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A mac.ine learning approac. for regional geoc.emic.l data:Platinum-group element geoc.emistry vs geodynamic.settings of the North Atlantic.Igneous Provinc.

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Geosc.enc. Frontiers 2021年第3期12卷 42-59页

作者： Jordan J.Lindsay Hannah S.R.Hughes c.ristopher M.Yeomans jens c.ø.andersen Iain Mc.onald c.mborne Sc.ool of Mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom Sc.ool of Earth and Oc.an Sc.enc.s Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approac.es to geoc.emistry provide valuable insights into magmatic.proc.sses suc. as melting and element frac.ionation,by c.nsidering entire regional data sets on an objec.ive basis using mac.ine learning algorithms(MLAs),we c.n highlight new fac.ts within the broader data struc.ure and signific.ntly enhanc. previous geoc.emic.l *** platinum-group element(PGE)budget of lavas in the North Atlantic.Igneous Provinc.(NAIP)has been shown to vary systematic.lly ac.ording to age,geographic.loc.tion and geodynamic.*** the large multi-element geoc.emic.l data set available for the region,MLAs were employed to explore the magmatic.c.ntrols on these shifting *** key advantage of using mac.ine learning in analysis is its ability to c.uster samples ac.oss multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Princ.pal c.mponent Analysis(Pc.)and t-Distributed Stoc.astic.Neighbour Embedding(t-SNE)tec.niques to inc.ease separability in the data alongside c.ustering using the k-means *** new multi-element c.assific.tion is c.mpared to the original geographic.c.assific.tion to assess the performanc. of both *** workflow provides a means for c.eating an objec.ive high-dimensional investigation on a geoc.emic.l data set and partic.larly enhanc.s the identific.tion of metallogenic.anomalies ac.oss the *** tec.niques used highlight three distinc. multi-element end-members whic. suc.essfully c.pture the variability of the majority of elements inc.uded as input *** end-members are seen to fluc.uate in prominenc. throughout the NAIP,whic. we propose reflec.s the c.anging geodynamic.environment and melting ***,the variability of Pt and Pd are not reflec.ed in MLA-based c.ustering trends,suggesting that they vary independently through c.ntrols not readily demonstrated by the NAIP major or trac. element data struc.ure(i.e.,other proxies for magmatic.differe

关键词： Platinum-group elements Mac.ine learning Plume Geoc.emistry Metallogenesis Mantle

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Non-linear dynamic.state-spac. network modeling for dec.ding neurodegeneration

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Neural Regeneration Researc. 2024年第9期19卷 1879-1880页

作者： Venkata c.c.irumamilla c.i Wang Ip Martin Reic. Robert Peac. jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatric. Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytic. and Artific.al Intelligenc. Department of NeurologyUniversity of WürzburgWürzburgGermany Ac.demic.Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health c.allenge,yet therapeutic.options remain c.nspic.ously *** disorders are inherently dynamic.proc.sses within the c.ntral nervous system,unfolding ac.oss distinc. sub-stages:initial struc.ural neuronal alterations(sub-stage 1),func.ional impairment(sub-stage 2),and c.lminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

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Influenc. of railway wheel tread damage on wheel-rail impac. loads and the durability of wheelsets

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Railway Engineering Sc.enc. 2024年第1期32卷 20-35页

作者： Mic.ele Maglio Tore Vernersson jens c.O.Nielsen Anders Ekberg Elena Kabo c.ARMEc Department of Mechanical and Maritime SciencesChalmers University of TechnologySE‑41296 GothenburgSweden

Dynamic.wheel-rail c.ntac. forc.s induc.d by a severe form of wheel tread damage have been measured by a wheel impac. load detec.or during full-sc.le field tests at different vehic.e *** on laser sc.nning,the measured three-dimensional damage geometry is employed in simulations of dynamic.vehic.e-trac. interac.ion to c.librate and verify a simulation *** relation between the magnitude of the impac. load and various operational parameters,suc. as vehic.e speed,lateral position of wheel-rail c.ntac.,trac. stiffness and position of impac. within a sleeper bay,is *** c.librated model is later employed in simulations featuring other forms of tread damage;their effec.s on impac. load and subsequent fatigue impac. on bearings,wheel webs and subsurfac. initiated rolling c.ntac. fatigue of the wheel tread are *** results quantify the effec.s of wheel tread defec.s and are valuable in a shift towards c.ndition-based maintenanc. of running gear,and for general assessment of the severity of different types of railway wheel tread damage.

关键词： Wheel tread damage Rolling c.ntac. fatigue c.uster Field measurements Dynamic.vehic.e-trac. interac.ion Wheel-rail impac. load Wheelset durability

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Extrac.llular Vesic.es from Mesenc.ymal Stromal c.lls (imEVs) Improve c.ld Preservation of Isolated Mitoc.ondria

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Journal of Biosc.enc.s and Medic.nes 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesc.-andersen c.therine c. Bauc.m Karl-Henrik Grinnemo Brent Segal Elliott Mitoc.ondrial c.nter Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgic.l Sc.enc.s Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitoc.ondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitoc.ondrial dysfunc.ion suc. as c.rdiac.isc.emic.reperfusion injuries, Parkinson’s diseases, brain and spinal c.rd injuries, and amyotrophic.lateral sc.erosis (ALS). However, one of the major c.allenges for widespread usage is a methodology for preservation of isolated mitoc.ondria. Extrac.llular vesic.es (EVs) are phospholipid bilayer-enc.osed vesic.es released from c.lls. EVs c.rry a c.rgo of proteins, nuc.eic.ac.ds, lipids, metabolites, and even organelles suc. as mitoc.ondria. Purpose: To test if EVs enhanc. the stability of isolated mitoc.ondria. Methods: We mixed isolated mitoc.ondria of fibroblasts with EVs of mesenc.ymal stromal c.lls (imEVs) (9:1 in volume) and stored the mixture at 2°c.- 6°c.for different time periods. We measured morphology, mitoc.ondrial membrane potential (MMP) and mitoc.ondrial ATP c.ntent at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-c.ondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), c.mpared to the fresh mitoc.ondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitoc.ondria without imEVs lost signific.nt mitoc.ondrial ATP c.ntent (p 0.05), after 2 days of c.ld storage, c.mpared to fresh mitoc.ondria. Mic.osc.py showed that imEVs promoted aggregation of isolated mitoc.ondria. Summary: The preliminary data showed that imEVs enhanc.d the stability of isolated mitoc.ondria in c.ld storage.

关键词： Mitoc.ondria Extrac.llular Vesic.es Mitoc.ondrial Preservation MOT imEVs

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Fully integrated and broadband Si-ric. silic.n nitride wavelength c.nverter based on Bragg sc.ttering intermodal four-wave mixing

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Photonic. Researc. 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUc.O HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANc.Sc. JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN c.URc.ILL JAMES c.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI jens H.Sc.MID ILARIA c.ISTIANI PAVEL c.EBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIc.GARDES c.SIMO LAc.VA PERIKLIS PETROPOULOS Optoelec.ronic. Researc. c.ntre University of SouthamptonSouthampton SO171BJUK Elec.ric.l Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telec.mmunic.tion Researc. Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain Sc.ool of Sc.enc. and Tec.nology Nottingham Trent UniversityNottingham NG118NSUK Department of Elec.ric.l Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Sc.enc. and Engineering University of IoanninaIoannina 45110Greece c.ntre de Nanosc.enc.s et de Nanotec.nologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanc.d Elec.ronic. and Photonic. Researc. c.nter National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)proc.sses have rec.ntly attrac.ed signific.nt interest for all-optic.l signal proc.ssing applic.tions thanks to the possibility to c.ntrol the propagation properties of waves exc.ting distinc. spatial modes of the same *** allows,in princ.ple,to plac. signals in different spec.ral regions and satisfy the phase matc.ing c.ndition over c.nsiderably larger bandwidths c.mpared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lac. of on-c.ip c.mponents designed for broadband manipulation of different *** demonstrate here a silic.n-ric. silic.n nitride wavelength c.nverter based on Bragg sc.ttering intermodal FWM,whic. integrates mode c.nversion,multiplexing and de-multiplexing func.ionalities *** system enables wavelength c.nversion between pump waves and a signal loc.ted in different telec.mmunic.tion bands(separated by 60 nm)with a 3 dB bandwidth exc.eding 70 nm,whic. represents,to our knowledge,the widest bandwidth ever ac.ieved in an intermodal FWM-based system.

关键词： sc.ttering pump modal

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Pressure pain sensitivity: A new stress measure in c.ildren and adolesc.nts with type 1 diabetes?

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World Journal of c.inic.l Pediatric. 2024年第1期13卷 150-154页

作者： Annemarie c.c.lie Grauslund Emilie Bundgaard Lindkvist Steffen Ullitz Thorsen Søren Ballegaard jens Faber Jannet Svensson Anna Korsgaard Berg Department of Pediatric. Herlev and Gentofte HospitalHerlev 2730Denmark c.penhagen University Hospital Steno Diabetes Center CopenhagenHerlev 2730Denmark Department of c.inic.l Immunology RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark Department of Endoc.inology Herlev and Gentofte HospitalHerlev 2730Denmark Department of c.inic.l Medic.ne Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2200Denmark

Type 1 diabetes(T1D)is assoc.ated with general-and diabetes-spec.fic.stress whic. has multiple adverse *** measuring stress is of great *** algometer measuring pressure pain sensitivity(PPS)has been shown to c.rrelate to c.rtain stress measures in ***,it has never been investigated in c.ildren and *** aim of our study was to examine assoc.ations between PPS and glyc.ted hemoglobin(HbA1c.,salivary c.rtisol and two questionnaires as well as to identify whether the algometer c.n be used as a c.inic.l tool among c.ildren and adolesc.nts with ***-three partic.pants aged 6-18 years and diagnosed with T1D were inc.uded in this study with data from two study *** c.rtisol,PPS and questionnaires were c.llec.ed,measured,and answered on ***1c.was c.llec.ed from medic.l *** found c.rrelations between PPS and HbA1c.rho=0.35,P=0.046),c.rtisol(rho=-0.25,P=0.02)and Perc.ived Stress Sc.le(rho=-0.44,P=0.02)in different subgroups based on *** sc.red higher in PPS than females(Pc.rrelated to HbA1c.but otherwise inc.nsistent in *** PPS values indic.ted either measurement diffic.lties or hypersensibility towards pain.

关键词： Stress c.ildren and adolesc.nts Type 1 diabetes Autonomic.dysfunc.ion

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Hard-thermal-loop QED thermodynamic.

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c.inese Physic. c 2010年第9期34卷 1527-1529页

作者：苏楠 jens O.andersen Mic.ael Stric.land Frankfurt Institute for Advanc.d Studies Department of Physic. Norwegian University of Science and Technology Department of Physic. Gettysburg College

The weak-c.upling expansion for thermodynamic.quantities in thermal field theories is poorly c.nvergent unless the c.upling c.nstant is *** disc.ss the c.lc.lation of the free energy for a hot gas of elec.rons and photons to three-loop order using hard-thermal-loop perturbation theory （HTLpt）.We show that the hard-thermal-loop perturbation reorganization improves the c.nvergenc. of the suc.essive approximations to the QED free energy at large c.upling,e ～ *** reorganization is gauge invariant by c.nstruc.ion,and due to the c.nc.llations among various c.ntributions,we obtain a c.mpletely analytic.result for the resummed thermodynamic.potential at three loops.

关键词： resummation hard-thermal-loop thermal field theory QED free Energy

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Targeting the EGF rec.ptor family in non-small c.ll lung c.nc.rinc.eased c.mplexity and future perspec.ives

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c.nc.r Biology & Medic.ne 2022年第11期19卷 1543-1564页

作者： Tobias Boc. jens Kohler Melanie Janning Sonja Loges DKFZ-Hec.or c.nc.r Institute at the University Medic.l c.nter Mannheim Mannheim 68135Germany Division of Personalized Medic.l Onc.logy(A420) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Personalized Onc.logy University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityMannheim 68135Germany

Lung c.nc.r remains the leading c.use of c.nc.r-assoc.ated mortality worldwide,but with the emergenc. of onc.gene targeted therapies,treatment options have tremendously *** to their biologic.l relevanc.,members of the ERBB rec.ptor family,inc.uding the EGF rec.ptor(EGFR),HER2,HER3 and HER4,are among the best studied onc.genic.*** EGFR mutations are frequently observed in non-small c.ll lung c.nc.r(NSc.c.,and small molec.le tyrosine kinase inhibitors(TKIs)are the established first line treatment option for patients whose tumors bear"typic.l/c.assic.l"EGFR mutations(exon 19 deletions,L858R point mutations).Additionally,new TKIs are rapidly evolving with better effic.c. to overc.me primary and sec.ndary treatment resistanc.(e.g.,that due to T790M or c.97S resistanc. mutations).Some atypic.l EGFR mutations,suc. as the most frequent exon 20 insertions,exhibit relative resistanc. to earlier generation TKIs through steric.*** this subgroup,newer TKIs,suc. as moboc.rtinib and the bi-spec.fic.antibody amivantamab have rec.ntly been approved,whereas less frequent atypic.l EGFR mutations remain *** c.ntrast to EGFR,HER2 has long remained a c.allenging target,but better struc.ural understanding has led to the development of newer generations of *** rec.nt FDA approval of the antibody-drug c.njugate trastuzumab-deruxtec.n for pretreated patients with HER2 mutant NSc.c.has been an important therapeutic.***3 and HER4 also exert onc.genic.potential,and targeted treatment approac.es are being developed,partic.larly for ***,strategies to inhibit the onc.genic.func.ion of ERBB rec.ptors in NSc.c.are c.rrently evolving at an unprec.dented pac.;therefore,this review summarizes c.rrent treatment standards and disc.sses the outlook for future developments.

关键词： Onc.logy NSc.c EGFR HER2 HER3 HER4

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The status of fertility c.ntrol for rodents—rec.nt ac.ievements and future direc.ions

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Integrative Zoology 2022年第6期17卷 964-980页

作者： Kyra JAc.BLINNERT jens JAc.B Zhibin ZHANG Lyn A.HINDS Julius Kühn-Institute(JKI) Federal Research Centre for Cultivated PlantsInstitute for Plant Protection in Horticulture and ForestsVertebrate ResearchMünsterGermany Department of Behavioral Biology University OsnabrückOsnabrückGermany State Key Laboratory of Integrated Management on Pest Insec.s and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina c.S c.nter for Exc.llenc. in Biotic.Interac.ions University of Chinese Academy of SciencesBeijingChina c.IRO Health and Biosec.rity CanberraACTAustralia

Management of overabundant rodents at a landsc.pe sc.le is c.mplex but often required to sustainably reduc. rodent abundanc. below damage *** c.nventional tec.niques suc. as poisoning are not spec.es spec.ﬁc.with some approac.es bec.ming inc.easingly unac.eptable to the general *** c.ntrol,ﬁrst proposed for vertebrate pest management over 5 dec.des ago,has gained public.ac.eptanc. bec.use it is perc.ived as a potentially more spec.es-spec.ﬁc.and humane approac. c.mpared with many lethal *** ideal fertility c.ntrol agent needs to induc. infertility ac.oss one or more breeding seasons,be easily delivered to an appro-priate proportion of the population,be spec.es spec.ﬁc.with minimal side-effec.s(behavioral or soc.al struc.ure c.anges),and be environmentally benign and c.st *** date,effec.ive fertility c.ntrol of rodents has not been demonstrated at landsc.pe sc.les and very few produc.s have ac.ieved *** targets for fertility c.ntrol inc.ude disrupting the hormonal feedbac. assoc.ated with the hypothalamic.pituitary-gonadal axis,gonad func.ion,fertilization,and/or early *** review progress on the oral delivery of various agents for whic. laboratory studies have demonstrated efﬁc.c. in females and/or males and synthesize progress with the development and/or use of synthetic.steroids,plant extrac.s,ovarian spec.ﬁc.peptides,and immunoc.ntrac.p-tive *** are promising results forﬁeld applic.tion of synthetic.steroids(levonorgestrel,quinestrol),c.emosterilants(4-vinylc.c.ohexene diepoxide),and some plant extrac.s(triptolide).For most fertility c.ntrol agents,more researc. is essential to enable their efﬁc.ent and c.st-effec.ive delivery suc. that rodent impac.s at a population level are mitigated and food sec.rity is improved.

关键词： ec.logic.lly based rodent management levonorgestrel quinestrol triptolide 4-vinylc.c.ohexene diepoxide

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2x40 Gbit/s Polarization Division Multiplexing With Bit Slot Sync.ronization

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光学学报 2003年第S1期23卷 554-555页

作者： jens c. Rasmussen George Ishikawa Tamio Saito Fujitsu Laboratories Ltd. Room B1003 Eagle Run Plaza No.26 Xiaoyun Road Chaoyang Dist. Beijing 100016 P.R.ChinaFujitsu Laboratories Ltd. Room B1003 Eagle Run Plaza No.26 Xiaoyun Road Chaoyang Dist. Beijing 100016 P.R.ChinaFujitsu R&D Center Co. Ltd. Room B1003 Eagle Run Plaza No.26 Xiaoyun Road Chaoyang Dist. Beijing 100016 P.R.China

Polarization division multiplexing (PDM) c.n double the spec.ral effic.enc. of an optic.l transmission system. By means of simulation, the 2x40Gbit/s NRZ PDM system performanc. under polarization mode dispersion (PMD) and c.romatic.dispersion has been investigated. To realize the best performanc., the bit slots of the two c.annels should be sync.ronized.

关键词： NRZ of be PDM Gbit/s Polarization Division Multiplexing With Bit Slot Sync.ronization EOP PMD that

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