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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

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Patients’experiences with‘sludge’(administrative burden)in the cancer screening process and its relationship with screening completion,experience and health system distrust

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Family Medicine and Community Health 2024年第S2期12卷 8-17页

作者： Michelle S Rockwell Brianna Chang Vivian Zagarese Jamie K Turner Ally Southworth YingXing Wu Paul Yeaton Li Li jeffrey S Stein Sarah H Parker John W Epling Department of Family and Community Medicine Virginia Tech Carilion School of MedicineRoanokeVirginiaUSA Department of Family and Community Medicine Carilion ClinicRoanokeVirginiaUSA Virginia Tech Carilion School of Medicine RoanokeVirginiaUSA Department of Health Systems and Implementation Science Virginia Tech Carilion School of MedicineRoanokeVirginiaUSA Graduate Program in Translational Biology Medicineand HealthVirginia TechRoanokeVirginiaUSA Health Analytics Research Team Carilion ClinicRoanokeVirginiaUSA Division of Gastroenterology Department of Internal MedicineCarilion ClinicRoanokeVirginiaUSA Department of Family Medicine University of Virginia School of MedicineCharlottesvilleVirginiaUSA Center for Health Behaviors Research Fralin Biomedical Research Institute at VTCRoanokeVirginiaUSA

Objective‘Sludge’refers to administrative burdens or frictions that preclude people from getting what they want or need(eg,duplicative forms,complicated instructions,long waiting times).This mixed methods study evaluated patients’perceptions of sludge in the colorectal cancer(CRC)screening process and some impacts of this *** We employed an exploratory sequential mixed methods study design that comprised patient interviews and a patient *** interviews informed final survey revisions and captured contextual data about patients’experiences with *** transcripts were inductively and deductively analysed to identify overarching *** survey quantified sludge,delayed or forgone screenings,screening experience(Net Promoter Score)and health system distrust(Health System Distrust Scale).We usedχ2 or t-tests for univariable comparisons and logistic or linear regressions to evaluate the association between cumulative sludge score and delayed or forgone screenings,screening experience and health system *** were integrated for *** Southeastern United *** Patients who were 45–75 years of age,at average risk for CRC and had either completed or been referred for CRC screening(colonoscopy or stool-based test)within the previous 12 *** 22 interview participants and 255 survey participants completed the study.38(15%)survey participants rated their screening experience as poor(Net Promoter Score=0–7 out of 10).The mean(SD)Health System Distrust Scale score was 22.4(6.3)out of 45 possible points(higher score=greater distrust).Perceptions of sludge in the CRC screening process varied,with long waiting times and burdensome communication being the most common sources(58%and 35%of participants,respectively).Sludge was positively associated with delayed or forgone screenings(OR=1.42,95%CI 1.28,1.57,p<0.001),poor screening experience(OR=1.15,95%CI 1.04,1.28,p=0.009)and health system distrust(β=0.47,p

关键词： sludge screening burden

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Relationships between Gene Structure and Genome Instability in Flowering Plants

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Molecular Plant 2018年第3期11卷 407-413页

作者： jeffrey L. Bennetzen Xuewen wang State Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Processing Ministry of Agriculture Anhui Agricultural University HefeiAnhui 230036 People's Republic of China Department of Genetics University of Georgia Athens GA 30602 USA

Flowering plant （angiosperm） genomes are exceptional in their variability with respect to genome size, ploidy, chromosome number, gene content, and gene arrangement. Gene movement, although observed in some of the earliest plant genome comparisons, has been relatively underinvestigated. We present here- in a description of several interesting properties of plant gene and genome structure that are pertinent to the successful movement of a gene to a new location. These considerations lead us to propose a model that can explain the frequent success of plant gene mobility, namely that Small Insulated Genes Move Around （SlGMAR）. The SIGMAR model is then compared with known processes for gene mobilization, and predic- tions of the SIGMAR model are formulated to encourage future experimentation. The overall results indicate that the frequent gene movement in angiosperm genomes is partly an outcome of the unusual properties of angiosperm genes, especially their small size and insulation from epigenetic silencing.

关键词： epigenetic silencing gene insulators gene movement illegitimate recombination inaccurate DNA break repair transposon mobilization

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寓言历久弥新

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青年视觉 2024年第1期 132-145页

作者： jeffrey Art D'Egypte(图) 不详

在过去的六十多年间,大地艺术已完成几次悄然的转向:整体上,Robert Smithson《螺旋码头》式的在地创作仍在继续,信手来以呼应自然,也有越来越多的创作者借助更多元的材料、形式,思考全球化和地域文明、历史和当下——从2021年开始,每年... 详细信息

在过去的六十多年间,大地艺术已完成几次悄然的转向:整体上,Robert Smithson《螺旋码头》式的在地创作仍在继续,信手来以呼应自然,也有越来越多的创作者借助更多元的材料、形式,思考全球化和地域文明、历史和当下——从2021年开始,每年一度在埃及吉萨金字塔群举办的Forever Is Now展览,再次扩大和丰富了这个艺术门类的内涵,它将文化遗产、自然、当代装置、创作者和欣赏者共同纳入一个互动情境中,讲述一个历久弥新的寓言:其发散的意义生成取决于地缘和创作者,也取决于欣赏的视角。

关键词：互动情境大地艺术意义生成文化遗产地域文明金字塔历久弥新全球化

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Storylines of family medicine Ⅺ:professional identity formation—nurturing one’s own story

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Family Medicine and Community Health 2024年第S3期12卷 99-108页

作者： William B Ventres Leslie A Stone Hamish J Wilson Sumi M Sexton David J Doukas Jessica P Cerdena David M Kelley Michael D Fetters jeffrey J Haney John J Frey III Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA General Practice and Rural Health University of Otago Dunedin School of MedicineDunedinNew Zealand Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine Tulane University School of MedicineNew OrleansLouisianaUSA Family Medicine Residency Program Middlesex HealthMiddletownConnecticutUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Medical Education and Clinical Sciences Washington State UniversitySpokaneWashingtonUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅺ:professional identity formation—nurturing one’s own story’,authors address the following themes:‘The social construction of professional identity’,‘On becoming a family physician’,‘What’s on the test?—professionalism for family physicians’,‘The ugly doc-ling’,‘Teachers—the essence of who we are’,‘Family medicine research—it starts in the clinic’,‘Socially accountability in medical education’,‘Personal philosophy and how to find it’and‘Teaching and learning with Storylines of Family Medicine’.May these essays encourage readers to find their own creative spark in medicine.

关键词： own becoming professional

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骨科教程脊柱外科的新进展

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中华骨科杂志 2010年第12期30卷 I0050-I0056页

作者： Keith H. Bridwell Paul A. Anderson Scott D. Boden Alexander R. Vaccaro jeffrey C. wang 许建中(译) 不详西南医院骨科重庆400038

目前，在美国获批的人工颈椎间盘置换器械主要有三种。这些人工椎间盘的运动学设计各不相同（球窝式、球槽式、可活动旋转轴心型），接触面也不同（不锈钢金属对金属，钴铬合金对聚乙烯，钛合金对聚碳酸酯一聚氨酯）。一些规模较大的临... 详细信息

目前，在美国获批的人工颈椎间盘置换器械主要有三种。这些人工椎间盘的运动学设计各不相同（球窝式、球槽式、可活动旋转轴心型），接触面也不同（不锈钢金属对金属，钴铬合金对聚乙烯，钛合金对聚碳酸酯一聚氨酯）。一些规模较大的临床试验正在研究钴铬合金的金属对金属接触面假体。

关键词：脊柱外科骨科教程人工椎间盘金属对金属颈椎间盘置换钴铬合金聚碳酸酯临床试验

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多样化二氧化碳去除方法下交通部门使用氢能的潜在效益和权衡（英文）

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Science Bulletin 2024年第1期 34-39页

作者：刘海峰 jeffrey Dankwa Ampah Sandylove Afrane Humphrey Adun 金超尧命发 State Key Laboratory of Engines Tianjin University School of Environmental Science and Engineering Tianjin University Energy Systems Engineering Department Cyprus International University

Climate change remains arguably one of the most important issues facing the world in the 21st *** to the Paris Agreement,the world should strive to limit global mean temperature change by 2100 to below 1.5-2℃above pre-industrial levels[1].To achieve this goal,global net carbon dioxide (CO2) emissions should reach zero no later than 2050 for the realization of the1.5℃target and 2070 for the 2℃target,respectively [2].Since the introduction of this global commitment,several mitigation options have been proposed to achieve the climate ***,

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A review of the origin of equiaxed grains during solidification under mechanical stirring,vibration,electromagnetic,electric-current,and ultrasonic treatments

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Journal of Materials Science & Technology 2023年第13期144卷 243-265页

作者： Nagasivamuni Balasubramani jeffrey Venezuela David StJohn Gui wang Matthew Dargusch Centre for Advanced Materials Processing and Manufacturing(AMPAM) School of Mechanical and Mining EngineeringUniversity of QueenslandSt.LuciaQLD 4072Australia

Refinement of grains and intermetallic phases in the as-solidified alloy structure offers uniform struc-tural properties,eliminates or minimizes common solidification defects,including segregation and hot cracking,and improves thermomechanical processing of wrought *** processing by an external field is an efficient process for achieving refinement of the solidification structure of Al and Mg alloys without altering the alloy composition.A wide range of melt processing methods and solidification stud-ies(conventional,directional,and in-situ approaches)have been reported in the literature that explore the mechanism of *** the dominant grain refinement mechanism has been a focus of most investigations because significant variations exist according to the casting conditions and the type of applied external *** origin of fine grains occurs through either one or a combination of heterogenous nucleation,fragmentation of dendrites and grains formed and then separated from the surface of the melt and mould wall under vibration or *** first part of this review describes the prominent external field techniques and the mechanisms proposed for the origin of fine *** second part critically compares the current understanding of these grain refinement mechanisms to de-termine differences and commonalities to identify the factors that promote the formation of equiaxed zones occupying a large volume fraction of the casting.

关键词： Grain refinement Solidification Melt processing Equiaxed grains Intermetallic refinement

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数字人文路径下的现代主义期刊研究与教学——以《小评论》为例

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数字人文研究 2024年第1期4卷 86-104页

作者：杰弗里·德鲁因王江(译) 美国塔尔萨大学重庆大学外国语学院

数字人文视域下的文学研究通常呈现出两种倾向:一种是对大规模数据集进行宏观层面的“远读”,另一种则是对单部作品的语言特性进行微观分析。其中,“大数据”项目利用软件对数百万卷期刊的出版数据或文学语料所构成的大规模数据集进行... 详细信息

数字人文视域下的文学研究通常呈现出两种倾向:一种是对大规模数据集进行宏观层面的“远读”,另一种则是对单部作品的语言特性进行微观分析。其中,“大数据”项目利用软件对数百万卷期刊的出版数据或文学语料所构成的大规模数据集进行可视化处理,进而揭示出学者们单凭自身的穷尽式阅读难以获知的各种历史模式。然而,这类方法无法深度阅读文学文本。与此同时,基于文本挖掘的微观分析也呈现出类似的优缺点。因此,本章旨在探索一种融合之道,即综合运用这两种方法解读1918年9月刊的《小评论》。

关键词：一战网络分析文本挖掘数据可视化语义标记

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Predictors of survival in autoimmune liver disease overlap syndromes

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World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams Gary P jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(P<0.05)in patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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