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Neural Regeneration Research 2014年第7期9卷 766-772页

作者： Alexandria m.Reynolds Denise m.Peters jennifer m.c.vendemia Lenwood P.Smith Raymond c.Sweet Gordon c.Baylis Debra Krotish Stacy L.Fritz Department of Psychology Barnwell College University of South Carolina Department of Exercise Science University of South Carolina Department of Psychology University of South Carolina Neurosurgery center University of South Carolina School of Medicine Western Kentucky University University of South carolina School of medicine

many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuro- nal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.

关键词： nerve regeneration magnetic resonance imaging stroke cerebral cortex motor cortex voxel-based lesion symptom mapping motor function prognosis neural regeneration

classifying moisture sources associated with snowfall in the mountains of Lesotho

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Journal of mountain Science 2024年第6期21卷 1941-1953页

作者： Alexi m.mARINAKI jennifer m.FITcHETT School of Geography Archaeology and Environmental StudiesUniversity of the WitwatersrandPrivate Bag X3Wits 2050South Africa

An average of eight snowfall events occur each year in the eastern Lesotho *** snowfall events are typically associated with cut-off low(coLs)systems and mid-latitude ***,the moisture sources of the snowfall are unclassified and *** Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)model,an air mass back trajectory model,has been used to evaluate moisture source waters locally in southern Africa and internationally in china and *** study uses HYSPLIT to determine the source moisture of snow in Lesotho.A list of all 82 snowfall events in Lesotho spanning 2017 to 2022 was compiled using the Snow Report SA Instagram page,including the date and location of snowfall.A 72-hour back trajectory for each snowfall event was initiated for both Afriski and the whole of *** amounts to models of moisture source trajectories for 28 and 82 snowfall days,*** air mass pathways are classified according to their frequency per snowfall event,per month in the snow season,per year and for the full *** this,associated moisture source regions and dominant air mass trajectories were *** study reports that the air mass trajectories associated with Afriski and Lesotho as a whole are very *** most common pathway of air mass trajectories transporting snow-bearing moisture to Lesotho was an inland trajectory from the northern regions of southern *** pathway makes up 16.6%of all trajectories reported and is associated with the Angola Low,the congo Air Boundary and the *** High Pressure.

关键词： Eastern Lesotho Highlands Afriski Snow cut-off Lows HYSPLIT Synoptic climatology

Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system

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Neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Amar Kumar jennifer N.Dulin Department of Biology Texas A&M UniversityCollege Station Texas A&m Institute for Neuroscience Texas A&M UniversityCollege Station

Neural stem and progenitor cell(NSPc)transpla ntation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease.A great deal of experimental work has investigated the biology of NSPc grafting in preclinical animal models;more recently.

关键词： neural system injured

New Opportunities for Neutrons in Environmental and Biological Sciences

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton coates Brian H.Davison James G.Elkins Xin Gu jennifer morrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron methods in environmental and biological sciences is rapidly emerging and accelerating with the development of new instruments at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environmental and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynamics,plant-microbe interactions,structure and dynamics of biological systems,applications in synthetic biology and enzyme engineering,next-generation bioproducts,biomaterials and bioenergy,nanoscale structure,and fluid dynamics of porous materials in *** provide an outlook on emerging opportunities with an emphasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** mission of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim to encourage researchers in the environmental and biological research community to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environment Biology Neutron imaging Neutron scattering Second Target Station(STS)

Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： matthew D.Geiger Anne m.Lynch Alan G.Palestine Nathan c.Grove Karen L.christopher Richard S.Davidson michael J.Taravella Naresh mandava jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIm:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BcVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%cI=0.7-0.9,P=0.0005).The BcVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

Germline Gene-Editing creates Enhanced Livestock-Technical and Especially Ethical Issues challenge Its Use in Humans

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Engineering 2024年第2期33卷 3-5页

作者： jennifer Welsh Senior Technology Writer

Using clustered regularly interspaced short palindromic repeats(cRISPR)-based molecular tools,scientists are engineering-as they are also doing with plants.-animals with advantageous traits,like disease resistance and improved food *** these innovative techniques could one day be applied in humans,technical hurdles and ethical concerns likely place this possibility far in the future,The enhancements rely on germline gene editing,which alters the genes in a way that passes the changes on to *** m-line gene editing differs from the somatic cell gene editing used in the highly promising new treatment recently approved for the human disease sickle cell anemia.

关键词： likely create editing

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal models and Experimental medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly jennifer A.munley Erick E.Pons Kolenkode B.Kannan Elizabeth m.Whitley Letitia E.Bible Philip A.Efron Alicia m.mohr Department of Surgery and Sepsis and critical Illness Research center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LcHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(Bm)erythroid progenitor(cFU-GEmm,BFU-E,and cFU-E)growth,plasma granulocyte colony-stimulating factor(G-cSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesma resulted in markedly more profound inhibition of weight gain compared to LcHS(p=0.0002)along with elevated plasma TLR4(pmoglobin(pcHS and PT demonstrated suppression of cFU-E and BFU-E growth compared to naive(pma G-cSF was elevated in PT compared to both na?ve and LcHS(pcHS and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Risk scores for allograft failure: Are they still useful in liver recipients from donation after circulatory death?

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World Journal of Transplantation 2024年第4期14卷 95-100页

作者： mohamed H mohamed chairi mónica mogollón González jennifer Triguero cabrera Inmaculada Segura Jiménez maria T Villegas Herrera Jesús m Villar del moral Transplant Surgery Division Department of SurgeryVirgen de las Nieves University HospitalGranada 18013AndalusiaSpain

BAcKGROUND Liver grafts from donation after circulatory death(DcD)are associated with a higher risk of early graft dysfunction,determined by the warm ischemia and cold ischemia *** is essential to have precise criteria to identify this complication in order to guide therapeutic *** To validate different graft and recipient survival scores in patients undergoing liver transplantation(LT)with DcD *** A retrospective and observational unicentric study was conducted on 65 LT patients with grafts obtained from controlled DcD donors from November 2013 to November *** United Kingdom(UK)risk score,early allograft dysfunction(EAD)Olthoff score,and model for early allograft function(mEAF)score were used to evaluate the risk of graft and recipient survival *** survival analysis purposes,we used the Kaplan-meier method,and the differences between subgroups were compared using the log-rank(mantel-cox)*** Sixty-five patients were included in the *** UK risk score did not demonstrate predictive capacity for recipient or graft ***,in donors aged over 70 years old(18.4%),it significantly predicted graft survival(Pccording to Kaplan-meier survival curves,graft survival rates at 6 months,2 years,and 5 years in the futility group dramatically decreased to 50%compared to the other groups(log-rank 8.806,PmEAF scores did not demonstrate predictive capacity for recipient or graft *** on Kaplan-meier survival curves,patients with a mEAF score≥7 had a lower graft survival rate at 6 months,2 years,and 5 years compared to patients with a lower mEAF score(log-rank 4.667,PcONcLUSION In our series,both UK DcD risk score and mEAF score showed predictive capability for graft survival.

关键词： Liver transplantation Donation after circulatory death Early allograft dysfunction Risk scores Graft surviva

Experimental evaluation of a“U”type earth-to-air heat exchanger planned for narrow installation space in warm climatic conditions

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Energy and Built Environment 2024年第5期5卷 772-786页

作者： Ricardo molina-Rodea Jorge Alejandro Wong-Loya Hugo Pocasangre-chávez jennifer Reyna-Guillén Institute of Renewable Energies National Autonomous University of MexicoTemixcoMorelosMexico

The thermal performance of a“U”type earth-to-air heat exchanger is presented in this experimental *** device has a serial-connected vertical *** wells where tubes were installed have a depth of fewer than 3 m and are separated every 1.5 m,using an installation area of *** experimentation was carried out in march in morelos,mexico when the environmental temperature reaches 35℃ during the *** performance of the device was measured and compared to the requirements of an office for cooling purposes within a university campus to reproduce the space restrictions found in urbanized *** using a small land surface,it is feasible for urbanized *** air temperature inside the“U”type earth-to-air heat exchanger,the surrounding soil temperature,the airspeed,and the power consumed by the fan were *** air temperature and the fan’s power consumption data were obtained by modifying the airspeed in four constant values,from 1.3 m/s to 6.6 m/*** show that the device evaluated in this work has adequate thermal performance for cooling purposes compared to the requirements of an office.A decrease in air temperature was recorded in a range of 5.1℃ to 9.4℃.Over 70%of the total temperature difference was reached in the first well,where the average soil thermal disturbance at 5 cm was 2.8℃.The device achieved a maximum cOP of 12.8 and a maximum effectiveness of 88.4%.With these results,it is concluded that the system is suitable for cooling purposes in areas with space *** work is novel since the dimensions available for installation in urbanized areas are considered and compared with the thermal requirements of an *** addition to the fact that there are no published works with vertical heat exchangers connected in series.

关键词： Low temperature geothermal energy Thermal performance Vertical heat exchangers Space restrictions in urbanized areas Geothermal direct uses

Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel m.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet chung Tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos m.T.Lee jennifer H.Y.Lam Sau man chan Wilfred H.S.Wong Issan Y.S.Tam masashi mori Sophie A.Valkenburg malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(Im)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over Im administration in *** Participants aged 11–17 years received two doses of Im or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(Im-cc versus ID-cc)and post-dose 3(Imccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm[sum of individual(S),nucleocapsid protein(N),and membrane protein(m)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNm-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and m-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to Im-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for Im-cc,ID-cc,Im-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and m-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine