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Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology

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World Journal of Gastroenterology 2011年第7期17卷 922-925页

作者： Mikkel Malham SΦren peter JΦrgensen peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre jens F Dahlerup Department of Medicine V (Hepatology and Gastroenterology) Aarhus University Hospital

AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.

关键词： Alcoholic liver cirrhosis Child-Pugh score Primary biliary cirrhosis Vitamin D deficiency

Heat development at the knife roller during leather shaving

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Journal of Leather Science and Engineering 2021年第1期3卷 202-212页

作者： Tilman Witt Anke Mondschein jens-peter Majschak Michael Meyer Chair of Processing Machines and Processing Technology Technische Universitat Dresden01062 DresdenGermany Forschungsinstitut fur Leder und Kunststoffbahnen(FILK)gGmbH MeißnerRing 1-509599 FreibergGermany

Leather,which is regularly tanned from whole hides of up to 5 m 2,needs a constant thickness over the entire surface in order to be processed into high-quality consumer goods such as shoes,furniture and car *** adjustment of the thickness is achieved by *** an industrial scale,rotating knife rollers are used to remove chips from the flesh side of semi-finished leathers whereby adjusting the specified thickness and generating a smooth *** must be taken to prevent the temperature from rising above the denaturation temperature of the leather during shaving in order to avoid any loss of *** this,temperature rise is always a sign of friction showing avoidable energy *** order to localize the source of friction during shaving,actual temperature development at the roller knife is *** measuring methods are used to evaluate the temperature increase at the blade roll of the shaving *** finite element method is used to thermally simulate the *** temperatures,the geometry of the blade roll and process data are taken into account for modelling the temperature development close to the blade *** obtained results enhance the understanding of temperature generating processes during machine operation and allow conclusions about potential improvements in the design of the machine and blades.

关键词： Leather Shaving Knife roller Transient thermal simulation

Sildenafil does not influence hepatic venous pressure gradient in patients with cirrhosis

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World Journal of Gastroenterology 2008年第40期14卷 6208-6212页

作者： jens Otto Clemmesen Annamaria Giraldi peter Ott Kim Dalhoff Bent Adel Hansen Fin Stolze Larsen Department of Hepatology RigshospitaletUniversity Hospital of Copenhagen Clinical Pharmacology RigshospitaletUniversity Hospital of Copenhagen

AIM： To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient （HVPG） in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown. METHODS： Ten patients with biopsy proven cirrhosis （five females/five males, mean age 54：1：8 years） and an HVPG above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick＇s principle, with correction for non-steady state. RESULTS： The plasma concentration of sildenafil was 222 ± 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 ±7 mmHg to 66 ± 12 mmHg, P = 0.003, while the splanchnicblood flow and oxygen consumption remained unchanged at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min, respectively. Also the HVPG remained unchanged （18 ± 2 mmHg vs 16 ± 2 mmHg） with individual changes ranging from -8 mmHg to ±2 mmHg. In seven patients, HVPG decreased and in three it increased. CONCLUSION： In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.

关键词： Cirrhosis Sildenafil Portal hypertension Portal hemodynamics Hepatic blood flow Erectile dysfunction Hepatic venous pressure gradient

Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT:Initial results

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World Journal of Gastroenterology 2009年第46期15卷 5827-5832页

作者： Miriam Klauβ Max Schbinger Ivo Wolf jens Werner Hans-peter Meinzer Hans-Ulrich Kauczor Lars Grenacher Department of Diagnostic and Interventional Radiology University of Heidelberg Department of Medical and Biological Informatics German Cancer Research Center(DKFZ) Surgical Clinic University of Heidelberg

AIM:To evaluate the use of three-dimensional imaging of pancreatic carcinoma using multidetector computed tomography(CT)in a prospective ***:Ten patients with suspected pancreatic tumors were examined prospectively using multidetec-tor CT(Somatom Sensation 16,Siemens,Erlangen,Germany).The images were evaluated for the pres-ence of a pancreatic carcinoma and invasion of the peripancreatic vessels and surrounding *** the isotropic CT data sets,a three-dimensional image was created with automatic vascular analysis and semi-automatic segmentation of the organs and pancreatic tumor by a *** CT examinations and the three-dimensional images were presented to the sur-geon directly before and during the patient's operation using the Medical Imaging Interaction Toolkit-based software "ReLiver".Immediately after surgery,the value of the two images was judged by the *** operation and the histological results served as the gold ***:Nine patients had a pancreatic carcinoma(all pT3),and one patient had a serous *** tumor inf iltrated the superior mesenteric *** inf iltration was correctly *** carcinomas were *** comparison to the CT image with axial and coronal reconstructions,the three-dimensional image was judged by the surgeons as better for operation planning and consistently described as ***:A 3D-image of the pancreas repre-sents an invaluable aid to the ***,the 3D-software must be further developed in order to be integrated into daily clinical routine.

关键词： Pancreatic carcinoma 3D-reconstruction Multidetector computed tomography Pancreatic carcinomainvasion Segmentation

Microvascular invasion of hepatocellular carcinoma predicts microvascular invasion of its recurrence: potential implications for salvage liver transplantation?

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 183-191页

作者： Stefan Heinrich jens Mittler Juliane Theurer Dirk ARidder jens UMarquardt Arndt Weinmann Uwe Scheuermann Gerd Otto peter RGalle Beate KStraub Hauke Lang General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany Institute of Pathology University Hospital of MainzMainzGermany Department of Medicine I University Medical Center Schleswig-HolsteinCampus LübeckGermany Department of Medicine I University Hospital of MainzMainzGermany Visceral TransplantationThoracic and Vascular SurgeryUniversity Hospital LeipzigLeipzigGermany

Background:Microvascular invasion(MVI)can only be assessed on a full surgical *** aimed at evaluating,whether the histology of the primary tumor is predictive of MVI in a hepatocellular carcinoma(HCC)***:Patients,who underwent liver resection or orthotopic liver transplantation(OLT)for recurrent HCC from January 2001 until June 2018 were eligible for this retrospective *** specimens were evaluated for HCC subtype/morphology,vessels encapsulating tumor clusters(VETC)-pattern and *** parameters were analyzed using χ^(2)-test andϕ-values,with P values<0.05 being considered ***:Of 230 HCC recurrences,37(16.1%)underwent repeated liver resection(n=22)or OLT(n=15).Of these,67.6%initially exceeded the Milan *** correlated Milan criteria(P=0.005),tumor size(P=0.015)and VETC-pattern(P=0.034)in the primary *** recurrences shared many features of the primary HCC such as tumor grade(P=0.002),VETC-pattern(P=0.035),and MVI(P=0.046).In recurrences,however,only the concordance with the Milan criteria correlated with MVI(P=0.018).No patient without MVI in the primary HCC revealed MVI on early recurrence(<2 years)(P=0.035).Conclusions:HCC recurrences share many biological features of the primary ***,early recurrences of MVI-negative HCC never revealed *** finding offers novel concepts,e.g.,patient selection for salvage OLT.

关键词： Microvascular invasion(MVI) resection selection vessels encapsulating tumor clusters(VETC) angioinvasion salvage transplantation

Deep hyperammonemic hepatic encephalopathy precipitated by fecal microbiota transplantation for fulminant Clostridioides difficile infection

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Gastroenterology Report 2022年第1期10卷 612-614页

作者： Lotte Lindgreen Eriksen Simon Mark Dahl Baunwall peter Lykke Eriksen Kirstine Petrea Bak-Fredslund jens Erik Nielsen jens Frederik Dahlerup Karen Louise Thomsen Hendrik Vilstrup Christian Lodberg Hvas Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus NDenmark Department of Hepatology and Gastroenterology Randers Regional HospitalRandersDenmark Department of Radiology Aarhus University HospitalAarhus NDenmark

Introduction Fecal microbiota transplantation(FMT)is highly effective and potentially life-saving for recurrent Clostridioides difficile infection(CDI)[1].Recent pilot trials also reported the use of FMT to revert hepatic encephalopathy(HE)in patients with decompensated liver cirrhosis without infectious colitis[2,3].Intestinal microbiota-driven hyperammonemia is central to HE development and most treatments aim to reduce ammonia levels by modulating the intestinal ***,FMT might lead to increased intestinal ammonia production,as we describe here.

关键词： hepatic infection encephalopathy

Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1

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World Journal of Gastroenterology 2007年第36期13卷 4881-4890页

作者： jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr peter Funch-jensen AsbjΦrn Mohr Drewes Hans Gregersen Center for Visceral Biomechanics and Pain Aalborg Hospital Aalborg Denmark Department of Radiology Aalborg Hospital Aalborg Denmark Department of Endocrinology M Aarhus University Hospital Aarhus Denmark Department of Surgical Gastroenterology L Aarhus University Hospital Aarhus Denmark Center for Sensory-Motor Interaction Department of Health Science and Technology Aalborg University Denmark Center for Sensory-Motor Interaction Department of Health Science and Technology Aalborg University Denmark National Center for Ultrasound in Gastro-enterology Haukeland University Hospital Bergen Norway

AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms.

关键词： Diabetes Autonomic Neuropathy Bio- mechanics Contractility Ultrasound Esophagus Duodenum Deformation Stress

Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection of Helicobacter pylori

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World Journal of Gastroenterology 2023年第10期29卷 1638-1647页

作者： Riccardo Vasapolli Florent Ailloud Sebastian Suerbaum jens Neumann Nadine Koch Lukas Macke Jörg Schirra Julia Mayerle peter Malfertheiner Christian Schulz Medical DepartmentⅡ University Hospital LMU MunichMunich 81377Germany Deutsches Zentrum für Infektionsforschung Partner Site MunichMunich 81377Germany Max von Pettenkofer Institute Faculty of MedicineLudwig-Maximilians University of MunichMunich 80336Germany National Reference Center for Helicobacter pylori Munich 81377Germany Institute of Pathology Faculty of MedicineLudwig-Maximilians-University of MunichMunich 81377Germany

BACKGROUND Endofaster is an innovative technology that can be combined with upper gastrointestinal endoscopy(UGE)to perform gastric juice analysis and real-time detection of Helicobacter pylori(***).AIM To assess the diagnostic performance of this technology and its impact on the management of *** in the real-life clinical *** Patients undergoing routine UGE were prospectively *** were taken to assess gastric histology according to the updated Sydney system and for rapid urease test(RUT).Gastric juice sampling and analysis was performed using the Endofaster,and the diagnosis of *** was based on real-time ammonium *** detection of *** served as the diagnostic gold standard for comparing Endofaster-based *** diagnosis with RUT-based *** *** A total of 198 patients were prospectively enrolled in an *** diagnostic study by Endofasterbased gastric juice analysis(EGJA)during the *** for RUT and histological assessment were performed on 161 patients(82 men and 79 women,mean age 54.8±19.2 years).*** infection was detected by histology in 47(29.2%)***,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value(NPV)for *** diagnosis by EGJA were 91.5%,93.0%,92.6%,84.3%,and 96.4%,*** patients on treatment with proton pump inhibitors,diagnostic sensitivity was reduced by 27.3%,while specificity and NPV were *** and RUT were comparable in diagnostic performance and highly concordant in *** detection(κ-value=0.85).CONCLUSION Endofaster allows for rapid and highly accurate detection of *** during *** may guide taking additional biopsies for antibiotic susceptibility testing during the same procedure and then selecting an individually tailored eradication regimen.

关键词： Helicobacter pylori diagnostic Chronic gastritis Gastric juice Endofaster Rapid urease test Antimicrobial susceptibility testing

Effects of 3 months of full-court and half-court street basketball training on health profile in untrained men

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Journal of Sport and Health Science 2018年第2期7卷 132-138页

作者： Morten B.Randers Marie Hagman Jonathan Brix Jesper F.Christensen Mogens T.Pedersen jens J.Nielsen peter Krustrup Department of Sports Science and Clinical Biomechanies SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 5230 Denmark Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen 2200 Denmark Centre oflnflammation and Metabolism (CIM) and Centre for Physical Activity Research (CFAS) Rigshospitalet Faculty of Health Science Copenhagen University Hospital 7641 University of Copenhagen Copenhagen 2100 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The aim of the present study was to investigate whether street basketball organized as 3 v 3 on either a half court(HC) with 1 basket or a full court(FC) with 2 baskets could improve fitness and health profiles of untrained men after 3 months of supervised ***: Thirty-five untrained men(aged 20—42 years) completed the pre-and post-intervention testing(FC: n = 13, HC: n = 12, CO(control):n = 10). The training attendance was 2.0 ± 0.4 and 1.9 ± 0.3 times per week in FC and HC, respectively. Mean heart rate(HR) was 83.8 ± 6.0 percent of maximal heart rate(%HR_(max)) and 84.5 ± 2.9 %HR_(max) in FC and HC, ***: The 3 months of street basketball training on an FC with 2 baskets increased maximal oxygen uptake(2.4 mL/min/kg(95% confidence interval(CI): 1.0—3.9)), time to exhaustion(47 s(95%CI: 26—67)), lean body mass(0.8 kg(95%CI: 0.1—1.5)), and bone mineral density(0.021 g/cm^2(95%CI: 0.011—0.031)), whereas mean arterial pressure(—5.6 mm Hg(95%CI: —7.5 to 3.7)), body fat percentage(—1.6%,(95%CI: —2.5 to —0.7)), heart rate(—18 bpm(95%CI: —24 to —12)), and blood lactate(median: —1.4 mmol/L(interquartile range: —1.5 to —0.6)) during submaximal running were lowered. The changes were less pronounced after the training period when playing on an HC with 1 basket, but increases in maximal oxygen uptake(1.6 mL/min/kg(95%CI: —0.1 to 3.3)), time to exhaustion(28 s(95%CI: 9—47)), lean body mass(1.3 kg(95%CI: 0.3—2.4)), and lower body fat percentage(—0.9%(95%CI: —1.9 to —0.1)) were observed in this ***: Three months of 3 v 3 street basketball training improved fitness and led to broad-spectrum improvements in variables related to overall health profile, with the most marked effects observed when playing on an FC with 2 baskets.

关键词： Blood pressure Body composition Cardiovascular fitness Maximal oxygen uptake Muscoloskeletal fitness Physical demands Small-sided games Team sport