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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

Late effects of the treatment of childhood cancer

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World Journal of Clinical Cases 2025年第7期13卷 6-12页

作者： jelena Roganovic Department of Pediatric Oncology and Hematology Children's Hospital ZagrebZagreb 10000Croatia Faculty of Biotechnology and Drug Development University of RijekaRijeka 51000Croatia

Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being ***,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer *** has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during ***,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.

关键词： Survivorship Cancer Children Treatment Late effects

Seismic loss assessment of RC high-rise buildings designed according to Eurocode 8

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 807-824页

作者： jelena Pejovic Nina Serdar Faculty of Civil Engineering University of MontenegroBulevar Dzordza Vasingtona bbPodgorica 81000Montenegro

A probabilistic seismic loss assessment of RC high-rise(RCHR)buildings designed according to Eurocode 8 and located in the Southern Euro-Mediterranean zone is presented *** loss assessment methodology is based on a comprehensive simulation approach which takes into account ground motion(GM)uncertainty,and the random effects in seismic demand,as well as in predicting the damage states(DSs).The methodology is implemented on three RCHR buildings of 20-story,30-story and 40-story with a core wall structural *** loss functions described by a cumulative lognormal probability distribution are obtained for two intensity levels for a large set of simulations(NLTHAs)based on 60 GM records with a wide range of magnitude(M),distance to source(R)and different site soil conditions(SS).The losses expressed in percent of building replacement cost for RCHR buildings are *** the estimation of losses,both structural(S)and nonstructural(NS)damage for four DSs are *** effect of different GM characteristics(M,R and SS)on the obtained losses are ***,the estimated performance of the RCHR buildings are checked to ensure that they fulfill limit state requirements according to Eurocode 8.

关键词： RC high-rise buildings seismic loss assessment loss functions nonlinear time-history analysis(NLTHA) cumulative lognormal probability distribution random effects Eurocode 8

Association between innate immunity gene polymorphisms and neonatal sepsis development:a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第10期18卷 654-670页

作者： Tamara Sljivancanin Jakovljevic jelena Martic jelena Jacimovic Nadja Nikolic jelena Milasin Tanja Lazić Mitrović Department of Neonatology The Obstetrics and Gynecology Clinic“Narodni Front”BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia Department of Neonatology Mother and Child Health Care Institute of Serbia“Dr Vukan Cupic”BelgradeSerbia Central Library School of Dental MedicineUniversity of BelgradeBelgradeSerbia Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgradeSerbia

Background The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis *** A comprehensive literature search,reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines,was performed with no language *** derived using the PICO(population,intervention,comparison and outcomes)strategy,with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without *** were analyzed using Review *** Cochran–Mantel–Haenszel test was used to calculate odds ratios with 95%confidence *** was tested using the I2 *** From a total of 9428 possibly relevant articles,33 qualified for inclusion in this systematic *** to the STrengthening the REporting of Genetic Association Studies,23 studies were found to be of moderate quality,while 10 were of low *** results showed an association of the mannose-binding lectin(MBL)exon 1 genetic polymorphism with the risk of culture-proven ***-like receptor(TLR)4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven *** certainty of evidence per GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)varied from very low to *** bias was not *** Out of the 11 investigated single-nucleotide polymorphisms,this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 *** is an evident need for larger well-designed,multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.

关键词： Genetic Immunity Innate Neonatal sepsis Polymorphism

Real-time assessment of tunnelling-induced damage to structures within the building information modelling framework

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Underground Space 2024年第1期14卷 99-117页

作者： jelena Ninic Ali Gamra Bahman Ghiassi School of Engineering University of BirminghamB152TTUK Centre for Structural Engineering and Informatics The University of NottinghamNG72RDUK

During the initial design phases of complex multi-disciplinary systems such as urban tunnelling,the appraisal of different design alternatives can ensure optimal designs in terms of costs,construction time,and *** enable the evaluation of a large number of design scenarios and to find an optimal solution that minimises impact of tunnelling on existing structures,the design and assessment process must be efficient,yet provide a holistic view of soil-structure interaction *** paper proposes an integrated tunnel design tool for the initial design phases to predict the ground settlements induced by tunnelling and building damage using empirical and analytical solutions as well as simulation-based meta ***,visualisation of ground settlements and building damage risk is enabled by integrating empirical and analytical models within our Building Information Modelling(BIM)framework for *** approach allows for near real-time assessment of structural damage induced by settlements with consideration of soil-structure interaction and non-linear material ***,because this approach is implemented on a BIM platform for tunnelling,first,the design can be optimised directly in the design environment,thus eliminating errors in data exchange between designers and computational ***,the effect of tunnelling on existing structures can be effectively visualised within the BIM by producing risk-maps and visualising the scaled deformation field,which allows for a more intuitive understanding of design actions and for collaborative *** a fully parametric design model and real-time predictions therefore enables the assessment and visualisation of tunneling-induced damage for large tunnel sections and multiple structures in an effective and computationally efficient way.

关键词： Building information modelling Soil-structure interaction Tunnelling Settlements Structural damage Visualisation Meta models

Interview with light-wave architect jelena Vuckovic

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Advanced Photonics 2024年第4期6卷 9-13页

作者： Mengjie Yu jelena Vuckovic University of Southern California Viterbi School of EngineeringDepartment of Electrical and Computer EngineeringLos AngelesCaliforniaUnited States Stanford University the National Academy of Sciences the Nanoscale and Quantum Photonics Lab in the Ginzton Laboratory

Mengjie Yu:Hello,*** interview is organized by the journal Advanced *** today we're really honored and privileged to have Professor jelena Vuckovic from Stanford University here with us.I'm from University of Southern... 详细信息

关键词： wave interview light

Diagnostics of laser-induced plasma on carbon-based polymer material using atomic and molecular emission spectra

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Plasma Science and Technology 2023年第4期25卷 175-183页

作者： jelena PETROVIC Dragan RANKOVIC Miroslav KUZMANOVIC jelena SAVOVIC Vasili KIRIS Alena NEVAR Mikhail NEDELKO Nikolai TARASENKO University of Belgrade Institute of Nuclear Sciences VincaMike Petrovica Alasa 12-14Belgrade 11001Serbia University of Belgrade Faculty of Physical ChemistryStudentski trg 12-16Belgrade 11000Serbia Institute of Physics National Academy of Sciences of BelarusNezalezhnasci Ave.68-2Minsk 220072Belarus

Time-integrated optical emission analysis of laser-induced plasma on Teflon is *** was induced under atmospheric pressure air using transversely excited atmospheric CO_(2) laser *** is a C-based polymer that is,among other things,interesting as a substrate for laser-induced breakdown spectroscopy analysis of liquid *** study aimed to determine the optimal experimental conditions for obtaining neutral and ionized C spectral lines and C2 and CN molecular band emission suitable for spectrochemical *** of plasma parameters was done using several spectroscopic *** profiles of appropriate C ionic lines were used to determine electron number *** ratio of the integral intensity of ionic-to-atomic C spectral lines was used to determine the ionization temperature.A spectral emission of C2 Swan and CN violet bands system was used to determine the temperature of the colder,peripheral parts of *** critically analyzed the use of molecular emission bands as a tool for plasma diagnostics and suggested methods for possible improvements.

关键词： spectroscopy of laser-induced plasma laser-induced breakdown spectroscopy transversely excited atmospheric CO_(2)laser plasma diagnostics atomic and molecular emission spectra Teflon

Monodelphis domestica: a new source of mammalian primary neurons in vitro

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Neural Regeneration Research 2022年第8期17卷 1726-1727页

作者： jelena Ban Miranda Mladinic Laboratory for Molecular Neurobiology Department of BiotechnologyUniversity of RijekaRijekaCroatia

In vi t ro mode ls have tremendously revolutionized cell biology and biomedical research,reducing the need for in vivo experiments,as well as offering the simplified models for easier investigations at molecular and cellular level(for example genetic manipulations,electrophysiological measurements,drug screening etc.).However,the major challenge is to develop long-surviving in vitro preparations of post-mitotic cells such as neurons or *** overcome the problem of neuronal inability to proliferate,the immortalized cell lines derived from neuronal tumors have been *** secondary neuronal cultures are restricted to neuroblastoma-like cells,but their biological relevance is often questionable due to genetic drift and lack of mature,differentiated neuronal phenotypes,which makes primary cultures the better *** central nervous system(CNS)in vitro primary cell cultures are mostly prepared from the late embryonic or early postnatal mice and *** mammalian species have been less used,meaning that inter-species diversity is not sufficiently investigated and that the additional comparative analyses are required to avoid misinterpretations in translating the knowledge to humans(Bonfanti and Peretto,2011).

关键词： overcome offering mostly

Light of the stars:calcium signals light up astrocytes in the presence of autoreactive CD4+T cells

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Neural Regeneration Research 2021年第12期16卷 2395-2396页

作者： jelena BogdanovićPristov Ljiljana Nikolić Department of Life Sciences University of BelgradeInstitute for Multidisciplinary ResearchBelgradeSerbia Department of Neurophysiology University of BelgradeInstitute for Biological Research Siniša StankovićNational Institute of Republic of SerbiaBelgradeSerbia

Introduction:Astrocytes play important roles in the central nervous system(CNS)to support and regulate CNS *** are abundant type of glia that form a meshwork of interconnected cells almost completely tiling the *** astrocyte extends densely ramified processes that establish close contacts and interaction with other astrocytes,neurons and blood vessels,placing these cells in an ideal position to control extracellular milieu and to exert global effects on CNS physiology.

关键词： function. astrocytes cytes