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Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study

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Military Medical Research 2021年第1期8卷 121-131页

作者： Muhammad R.Baig Robert D.Beck jennifer l.Wilson jennifer A.lemmer Adeel Meraj Eric C.Meyer Jim Mintz Alan l.Peterson John D.Roache Mental Health South Texas Veterans Healthcare System116 A7400 Merton Minter BIvdSan AntonioTX 78229USA Polytrauma Rehabilitation Center South Texas Veterans Healthcare SystemSan AntonioTXUSA Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center at San AntonioSan AntonioTXUSA Department of Veterans Affairs VISN 17 Center of Excellence for Research on Returning War Veterans WacoTXUSA Central Texas Veterans Healthcare System WacoTXUSA Department of Psychology and Neuroscience Baylor UniversityWacoTXUSA Department of Epidemiology and Biostatistics University of Texas Health Science Center at San AntonioSan AntonioTXUSA Department of Psychology University of Texas at San AntonioSan AntonioUSA Department of Pharmacology University of Texas Health Science Center at San AntonioSan AntonioTXUSA

Background: Selective serotonergic reuptake inhibitors(SSRIs) are first-line pharmacologic treatments for patients with posttraumatic stress disorder(PTSD), but must be given over extended period of time before the onset of action. The use of SSRIs in PTSD patients with mild traumatic brain injury(m TBI) is problematic since SSRIs could exacerbate post-concussion syndrome(PCS) symptoms. VA/DOD guidelines identify trauma-focused psychotherapy as the best evidence-based treatment for PTSD, but overall effectiveness is limited by reduced levels of patient engagement and retention. A previous study from this research group suggested that quetiapine monotherapy, but not risperidone or valproate, could increase engagement in trauma-focused ***: We report the study protocol of a pilot study funded under the South-Central Mental Illness Research, Education, and Clinical Center pilot study program from the U.S. Department of Veterans Affairs. This randomized, open-label study was designed to evaluate the feasibility of completing a randomized trial of quetiapine vs. treatment as usual to promote patient engagement in PTSD patients with a history of m ***: We expect that the success of this ongoing study should provide us with the preliminary data necessary to design a full-scale randomized trial. Positive efficacy results in a full-scale trial should inform new VA guidelines for clinical practice by showing that quetiapine-related improvements in patient engagement and retention may be the most effective approach to assure that VA resources achieve the best possible outcome for *** registration: NCT04280965.

关键词： Quetiapine Trauma-focused psychotherapy Posttraumatic stress disorder Mild traumatic brain injury Veterans

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Clinician’s perspectives in using head impulse-nystagmus- test of skew (HINTS) for acute vestibular syndrome: UK experience

作者： (美)莎拉·l.哈里斯(Sarah l.harris)，(美)戴维·莫尼·哈里斯(David Money harris)

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Stroke & Vascular Neurology 2022年第2期7卷 172-175页

作者： Charlotte l Warner lisa Bunn Nehzat Koohi Gunnar Schmidtmann jennifer Freeman Diego Kaski School of Health Professions University of PlymouthPlymouthUK Department of Clinical and Movement Neurosciences University College LondonLondonUK The Ear Institute University College LondonLondonUK Neuro-otology Department University College London HospitalsLondonUK

Background Acute vestibular syndrome(AVS)features continuous dizziness and may result from a benign inner ear disorder or *** head impulse-nystagmus-test of skew(HINTS)bedside assessment is more sensitive than brain MRI in identifying stroke as the cause of AVS within the first 24 ***’perspectives of the test in UK secondary care remains ***,we explore front-line clinicians’perspectives of use of the HINTS for the diagnosis of *** Clinicians from two large UK hospitals who assess AVS patients completed a short online survey,newly designed with closed and open *** Almost half of 73 total responders reported limited(n=33),or no experience(n=19),reflected in low rates of use of HINTS(n=31).While recognising the potential utility of HINTS,many reported concerns about subjectivity,need for specialist skills and poor patient *** clinicians reported high levels of confidence in performing HINTS,with 98%identifying training needs.A lack of formalised training was associated with onward specialist referrals and neuroimaging(p=0.044).Conclusions Although the low sample size in this study limits the generalisability of findings to wider sites,our preliminary data identified barriers to the application of the HINTS in AVS patients and training needs to improve rapid,cost-effective and accurate clinical diagnosis of stroke presenting with vertigo.

关键词： AVS diagnosis formal

Comparison of intraocular pressure readings with Perkins,Tonopen,iCare 200,and iCare Home to manometry in cadaveric eyes

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2022-2027页

作者： Monica K Ertel leonard K Seibold jennifer l Patnaik Malik Y Kahook Department of Ophthalmology University of ColoradoUC Health Sue Anschutz-Rodgers Eye CenterAuroraColorado 80045USA

AIM:To compare intraocular pressure(IOP)readings obtained with Perkins tonometry,i Care Home,i Care 200,and Tonopen to IOP readings obtained with the manometer of a perfusion system to assess the accuracy and reproducibility of each method of tonometry at set ***:The IOP of human cadaveric eyes(n=2)was measured using a manometer inserted into the eye through the optic *** measurements were obtained using a Perkins tonometer,i Care Home,i Care 200,and *** measurements were compared to set point IOP measurements of a manometer to determine accuracy and reproducibility of each ***:Mean IOP readings obtained with the Perkins tonometer compared to manometer readings demonstrated a difference of-1.0±5.0 mm Hg(P=0.45),indicating a lower reading on average than manometery although not *** IOP difference between iCare 200 and manometer was 5.3±2.2 mm Hg(Ple the Tonopen measurements demonstrated a 4.0 mm Hg standard *** comparison,iCare 200 and iCare Home demonstrated 2.2 and 2.4 mm Hg standard deviation,***:Applanation tonometry produces more accurate IOP readings than rebound tonometry or Tonopen,however it demonstrates greater variability than the other forms of *** tonometry is more reproducible but tends to over-estimate IOP.

关键词： intraocular pressure ocular tonometry manometry

Diet quality in patients with stroke

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Stroke & Vascular Neurology 2019年第3期4卷 154-157页

作者： jennifer l Dearborn Tehmina Khera Meghan Peterson Zartashia Shahab Walter N Kernan Department of Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Yale UniversityNew HavenConnecticutUSA Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA

Objective A healthy diet is associated with reduced risk for stroke,myocardial infarction,cancer and *** examined the prevalence of a healthy diet in patients with a recent stroke or transient ischaemic attack(TIA).Methods We recruited a convenience sample of 95 patients with a recent ischaemic stroke or *** information from a 125-item Food Frequency Questionnaire,we calculated dietary quality and the percentage of patients meeting recommended daily intake(RDI)for common macronutrients and *** The mean age of patients was 66 years(SD:16)and 46%were women.39 patients(41%)were classified as having a healthy diet(35%of men and 48%of women).The majority of patients were within the RDI for carbohydrates(56.8%),total fat(61.1%),long-chain n-3 fats(68.4%),polyunsaturated fats(79.0%)and protein(96.8%).Very few patients consumed the recommended intake for sodium(25.3%),and even fewer consumed the RDI for potassium(4.2%),with the majority of patients consuming too much sodium and too little *** We found that most patients with recent stroke or TIA were not following a healthy diet before their stroke *** most patients,sodium intake was much above and potassium intake was much below RDI.

关键词： patients intake potassium

Town-scale microbial sewer community and H2S emissions response to common chemical and biological dosing treatments

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Journal of Environmental Sciences 2020年第1期32卷 133-148页

作者： Elizabeth R.Mathews jennifer l.Wood Dean Phillips Nathan Billington Dean Barnett Ashley E.Franks Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityMelbourneAustralia Centre for Future landscapes La Trobe UniversityMelbourneAustralia Faculty of Science Engineering and TechnologySwinburne University of TechnologyMelbourneAustralia Western Water SunburyAustralia

Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced by many water *** of a sewer diversion provided the opportunity to compare the effectiveness of magnesium hydroxide(Mg(OH)2)and two biological dosing compounds(Bioproducts A and B),with different modes of action(MOA),in a field-test across a large sewer ***(OH)2 increases sewer p H allowing suppression of H2S release into the sewer environment while Bioproduct A acts to disrupt microbial communication through quorum sensing(QS),reducing biofilm *** B reduces H2S odors by scouring the sewer of fats,oils and grease(FOGs),which provide adhesion points for the microbial *** revealed that only Mg(OH)2 altered the microbial community structure and reduced H2S emissions in a live sewer system,whilst Bioproducts A and B did not reduce H2S emissions or have an observable effect on the composition of the microbial community at the dosed *** results recommend in situ testing of dosing treatments before implementation across an operational system.

关键词： Microbially induced concrete corrosion Biological dosing treatments Magnesium hydroxide Hydrogen sulfide Sulfate-reducing bacteria Microbial ecology

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Dental microwear of sympatric rodent species sampled across habitats in southern Africa: Implications for environmental influence

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Integrative Zoology 2016年第2期11卷 111-127页

作者： Jenny H.E.BURGMAN jennifer lEICHlITER Nico l.AVENANT Peter S.UNGAR Environmental Dynamics Program University of ArkansasFayettevilleArkansasUSA Department of Anthropology University of Colorado BoulderBoulderColoradoUSA National Museum and University of the Free State BloemfonteinSouth Africa Department of Anthropology University of ArkansasFayettevilleArkansasUSA

Dental microwear textures have proven to be a valuable tool for reconstructing the diets of a wide assortment of fossil ***,some studies have recently questioned the efficacy of this approach,suggesting that aspects of habitat unrelated to food preference,especially environmental grit load,might have a confounding effect on microwear patterning that obscures the diet *** we evaluate this hypothesis by examining microwear textures of 3 extant sympatric rodent species that vary in diet breadth and are found in a variety of habitat types:Mastomys coucha,Micaelamys namaquensis and Rhabdomys *** sample each of these species from 3 distinct environmental settings in southern Africa that differ in rainfall and vegetative cover:Nama-Karoo shrublands(semi-desert)and Dry Highveld grasslands in the Free State Province of South Africa,and Afromontane(wet)grasslands in the highlands of *** differences between habitat types are evident for some of the species,inconsistency in the pattern suggests that the microwear signal is driven by variation in foods eaten rather than grit-level per *** is clear that,at least for species and habitats sampled in the current study,environmental grit load does not swamp diet-related microwear signatures.

关键词： diet grit tooth wear

Seasonal shifts in the solute ion ratios of vadose zone rock moisture from the Eel River Critical Zone Observatory

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Acta Geochimica 2017年第3期36卷 385-388页

作者： jennifer l.Druhan Nicole Fernandez Jia Wang William E.Dietrich Daniella Rempe Department of Geology University of Illinois Urbana Champaign Department of Earth and Planetary Science University of California Berkeley Jackson School of Geosciences University of Texas at Austin

One of the greatest challenges in critical zone studies is to document the moisture dynamics, water flux,and solute chemistry of the unsaturated, fractured and weathered bedrock that lies between the soil and groundwater table. The central impediment to quantifying this component of the subsurface is the difficulty associated with direct observations. Here, we report solute chemistry as a function of depth collected over a full year across the shale-derived vadose zone of the Eel River Critical Zone Observatory using a set of novel sub-horizontal wellbores,referred to as the vadose zone monitoring system. The results of this first geochemical glimpse into the deep vadose zone indicate a dynamic temporal and depth-resolved structure. Major cation concentrations reflect seasonal changes in precipitation and water saturation, and normalized ratios span the full range of values reported for the world's largest rivers.

关键词： Vadose zone Solute ion ratios Critical Zone Observatory Seasonal solute dynamics

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A framework for the regional critical zone classi?cation: the case of the Chinese loess Plateau

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National Science Review 2019年第1期6卷 14-18页

作者： Yihe lü Jian Hu Bojie Fu Paul.harris lianhai Wu Xiaolin Tong Yingfei Bai Alexis J.Comber State Key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Joint Center for Global Change Studies Institute of Qinghai-Tibetan Plateau Southwest Minzu University Sustainable Agriculture Sciences Rothamsted Research

The concept of the Earth’s Critical Zone(CZ)—the near-surface heterogeneous environment of our planet—was originally defined to include the land surface,vegetation canopy, rivers, lakes and shallow seas [1]. CZ accommodates interactions among air, water, soil, rock and living organisms, and determines the availability of life-sustaining resources needed for the well-being and sustainability of human society. Therefore, there are new opportunities for integrative studies of

关键词： the case of the Chinese loess Plateau ClP CZ