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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke jennie e.pryce Nicole M.Steele Peter R.Amer Susanne Meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGeP4),which generally coincides with onset of puberty,as an example *** We produced AGeP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(eBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

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The effect of a urinary incontinence selfmanagement program for older women in South Korea:A pilot study

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International Journal of Nursing Sciences 2015年第1期2卷 39-46页

作者： jennie C.De Gagne Aeyoung So Bei Wu Mary H.Palmer eleanor S.McConnell School of Nursing Duke UniversityDurhamNCUSA Department of Nursing Gangneung-Wonju National UniversityWonjuSouth Korea School of Nursing University of North CarolinaChapel HillNCUSA Geriatric Research education and Clinical Center Durham Veterans Affairs Medical CenterDurhamNCUSA

Background:Although self-management approaches have shown strong evidence of positive outcomes for urinary incontinence prevention and management,few programs have been developed for Korean rural ***:This pilot study aimed to develop,implement,and evaluate a urinary incontinence self-management program for community-dwelling women aged 55 and older with urinary incontinence in rural South ***:This study used a one-group pre-post-test design to measure the effects of the intervention using standardized urinary incontinence symptom,knowledge,and attitude *** community-dwelling older women completed weekly 90-min group sessions for 5 *** statistics and paired t-tests and were used to analyze ***:The mean of the overall interference on daily life from urine leakage(pre-test:M=5.76±2.68,post-test:M=2.29±1.93,t=4.609,pe sum of International Consultation on Incontinence Questionnaire scores(pre-test:M=11.59±3.00,post-test:M=5.29±3.02,t=-5.881,ped significant improvement after the *** was also noted on the mean knowledge(pre-test:M=19.07±3.34,post-test:M=23.15±2.60,t=7.550,pe scores(pre-test:M=2.64±0.19,post-test:M=3.08±0.41,t=5.150,peekly assignments were completed 82.4%of the *** showed a high satisfaction level(M=26.82±1.74,range 22e28)with the group ***:Implementation of a urinary incontinence self-management program was accompanied by improved outcomes for Korean older women living in rural communities who have scarce resources for urinary incontinence management and *** incontinence self-management education approaches have potential for widespread implementation in nursing practice.

关键词： evidence-based nursing Intervention studies Urinary incontinence Self-management Chronic disease Community health nursing Republic of Korea

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A Stakeholder-Guided Collaborative Approach to Improve Water Quality in a Nutrient Surplus Watershed

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Journal of Water Resource and Protection 2014年第6期6卷 571-582页

作者： Hector German Rodriguez jennie Popp edward Gbur John Pennington Agricultural Statistics Laboratory University of Arkansas Fayetteville USA Beaver Watershed Alliance Fayetteville USA Department of Agricultural economics and Agribusiness University of Arkansas Fayetteville USA

The need for water quality improvement in nutrient surplus watersheds is a pressing issue on the agenda of some government agencies and environmental organizations. Including the water quality perceptions of different affected stakeholder groups in the decision-making process may help in addressing this issue. Unfortunately, there is a lack of published research focusing specifically on understanding how Arkansas stakeholders’ perceptions of water quality issues can be used to build and implement comprehensive and workable water quality management plans. Therefore, the objective of this study was to use a stakeholder-guided collaborative approach to help research and outreach personnel to understand water quality perceptions of key stakeholders and to integrate stakeholder engagement in both the decision-making process and in the implementation of water quality management strategies within the Lincoln Lake Watershed in northwest Arkansas. Two key stakeholder groups (i.e., Locals—residents and agricultural producers—and Outsiders—water quality specialist across the state) were surveyed to assess their perceptions regarding: 1) causes of watershed water quality problems, 2) parties responsible for water quality improvement, 3) effectiveness and affordability of best management practices to reduce water quality degradation, and 4) the stakeholders’ interactions with county, state and federal government. A total of 209 complete surveys (49% response rate) were received. Survey responses were compared to determine if significant differences existed between the two stakeholder groups’ perceptions of water quality performing Fisher’s exact tests. Results from the study showed that water quality is still perceived as an issue in the Lincoln Lake Watershed. Significant differences were found between the two stakeholder groups’ perceptions regarding: 1) different groups’ contributions to water degradation, 2) groups’ responsibilities for cleanup, 3) effectiveness of five best

关键词： Stakeholders’ Perceptions environmental Decision Making Best Management Practices Nutrient Surplus Watershed Watershed Management

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Corn and Soybean Growth as Affected by Wastewater-Derived Struvite-Phosphorus Sources and Irrigation Water Types

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Agricultural Sciences 2024年第4期15卷 472-504页

作者： Machaela Morrison Kristofor R. Brye Gerson Drescher jennie Popp Lisa S. Wood Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA Department of Agricultural economics & Agribusiness University of Arkansas Fayetteville AR USA

Struvite (MgNH4PO4·6H2O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops, but little is known about the potential agronomic effectiveness of struvite created from an actual municipal wastewater source. The objective of this study was to evaluate the effects of soil [i.e., Creldon silt loam (Oxyaquic Fragiudalf) and Calloway silt loam (Aquic Fraglossudalf) series], fertilizer-P source [i.e., synthetically produced electrochemically precipitated struvite (eCSTsyn), real-wastewater-derived eCST (eCSTreal), chemically precipitated struvite (CPST), monoammonium phosphate (MAP), and an unamended control (UC)], and irrigation water type (i.e., tapwater and struvite-removed wastewater) on corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] growth and N, P, and magnesium (Mg) uptake in a 60-day, greenhouse potted-plant study. Crop growth and N, P, and Mg uptakes for the struvite treatments (i.e., CPST, eCSTsyn, and eCSTreal) were generally similar to or at least 1.2 times greater than MAP. The eCSTsyn material commonly had up to five times greater N, P, and Mg uptake in corn and soybean than any other fertilizer-P source. Struvite-removed wastewater resulted in at least 1.3 times lower dry matter and N, P, and Mg uptake than tapwater. Similar corn and soybean results from the struvite fertilizers among the various soil-water type combinations compared to MAP suggest that struvite generates similar crop responses as at least one widely used, commercially available, multi-nutrient fertilizer-P source.

关键词： Arkansas Corn Production Soybean Production Struvite Recovered Nutrients

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Runoff-Water Properties from Various Soils as Affected by Struvite-Phosphorus Source and Water Type

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Journal of environmental Protection 2023年第10期14卷 789-823页

作者： Machaela Morrison Kristofor R. Brye Gerson Drescher jennie Popp Lisa S. Wood Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville USA Department of Agricultural economics & Agribusiness University of Arkansas Fayetteville USA

Struvite (MgNH4PO4?6H2O) can be produced from municipal wastewater and has been shown to be an alternative fertilizer-phosphorus (P) source for various crops, but little is known about the runoff-water-quality implications from soil-applied struvite. The objective of this study was to evaluate the effects of soil [Creldon (Oxyaquic Fragiudalfs), Dapue (Fluventic Hapludolls), Roxana (Typic Udifluvents), and Calloway (Aquic Fraglossudalfs) series], fertilizer-P source [synthetically produced electrochemically precipitated struvite (eCSTsyn), real-wastewater-derived eCST (eCSTreal), chemically precipitated struvite (CPST), and monoammonium phosphate (MAP)], and water source (rainwater, groundwater, and struvite-removed real wastewater) over time on runoff-water-quality parameters from laboratory-conducted, rainfall-runoff simulations. Mesh tea bags containing each soil-fertilizer treatment combination were rained on with each water source (Trial 1), incubated for 6 months, and rained on again (Trial 2) to evaluate runoff-water quality. Struvite fertilizers had similar runoff-water-quality properties to those from MAP. In Trial 1, runoff total P (TP) concentration differences (i.e., soil-fertilizer-water-type response minus control response minus blank response) from eCSTsyn or eCSTreal were 1 to 5 times larger than MAP and CPST for all water-soil-fertilizer-P source treatment combinations, except for the Creldon-groundwater and Roxana-wastewater combinations. In both trials, runoff TP decreased over time in all water-soil and soil-fertilizer-P source treatment combinations, except for the Roxana-CPST combination where TP increased over time by 46%. The similar water-quality responses from the struvite fertilizers among the various soils and water types compared to MAP suggest that struvite has similar runoff-water-quality implications as at least one widely used, commercially available fertilizer-P source.

关键词： Rainfall Simulation Runoff Struvite Phosphorus Water Quality

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Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer

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Journal of Cancer Metastasis and Treatment 2019年第11期4卷 47-57页

作者： Kimberley C.Agbo Jessie Z.Huang Amr M.Ghaleb jennie L.Williams Kenneth R.Shroyer Agnieszka B.Bialkowska Vincent W.Yang Department of Medicine Stony Brook University School of MedicineStony BrookNY 11794USA Department of Pathology Stony Brook University School of MedicineStony BrookNY 11794USA Department of Family Population and Preventive MedicineStony BrookNY 11794USA Department of Physiology and Biophysics Stony Brook University School of MedicineStony BrookNY 11794USA

Aim: Colorectal cancer (CRC) is the third leading cancer-related cause of death due to its propensity to metastasize. epithelial-mesenchymal transition (eMT) is a multistep process important for invasion and metastasis of CRC. Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor highly expressed in differentiated cells of the intestinal epithelium. KLF4 has been shown to play a tumor suppressor role during CRC tumorigenesis - its loss accelerates development and progression of cancer. The present study examined the relationship between KLF4 and markers of eMT in CRC. Methods: Immunofluorescence staining for KLF4 and eMT markers was performed on archived patient samples after colorectal cancer resection and on colonic tissues of mice with colitis-associated cancer. Results: We found that KLF4 expression is lost in tumor sections obtained from CRC patients and in those of mouse colon following azoxymethane and dextran sodium sulfate (AOM/DSS) treatment when compared to their respective normal appearing mucosa. Importantly, in CRC patient tumor sections, we observed a negative correlation between KLF4 levels and mesenchymal markers including TWIST, β-catenin, claudin-1, N-cadherin, and ;vimentin. Similarly, in tumor tissues from AOM/DSS-treated mice, KLF4 levels were negatively correlated with mesenchymal markers including SNAI2, β-catenin, and vimentin and positively correlated with the epithelial marker e-cadherin. Conclusion: These findings suggest that the loss of KLF4 expression is a potentially significant indicator of eMT in CRC.

关键词： Krüppel-like factor 4 colorectal cancer epithelial-mesenchymal transition

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消费者行为分析：多媒体丰富通信最为期待

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通讯世界 2006年第9期12卷 72-73页

作者： Mikael e. Bjorling jennie Carlsten Piotr Kessler erik Kruse Mats Stille

如果电信行业密切关注并充分利用已知的用户行为模式，同时采取措施来丰富语音通信并增进语音与数据业务之间的互动性，电信行业就可以在更大程度上改善个人之间的通信。当计划并开发更加丰富的通信业务（如爱立信IMS weShare）时，易... 详细信息

如果电信行业密切关注并充分利用已知的用户行为模式，同时采取措施来丰富语音通信并增进语音与数据业务之间的互动性，电信行业就可以在更大程度上改善个人之间的通信。当计划并开发更加丰富的通信业务（如爱立信IMS weShare）时，易用性是电信行业需要考量的一项关键因素。

关键词：语音通信行为分析多媒体消费者电信行业行为模式数据业务通信业务

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消费者行为分析:多媒体丰富通信最为期待

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互联网天地 2006年第11期 78-79页

作者： Mikael e.Bj.rling jennie Carlsten Piotr Kessler erik Kruse jMats Stille

关键词：语音通信行为分析多媒体消费者电信行业行为模式数据业务通信业务

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爱立信IMSweShare分享每一天（系列之二）如何提供出色的用户体验？

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通讯世界 2006年第10期12卷 88-89页

作者： Mikael e．Bjō1ing jennie Carlsten Piotr Kessler erik Kruse MatsStille

爱立信IMS weShare业务有20％的开发与用户视觉体验相关（用户界面、图标、标签以及进度条），其它的80％则主要致力于设备间的系统。与此相对比，用户的体验则完全（100％）有赖于其可接触的事物。移动业务内置于移动电话有限的空间里... 详细信息

爱立信IMS weShare业务有20％的开发与用户视觉体验相关（用户界面、图标、标签以及进度条），其它的80％则主要致力于设备间的系统。与此相对比，用户的体验则完全（100％）有赖于其可接触的事物。移动业务内置于移动电话有限的空间里，而这里也是用户体验的诞生之处。然而，体验的质量则取决于同支持系统如何交互，及系统的性能如何？

关键词：用户界面爱立信支持系统移动业务移动电话 IMS 进度条

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Feasibility, effectiveness, and perceptions of an Internet-and incentive-based behavioral weight loss intervention for overweight and obese college freshmen: A mixed methods approach

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Open Journal of Preventive Medicine 2013年第7期3卷 429-440页

作者： Brenda M. Davy Kerry L. Potter elizabeth A. Dennis Parker Samantha Harden jennie L. Hill Tanya M. Halliday Paul A. estabrooks Bon Secours Health System Porstmouth USA Department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA Department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA Department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA Department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA Department of Family and Community Medicine Carilion Clinic Roanoke USA Office of Minority Health & Health Disparities Research Georgetown University Washington DC USA

Challenges inherent with the transition to college are often accompanied by weight gain among college freshmen. Weight gain and duration of obesity increase metabolic syndrome and cardiovascular disease risk in young adulthood, which supports the need for weight loss interventions tailored to college students. The purpose of this investigation was to conduct a mixed methods pilot trial to determine the efficacy and acceptability of a semester long Internet-and incentive-based weight loss intervention for overweight/obese college freshmen. Participants (n = 27, aged >18 yrs, BMI >25) were randomly assigned to a 12-week social cognitive theory (SCT)-based intervention (Fit Freshmen [FF]) or a health information control group. The FF intervention also included modest financial incentives for weight loss. Primary outcomes included body weight/composition, dietary and physical activity (PA) behaviors, and psychosocial measures (i.e. self-efficacy, self-regulation) associated with diet, PA, and weight loss. Students in the FF intervention participated in focus groups to provide qualitative feedback on program structure and design. FF participants demonstrated significant reductions (all group differences

关键词： College Freshmen Weight Gain Social Cognitive Theory Diet Physical Activity

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