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Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a special.st diabetes team

Worl. Journal.of Diabetes 2024年第4期15卷 598-605页

作者： Vasil.ios K Mavroeidis jennifer Knapton Francesca Saffioti Daniel.l.Morganstein Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Gastrointestinal.Surgery Southmead HospitalNorth Bristol NHS TrustBristol BS105NBUnited Kingdom Department of Academic Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Gastroenterol.gy and Hepatol.gy Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom UCl.Institute for l.ver and Digestive Heal.h University College LondonLondon NW32PFUnited Kingdom Department of Endocrinol.gy Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom Department of Gastrointestinal.Unit Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Pancreatic surgery units undertake several.compl.x operations,al.eit with consi-derabl. morbidity and mortal.ty,as is the case for the management of compl.cated acute pancreatitis or chronic *** central.sation of pancreatic surgery services,with the devel.pment of designated l.rge-vol.me centres,has contribu-ted to significantl. improved *** this editorial.we discuss the compl.x associations between diabetes mel.itus(DM)and pancreatic/periampul.ary disease in the context of pancreatic surgery and overal. management of compl.x pancreatitis,highl.ghting the consequential.needs and the indispensabl. rol. of special.st diabetes teams in support of tertiary pancreatic *** 3c pan-creatogenic DM,refers to DM devel.ping in the setting of exocrine pancreatic disease,and its identification and management can be chal.enging,whil. the gl.caemic control.of such patients may affect their course of treatment and *** preoperative diabetes assessment is warranted to aid identification of patients who are l.kel. to need commencement or escal.tion of gl.cose l.wering therapy in the postoperative *** incidence of new onset diabetes after pancreatic resection is widel. variabl. in the l.terature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal.l.ss in the context of severe *** invol.ement of a special.st diabetes team is essential.to ensure a hol.stic *** the current era,l.rge vol.me pancreatic surgery services commonl. abide by the principl.s of enhanced recovery after surgery,with incl.sion of provisions for optimisation of the perioperative gl.caemic control.to improve *** various guidel.nes are avail.bl. to aid perioperative management of DM,auditing and qual.ty improvement pl.tforms have highl.ghted deficiencies in the perioperative management of diabetic patients and areas of required *** need for perioperative support of diabetic

关键词： Pancreatectomy Pancreatoduodenectomy Whippl.’s Pancreatitis Diabetes special.st Type 3c pancreatogenic diabetes mel.itus

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Primary care providers practice patterns regarding femal. pel.ic fl.or disorders

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Famil. Medicine and Community Heal.h 2024年第1期12卷 9-15页

作者： Anna Weimer jennifer l.Hal.ock Chi Chiung Grace Chen Magee-Women's Hospital.of UPMC PittsburghPennsylvaniaUSA Kaiser Permanente Northern Cal.fornia SacramentoCaliforniaUSA Johns Hopkins Medical.Institutions Campus BaltimoreMarylandUSA

Introduction Pel.ic fl.or disorders(PFDs)pose substantial.physical.and psychol.gical.burdens for a growing number of *** the ubiquity of these conditions and known patient rel.ctance to seek care,primary care providers(PCPs)have a unique opportunity to increase treatment and provide appropriate referral. for these *** An onl.ne survey was administered to PCPs to assess provider practices,knowl.dge,comfort managing and ease of referral.for *** regression was used to assess the association between demographic/practice characteristics of PCPs and two primary outcomes of interest:discomfort with management and difficul.y with referral.of *** Of the 153 respondents to the survey,more fel. comfortabl. managing stress urinary incontinence(SUI)and overactive bl.dder(OAB),compared with pel.ic organ prol.pse(POP)and faecal.incontinence(FI)and were l.ss l.kel. to refer patients with urinary *** providers el.cited symptoms for POP and FI as compared with SUI and *** variabl.s that were significantl. associated with discomfort with management varied by PFD,but tended to correl.te with l.ss exposure to PFDs(eg,those with fewer years of practice,and internal.medicine and famil. physicians as compared with geriatricians);whereas the factors that were significantl. associated with difficul.y in referral.again varied by PFD,but were rel.ted to practice characteristics(eg,special.st network,type of practice,practice setting and quantity of patients).Concl.sion These findings highl.ght the need to increase PCPs awareness of PFDs and devel.p effective standardised screening protocol.,as wel. as col.aboration with pel.ic fl.or special.sts to improve screening,treatment and referral.for patients with PFDs.

关键词： bl.dder fl.or difficul.y

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Impl.mentation of an international.medical.student pen-pal.cl.b:survey outcomes of perceptions in cul.ural.competency and gl.bal.heal.h

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Gl.bal.Heal.h Journal 2024年第1期8卷 11-15页

作者： Max J.Goodman jennifer l.vschitz Ji Won Kim Megan l.Schul.z Medical.Col.ege of Wisconsin MilwaukeeWI 53226USA Department of Pediatrics Division of Emergency MedicineMedical College of WisconsinMilwaukeeWI53226USA

Background:Pen-pal.cl.bs(PPC)are used worl.wide for students to l.arn about different cul.ures and other skil.sets without the need for *** medical.students are interested in gl.bal.heal.h opportunities abroad but costs,schedul.ng,and other barriers al.ow few to participate in such *** is important that medical.students have nuanced gl.bal.medical.perspectives and can contribute to the gl.bal.medical.***:The purpose of this study is to demonstrate that an international.medical.student PPC improves medical.students'perspectives of cul.ural.competency and gl.bal.heal.h ***:In 2021,a novel.medical.student PPC was establ.shed that began between an American and Japanese medical.*** a sharehol.ers meeting,it was decided that the number of medical.school. invol.ed gl.bal.y be expanded through previous institutional.affil.ations and onl.ne *** total.the cl.b connected 50 American medical.students and 52 medical.students from 17 high-and middl.-income *** primary form of communication was onl.ne;pen-pal. were encouraged to communicate monthl. using provided topics,al.hough frequency and way of communication was their *** February 2022,American PPC members were email.d a qual.tative survey to assess the PPC's ***:The survey was compl.ted by 42%of American PPC members,95%of which were 22-26 *** were precl.nical.medical.students,60%whom were femal. and the majority either white(47%)or Asian(43%).Overal.,the PPC positivel. infl.enced American medical.students'perception of gl.bal.medicine,medical.education,and their cul.ural.competency after joining the PPC compared to prior(P=0.004).Concl.sion:PPCs encourage medical.students to think from a gl.bal.perspective and foster open-mindedness within varying social.and cul.ural.*** a gl.bal.communication pl.tform for students during medical.school.education may be an additional.way to train aspiring gl.bal.l

关键词： Pen-pal. Medical.student Gl.bal.heal.h Cul.ural.competency

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A predictive model.for ethyl.ne-mediated auxin and cytokinin patterning in the Arabidopsis root

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Pl.nt Communications 2024年第7期5卷 120-137页

作者： Simon Moore George Jervis jennifer F.Topping Chunl. Chen Junl. l.u Keith l.ndsey Department of Biosciences Durham UniversitySouth RoadDurham DH13LEUK Hubei Hongshan l.boratory College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China National.Key l.boratory for Germpl.sm Innovation and Util.zation for Fruit and Vegetabl. Horticul.ural.Crops Huazhong Agricultural UniversityWuhanHubei 430070China

The interaction between auxin and cytokinin is important in many aspects of pl.nt *** measurements of both auxin and cytokinin concentration and reporter gene expression cl.arl. show the coexistence of auxin and cytokinin concentration patterning in Arabidopsis root ***,in the context of crosstal. among auxin,cytokinin,and ethyl.ne,l.ttl. is known about how auxin and cytokinin concentration patterns simul.aneousl. emerge and how they regul.te each other in the Arabidopsis *** work util.zes a wide range of experimental.observations to propose a mechanism for simul.aneous patterning of auxin and cytokinin *** addition to reveal.ng the regul.tory rel.tionships between auxin and cytokinin,this mechanism shows that ethyl.ne signal.ng is an important factor in achieving simul.aneous auxin and cytokinin patterning,whil. al.o predicting other experimental.*** the mechanism with a real.stic in sil.co root model.reproduces experimental.observations of both auxin and cytokinin *** made by the mechanism can be compared with a variety of experimental.observations,incl.ding those obtained by our group and other independent experiments reported by other *** of these predictions incl.de patterning of auxin biosynthesis rate,changes in PIN1 and PIN2 patterns in pin3,4,7 mutants,changes in cytokinin patterning in the pl. mutant,Pl. patterning,and various trends in different *** research reveal. a pl.usibl. mechanism for simul.aneous patterning of auxin and cytokinin concentrations in Arabidopsis root devel.pment and suggests a key rol. for ethyl.ne pattern integration.

关键词： Arabidopsis root auxin patterning cytokinin patterning ethyl.ne signal.ng in sil.co digital.root spatiotemporal.model.ng

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CSPP1 stabil.zes microtubul.s by capping both pl.s and minus ends

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Journal.of Mol.cul.r Cel. Biol.gy 2024年第2期16卷 36-46页

作者： Zhikai Wang Wenwen Wang Shuaiyu l.u Fengrui Yang Xu l.u Shasha Hua l.uan Zhu Aoqing Xu Donal. l.il. Dongmei Wang Kai Jiang jennifer l.ppincott-Schwartz Xing l.u Xuebiao Yao MOE Key l.boratory for Membranel.ss Organel.es and Cel.ul.r Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Anhui Key l.boratory for Cel.ul.r Dynamics and Chemical.Biol.gy Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230027China Frontier Science Center for Immunol.gy and Metabol.sm Medical Research InstituteWuhan UniversityWuhan 430071China Comprehensive Cancer Center University of AlabamaBirminghamAL 35233USA Janel.a Research Campus Howard Hughes Medical InstituteAshburnVA 20147USA

Al.hough the dynamic instabil.ty of microtubul.s(MTs)is fundamental.to many cel.ul.r functions,quiescent MTs with unattached free distal.ends are commonl. present and pl.y important rol.s in various events to power cel.ul.r ***,how these free MT tips are stabil.zed remains poorl. ***,we report that centrosome and spindl. pol. protein 1(CSPP1)caps and stabil.zes both pl.s and minus ends of static ***-time imaging of l.ser-abl.ted MTs in l.ve cel.s showed deposition of CSPP1 at the newl. generated MT ends,whose dynamic instabil.ty was concomitantl. ***,MT ends in CSPP1-overexpressing cel.s were hyper-stabil.zed,whil. those in CSPP1-depl.ted cel.s were much more *** CSPP1-el.cited stabil.zation of MTs was demonstrated to be achieved by suppressing intrinsic MT catastrophe and restricting ***,CSPP1-bound MTs were resistant to mitotic centromere-associated kinesin-mediated *** findings del.neate a previousl. uncharacterized CSPP1 activity that integrates MT end capping to orchestrate quiescent MTs.

关键词： CSPP1 microtubul. pl.s end minus end capping

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The effect of gas phase pol.dimethyl.il.xane surface treatment of metal.ic al.minum particl.s： Surface characterization and fl.w behavior

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Particuol.gy 2017年第1期15卷 92-101页

作者： Bel.amarie l.dwia jennifer l. Gray Appl.ed Research l.boratory The Pennsylvania State University North Atherton Street State College PA 16801 USA Material. Research Institute The Pennsylvania State University USA

Al.minum particl.s were exposed to gaseous pol.dimethyl.il.xane （PDMS） to produce a hydropho- bic surface coating for enhanced fl.w and fl.idity. Surface retention of the intact PDMS was confirmed through infrared and X-ray photoel.ctron spectroscopy. Transmission el.ctron microscopy was used to image cross-sections of the treated particl.s and energy dispersive spectroscopy el.ment maps demon- strated the presence of a surface l.yer consisting of sil.con and oxygen. Density measurements provided evidence for improvements in the Hausner ratio and Carr index of the PDMS-treated al.minum, indicating a reduction in inter-particul.te cohesion through increased bul. density. Stabil.ty, compressibil.ty, shear, aeration, and permeabil.ty of the particl.s were assessed by powder rheometer. The compressibil.ty was reduced by approximatel. 32% fol.owing surface treatment, reveal.ng a reduction in void space, whil. Mohr＇s circl. anal.sis and shear testing determined that the extrapol.ted cohesion val.e was reduced by approximatel. 53% and the fl.w factor at 6 kPa was doubl.d. Aeration testing showed that the air vel.city required to obtain a fl.idized bed was on the order of 0.35 mm/s for the treated powder, whereas the raw powder coul. not be uniforml. fl.idized. PDMS may be a viabl. option for the l.rge-scal. treatment of al.minum powder for fl.w appl.cations.

关键词： Al.minum powder Pol.dimethyl.il.xane X-ray photoel.ctron spectroscopy Diffuse refl.ctance infrared Fourier transform spectroscopy Fl.wabil.ty FT4 powder rheometer

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How compl.tel. are randomized control.ed trial. of non-pharmacol.gical.interventions fol.owing concussion reported? A systematic review

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Journal.of Sport and Heal.h Science 2024年第4期13卷 537-547页

作者： Jacquel.ne Josee van Ierssel.Ol.via Gal.a Kirsten Hol.e Carol.ne l.szawski El.zabeth Jenkins jennifer O’Neil.Carol.n A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Chil.ren’s Hospital.of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Heal.h Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Al.erta Chil.ren’s Hospital.Research Institute University of Cal.ary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychol.gy University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School.of Rehabil.tation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting compl.teness of randomized control.ed trial.(RCTs)of non-pharmacol.gical.interventions fol.owing ***:We searched MEDl.NE,Embase,PsycInfo,CINAHl.and Web of Science up to May *** reviewers independentl. screened studies and assessed reporting compl.teness using the Templ.te for Intervention Description and Repl.cation(TIDieR),Consensus on Exercise Reporting Templ.te(CERT),and international.Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacol.gical.interventions fol.owing ***:We incl.ded 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshol. aerobic exercise,cervicovestibul.r therapy,physical.cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial.magnetic stimul.tion,bl.e l.ght therapy,osteopathic manipul.tion,and head/neck *** scores were:TIDieR 9/12(75%;interquartil. range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies compl.tel. reporting al. items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more compl.tel. reported after publ.cation of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting compl.teness was not strongl. associated with journal.impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Concl.sion:RCTs of non-pharmacol.gical.interventions fol.owing concussion demonstrate moderate to good reporting compl.teness,but are often missing key components,particul.rl. modifications,motivational.strategies,and qual.fied *** compl.teness improved after TIDieR and CERT publ.cation,but p

关键词： Concussion Intervention Randomized control.ed trial Systematic review

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Synthesis and crystal.structure of a neodymium coordination pol.mer with 2,6-anthraquinonedisul.onate

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Particuol.gy 2010年第3期8卷 221-224页

作者： jennifer l. Nichol.s John Bacsa Andrew M. Fogg Department of Chemistry University of Liverpool Crown Street Liverpool L69 7ZD United Kingdom

The coordination pol.mer, （Nd（H2O）5）2（2,6-AQDS）3.2H2O where 2,6-AQDS = 2,6- anthraquinonedisul.onate, has been synthesised via a hydrothermal.route. Structural.y, it consists of l.yers of monomeric Nd pol.hedra which are l.nked by 2,6-AQDS anions forming a pol.meric, three-dimensional.network. Each Nd atom is nine coordinate, bonding to five water mol.cul.s and to four oxygen atoms from four 2,6-AODS anions which in turn pil.ar the l.yers by bridging two Nd atoms in one l.yer, and coordinating to a singl. Nd in the other.

关键词： l.nthanide l.yered material. Sul.onate Coordination pol.mer

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El.cidating regul.tory processes of intense physical.activity by mul.i-omics anal.sis

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Mil.tary Medical.Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim jennifer E.Kyl. Kel.y G.Stratton Carrie D.Nicora Nathal.e Munoz Kathl.en M.Navarro Daniel.Cl.borne Yuqian Gao Karl.K.Weitz Vanessa l.Paurus Kent J.Bl.odsworth Kel.ey A.Al.en l.sa M.Bramer Fernando Montes Kathl.en A.Cl.rk Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biol.gical.Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental.and Mol.cul.r Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control.and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational.Anal.tics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National.Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA l.s Angel.s County Fire Department Los AngelesCA 90063USA Centers for Disease Control.and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental.and Mol.cul.r Toxicol.gy Oregon State UniversityCorvallisOR 97331USA

Background:Physiol.gical.and biochemical.processes across tissues of the body are regul.ted in response to the high demands of intense physical.activity in several.occupations,such as firefighting,l.w enforcement,mil.tary,and sports.A better understanding of such processes can ul.imatel. hel. improve human performance and prevent il.nesses in the work ***:To study regul.tory processes in intense physical.activity simul.ting real.l.fe conditions,we performed a mul.i-omics anal.sis of 3 biofl.ids(bl.od pl.sma,urine,and sal.va)col.ected from 11 wil.l.nd firefighters before and after a 45 min,intense exercise *** profil.s ***-exercise were compared by Student’s t-test fol.owed by pathway anal.sis and comparison between the different omics ***:Our mul.i-omics anal.sis identified and quantified 3835 proteins,730 l.pids and 182 metabol.tes combining the 3 different types of *** bl.od pl.sma anal.sis reveal.d signatures of tissue damage and acute repair response accompanied by enhanced carbon metabol.sm to meet energy *** urine anal.sis showed a strong,concomitant regul.tion of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabol.tes,reabsorption of nutrients and maintenance of fl.id *** sal.va,we observed a decrease in 3 pro-infl.mmatory cytokines and an increase in 8 antimicrobial.peptides.A systematic l.terature review identified 6 papers that support an al.ered susceptibil.ty to respiratory ***:This study shows simul.aneous regul.tory signatures in biofl.ids indicative of homeostatic maintenance during intense physical.activity with possibl. effects on increased infection susceptibil.ty,suggesting that caution against respiratory diseases coul. benefit workers on highl. physical.demanding jobs.

关键词： Mul.i-omics anal.sis Intense exercise Human performance Biofl.ids Metabol.sm Immunity

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Are there sex-based disparities in cataract surgery?

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.l.nch Al.n G.Pal.stine Nathan C.Grove Karen l.Christopher Richard S.Davidson Michael.J.Taravel.a Naresh Mandava jennifer l.Patnaik Department of Ophthal.ol.gy University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative compl.cations and associated visual.outcomes fol.owing cataract ***:This was a retrospective study of patients who had phacoemul.ification cataract surgery at the University of Col.rado School.of *** col.ected incl.ded the patient’s heal.h history,ocul.r comorbidities,operative and post-operative compl.cations,and the post-operative best corrected visual.acuity(BCVA).The data were anal.zed using univariate and mul.ivariabl. l.gistic regression with general.zed estimating equations to account for the correl.tion of some patients having two eyes incl.ded in the ***:A total.of 11977 eyes from 7253 patients were incl.ded in the *** comorbidities differed by sex,with mal.s having significantl. higher percentages of traumatic cataracts(mal.s 0.7%vs femal.s 0.1%),prior ocul.r surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversel.,femal.s had significantl. higher rates of pseudoexfol.ation(2.0%vs 3.2%).In unadjusted anal.sis,mal.s had higher rates of posterior capsul.r rupture(0.8%vs 0.4%)and vitreous l.ss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantl. increased risk of post-operative retinal.detachment,but in mul.ivariabl. anal.sis this was no l.nger *** were significantl. l.ss l.kel. to undergo post-operative neodymium-doped yttrium al.minum garnet(Nd:YAG)l.ser capsul.tomy for posterior capsul. opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was sl.ghtl. worse for mal.s pre-operativel.;but post-operativel.,both sexes exhibited simil.r visual.acuity of Snel.en equival.nt 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical.characteristics that contribute to higher rates of some compl.cations for ***,observed surgical.compl.catio

关键词： cataract surgery sex-based disparity phacoemul.ification outcomes

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