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Hepatocellular carcinoma and musculoskeletal system: A narrative literature review

World Journal of Gastroenterology 2024年第15期30卷 2109-2117页

作者： jelena jadzic Danijela Djonic Center of Bone Biology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia

Musculoskeletal alterations in hepatocellular carcinoma(HCC)are less common than liver-related ***,they can significantly impact the quality of life and overall prognosis of patients with *** main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asym-ptomatic and unapparent during routine clinical *** narrative literature review aimed to provide a comprehensive overview of the contem-porary literature related to the changes in the musculoskeletal system in patients with HCC,focusing on its clinical implications and underlying etiopathogenetic *** bone metastases are the most common skeletal alterations associated with HCC,which could be associated with an increased risk of low-trauma bone ***,previous studies reported that osteopenia,sarcopenia,and myosteatosis are associated with poor clinical outcomes in patients with *** though low bone mineral density and sarcopenia are consistently reported as reliable predictors of pretransplantation and post-transplantation mortality in HCC patients,these complications are frequently overlooked in the clinical management of patients with *** together,contemporary literature suggests that a multidisciplinary approach is essential for early recognition and clinical management of HCC-associated musculoskeletal alterations to improve patient *** research into the mechanisms and treatment options for musculoskeletal complications is warranted to enhance our understanding and clinical management of this aspect of HCC.

关键词： Hepatocellular carcinoma Osteopenia Osteoporosis Sarcopenia Bone metastases Bone fragility

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Bone loss in chronic liver diseases:Could healthy liver be a requirement for good bone health?

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World Journal of Gastroenterology 2023年第5期29卷 825-833页

作者： jelena jadzic Danijela Djonic Center of Bone Biology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia

Given that the liver is involved in many metabolic mechanisms,it is not surprising that chronic liver disease(CLD)could have numerous *** osteoporosis and increased bone fragility are frequently overlooked complications in CLD *** studies implied that up to one-third of these individuals meet diagnostic criteria for osteopenia or *** publications indicated that CLD-induced bone fragility depends on the etiology,duration,and stage of liver ***,the increased fracture risk in CLD patients puts a severe socioeconomic burden on the health system and urgently requires more effective prevention,diagnosis,and treatment *** pathogenesis of CLD-induced bone loss is multifactorial and still insufficiently understood,especially considering the relative impact of increased bone resorption and reduced bone formation in these *** is essential to note that inconsistent findings regarding bone mineral density measurement were previously reported in these *** mineral density is widely used as the“golden standard”in the clinical assessment of bone fragility although it is not adequate to predict individual fracture ***,microscale bone alterations(bone microstructure,mechanical properties,and cellular indices)were analyzed in CLD *** studies further support the thesis that bone strength could be compromised in CLD individuals,implying that an individualized approach to fracture risk assessment and subsequent therapy is necessary for CLD ***,more well-designed studies are required to solve the bone fragility puzzle in CLD patients.

关键词： Chronic liver disease Fracture risk Hepatic osteodystrophy Osteoporosis Bone strength

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