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Assessment of the carbon abatement and removal opportunities of the Arabian Gulf Countries

Clean Energy 2021年第2期5卷 340-353页

作者： Abdulrahman Alatiq Wail Aljedani Abdullah Abussaud Omar Algarni Hélène Pilorgé jennifer wilcox Department of Chemical Engineering Worcester Polytechnic InstituteGoddard Hall100 Institute RoadWorcesterMA 01609USA Department of Chemical and Biomolecular Engineering University of Pennsylvania220 S.33rd StreetPhiladelphiaPA 19104USA

The Arabian Gulf Countries(AGC)are strongly reliant on the economic export of fossil fuels,while being vulnerable to climate change that is resulting in temperature increase,air pollution and sea-level rise,and threatening the health of the population and *** agreement with the Paris Accords,most of the AGC have published short-term goals to reduce their carbon emissions in the coming *** relation to these goals,this study explores the potential CO_(2)reduction,avoidance and removal in the region,by comparing a business-as-usual(BAU)scenario to three decarbonization scenarios for the power *** 2018,the total greenhouse gas(GHG)emissions in the AGC were~1333 MtCO_(2)/yr and are expected to rise to 1568 MtCO_(2)/yr in 2030 following a BAU scenario,which is likely to be reduced to 1522 MtCO_(2)/yr in 2030 by following the countries’*** issued plans for the coming decades that focus on increasing the share of renewable energy in their grid *** three decarbonization scenarios presented in this study focus on supply-side technological *** retirement of the oldest natural-gas and oil power plants could lead to a total emissions reduction of~75 MtCO_(2)/yr,without accounting for the embodied carbon emissions associated with renewable *** addition,the implementation of point-source capture at power plants expected to retire in>10 years’time could avoid emissions of~240 MtCO_(2)/yr,provided the CO_(2)is permanently sequestered in appropriate geological *** region also shows high-quality solar resources and large CO_(2)-storage potential that could couple to direct air-capture plants to offset difficult-to-avoid *** last scenario has the potential to ultimately result in net negative emissions.

关键词： carbon capture CCUS direct air capture

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High-performance oxygen reduction and evolution carbon catalysis： From mechanistic studies to device integration

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Nano Research 2017年第4期10卷 1163-1177页

作者： John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae jennifer wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao Department of Chemical Engineering Stan ford University Stanford CA 94305 USA Institute of Chemical and Engineering Sciences Agency for Science Technology and Research Jurong Island 627833 Singapore Stanford Nano Shared Facilities Stanford University Stanford CA 94305 USA Department of Physics Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea Department of Chemical and Biological Engineering Colorado School of Mines Golden CO 80401 USA UNIST Central Research Facilities (UCRF) Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA Institute of Catalysis Research and Technology Karlsruhe Institute of Technology Hermann-von-Helmholtz Platz 1 76344 Eggenstein-Leopoldshafen Germany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology Engesserstr. 18 76131 Karlsruhe Germany

The development of high-performance and low-cost oxygen reduction and evolution catalysts that can be easily integrated into existing devices is crucial for the wide deployment of energy storage systems that utilize O2-H2O chemistries, such as regenerative fuel cells and metal-air batteries. Herein, we report an NHB-activated N-doped hierarchical carbon （NHC） catalyst synthesized via a scalable route, and demonstrate its device integration. The NHC catalyst exhibited good performance for both the oxygen reduction reaction （ORR） and the oxygen evolution reaction （OER）, as demonstrated by means of electrochemical studies and evaluation when integrated into the oxygen electrode of a regenerative fuel cell. The activities observed for both the ORR and the OER were comparable to those achieved by state-of-the-art Pt and Ir catalysts in alkaline environments. We have further identified the critical role of carbon defects as active sites for electrochemical activity through density functional theory calculations and high-resolution TEM visualization. This work highlights the potential of NHC to replace commercial precious metals in regenerative fuel cells and possibly metal-air batteries for cost-effective storage of intermittent renewable energy.

关键词： electrocatalysis porous carbon density functional theory

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2018年第1期7卷 427-439页

作者： jennifer A.Steele Carsten H.Richter Pierre Echaubard Parichat Saenna Virginia Stout Paiboon Sithithaworn Bruce A.wilcox Department of Infectious Disease and Global Health Tufts UniversityCummings School of Veterinary MedicineNorth GraftonMAUSA Global Health Asia Integrative Education and Research ProgrammeFaculty of Public HealthFaculty of Public Health StudiesBangkokThailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunmingChina Department of Biology Laurentian UniversityGreater SudburyONCanada Department of Science Education Khon Kaen UniversityFaculty of EducationKhon KaenThailand Department of Parasitology Khon Kaen UniversityFaculty of MedicineKhon KaenThailand

Background:Cholangiocarcinoma(CCA)is a fatal bile duct cancer associated with infection by the liver fluke,Opisthorchis viverrini,in the lower Mekong *** public health interventions have focused on reducing exposure to ***,but incidence of CCA in the region remains *** this may indicate the inefficacy of public health interventions due to complex social and cultural factors,it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of *** systematic review aims to provide a comprehensive analysis of described risk factors for CCA in addition to *** to guide future integrative *** body:We searched five international and seven Thai research databases to identify studies relevant to risk factors for CCA in the lower Mekong *** studies were assessed for risk of bias and quality in terms of study design,population,CCA diagnostic methods,and statistical *** final 18 included studies reported numerous risk factors which were grouped into behaviors,socioeconomics,diet,genetics,gender,immune response,other infections,and treatment for *** risk factors were reported by two or more studies and were assessed with random effects models during *** meta-analysis indicates that the combination of alcohol and smoking(OR=11.1,95%CI:5.63-21.92,P<0.0001)is most significantly associated with increased risk for CCA and is an even greater risk factor than *** *** analysis also suggests that family history of cancer,consumption of raw cyprinoid fish,consumption of high nitrate foods,and praziquantel treatment are associated with significantly increased *** risk factors may have complex relationships with the host,parasite,or pathogenesis of CCA,and many of these risk factors were found to interact with each other in one or more ***:Our findings suggest that a complex variety of risk factors in ad

关键词： Cholangiocarcinoma Risk factors Opisthorchis viverrini Mekong Southeast Asia Thailand Public health

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Investigation of Influencing Parameters for Tribological Conditions in Dry Forming Processes

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1435-1441页

作者： jennifer Steiner Marion Merklein Institute of Manufacturing Technology Friedrich-Alexander-Universitat Erlangen-Nürnberg

Environmental awareness and a growing demand for efficient resource utilization encourage the realization of lubricant-free forming processes. A first step in accomplishing dry sheet metal forming is to gain knowledge about the changing tribological conditions and to identify the relevant influencing parameters. The commonly used flat strip drawing test was selected to investigate the tribological conditions in the flange area of deep drawing processes. The influencing factors of contact pressure and varying drawing velocities were analyzed under dry and lubricated conditions. Additionally,the tool and workpiece surfaces were characterized. Besides lubrication, the contact pressure mainly determines the tribological conditions. In lubricated tests higher normal pressure reduces friction, whereas without lubrication higher pressure results in slightly increasing friction. A changing drawing velocity affects the friction when lubricant is applied. In dry experiments, no influence of velocity was found. Results of surface characterization reveal adhesion as main wear mechanism under dry conditions. Based on the investigated influence of the process parameters, an increase in process understanding for dry forming operations is derived.

关键词： Deep drawing Tribology Friction Dry forming

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The Effect of Natural Hazard Damage on Manufacturing Value Added and the Impact of Spatiotemporal Data Variations on the Results

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International Journal of Disaster Risk Science 2022年第5期13卷 691-704页

作者： Douglas Thomas jennifer Helgeson National Institute of Standards and Technology GaithersburgMD 20899USA

This study examined the effect of natural hazards on manufacturing industry value added and the sensitivity of the results from changes to spatiotemporal resolution of the *** measured the negative effects of hazards,rather than the net *** models were developed with varying spatio temporal units for the continental United States:annual/county units;annual/state units;and quarterly/state *** simulations were run using each model to estimate the negative effect of damage from all natural hazards on value added across spatiotemporal ***,an investment analysis was conducted to examine the return from public investments in hazard *** results do not demonstrate that,locally,natural hazards reduce value ***,the evidence suggests that natural hazards in the upstream supply chain have statistically significant impact when modeled at the annual/county scale and at the quarterly/state *** local nor supply chain hazards have a statistically significant effect when modeled at the annual/state scale,suggesting that broader spatiotemporal units may obscure the true downstream effects of natural *** investment analysis,utilizing model results,suggests that an investment of USD 100 billion or less is economical if it results in a reduction in losses of 10% or more.

关键词： Manufacturing Natural hazards Spatiotemporal impacts United States Value added

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Klotho and neurons: mutual crosstalk between autophagy, endoplasmic reticulum, and inflammatory response

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Neural Regeneration Research 2021年第8期16卷 1542-1543页

作者： jennifer Mytych Department of Animal Physiology and Reproduction Institute of Biology and BiotechnologyCollegium Scientarium NaturaliumUniversity of RzeszowWerynia 236-100 KolbuszowaPoland

Klotho is one of a number of well-known longevity-associated *** depletion in aging or disease may promote several neuropathologies associated with the central nervous system,including hypomyelination and phosphorylat... 详细信息

关键词： Klotho inflammation reticulum

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