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辅助化疗后的中低位直肠癌采用腹腔镜手术不影响远期无瘤生存(COREAN研究)

消化肿瘤杂志（电子版） 2015年第3期7卷 160-160页

作者： jeong sy Park JW Nam BH 侯洵

背景和目的既往研究表明,在结肠癌的治疗上,腹腔镜手术与开放手术相比不增加并发症的发生率,且具有更好的短期疗效及类似的远期疗效。对于直肠癌患者来说,尽管腹腔镜手术相比开放手术在近期疗效上有一定优势,但在远期疗效的获益上缺少... 详细信息

背景和目的既往研究表明,在结肠癌的治疗上,腹腔镜手术与开放手术相比不增加并发症的发生率,且具有更好的短期疗效及类似的远期疗效。对于直肠癌患者来说,尽管腹腔镜手术相比开放手术在近期疗效上有一定优势,但在远期疗效的获益上缺少足够的高级别证据支持。COREAN研究旨在比较新辅助化疗后中低位直肠癌选择开放或腹腔镜手术的远期生存情况,从而为腹腔镜手术治疗中低位直肠癌提供循证医学证据。方法 COREAN研究是一项非盲、非劣的随机对照研究。该研究从2006年4月4日开始,2009年8月26日结束,共有3个韩国医疗中心参与。研究对象为术前曾接受新辅助放化疗的18~80岁、c T_3N0-2M0、中低位直肠腺癌(距离肛缘≤9 cm)患者。受试者术前接受5.5周、累计50.4Gy的放射治疗,其中45 Gy分25份行盆腔照射,5.4 Gy分3份作为肿瘤局部照射的补量,同时在放疗期间予每天两次、每次825 mg/m^2的卡培他滨口服,或是在放疗的第1、5周分别给予一个疗程静脉化疗,方案为每天400 mg/m2的5-FU及20 mg/m2的外消旋D,L-甲酰四氢叶酸静脉输注,每个疗程共3天。6~8周后受试者1∶1随机分配到开放手术组或腹腔镜手术组,并按性别及术前新辅助化疗方案随机分层,所有病例均完成全直肠系膜切除并保留自主神经。主要研究终点为3年无瘤生存率。本研究在Clinical ***注册,注册号为NCT0040951。结果该研究一共纳入340例患者,开放手术组(170例)和腹腔镜手术组(170例)在年龄、性别、ASA分级、术前CEA水平、临床N分期、肿瘤距肛缘距离、术前化疗方案、术后化疗方案上无统计学差异。术后3年两组的无瘤生存率分别为72.5%(95%CI:65.0~78.6)和79.2%(95%CI:72.3~84.6),两者间的差异(-6.7%,95%CI:-15.8~2.4,P<0.0001)低于预先定义的非劣区间(15%)。开放手术组和腹腔镜手术组分别有25例(15%)和20例(12%)患者死亡,均与治疗无关。开放手术组和腹腔镜手术组分别有39例(23%)及31例(18%)患者复发。结论本研究显示,局部进展期直肠癌在进行新辅助放化疗后选择腹腔镜手术与开放手术有相似的无瘤生存率,这为腹腔镜手术在直肠癌治疗中的应用提供了有力证据。

关键词：中低位直肠癌腹腔镜手术化疗后无瘤生存直肠癌患者循证医学证据随机对照研究新辅助放化疗

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Tertiary syphilis mimicking hepatic metastases of underlying primary peritoneal serous carcinoma

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World Journal of Hepatology 2010年第9期2卷 362-366页

作者： Hyun jeong Shim Chonnam National University Hwasun Hosp ital 160 IlsimriHwasun-eupHwasun-gun

Tertiary syphilis,especially in cases involving visceral gummatous disease,can be confused with cancer of the solid *** report a case of tertiary hepatic syphilis that manifested with intrahepatic masses in a patient who had an underlying primary peritoneal serous carcinoma (PPSC).The patient was diagnosed with PPSC and achieved a complete remission of PPSC following six cycles of platinum-based *** hepatic nodules developed during the follow-up period and were initially labeled as hepatic metastases from the underlying PPSC,based on radiological findings.A resection of hepatic nodules was performed for therapeutic and diagnostic purposes,because there were no other metastatic foci except in the ***-pectedly,serology and histology confirmed tertiary sy *** rare case emphasizes the importance of including tertiary syphilis in the differential diagnosis of a space-occupying lesion,even with an existing diagn osis of underlying cancer.

关键词： syphilis Neoplasm Peritoneal carcinoma Liver

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Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-Woong Woo Sang-Tae Kim Jae-Im Kwon Monica Young Choi Yu Sub Sung Kyung Won Kim jeong Kon Kim Yoonseok Choi Dong-Cheol Woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-sy)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-sy ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-sy group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

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支气管哮喘患者的BAL液中的IL-6和TNF-α

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中华结核和呼吸杂志 1997年第Z1期20卷 67-67页

作者： Park CS Lim GI Ki sy Moon SH jeong SW Kim HT Uh ST Kim YH 傅锦红(译) DivisionofAllergyandRespiratoryMedicain SoonChunHyangUniversitySeoulKorea

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Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144Bagnacavallo

Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,***,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species

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