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Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

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Open Journal of Gastroenterology 2013年第1期3卷 12-24页

作者： Mihir Patel Justin Olinde Allison Tatum Chaitanya V. Ganta Walter E. Cromer Ankur R. sheth Merilyn H. jennings J. Michael Mathis Traci Testerman Paul A. Jordan Kenneth Manas Christopher P. Monceaux J. steven Alexander Department of Cellular Biology and Anatomy LSU Health Shreveport Shreveport USA Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA

Inappropriate responses to normal commensal bacteria trigger immune activation in both inflammatory bowel disease and experimental colitis. How gut flora contribute to the pathogenesis of inflammatory bowel disease is unclear, but may involve entrapment of leukocytes and remodeling of the vascular system. Here we evaluated how the progression and tissue remodeling in experimental colitis differ in a germ- free model of mouse colitis. Four treatment groups were used: control, antibiotic-treated (ABX), dextran sulfate colitis (Dss) and Dss pre- and co-treated with antibiotics (Dss + ABX). In days 0 - 3 of the study, germ-free mice received antibiotics (vancomycin, neomycin, and metronidazole). During the next 11 days, antibiotics were continued and Dss (3%) added to “colitis” groups. Disease activity, weight, stool form and blood were monitored daily. Mice were sacrificed and tissue samples harvested. Histopathological scores in controls (0.00) and in ABX (1.0+/–0.81) were significantly (p –0). Extents of injury, inflammation and crypt damage were all improved in Dss + ABX. The Disease Activity Index score (day 11) was significantly worse in the Dss group compared to the Dss + ABX group. stool blood and form scores were also significantly improved among these groups. Importantly, myeloper- oxidase was significantly reduced in Dss + ABX, indicating that neutrophil infiltration was blocked. Colitis was associated with an increase in blood and lymphatic vessels;both of these events were also significantly reduced by gut sterilization. Our experiment shows that clinical and histopathological severity of colitis was significantly worse in the Dss colitis group compared to the Dss + ABX group, supporting the hypothesis that development of IBD is likely to be less severe with appropriate antibiotic treatment. In particular, gut sterilization effectively reduces leuko- cyte-dependent (PMN) injury to improve outcomes and may be an important target for therapy.

关键词： Crohn’s Disease Antibiotics Myeloperoxidase Lymphatics Angiogenesis

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standardizing a simpler, more sensitive and accurate tail bleeding assay in mice

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World Journal of Experimental Medicine 2012年第2期2卷 30-36页

作者： Yang Liu Nicole L jennings Anthony M Dart Xiao-Jun Du Experimental Cardiology Laboratory Baker IDI Heart and Diabetes Institute Monash University Alfred Heart Centre Alfred Hospital Monash University Faculty of Medicine and Central Clinical school Monash University

AIM: To optimize the experimental protocols for a simple, sensitive and accurate bleeding ***: Bleeding assay was performed in mice by tail tip amputation, immersing the tail in saline at 37 ℃, continuously monitoring bleeding patterns and measuring bleeding volume from changes in the body weight. sensitivity and extent of variation of bleeding time and bleeding volume were compared in mice treated with the P2 Y receptor inhibitor prasugrel at various doses or in mice deficient of Fc Rγ, a signaling protein of the glycoprotein VI ***: We described details of the bleeding assay with the aim of standardizing this commonly used assay. The bleeding assay detailed here was simple to operate and permitted continuous monitoring of bleedingpattern and detection of re-bleeding. We also reported a simple and accurate way of quantifying bleeding volume from changes in the body weight, which correlated well with chemical assay of hemoglobin levels(r2 = 0.990, P ssay the dose-effect relation of the anti-platelet drug prasugrel from 0.015 to 5 mg/kg. Our results showed that the correlation of bleeding time and volume was unsatisfactory and that compared with the bleeding time, bleeding volume was more sensitive in detecting a partial inhibition of platelet's haemostatic activity(P similarly, in mice with genetic disruption of Fc Rγ as a signaling molecule of P-selectin glycoprotein ligand-1 leading to platelet dysfunction, both increased bleeding volume and repeated bleeding pattern defined the phenotype of the knockout mice better than that of a prolonged bleeding ***: Determination of bleeding pattern and bleeding volume, in addition to bleeding time, improved the sensitivity and accuracy of this assay, particularly when platelet function is partially inhibited.

关键词： Mouse or mice Tail bleeding assay Prasugrel Platelets Hemostasis FcRγ

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<i>Helicobacter</i>infection decreases basal colon inflammation, but increases disease activity in experimental IBD

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Open Journal of Gastroenterology 2013年第3期3卷 177-189页

作者： Christopher P. Monceaux Traci L. Testerman Moheb Boktor Paul Jordan Patrick Adegboyega David J. McGee Merilyn H. jennings Courtney P. Parker shelly Gupta Ping Yi Vijay C. Ganta Haidy Galous Kenneth Manas J. steven Alexander Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA Department of Pathology LSU Health Shreveport Shreveport USA

Background: Helicobacter species are best known for their roles in the pathology of gastritis;however, several Helicobacter species also colonize the intestine, and less is known about effects of Helicobacter on the development of intestinal inflammation. To evaluate contributions of Helicobacter in inflammatory bowel disease, we investigated whether and how pre-existing intestinal colonization would affect disease severity and biomarkers of inflammation in experimental IBD. Materials and Methods: Mice were infected with H. muridarum 2 weeks prior to induction of colitis mediated by 3% dextran sulfate (Dss). Disease activity index, stool blood and consistency, colon length, myeloperoxidase, histopathology, blood and lymphatic vessels, and numbers of dilated mucosal crypts were measured in control, Dss-only, H. muridarum-infected, and H. muridarum-infected + Dss mice. Results: Prior to Dss challenge, H. muridarum-infected mice showed little distal gut injury by several indices of colon inflammation with decreased blood vessel density in the submucosa, and lower lymphatic density in the mucosa and submucosa. However, after Dss colitis, H. muridarum-infected mice exhibited significantly greater disease. Weight change, stool bleeding, diarrhea, and angiogenesis were all increased in H. muridarum-infected mice in Dss colitis compared to Dss controls. Conclusions: Our data show that Helicobacter colonization of the intestine, unlike that of the stomach, lowers basal gut inflammatory scores, but increases disease activity and inflammation in an acute colitis model. Intestinal Helicobacter infection may therefore represent a significant sub-clinical factor which predisposes the gut to inflammatory injury.

关键词： Helicobacter Colon Lymphatics Crohn’s Disease Ulcerative Colitis

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食物大战,狼蛛vs茅膏菜

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小哥白尼（野生动物） 2010年第10期 11-11页

作者：麦格 David jennings

在自然界中，奇所有动物朝思暮想的莫过于两个字——食物．它们费尽心思地找寻它、抢夺它，甚至会为了它而大动干戈。和动物们共同生活在地球上的植物看上去安静而又文气，

关键词：食物茅膏菜 Vs 狼蛛自然界动物

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胰泌素刺激后3.0TMR表观扩散系数的测量

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国际医学放射学杂志 2009年第5期32卷 496-496页

作者： M.F.Akisik K.sandrasegaran s.G.jennings A.M.Aisen s.sherman 唐光健 Department of Radiology Indiana University School of Medicine550 N University Blvd

目的对有与没有慢性胰腺炎（CP）的病人进行3．0TMR胆胰管成像扩散加权（DW）扫描，前瞻性测量胰腺的表观扩散系数（ADC）。材料与方法研究由学术委员会批准并符合HIPAA法案。对预约行MR胆胰管成像的健康志愿者与怀疑和（或）已知有CP... 详细信息

目的对有与没有慢性胰腺炎（CP）的病人进行3．0TMR胆胰管成像扩散加权（DW）扫描，前瞻性测量胰腺的表观扩散系数（ADC）。材料与方法研究由学术委员会批准并符合HIPAA法案。对预约行MR胆胰管成像的健康志愿者与怀疑和（或）已知有CP的病人均给予知情同意通知。所有受试者均行3．0TMR胆胰管成像，包括系列DWI序列（b=0、200、400s／mm2），给予胰泌素后15min采集数据。

关键词：表观扩散系数胰泌素刺激测量 MR胆胰管成像慢性胰腺炎学术委员会健康志愿者扩散加权

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胰泌素增强后MR扩散加权成像对慢性胰腺炎的评价

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国际医学放射学杂志 2009年第2期32卷 177-177页

作者： M.F.Akisik A.M.Aisen K.sandrasegaran s.G.jennings s. sherman 蒋涛 Department of Radiology Indiana University School of Medicine550 N University Blvd

目的回顾性测量并比较在接受磁共振胆胰管成像（MRCP）及MR扩散加权成像（DWI）检查的慢性胰腺炎（CP）及非慢性胰腺炎病人中，注射胰泌素增强后表观扩散系数（ADC）的变化情况。方法本回顾性研究经审查委员会同意，符合HIPPA法案... 详细信息

目的回顾性测量并比较在接受磁共振胆胰管成像（MRCP）及MR扩散加权成像（DWI）检查的慢性胰腺炎（CP）及非慢性胰腺炎病人中，注射胰泌素增强后表观扩散系数（ADC）的变化情况。方法本回顾性研究经审查委员会同意，符合HIPPA法案，无需知情同意书。由胃肠病学专家根据剑桥标准规范和（或）临床病程，将89例病人分为3组，

关键词： MR扩散加权成像慢性胰腺炎胰泌素磁共振胆胰管成像 HIPPA法案知情同意书表观扩散系数胃肠病学专家

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儿童睾丸微石症及其与睾丸肿瘤的关系

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国际医学放射学杂志 2014年第3期 278-278页

作者： M.L.Cooper M.Kaefer R.Fan R.C.Rink s.G.jennings B.Karmazyn 唐光健 Department of Radiology and Imaging sciences Riley Hospital for ChildrenIndiana University School of Medicine705 Riley Hospital DrRoom 1053IndianapolisIN 46202USA

摘要目的评价行阴囊超声(Us)检查儿童睾丸微石症(TM)的发生率及其与睾丸肿瘤的关系。方法本研究由学院审查委员会批准无需知情同意书,符合HIPAA要求。2003

关键词：睾丸肿瘤 TM 睾丸微石症儿童

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MRI与FDG PET对于前期或早期阿尔茨海默病相关改变的显示能力

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国际医学放射学杂志 2010年第6期 568-568页

作者： D.s.Karow L.K.McEvoy C.Fennema-Notestine D.J.Hagler R.G.jennings J.B.Brewer 冀晓东 Department of Radiology University of CaliforniaSan Diego9500 Gilman DrMail Code 0841La JollaCA 92093

目的量化评价临床前期和轻度阿尔茨海默病(AD)的局部代谢与形态学异常,从而确定AD早期检测的无创生物指标。材料与方法本研究获得单位伦理委员会的批

关键词：阿尔茨海默病临床前期 AD FDG PET PET 海马体积 MRI

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垃圾填埋场—经济生活与价值评估

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经济资料译丛 2012年第2期 39-49页

作者： Daniel s.siegel 马铮纪益成 siegel SiegelJohnson&JenningsCo.L.P.A. 厦门大学评估研究中心 361005

以从价税征收为目的的垃圾填埋场评估是一项很困难的工作，尤其是现在的填埋场已经成了一种不动产和技术经营相结合的复杂的综合体。在对某一个体填埋场做出评估前，我们必须了解一些垃圾池所包含的独特性质。下面是现代填埋场的简要描... 详细信息

以从价税征收为目的的垃圾填埋场评估是一项很困难的工作，尤其是现在的填埋场已经成了一种不动产和技术经营相结合的复杂的综合体。在对某一个体填埋场做出评估前，我们必须了解一些垃圾池所包含的独特性质。下面是现代填埋场的简要描述和历史，紧接其后的是介绍在评估这些特殊财产时的技术建议。

关键词：垃圾填埋场价值评估经济生活技术经营从价税综合体不动产

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应用定向双极射频消融装置治疗转移性后椎体骨肿瘤:技术说明

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国际医学放射学杂志 2014年第6期 590-590页

作者： T.J.Hillen P.Anchala M.V.Friedman J.W.jennings 张会平 Mallinckrodt Institute of Radiology Washington University School of Medicine510 S Kingshighway BlvdSt LouisMO 63110

摘要目的探讨定向射频消融(RFA)治疗转移性后椎体肿瘤的可行性和安全性。材料与方法该回顾性研究经伦理审查委员会批准并符合HIPAA,免除签署病人知情同意。

关键词：转移性 RFA 双极椎体椎体肿瘤

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