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Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： Jwa Hoon Kim jeong Eun Kim Yong Sang Hong Sun Young Kim Kyu-pyo Kim Ki Eun Choi Ji Hoon shin Tae Won Kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

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Signal processing for real-time identification of similar metals by laser-induced breakdown spectroscopy

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Plasma Science and Technology 2019年第3期21卷 84-91页

作者： Sungho shin Youngmin MOON Jaepil LEE Hyemin JANG Euiseok HWANG Sungho jeong School of Mechanical Engineering Gwangju Institute of Science and Technology

Laser-induced breakdown spectroscopy(LIBS) is regarded as a promising technique for realtime sorting of scrap metals due to its capability of fast multi-elemental and in-air analysis. This work reports a method for signal processing which ensures high accuracy and high speed during similar metal sorting by LIBS. Similar metals such as aluminum alloys or stainless steel are characterized by nearly the same constituent elements with slight variations in elemental concentration depending on metal type. In the proposed method, the original data matrix is substantially reduced for fast processing by selecting new input variables(spectral lines) using the information for the constituent elements of similar metals. Specifically, principal component analysis(PCA) of full-spectra LIBS data was performed and then, based on the loading plots, the input variables of greater significance were selected in the order of higher weights for each constituent element. The results for the classification test with aluminum alloy, copper alloy,stainless steel and cast steel showed that the classification accuracy of the proposed method was nearly the same as that of full-spectra PCA, but the computation time was reduced by a factor of 20 or more. The results demonstrated that incorporating the information for constituent elements can significantly accelerate classification speed without loss of accuracy.

关键词： laser-induced breakdown spectroscopy classification similar metal reduced number of spectral lines

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Phase-controlled synthesis of thermally stable nitrogen-doped carbon supported iron catalysts for highly efficient Fischer-Tropsch synthesis

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Nano Research 2019年第10期12卷 2568-2575页

作者： Jin Hee Lee Hack-Keun Lee Dong Hyun Chun Hyunkyung Choi Geun Bae Rhim Min Hye Youn Heondo jeong shin Wook Kang Jung-ll Yang Heon Jung Chui Sung Kim Ji Chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

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Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket

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World Journal of Gastroenterology 2012年第25期18卷 3327-3330页

作者： Hyun Jung Chung Seok jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Byoung Wook Bang Kye Sook Kwon Hyung Kil Kim Yong Woon shin Young Soo Kim Division of Gastroenterology Department of Internal MedicineInha University School of MedicineIncheon 400-711South Korea

Mechanical lithotripsy(ML) is usually considered as a standard treatment option for large bile duct ***,it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the ***,there is no established endoscopic extraction method for such giant stone *** describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket.A 78-year-old woman had suffered from upper abdominal pain for 20 ***-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct(CBD).Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large *** attempt to capture the stone using a standard lithotripsy basket failed due to the large stone ***,we used a gastric bezoar basket to successfully capturethe *** stone was fragmented into small pieces and *** stone was completely removed after two sessions of endoscopic retrograde cholangiopancreatography;each of which took 30 *** complications occurred during or after the *** patient was fully recovered and discharged on day 11 of *** using a gastric bezoar basket is a safe and effective retrieval method in select cases,and is considered as an alternative nonoperative option for the management of difficult CBD stones.

关键词：胆总管结石手术治疗碎石机械粪胃提取方法使用标准

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Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee jeong-Tae Koh Hong-In shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

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Effect of ischemic preconditioning on antioxidant status in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第7期11卷 1081-1089页

作者： Seung Min Park Chan Woo Park Tae-Kyeong Lee jeong Hwi Cho Joon Ha Park Jae-Chul Lee Bai Hui Chen Bich-Na shin Ji Hyeon Ahn Hyun-Jin Tae Myoung Cheol shin Taek Geun Ohk Jun Hwi Cho Moo-Ho Won Soo Young Choi In Hye Kim Department of Emergency Medicine Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University Department of Neurobiology School of MedicineKangwon National University Department of Physiology College of MedicineHallym University Department of Biomedical Science Research Institute of Bioscience and BiotechnologyHallym University

Ischemic preconditioning（IPC） is a condition of sublethal transient global ischemia and exhibits neuroprotective effects against subsequent lethal ischemic ***,in this study,examined the neuroprotective effects of IPC and its effects on immunoreactive changes of antioxidant enzymes including superoxide dismutase（SOD） 1 and SOD2,catalase（CAT） and glutathione peroxidase（GPX） in the gerbil hippocampal CA1 region after transient forebrain *** neurons of the stratum pyramidale（SP） in the hippocampal CA1 region of animals died 5 days after lethal transient ischemia without IPC（8.6%（ratio of remanent neurons） of the sham-operated group）;however,IPC prevented the pyramidal neurons from subsequent lethal ischemic injury（92.3%（ratio of remanent neurons） of the sham-operated group）.SOD1,SOD2,CAT and GPX immunoreactivities in the sham-operated animals were easily detected in pyramidal neurons in the stratum pyramidale（SP） of the hippocampal CA1 region,while all of these immunoreactivities were rarely detected in the stratum pyramidale at 5 days after lethal transient ischemia without ***,their immunoreactivities in the sham-operated animals with IPC were similar to（SOD1,SOD2 and CAT） or higher（GPX） than those in the sham-operated animals without ***,their immunoreactivities in the stratum pyramidale of the ischemia-operated animals with IPC were steadily maintained after lethal ischemia/*** of western blot analysis for SOD1,SOD2,CAT and GPX were similar to immunohistochemical *** conclusion,IPC maintained or increased the expression of antioxidant enzymes in the stratum pyramidale of the hippocampal CA1 region after subsequent lethal transient forebrain ischemia and IPC exhibited neuroprotective effects in the hippocampal CA1 region against transient forebrain ischemia.

关键词： hippocampal operated antioxidant stratum subsequent superoxide glutathione neuronal hippocampus peroxidase

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Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

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Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： Kyungmin Hwang Yeong-Hyeon Seo Daniel YKim Jinhyo Ahn Soyoung Lee Kyung Hee Han Koun-Hee Lee Sangyong Jon Pilhan Kim Kate EYu Hyungsin Kim shin-Hyuk Kang Ki-Hun jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

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Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-Yeon Go Ju Ah Lee Sunyoung Park Sunju Park jeong-Su Park Chunhoo Cheon Seong-Gyu Ko Kyung-Hwan Kong Chan-yong Jun Jong-hyeong Park Mi-Ran shin Se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical Research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University Center for Clin ical Research and Genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词：随机对照试验温度差木炭艾草健康体内临床试验交叉设计

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Glutathione-S-transferase (GSTM1,GSTT1) and the risk of gastrointestinal cancer in a Korean population

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World Journal of Gastroenterology 2009年第45期15卷 5716-5721页

作者： Jin-Mei Piao Min-Ho shin Sun-Seog Kweon Hee Nam Kim Jin-Su Choi Woo-Kyun Bae Hyun-jeong Shim Hyeong-Rok Kim Young-Kyu Park Yoo-Duk Choi Soo-Hyun Kim Department of Preventive Medicine Chonnam National University Medical School Gwangju 501-746 South Korea Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Genome Research Center for Hematopoietic Diseases Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Surgery Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Department of Laboratory Medicine Chormam National University Medical School Gwangju 501-746 South Korea

AIM: To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean ***: We conducted a population-based, largescale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypesof GSTM1 and GSTT1 were determined using realtime ***: The null genotypes of GSTM1 and GSTT1 were not signifi cantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorec-tal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal ***: GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans.

关键词： GSTM1基因谷胱甘肽S 胃肠道肿瘤韩国人转移酶风险人口聚合酶链反应

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Differentiation of hepatocellular carcinoma from its variousmimickers in liver magnetic resonance imaging:What arethe tips when using hepatocyte-specific agents?

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World Journal of Gastroenterology 2016年第1期22卷 284-299页

作者： Yang shin Park Chang Hee Lee jeong Woo Kim Sora shin Cheol Min Park Department of Radiology Korea University Guro HospitalKorea University College of MedicineSeoul 152-703South Korea Korea University College of Medicine Anam-dong 5-gaSeongbuk-GuSeoul 136-701South Korea

Hepatocellular carcinoma is the most common primary hepatic malignant *** widespread use of liver imaging,various cirrhosis-related nodules are frequently detected in patients with chronic liver disease,while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging(MRI).However,use of hepatocyte-specific MR contrast agents with combined perfusion and hepatocyte-selective properties have improved diagnostic performance in detection and characterization of focal liver ***,the enhancement patterns observed during dynamic phases using hepatocyte-specific agents may be different from those observed during MRI using conventional extracellular fluid agents,leading to confusion in ***,we discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.

关键词： Hepatocellular carcinoma Gadoxetic acid Magnetic resonance imaging Liver cirrhosis

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