometric signal owing to discrete spectral sweeping, which does not occur in conventional optical interferometry that uses a continuous swept laser. In this paper, we introduce an optical Vernier sampling method using a dual-comb-swept laser to measure the absolute distances in a multi-layer target. For this, we designed a new type of dual-comb-swept laser to include two different free spectral ranges(FSRs) in separated wavelength bands to provide a stable lasing condition. Using a principle similar to that of a Vernier caliper for length measurement, the two different FSRs can be used to recover a higher frequency of an optical interferometric signal to measure longer distances from different layers in a *** the dual-comb-swept laser in optical interferometry, we solved the optical aliasing issue and measured the absolute distances of three layers separated over 83 mm using a point-scanning imaging setup and the simultaneous absolute distance of the top surfaces separated over 45 mm using a full-field imaging setup at14 and 8 times lower acquisition bandwidth than a conventional continuous swept laser that is based on optical interferometry.

关键词： laser interferometry absolute

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Study of Spiral Flow Generated through an Annular Slit

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Journal of Thermal Science 2005年第2期14卷 97-102页

作者： Tae hun kim Shigeru MATSUO Toshiaki SETOGUCHI Heuy-Dong kim Graduate school of Science and Technology Saga University 1Honjo-machiSaga shiSaga 840-8502JapanDepartment of Mechanical Engineering Saga University1Honjo-machiSaga shiSaga 840-8502JapanDepartment of Mechanical Engineering Saga University1Honjo-machiSaga shiSaga 840-8502JapanSchool of Mechanical Engineering College of Natural ScienceAndong National University388Song Cheon DongAndongKyung PookKorea

The effect of pressurized air inlets in the reservoir upstream of the annular slit on characteristics of the axial and tangential velocity components is investigated numerically, and the mechanism of occurrence of spiral nozzle flow is clarified. In simulations, Unified Platform for Aerospace Computational Simulation (UPACS) is used. The governing equations under consideration are the unsteady compressible Navier - Stokes. A second-order finite volume scheme with MUSCL (Roe scheme) is used to discretize the spatial derivatives, and a second order-central difference scheme for the viscous terms, and a MFGS (Matrix Free Gauss Seidel) is employed for time integration. Spalart-Allmaras model was used as a turbulence model. The results obtained are compared with velocity distributions in the experiment measured by the two-component fiber optic laser Doppler velocimeter system. The existence of discrete pressurized air inlets that leads to the occurrence of asymmetrical characteristics is a very important factor for the formation of spiral flow.

关键词：旋转喷嘴流柯恩达效应渐缩喷嘴环形裂缝计算机仿真

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Publisher Correction to:Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第8期16卷 417-417页

作者： jeong‑Woong Shin Dong‑Je kim Tae‑Min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay JBandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Due to typesetting mistake,Hanul Min was missed to be denoted as a corresponding author in the *** type-setter apologizes for *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were *** images or other third party material in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the *** material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.

关键词： Creative Elastic Highly

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Method for process-based modeling of combat scenarios using interaction analysis weapon systems

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Frontiers of Information Technology & Electronic Engineering 2021年第3期22卷 415-436页

作者： Dongsu jeong Dohyun kim Yoonho SEO Department of Industrial and Management Engineering Korea UniversitySeoul KS013Korea

With technological advancements,weapon system development has become increasingly complex and *** modeling and simulation(M&S)technology in the conceptual design stage is effective in reducing the development time and cost of *** way to reduce the complexity and trial-and-error associated with weapon development using M&S technology is to develop combat scenarios to review the functions assigned to new *** the M&S technology is applicable,it is difficult to analyze how effectively the weapons are functioning,because of the dynamic features inherent in combat scenario modeling,which considers interrelations among different weapon *** support review of weapon functions including these characteristics,this study develops a process-based modeling(PBM)method to model the interactions between weapons in the combat *** method includes the following three steps:(1)construct virtual models by converting the weapons and the weapon functions into their corresponding components;(2)generate the combat process from the combat scenario,which is derived from the interrelations among weapons under consideration using reasoning rules;(3)develop a process-based model that describes weapon functions by combining the combat process with virtual ***,a PBM system based on this method is *** case study executed on this system shows that it is useful in deriving process-based models from various combat scenarios,analyzing weapon functions using the derived models,and reducing weapon development issues in the conceptual design stage.

关键词： Weapon systems Process-based modeling(PBM) Combat scenario Interaction analysis Metamodel Petri net

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Can an Invasive Prey Species Induce Morphological and Behavioral Changes in an Endemic Predator? Evidence from a South Korean Snake(Oocatochus rufodorsatus)

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Asian Herpetological Research 2014年第4期5卷 245-254页

作者： Jun-Haeng HEO Heon-Joo LEE Il-hun kim Jonathan J.FONG Ja-Kyeong kim Sumin jeong Daesik PARK Department of Biology Kangwon National University Division of Science Education Kangwon National University

Introduction of an invasive prey species into an ecosystem may affect an endemic predator＇s fitness by altering the prey-predator system. Successful adaptation may allow the endemic predator to eat and control the invasive species, while unsuccessful adaptation may result in extinction of the predator. We examine the possible effects of the invasive North American bullfrog （Rana [Lithobates] catesbeiana） on the endemic Red-backed rat snake （Oocatochus rufodorsatus） in South Korea. We do so by comparing the morphology and behavior of adult and hatchling snakes from bullfrog-exposed （Taean） and bullfrog-unexposed （Hongcheon） populations. Among the seven morphological characteristics investigated, relative tail length （tail length/snout-vent length） of both adults and hatchlings from Taean was significantly greater than that of adults and hatchlings from Hongcheon. Also, adult snakes from Taean had a signiifcantly shorter latency of ifrst tongue lfick in response to prey compared to adults from Hongcheon. This difference was not observed in hatchlings. In other snake species, a longer relative tail length and shorter latency of ifrst tongue lfick are known to improve foraging efifciency, and these characters may be adaptations ofO. rufodorsatus to prey on bullfrogs. This study provides preliminary evidence that the presence of an invasive prey species may cause morphological and behavioral changes in an endemic predator.

关键词： invasive prey bullfrog Rana catesbeiana Oocatochus rufodorsatus predator response

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A TMA-Seq2seq Network for Multi-Factor Time Series Sea Surface Temperature Prediction

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Computers, Materials & Continua 2022年第10期73卷 51-67页

作者： Qi He Wenlong Li Zengzhou Hao Guohua Liu Dongmei Huang Wei Song Huifang Xu Fayez Alqahtani jeong-Uk kim Department of Information Technology Shanghai Ocean UniversityShanghai201306China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China College of Computer Dong Hua UniversityShanghai200051China College of Information Technology Shanghai Jian Qiao UniversityShanghai201306China Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh 12372Saudi Arabia Department of Electrical Engineering Sangmyung UniversitySouth KoreaKorea

Sea surface temperature (SST) is closely related to global climatechange, ocean ecosystem, and ocean disaster. Accurate prediction of SST isan urgent and challenging task. With a vast amount of ocean monitoring dataare continually collected, data-driven methods for SST time-series predictionshow promising results. However, they are limited by neglecting complexinteractions between SST and other ocean environmental factors, such as airtemperature and wind speed. This paper uses multi-factor time series SSTdata to propose a sequence-to-sequence network with two-module attention(TMA-Seq2seq) for long-term time series SST prediction. Specifically, TMASeq2seq is an LSTM-based encoder-decoder architecture facilitated by factorand temporal-attention modules and the input of multi-factor time series. Ittakes six-factor time series as the input, namely air temperature, air pressure,wind speed, wind direction, SST, and SST anomaly (SSTA). A factor attentionmodule is first designed to adaptively learn the effect of different factors onSST, followed by an encoder to extract factor-attention weighted features asfeature representations. And then, a temporal attention module is designedto adaptively select the hidden states of the encoder across all time steps tolearn more robust temporal relationships. The decoder follows the temporalattention module to decode the feature vector concatenated from the weightedfeatures and original input feature. Finally, we use a fully-connect layer tomap the feature into prediction results. With the two attention modules, ourmodel effectively improves the prediction accuracy of SST since it can notonly extract relevant factor features but also boost the long-term *** experiments on the datasets of China Coastal Sites (CCS) demonstrate that our proposed model outperforms other methods, reaching 98.29%in prediction accuracy (PACC) and 0.34 in root mean square error (RMSE).Moreover, SST prediction experiments in China’s East, South,

关键词： Sea surface temperature multi-factor attention long short-term memory

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Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice,an AD model

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Translational Neurodegeneration 2022年第1期11卷 31-45页

作者： Chanho Kong Eun-jeong Yang Jaewoo Shin Junwon Park Si-Hyun kim Seong-Wook Park Won Seok Chang Chang-Han Lee Hyunju kim Hye-Sun kim Jin Woo Chang Department of Neurosurgery Yonsei University College of Medicine50 Yonsei-RoSeodaemun-GuSeoulRepublic of Korea Department of Pharmacology College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Neuroscience Research Center College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Department of Biomedical Sciences College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Bundang Hospital Seoul National University College of MedicineBundang-GuSungnamRepublic of Korea.

Background:Aducanumab(Adu),which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid,has been reported to reduce amyloid pathology and improve impaired cognition after administration of a high dose(10 mg/kg)of the drug in Alzheimer’s disease(AD)clinical *** purpose of this study was to investigate the effects of a lower dose of Adu(3 mg/kg)with enhanced delivery via focused ultrasound(FUS)in an AD mouse ***:The FUS with microbubbles opened the blood-brain barrier(BBB)of the hippocampus for the delivery of *** combined therapy of FUS and Adu was performed three times in total and each treatment was performed biweekly.Y-maze test,Brdu labeling,and immunohistochemical experimental methods were employed in this *** addition,RNA sequencing and ingenuity pathway analysis were employed to investigate gene expression profiles in the hippocampi of experimental ***:The FUS-mediated BBB opening markedly increased the delivery of Adu into the brain by approximately 8.1 times in the *** combined treatment induced significantly less cognitive decline and decreased the level of amyloid plaques in the hippocampi of the 5×FAD mice compared with Adu or FUS *** treatment with FUS and Adu activated phagocytic microglia and increased the number of astrocytes associated with amyloid plaques in the hippocampi of 5×FAD ***,RNA sequencing identified that 4 enriched canonical pathways including phagosome formation,neuroinflammation signaling,CREB signaling and reelin signaling were altered in the hippocami of 5×FAD mice receiving the combined ***:In conclusion,the enhanced delivery of a low dose of Adu(3 mg/kg)via FUS decreases amyloid deposits and attenuates cognitive function ***-mediated BBB opening increases adult hippocampal neurogenesis as well as drug *** present an AD treatment strategy through the synergistic effect of the combined therapy of

关键词： Aducanumab Alzheimer’s disease Focused ultrasound Transcriptome profiling

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