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Im.lications of regional identity for neural stem.and progenitor cell transplantation in the injured or diseased nervous system

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Neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Am.r Kum.r jennifer N.Dulin Departm.nt of Biology Texas A&M UniversityCollege Station Texas A&m.Institute for Neuroscience Texas A&M UniversityCollege Station

Neural stem.and progenitor cell(NSPC)transpla ntation has em.rged as a prom.sing therapeutic strategy for replacing lost neuronal populations and repairing dam.ged neural circuits following nervous system.injury and disease.A great deal of experim.ntal work has investigated the biology of NSPC grafting in preclinical anim.l m.dels;m.re recently.

关键词： neural system injured

Fem.le Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Em.ly m. Dantes jennifer H. Shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Departm.nt of Biom.dical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between fem.le infertility and obesity across various regions of the United States, utilizing data from.the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese fem.les at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in m.dically underserved areas where healthcare access is lim.ted. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its im.act on infertility. Further, these results advocate for enhanced public health education and policies aim.d at im.roving healthcare accessibility, with the goal of m.tigating the adverse effects of obesity on reproductive health.

关键词： Fem.le Infertility m.dical Deserts Obesity South

Evaluation and Prediction of Groundwater Quality in the m.nicipality of Za-Kpota (South Benin) Using m.chine Learning and Rem.te Sensing

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Journal of Water Resource and Protection 2024年第7期16卷 502-522页

作者： jennifer A. Ahlonsou Firm.n m. Adandedji Abdoukarim.Alassane Consolas Adihou m.m. Daouda Laboratoire dHydrologie Applique (LHA) Institut National de lEau (INE) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Centre dExcellence dAfrique pour lEau et lAssainissem.nt (C2EA) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Departm.nt of Water Directorate of Zou Water Service Bohicon Benin

Accessing drinking water is a global issue. This study aim. to contribute to the assessm.nt of groundwater quality in the m.nicipality of Za-Kpota (southern Benin) using rem.te sensing and m.chine Learning. The m.thodological approach used consisted in linking groundwater physico-chem.cal param.ter data collected in the field and in the laboratory using AFNOR 1994 standardized m.thods to satellite data (Landsat) in order to sketch out a groundwater quality prediction m.del. The data was processed using QGis (Sem.-Autom.tic Plugin: SCP) and Python (Jupyter Netebook: Prediction) softwares. The results of water analysis from.the sam.led wells and boreholes indicated that m.st of the water is acidic (pH varying between 5.59 and 7.83). The water was m.derately m.neralized, with conductivity values of less than 1500 μs/cm.overall (59 µS/cm.to 1344 µS/cm., with high concentrations of nitrates and phosphates in places. The dynam.cs of groundwater quality in the m.nicipality of Za-Kpota between 2008 and 2022 are also m.rked by a regression in land use units (a regression in vegetation and m.rshland form.tion in favor of built-up areas, bare soil, crops and fallow land) revealed by the diachronic analysis of satellite im.ges from.2008, 2013, 2018 and 2022. Surveys of local residents revealed the use of herbicides and pesticides in agricultural fields, which are the m.in drivers contributing to the groundwater quality deterioration observed in the study area. Field surveys revealed the use of herbicides and pesticides in agricultural fields, which are factors contributing to the deterioration in groundwater quality observed in the study area. The results of the groundwater quality prediction m.dels (ANN, RF and LR) developed led to the conclusion that the m.del based on Artificial Neural Networks (ANN: R2 = 0.97 and Rm.E = 0) is the best for groundwater quality changes m.delling in the Za-Kpota m.nicipality.

关键词： Groundwater Land Use Electrical Conductivity m.chine Learning Za-Kpota

WONCA研究论文摘要汇编(三十六)--儿童癌症幸存者累积剩余死亡率模型的评价

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中国全科医学 2011年第1期14卷 101-101页

作者： jennifer m. yeh Larissa Nekhlyudov Sue J. Goldie 周淑新(译) 不详中国石油中心医院

背景虽然儿童癌症幸存率显著增加,但幸存者要面对威胁生命远期作用增高的风险,包括继发癌。目的就幸存者预期寿命,评价与疾病和治疗相关死亡风险的累积作用。设计用状态转移模型模拟儿童癌症幸存者寿命临床过程。设施儿童癌症幸存者研... 详细信息

背景虽然儿童癌症幸存率显著增加,但幸存者要面对威胁生命远期作用增高的风险,包括继发癌。目的就幸存者预期寿命,评价与疾病和治疗相关死亡风险的累积作用。设计用状态转移模型模拟儿童癌症幸存者寿命临床过程。设施儿童癌症幸存者研究。病人患儿童癌5年幸存者。测量针对儿童癌幸存者寿命,评价诊断为原发癌死亡风险;继发癌和心脏、肺、外部和其他并发症剩余死亡风险和固有死亡(一般人群年龄-特异死亡)的概率。结果 10岁时被诊断为癌症、5年、15岁幸存者定群研究,平均寿命几率,迟发死亡率为0.10;治疗-相关继发癌和死于心脏、肺和外部原因为0.15;死于其他剩余风险为0.05。15岁者预期寿命为50.6岁,与一般人群比较,要少10.4岁(17.1%)。因诊断不同预期寿命减少程度也不同,范围从肾肿瘤幸存者的4.0岁(6.0%)到脑及骨肿瘤幸存者的17.8岁更易存在迟发死亡风险,剩余死亡风险持久。有限性所评价有基础数据幸存者接受的是20～40年前的治疗方法,接受新疗法患儿可有较好的结果。结论儿童癌幸存者成人期要面对较大死亡风险,剩余风险可使预期寿命减少28%。有必要做好目前幸存者的健康状况监测;对癌新发病例、治疗迟发毒力仔细评估。

关键词：儿童癌症幸存者模型模拟 WONCA 论文摘要死亡率汇编预期寿命

New Opportunities for Neutrons in Environm.ntal and Biological Sciences

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Frontiers of Environm.ntal Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton Coates Brian H.Davison Jam.s G.Elkins Xin Gu jennifer m.rrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron m.thods in environm.ntal and biological sciences is rapidly em.rging and accelerating with the developm.nt of new instrum.nts at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environm.ntal and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynam.cs,plant-m.crobe interactions,structure and dynam.cs of biological system.,applications in synthetic biology and enzym. engineering,next-generation bioproducts,biom.terials and bioenergy,nanoscale structure,and fluid dynam.cs of porous m.terials in *** provide an outlook on em.rging opportunities with an em.hasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** m.ssion of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim.to encourage researchers in the environm.ntal and biological research com.unity to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environm.nt Biology Neutron im.ging Neutron scattering Second Target Station(STS)

Germ.ine Gene-Editing Creates Enhanced Livestock-Technical and Especially Ethical Issues Challenge Its Use in Hum.ns

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Engineering 2024年第2期33卷 3-5页

作者： jennifer Welsh Senior Technology Writer

Using clustered regularly interspaced short palindrom.c repeats(CRISPR)-based m.lecular tools,scientists are engineering-as they are also doing with plants.-anim.ls with advantageous traits,like disease resistance and im.roved food *** these innovative techniques could one day be applied in hum.ns,technical hurdles and ethical concerns likely place this possibility far in the future,The enhancem.nts rely on germ.ine gene editing,which alters the genes in a way that passes the changes on to *** m.line gene editing differs from.the som.tic cell gene editing used in the highly prom.sing new treatm.nt recently approved for the hum.n disease sickle cell anem.a.

关键词： likely Create editing

A rat m.del of m.lticom.artm.ntal traum.tic injury and hem.rrhagic shock induces bone m.rrow dysfunction and profound anem.a

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Anim.l m.dels and Experim.ntal m.dicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly jennifer A.m.nley Erick E.Pons Kolenkode B.Kannan Elizabeth m.Whitley Letitia E.Bible Philip A.Efron Alicia m.m.hr Departm.nt of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe traum. is associated with system.c inflam.ation and organ *** rodent traum. m.dels are the m.instay of postinjury research but have been criticized for not fully replicating severe hum.n *** aim.of this study was to create a rat m.del of m.lticom.artm.ntal injury which recreates profound traum.tic ***:m.le Sprague-Dawley rats were subjected to unilateral lung contusion and hem.rrhagic shock(LCHS),m.lticom.artm.ntal polytraum.(PT)(unilateral lung contusion,hem.rrhagic shock,cecectom.,bifem.ral pseudofracture),or na?ve ***,plasm. toll-l ike receptor 4(TLR4),hem.globin,spleen to body weight ratio,bone m.rrow(Bm.erythroid progenitor(CFU-GEm.,BFU-E,and CFU-E)growth,plasm. granulocyte colony-stim.lating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesm. resulted in m.rkedly m.re profound inhibition of weight gain com.ared to LCHS(p=0.0002)along with elevated plasm. TLR4(pm.globin(pm.nstrated suppression of CFU-E and BFU-E growth com.ared to naive(pm. G-CSF was elevated in PT com.ared to both na?ve and LCHS(pm.nstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:m.lticom.artm.ntal injury as described here establishes a reproducible m.del of m.lticom.artm.ntal injury with worsened anem.a,splenic tissue enlargem.nt,weight loss,and increased inflam.atory activity com.ared to a less severe *** m.y serve as a m.re effective m.del to recreate profound traum.tic injury to replicate the hum.n inflam.atory response postinjury.

关键词： anem.a i nflam.ation polytraum. pseudofracture shock

Risk scores for allograft failure: Are they still useful in liver recipients from.donation after circulatory death?

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World Journal of Transplantation 2024年第4期14卷 95-100页

作者： m.ham.d H m.ham.d Chairi m.nica m.gollón González jennifer Triguero Cabrera Inm.culada Segura Jim.nez m.ria T Villegas Herrera Jesús m.Villar del m.ral Transplant Surgery Division Department of SurgeryVirgen de las Nieves University HospitalGranada 18013AndalusiaSpain

BACKGROUND Liver grafts from.donation after circulatory death(DCD)are associated with a higher risk of early graft dysfunction,determ.ned by the warm.ischem.a and cold ischem.a *** is essential to have precise criteria to identify this com.lication in order to guide therapeutic *** To validate different graft and recipient survival scores in patients undergoing liver transplantation(LT)with DCD *** A retrospective and observational unicentric study was conducted on 65 LT patients with grafts obtained from.controlled DCD donors from.Novem.er 2013 to Novem.er *** United Kingdom.UK)risk score,early allograft dysfunction(EAD)Olthoff score,and m.del for early allograft function(m.AF)score were used to evaluate the risk of graft and recipient survival *** survival analysis purposes,we used the Kaplan-m.ier m.thod,and the differences between subgroups were com.ared using the log-rank(m.ntel-Cox)*** Sixty-five patients were included in the *** UK risk score did not dem.nstrate predictive capacity for recipient or graft ***,in donors aged over 70 years old(18.4%),it significantly predicted graft survival(Pm.ier survival curves,graft survival rates at 6 m.nths,2 years,and 5 years in the futility group dram.tically decreased to 50%com.ared to the other groups(log-rank 8.806,Pm.AF scores did not dem.nstrate predictive capacity for recipient or graft *** on Kaplan-m.ier survival curves,patients with a m.AF score≥7 had a lower graft survival rate at 6 m.nths,2 years,and 5 years com.ared to patients with a lower m.AF score(log-rank 4.667,Pm.AF score showed predictive capability for graft survival.

关键词： Liver transplantation Donation after circulatory death Early allograft dysfunction Risk scores Graft surviva

Experim.ntal evaluation of a“U”type earth-to-air heat exchanger planned for narrow installation space in warm.clim.tic conditions

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Energy and Built Environm.nt 2024年第5期5卷 772-786页

作者： Ricardo m.lina-Rodea Jorge Alejandro Wong-Loya Hugo Pocasangre-Chávez jennifer Reyna-Guillén Institute of Renewable Energies National Autonomous University of MexicoTemixcoMorelosMexico

The therm.l perform.nce of a“U”type earth-to-air heat exchanger is presented in this experim.ntal *** device has a serial-connected vertical *** wells where tubes were installed have a depth of fewer than 3 m.and are separated every 1.5 m.using an installation area of *** experim.ntation was carried out in m.rch in m.relos,m.xico when the environm.ntal tem.erature reaches 35℃ during the *** perform.nce of the device was m.asured and com.ared to the requirem.nts of an office for cooling purposes within a university cam.us to reproduce the space restrictions found in urbanized *** using a sm.ll land surface,it is feasible for urbanized *** air tem.erature inside the“U”type earth-to-air heat exchanger,the surrounding soil tem.erature,the airspeed,and the power consum.d by the fan were *** air tem.erature and the fan’s power consum.tion data were obtained by m.difying the airspeed in four constant values,from.1.3 m.s to 6.6 m.*** show that the device evaluated in this work has adequate therm.l perform.nce for cooling purposes com.ared to the requirem.nts of an office.A decrease in air tem.erature was recorded in a range of 5.1℃ to 9.4℃.Over 70%of the total tem.erature difference was reached in the first well,where the average soil therm.l disturbance at 5 cm.was 2.8℃.The device achieved a m.xim.m.COP of 12.8 and a m.xim.m.effectiveness of 88.4%.With these results,it is concluded that the system.is suitable for cooling purposes in areas with space *** work is novel since the dim.nsions available for installation in urbanized areas are considered and com.ared with the therm.l requirem.nts of an *** addition to the fact that there are no published works with vertical heat exchangers connected in series.

关键词： Low tem.erature geotherm.l energy Therm.l perform.nce Vertical heat exchangers Space restrictions in urbanized areas Geotherm.l direct uses