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Interleukin-18 levels in the hippocampus and behavior of adult rat offspring exposed to prenatal restraint stress during early and late pregnancy

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Neural Regeneration Research 2020年第9期15卷 1748-1756页

作者： Mo-Xian Chen Qiang Liu Shu Cheng Lei Lei Ai-Jin lin Ran Wei Tomy C.k.Hui Qi Li Li-Juan Ao Pak C.Sham School of Rehabilitation Kunming Medical UniversityKunmingYunnan ProvinceChina Department of Surgery The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation China Resources&WISCO General HospitalWuhanHubei ProvinceChina Department of Rehabilitation Medicine the Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Institute of Basic Medicine Shandong Academy of Medical SciencesJinanShandong ProvinceChina Department of Psychiatry The University of Hong KongHong Kong Special Administrative RegionChina State key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina Centre for Genomic Sciences The University of Hong KongHong Kong Special Administrative RegionChina

Exposure to maternal stress during prenatal life is associated with an increased risk of neuropsychiatric disorders, such as depression and anxiety, in offspring. It has also been increasingly observed that prenatal stress alters the phenotype of offspring via immunological mechanisms and that immunological dysfunction, such as elevated interleukin-18 levels, has been reported in cultures of microglia. Prenatal restraint stress(PRS) in rats permits direct experimental investigation of the link between prenatal stress and adverse outcomes. However, the majority of studies have focused on the consequences of PRS delivered in the second half of pregnancy, while the effects of early prenatal stress have rarely been examined. Therefore, pregnant rats were subjected to PRS during early/middle and late gestation(days 8–14 and 15–21, respectively). PRS comprised restraint in a round plastic transparent cylinder under bright light(6500 lx) three times per day for 45 minutes. Differences in interleukin-18 expression in the hippocampus and in behavior were compared between offspring rats and control rats on postnatal day 75. We found that adult male offspring exposed to PRS during their late prenatal periods had higher levels of anxiety-related behavior and depression than control rats, and both male and female offspring exhibited higher levels of depression-related behavior, impaired recognition memory and diminished exploration of novel objects. Moreover, an elevated level of interleukin-18 was observed in the dorsal and ventral hippocampus of male and female early-and late-PRS offspring rats. The results indicate that PRS can cause anxiety and depression-related behaviors in adult offspring and affect the expression of interleukin-18 in the hippocampus. Thus, behavior and the molecular biology of the brain are affected by the timing of PRS exposure and the sex of the offspring. All experiments were approved by the Animal Experimentation Ethics Committee at kunming Medical u

关键词： behavior depression dorsal hippocampus interleukin-18 prenatal restraint stress recognition memory sex ventral hippocampus

2008年3月4日台湾东北部两次TAIGER爆破记录的地面旋转和平移运动

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世界地震译丛 2010年第2期41卷 38-53页

作者： Chin-jen lin Chun-Chi Liu William H. k. Lee 冯静（译）赵仲和（校）不详中国地震局地球物理研究所

2008年3月4日在台湾东北部的N3爆破点实施了两次爆破。第一次3000kg炸药的爆破编号为N3P,第二次750kg炸药的爆破编号为N3。为了记录这两次爆破,我们使用了8个三轴旋转传感器、13个三轴加速度计以及12个装有全球定位系统接收器的6通道24... 详细信息

2008年3月4日在台湾东北部的N3爆破点实施了两次爆破。第一次3000kg炸药的爆破编号为N3P,第二次750kg炸药的爆破编号为N3。为了记录这两次爆破,我们使用了8个三轴旋转传感器、13个三轴加速度计以及12个装有全球定位系统接收器的6通道24位数据记录仪在爆破前后几小时进行连续观测。这些仪器安装在距离爆破点250m(1个台)、500m(11个台)、600m(1个台)的地方,其中距离爆破点500m的11个台站形成了台站间距约为5m的中心台阵。除一个旋转传感器外,都得到了量程内的记录。尽管N3P爆破使用的炸药是N3爆破的4倍,但是13个台站记录的N3P爆破的平移加速度和旋转速度的峰值却只有N3爆破的1.5倍。在台站间距大约5m的中心台阵的记录中,我们还发现平移加速度和旋转速度变化很大(百分之几十)。N3P和N3爆破的最大峰值旋转速度分别为2.74mrad/s和1.75mrad/s。本文的主要目的是报告台湾这两次爆破的旋转和平移运动记录,并在网上发布以开放访问。Langston等(2009)已经对本次试验的平移加速度数据进行了分析,我们计划未来发表一篇关于分析旋转速度数据的文章。

关键词：旋转传感器平移运动爆破点东北部台湾地区地面全球定位系统加速度计

POLE2 Regulates Apoptosis of Oral Squamous Cell Carcinoma Cells through the PI3k/AkT Signaling Pathway

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Current Medical Science 2023年第6期43卷 1162-1172页

作者： Ming-yu SuN lin WANG Zhen-yu SHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Province key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan430022China Department of Oral and Maxillofacial Surgery the Affiliated Hospital of Qingdao UniversityQingdao266000China key Laboratory of Oral Clinical Medicine Qingdao266000China

Objective Oral squamous cell carcinoma(OSCC)is the most common malignant tumor of the head and neck,but its occurrence and progression mechanisms remain *** addition-there is a lack of effective targeting *** second major subunit of DNA polymerase(POLE2)catalyzes the prolongation of new strand replication and modifies exonuclease domain *** previous study found that POLE2 was associated with OSCC progression,but the mechanism remains *** The expression of POLE2 in OSCC tissues was detected using immunological ***-Whitney u analysis was used to investigate the relationship between POLE2 gene expression and tumor classification and prognosis of ***2 expression was inhibited in OSCC cells,and the effects of gene and protein expression were detected using RT-PCR and Western *** POLE2 knock.ut model was constructed by transfecting a lentiviral *** proliferation,apoptosis,and migration were detected using various assays including colony formation,MTT,flow cytometry,wound healing assay,Transwell assay,and the Human Apoptosis Antibody *** animal model of OSCC was established by subcutaneous injection of transfected HN6 into 4-week-old female nude *** 30 days,tumors were removed under anesthesia and tumor weight and dimension were *** cell proliferation was analyzed using ki67 *** POLE2 gene levels were significantly higher in the OSCC tissues than in the normal *** addition,POLE2 gene levels were statistically correlated with tumor classification and *** POLE2 inhibited the proliferation of oral cancer cells and promoted apoptosis in *** experiments also supported a positive correlation between POLE2 and OSCC tumor *** further demonstrated that POLE2 could upregulate the expression of apoptosis-related proteins such as caspase-3,CD40,CD40L,DR6,Fas,IGFBP-6,p21,and *** addition,POLE2 regulated OSCC development by inhibiting the PI3

关键词： second major subunit of DNA polymerase oral squamous cell carcinoma PI3k/AkT

A phenomenological model for plastic flow behavior of rotating band material with a large temperature range

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Defence Technology（防务技术） 2023年第7期25卷 121-133页

作者： Yi-cheng Zhu Jia-wei Fu lin-fang Qian Jing-hua Cao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina Northwest Institute of Mechanical and Electrical Engineering Xianyang712099ShaanxiChina School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

The plastic flow behavior of the rotating band material is investigated in this paper. The rotating band material is processed from H96 brass alloy, which is hardened to a much higher yield strength compared to the annealed one. The dynamically uniaxial compression behavior of the material is tested using the split Hopkinson pressure bar(SHPB) with temperature and strain rate ranging from 297 to 1073 k and500 to 3000 s^(-1), respectively, and a phenomenological plastic flow stress model is developed to describe the mechanical behavior of the material. The material is found to present noticeable temperature sensitivity and weak strain-rate sensitivity. The construction of the plastic flow stress model has two steps. Firstly, three univariate stress functions, taking plastic strain, plastic strain rate and temperature as independent variable, respectively, are proposed by fixing the other two variables. Then, as the three univariate functions describe the special cases of flow stress behavior under various conditions, the principle of stress compatibility is adopted to obtain the complete flow stress function. The numerical results show that the proposed plastic flow stress model is more suitable for the rotating band material than the existing well-known models.

关键词： Rotating band Plastic flow behavior Large temperature range Phenomenological model

Effect of AI_(2)O_(3)and MgO on crystallization and structure of Ca0-Si0_(2)-B_(2)0_(3)-based fluorine-free mold flux

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Journal of Iron and Steel Research International 2021年第5期28卷 552-562页

作者： Jun-yu Chen Wan-lin Wang Le-jun Zhou Zi-hang Pan School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina National Center for International Cooperation of Clean Metallurgy Changsha 41(K)83HunanChina

The crytallization behavior and melt structure of the CaO-Si0^(2-)B20_(3)-based fluorine-free mold fux were *** results show that the crytallization of the mold fux was first inhibited and then promoted with the increase in Al_(2)0_(3) content from 4 to 12 wt.%.However,it was enhanced by MgO in the range of 2-10 wt.%.The results of Fourier transform infrared spectroscopy and Raman spectroscopy showed that Al_(2)0_(3) worked as a network former in the mold flux melt when its content was in the range of 4-8 wt.%,whereas it worked as the network breaker to provide 0^(2-)when its content was in the range of 8-12 wt.%.In addition,the combined efects from the charge compensation by Mg^(2+)and the network broken by 0^(2-)led to the increase in some typicalT-O-T(AI-O-A1,B-O-B,etc.,)and simpler structural units(Q^(2)(Si),B_^(O-)in the[B0_(2)0^(-)],.etc.)when the MgO content was in the range of 2-6 wt.%.The continuous increase in 0^(2-)provided by the addition of MgO from 6 to 10 wt.%further depolymerized the network of the melt and fnally caused fast crystallizationo.

关键词： Crystallization Single hot thermocouple technique Melt structure Fluorine-free mold flux

A Revisit of Shape Editing Techniques:From the Geometric to the Neural Viewpoint

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Journal of Computer Science & Technology 2021年第3期36卷 520-554页

作者： Yu-Jie Yuan Yu-kun Lai Tong Wu lin Gao Ligang Liu Beijing key Laboratory of Mobile Computing and Pervasive Device Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China university of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAU.K. School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

3D shape editing is widely used in a range of applications such as movie production,computer games and computer aided *** is also a popular research topic in computer graphics and computer *** past decades,researchers have developed a series of editing methods to make the editing process faster,more robust,and more ***,the deformed shape is determined by the optimal transformation and weights for an energy *** increasing availability of 3D shapes on the Internet,data-driven methods were proposed to improve the editing *** recently as the deep neural networks became popular,many deep learning based editing methods have been developed in this field,which are naturally *** mainly survey recent research studies from the geometric viewpoint to those emerging neural deformation techniques and categorize them into organic shape editing methods and man-made model editing *** traditional methods and recent neural network based methods are reviewed.

关键词： mesh deformation man-made model editing deformation representation optimization deep learning

Large-scale multirole Zn(Ⅱ) programmed synthesis of ultrathin hierarchically porous carbon nanosheets

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Science China(Technological Sciences) 2020年第9期63卷 1730-1738页

作者： Xu lingSong MENG FanCheng WEI XiangFeng lin ChangHao ZHENG LianXi LIu JicHua Future Energy Laboratory School of Materials Science and EngineeringHefei University of TechnologyHefei230009China Department of Mechanical Engineering School of EngineeringKhalifa University of Science and TechnologyAbu Dhabi127788United Arab Emirates Engineering Research Center of High-Performance Copper Alloy Materials and Processing Ministry of EducationKey Laboratory of Advanced Functional Materials and Devices of Anhui ProvinceHefei230009China

ZIF-derived carbon structures are considered as desired electrode materials for supercapacitors due to their high surface area,high conductivity, and porous structure. However, the most reported ratio of 2-methylimidazole and Zn(II) is 4:1 to 20:1, which limits commercial applications due to the increasing cost. In this paper, a multirole Zn(II)-assisted method is presented from Zn(II) solution, Zn O, Zn O/ZIF-8 core-shell nanostructure, to 3 D hierarchical micro-meso-macroporous carbon structures with a1:1 ratio of 2-methylimidazole and Zn(II). The hierarchically porous carbon has a high surface area of 1800 m2 g^(-1) due to the synergistic effect of multirole Zn(II). The unique carbon-based half-cell delivers the specific capacitances of 377 and 221 F g^(-1) at the current densities of 1.0 and 50 A g^(-1), respectively. As a 2.5 V symmetrical supercapacitor, the device reveals a high doublelayer capacitance of 24.4 F g^(-1), a power density of 62.5 k W kg^(-1), and more than 85.8% capacitance can be retained over 10000 cycles at 10 A g^(-1). More importantly, the low-cost hierarchically porous carbon could be easily produced on a large scale and almost all chemicals can be reused in the sustainable method.

关键词： multirole Zn(Ⅱ) hierarchically porous carbon N doping carbon nanosheets supercapacitor

加味少腹逐瘀汤调控EGFR/PI3k/AkT信号通路诱导子宫内膜细胞自噬的作用机制

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北京中医药大学学报 2024年第9期47卷 1191-1202页

作者：杨亚玲王婉润张作良王家兴林祥羽武权生甘肃中医药大学附属医院兰州730000 甘肃中医药大学

目的从表皮生长因子受体(EGFR)/磷酸肌醇3-激酶(PI3k)/蛋白激酶B(AkT)信号通路介导异位子宫内膜组织细胞自噬角度探讨加味少腹逐瘀汤治疗子宫内膜异位症的潜在分子机制。方法72只雌性SD大鼠按照随机数字表法分为空白组、模型组、孕三烯... 详细信息

目的从表皮生长因子受体(EGFR)/磷酸肌醇3-激酶(PI3k)/蛋白激酶B(AkT)信号通路介导异位子宫内膜组织细胞自噬角度探讨加味少腹逐瘀汤治疗子宫内膜异位症的潜在分子机制。方法72只雌性SD大鼠按照随机数字表法分为空白组、模型组、孕三烯酮组及加味少腹逐瘀汤高、中、低剂量组,每组12只。采用自体移植法构建子宫内膜异位症模型。孕三烯酮组大鼠灌胃孕三烯酮混悬液0.25 mg/(kg·d),加味少腹逐瘀汤高、中、低剂量组大鼠分别灌胃加味少腹逐瘀汤水煎剂30、15、7.5 g/(kg·d),空白组及模型组大鼠灌胃等量生理盐水,连续4周。给药结束后,每只大鼠给予缩宫素2 u诱发宫缩,观察大鼠疼痛情况;记录大鼠异位子宫内膜组织的质量和体积;苏木素-伊红(HE)染色法观察各组大鼠子宫内膜组织病理变化;透射电镜观察各组大鼠子宫内膜组织超微结构;酶联免疫吸附测定法检测各组大鼠血清中雌二醇(E2)、孕酮(P)、白细胞介素-1β(IL-β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)、表皮生长因子(EGF)、EGFR含量;免疫荧光法检测各组大鼠子宫内膜组织中重组人自噬效应蛋白Beclin 1(Beclin-1)、微管相关蛋白1轻链3(LC3B)平均荧光强度;蛋白质印迹法检测各组大鼠子宫内膜组织中EGFR、PI3k、磷酸化磷酸肌醇3-激酶(p-PI3k)、AkT、磷酸化蛋白激酶B(p-AkT)的蛋白表达水平;实时荧光PCR法检测EGFR、PI3k、AkT mRNA表达水平。结果与空白组比较,模型组大鼠出现典型扭体反应,腹壁可见异位子宫内膜组织,HE结果显示,异位内膜组织增厚,间质增生,腺体扩张;超微结构仅见自噬小体,部分视野未见明显自噬结构;大鼠血清E2、IL-6、IL-1β、TNF-α、TGF-β、EGF、EGFR含量升高,P含量降低;自噬相关蛋白Beclin-1、LC3B平均荧光强度降低;EGFR、PI3k、AkT、p-PI3k、p-AkT蛋白表达升高;EGFR、PI3k、AkT mRNA表达升高(均Plin-1、LC3B平均荧光强度升高;EGFR、PI3k、AkT、p-PI3k、p-AkT蛋白表达降低;EGFR、PI3k、AkT mRNA表达降低(均Pk/AkT信号通路介导的异位子宫内膜组织自噬、减轻炎性反应有关。

关键词：子宫内膜异位症加味少腹逐瘀汤表皮生长因子受体(EGFR)/磷酸肌醇3-激酶(PI3k)/蛋白激酶B(AkT)信号通路自噬炎症大鼠

适用于单个流体包裹体LA-ICP-MS分析的多元素流体包裹体标样合成及飞秒激光分析方法建立

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矿物岩石地球化学通报 2024年第2期43卷 409-417页

作者：蒋子琦蓝廷广郭海浩尚林波王新松唐燕文中国科学院地球化学研究所矿床地球化学国家重点实验室贵阳550081 中国地质大学(武汉)地球科学学院武汉430074

单个流体包裹体成分LA-ICP-MS分析在精准示踪成矿物质来源和精细刻画成矿过程方面具有独特优势,但目前流体包裹体标样的研究还较缺乏,制约了该分析方法的发展和应用。本文通过高温加热-淬火法,结合金刚石磨片打磨和HF酸蚀,在石英中合成... 详细信息

单个流体包裹体成分LA-ICP-MS分析在精准示踪成矿物质来源和精细刻画成矿过程方面具有独特优势,但目前流体包裹体标样的研究还较缺乏,制约了该分析方法的发展和应用。本文通过高温加热-淬火法,结合金刚石磨片打磨和HF酸蚀,在石英中合成了数量多、大小适中且多为规则状/椭圆状的适用于LA-ICP-MS分析的多元素(B、Na、k、Mn、Co、Rb、Sr、Mo、Cs、W)流体包裹体标样。合成的流体包裹体标样冰点相对标准偏差(RSD)小于2%,显示均一性很好。193 nm激光和飞秒激光对该标样进行对比分析,结果显示193 nm激光获得的元素含量相对误差绝大多数(>85%)在±20%以内,RSD变化在5%~17%之间,测试准确度和精度与国际同行实验室相当。飞秒激光获得的元素含量多数(>80%)相对误差在±30%以内,RSD变化在11%~25%之间,准确度和精度比193 nm激光略差,但与国际同行实验室相当甚至更优,表明飞秒激光分析方法是可行的。飞秒激光能够极大地提高流体包裹体分析成功率和效率,具有广泛的应用前景,值得开展深入研究。

关键词：人工合成流体包裹体 LA-ICP-MS 飞秒激光