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流程工业 2013年第1期 42-43页

作者： jens-peter kraus Klaus peter Mont Kumpugdee Vollrath 柏林Beuth枝术学院柏林Libel工程技术公司

在某一合作项目中，Beuth技术学院研发设计了一台新型的、利用喷雾技术生产较大面积薄膜的实验室设备。这一设备使得在实验室辊涂机外，通过重复生产对保护膜的形成和性能进行检验成为可能。本文介绍了这一设备的结构设计和首次测试的... 详细信息

在某一合作项目中，Beuth技术学院研发设计了一台新型的、利用喷雾技术生产较大面积薄膜的实验室设备。这一设备使得在实验室辊涂机外，通过重复生产对保护膜的形成和性能进行检验成为可能。本文介绍了这一设备的结构设计和首次测试的结果。

关键词：实验室设备制膜压铸喷膜喷雾技术结构设计合作项目辊涂机

Semen analysis from an epidemiologic perspective

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Asian Journal of Andrology 2010年第1期12卷 91-94页

作者： jens peter Ellekilde Bonde Department of Environmental and Occupational Medicine Copenhagen University Hospital Bispebjerg Bakke 23 2400Copenhagen NV Denmark

The fifth edition of the World Health Organization （WHO） manual for semen analysis includes for the first time reference values for human semen characteristics. This paper considers whether such values will help to resolve the intensely debated data indicating temporal and geographical shifts in sperm counts and hypotheses that anthropogenic activities that result in the release of chemicals into the environment are detrimental to male reproductive health. The reasons that these reference values will not fulfil these purposes are also explained. Although established reference values for semen characteristics are of limited value in analytical epidemiologic research, the WHO guidelines are of utmost importance for supporting the development of appropriate research protocols. Moreover, in spite of its limitations, semen analysis is still a useful research tool in epidemiological research, and no superior alternatives are on the horizon.

关键词： decline epidemiology reference values research semen analysis sperm counts

Environmental xenobiotics and male reproductive health

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Asian Journal of Andrology 2014年第1期16卷 3-4页

作者： jens peter Bonde Aleksander Giwercman Department of Occupational and Environmental Medicine Frederiksberg and Bispebjerg Hospital University of Copenhagen Denmark Reproductive Medicine Centre Skne University Hospital Maim6 Sweden.

Lessons from the occupational arena fdemonstrate the potential of industrial 4chemicals to damage human testicular function. An important but still unresolved question is whether low-level xenobiotic exposure of the general population poses a hazard. In this volume of the Asian Journal of Andrology, this issue is addressed by a series of reviews on xenobiotic exposure profiles, possible biological mechanisms, research methods and knowledge on impact of specific exposures. Interdisciplinary research fields as gene-environment interaction and male-mediated developmental toxicity is also addressed. Papers are cross-linked by answers to questions mutually put forward by the authors.

关键词： xenobiotics chemicals occupational

Barriers to WHO Mental Health Action Plan updates to expand family and caregiver involvement in mental healthcare

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General Psychiatry 2022年第2期35卷 154-156页

作者： jens peter Eckardt Research Unit Bedre PsykiatriCopenhagenDenmark

In 2021,the 74th World Health Assembly endorsed updates to the WHO's Comprehensive Mental Health Action Plan extending to 2030,including revised indicators to measure progress towards reaching defined targets and expa... 详细信息

关键词： expanded revised Action

Persistent organic pollutants and male reproductive health

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Asian Journal of Andrology 2014年第1期16卷 71-80页

作者： Anne Vested Aleksander Giwercman jens peter Bonde Gunnar Toil- Department of Occupational Medicine Danish Ramazzini Centre Aarhus University Hospital Aarhus Denmark Reproductive Medicine Centre Lund University Skane University Hospital Malm6 Sweden Department of Occupational and Environmental Medicine Bispebjerg Hospital of Copenhagen University

Environmental contaminants such as persistent organic pollutants （POPs） are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consumer products during the twentieth century. Wildlife and animal studies have long suggested adverse effects of exposure to these compounds on human reproductive health, which, according to the endocrine disrupter hypothesis, are ascribed to the compounds＇ potential to interfere with endocrine signaling, especially when exposure occurs during certain phases of fetal and childhood development. An extensive number of epidemiological studies have addressed the possible effects of exposure to POPs on male reproductive health, but the results are conflicting. Thus far, most studies have focused on investigating exposure and the different reproductive health outcomes during adulthood. Some studies have addressed the potential harmful effects of fetal exposure with respect to malformations at birth and/ or reproductive development, whereas only a few studies have been able to evaluate whether intrauterine exposure to POPs has long-term consequences for male reproductive health with measurable effects on semen quality markers and reproductive hormone levels in adulthood. Humans are not exposed to a single compound at a time, but rather, to a variety of different substances with potential divergent hormonal effects. Hence, how to best analyze epidemiological data on combined exposures remains a significant challenge. This review on POPs will focus on current knowledge regarding the potential effects of exposure to POPs during fetal and childhood life and during adulthood on male reproductive health, including a critical revision of the endocrine disruption hypothesis, a comment on pubertal development as part of reproductive development and a comment on how to account for combined exposures in epidemiological research.

关键词： endocrine disruption male reproduction persistent organic compounds reproductive hormones semen quality

Misconceptions about falling sperm counts and fertility in Europe

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Asian Journal of Andrology 2013年第2期15卷 195-198,I0005页

作者： Egbert R te Velde jens peter Bonde Department of Public Health Erasmus University MC Rotterdam GE 3015 The Netherlands Reproductive Medicine Utrecht University Utrecht CM 3584 The Netherlands Department of Occupational and Environmental Medicine Bispebjerg Hospital University of Copenhagen Copenhagen NV 24C0 Denmark

The Science Policy Briefing on male reproductive health pubfished by the authoritative European Science Foundation （ESF） in 2010 echoes the views expressed in the famous paper by *** et al, suggesting that mean sperm counts decreased by 50%. The authors are convinced that the male reproductive system in industrialized countries is under attack from envi- ronmental chemicals. This may have farreaching consequences for the reproductive capacity of future generations. Their arguments, however, contain some misconceptions about declining sperm quality and fertifity. Although there is reason for concern about the effect of environmental pollution, the authors＇ pessimism is not justified.

关键词： TIME TRENDS INFERTILITY TREATMENT REGIONAL DIFFERENCES WAITING TIME PREGNANCY SEMEN EPIDEMIOLOGY POPULATION PREVALENCE FECUNDITY

On environmental threats to male infertility

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Asian Journal of Andrology 2013年第2期15卷 199-200,I0005页

作者： Allen J Wilcox jens peter E Bonde Epidemiology Branch National Institute of Environmental Health Sciences Durham NC 27709-2233 USA Department of Occupational and Environmental Medicine University Hospital of Copenhagen Copenhagen NV DK-2400 Denmark

The possibility that environmental pollutants damage human fertility is a topic of both public concern and scientific interest. The effect of environmental factors on male fertility （semen parameters） has been a special focus, stimulated in part by the dramatic damage inflicted by the pcstlcide DBCP on testicular function. Extensive searches for testicular toxicants （in particular, the proposed effects of endocrine-disrupting compounds through fetal exposure） have produced little hard evidence of impairment in humans. This scarcity of evidence may reflect the difficultles of studying human fertility. Future fertifity studies should consider the wide spectrum of environmental exposures that plausibly affect reproduction.

关键词： TESTICULAR DYSGENESIS SYNDROME IN-UTERO EXPOSURE SPERM COUNTS SEMEN QUALITY ENDOCRINE DISRUPTION REPRODUCTIVE-TRACT FERTILITY PREGNANCY PHTHALATE SMOKING

Elastomeric lenses with tunable astigmatism

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Light(Science & Applications) 2013年第1期2卷 73-78页

作者： peter Liebetraut Sebastian Petsch jens Liebeskind Hans Zappe Gisela and Erwin Sick Chair of Micro-optics Department of Microsystems EngineeringUniversity of FreiburgFreiburg 79110Germany

Microlenses fabricated using flexible elastomers can be tuned in focal length by application of controlled *** varying the strain azimuthally,the lenses may be deformed asymmetrically such that aberrations may be *** approach is used to tune the astigmatism of the tunable lenses,and it is shown that the generated wavefront may be accurately *** lens presented here has an initial focal length of 32.6 mm and a tuning range of 12.3 mm for approximately 10%applied *** range of directly tunable Zernike polynomials representing astigmatism is about 3 mm,while the secondary lens errors,which cannot be tuned directly,vary only by about 0.2 mm.

关键词： aberrations active or adaptive optics micro-optical devices polymers

Low-income and overweight in China:Evidence from a life-course utility model

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Journal of Integrative Agriculture 2019年第8期18卷 1753-1767页

作者： REN Yan-jun Bente Castro Campos jens-peter Loy Stephan Brosig Institute of Agricultural Economics University of Kiel Kiel 24118 Germany Leibniz Institute of Agricultural Development in Transition Economies Halle (Saale) 06120 Germany

Previous literature has demonstrated that low-income people are more likely to settle for poor health choices in developed countries. By using income as a budget constraint and signal for future wellbeing in a life-course utility model, we examine the association amongst income and overweight. The data used for this study are from the China Health and Nutrition Survey(CHNS). Estimations are conducted for overweight initiation, cessation, and participation mirroring a decision to begin and a past decision to not terminate. Our findings propose that body weight and the likelihood of overweight commencement rise with additional income but at a diminishing degree, representing a concave relation;while the likelihood of overweight discontinuance declines with additional income but at an accelerating degree, suggesting a convex *** presume that, as opposed to developed countries, low-income people are less inclined to be overweight in China, a country in transition. This could be explained by an income constraint for unhealthy foodstuff. Nevertheless, it will switch when income surpasses the critical threshold of the concave or inverted U-shape curve indicating that low-income people appear to receive not as much utility from future health. Specifically, this adjustment seems to occur earlier for females and inhabitants of urban areas.

关键词： low-income overweight life-course utility China

Extracellular matrices for gastrointestinal surgery:Ex vivo testing and current applications

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World Journal of Gastroenterology 2010年第32期16卷 4031-4038页

作者： jens Hoeppner Goran Marjanovic peter Helwig Ulrich Theodor Hopt Tobias Keck Department of General and Visceral Surgery University of FreiburgFreiburg 79106Germany Department of Orthopedics and Traumatology University of FreiburgFreiburg 79106Germany

AIM:To assess the effects of bile and pancreatic juice on structural and mechanical resistance of extracellular matrices(ECMs) in ***:Small-intestinal submucosa(SIS),porcine dermal matrix(PDM),porcine pericardial matrix(PPM) and bovine pericardial matrix(BPM) were incubated in human bile and pancreatic juice in *** were examined by macroscopic observation,scanning electron microscopy(SEM) and testing of mechanical ***:PDM dissolved within 4 d after exposure to bile or pancreatic ***,PPM and PDM retained their integrity for > 60 d when incubated in either digestive *** effect of bile was found to be far more detrimental to mechanical stability than pancreatic juice in all tested *** SIS,the loss of mechanical stability after incubation in either of the digestive secretions was less distinct than in PPM and BPM [mFmax 4.01/14.27 N(SIS) vs 2.08/5.23 N(PPM) vs 1.48/7.89 N(BPM)].In SIS,the extent of structural damage revealed by SEM was more evident in bile than in pancreatic *** PPM and BPM,structural damage was comparable in both ***:PDM is less suitable for support of gastrointestinal *** SIS,PPM and BPM should also be evaluated experimentally for gastrointestinal indications.

关键词： Extracellular matrix Intestinal regeneration Ex-vivo testing Gastrointestinal surgery Gastrointestinal fistula Bioscaffolding