检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

长效β受体激动剂安全性亟待证明

中国处方药 2009年第4期8卷 10-10页

作者： jeffrey m.drazen Paul m.O'Byrne 梁伟

虽然从未有人对长效β受体激动剂治疗哮喘的疗效产生过质疑,但关于其安全性却在上市后十几年的时间里都未进行过系统的评价。为了更好的开发和使用此类药物,必须进行一次大规模的安全性评价研究。

关键词：长效β受体激动剂安全性安全评价上市后类药物

Data analytics and parallel-coordinate materials property charts

在线全文

学校读者我要写书评

暂无评论

npj Computational materials 2018年第1期4卷 631-638页

作者： jeffrey m.Rickman Department of materials Science and Engineering and Department of Physics Lehigh UniversityBethlehemPA 18015USA

It is often advantageous to display material properties relationships in the form of charts that highlight important correlations and thereby enhance our understanding of materials behavior and facilitate materials ***,in many cases,these correlations are highly multidimensional in nature,and one typically employs low-dimensional cross-sections of the property space to convey some aspects of these *** overcome some of these difficulties,in this work we employ methods of data analytics in conjunction with a visualization strategy,known as parallel coordinates,to represent better multidimensional materials data and to extract useful relationships among *** illustrate the utility of this approach by the construction and systematic analysis of multidimensional materials properties charts for metallic and ceramic *** charts simplify the description of high-dimensional geometry,enable dimensional reduction and the identification of significant property correlations and underline distinctions among different materials classes.

关键词： properties. property analytic

INVARIANCE AND STABILITY OF THE PROFILE EQUATIONS OF GEOmETRIC OPTICS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta mathematica Scientia 2011年第6期31卷 2141-2158页

作者： Guy mtivier jeffrey Rauch Institut de mathmatiques de Bordeaux Universit de Bordeaux Department of mathematics University of Michigan

The profile equations of geometric optics are described in a form invariant under the natural transformations of first order systems of partial differential equations. This allows us to prove that various strategies for computing profile equations are equivalent. We prove that if L generates an evolution on L2 the same is true of the profile equations. We prove that the characteristic polynomial of the profile equations is the localization of the characteristic polynomial of the background operator at （y, dφ（y）） where φ is the background phase. We prove that the propagation cones of the profile equations are subsets of the propagation cones of the background operator.

关键词： geometric optics profile equation localisation vector bundles propagation cones

Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第42期20卷 15564-15579页

作者： jeffrey m Sutton Daniel E Abbott Department of Surgery Division of Surgical Oncology University of Cincinnati Medical Center

Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy demonstrate a modest survival advantage over those patients who undergo resection alone. As such, most practitioners believe that completion of multimodality therapy is the optimal treatment. However, the sequence of surgery, chemotherapy and radiation therapy is frequently debated, as patients may benefit from a neoadjuvant approach by initiating chemotherapy and/or chemoradiation prior to resection. Here we review the rationale for neoadjuvant therapy, which includes a higher rate of completion of multimodality therapy, minimizing the risk of unnecessary surgical resection for patients who develop early metastatic disease, improved surgical outcomes and the potential for longer overall survival. However, there are no prospective, randomized studies of the neoadjuvant approach compared to a surgeryfirst strategy; the established and ongoing investigations of neoadjuvant therapy for pancreatic cancer are discussed in detail. Lastly, as the future of therapeutic regimens is likely to entail patient-specific genetic and molecular analyses, and the treatment that is best applied based on those data, a review of clinically relevant biomarkers in pancreatic cancer is also presented.

关键词： Pancreatic cancer Neoadjuvant therapy Chemotherapy Chemoradiation Biomarkers

Effects of ambient DIN:DIP ratio on the nitrogen uptake of harmful dinoflagellate Prorocentrum minimum and Prorocentrum donghaiense in turbidistat

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and Limnology 2011年第4期29卷 746-761页

作者：李纪 Patricia m. GLIBERT jeffrey A. ALEXANDER University of maryland Center for Environmental Science Horn Point Laboratory PO Box 775 Cambridge MD 21613 USA

The effects of varying nitrogen （N）： phosphorus （P） ratios on the growth and N-uptake and assimilation of the harmful dinoflagellates Prorocentrum minimum and Prorocentrum donghaiense were examined in turbidistat culture experiments. Algal cultures were supplied with media containing PO4^3- in various concentrations to obtain a wide range of N：P ratios. Experiments to determine rates of N uptake and assimilation of different N sources （NO^3-, NH4^＋, urea and glycine by P. minimum and NO3^-, NH4^＋ by P. donghaiense） were conducted using ^15-N tracer techniques at each N：P ratio. The growth rates suggested nutrient limitation at both high and low N：P ratios relative to the Redfield ratio. On a diel basis, the growth of both species was regulated by the light-dark cycle, which may be a result of regulation of both lightdependent growth and light-independent nutrient uptake. maximum growth rates of both species always occurred at the beginning of light phase. In P-rich medium （low N：P ratio）, both species had higher N assimilation rates, suggesting N limitation. Low assimilation coefficients at high N：P ratios suggested P limitation of N uptake and assimilation. NO3 ^-and NH4^＋ contributed more than 90% of the total N uptake of P. minimum. Reduced N sources were more quickly assimilated than NO3^-. Highest average daily growth rates were recorded near an N：P ratio of 12 for both species. The N uptake rates of cultures at N：P ratios near Redfield ratio were more balanced with growth rates. The linkage between growth rates and N uptake/assimilation rates were conceptually described by the variation of cell N quota. The N：P ratios affect the N uptake and growth of Prorocentrum spp., and may regulate their bloom progression in eutrophic ecosystems.

关键词： harmful dinoflagellate N:P ratio nitrogen uptake continuous culture Prorocentrum spp

Pain management strategies in penile implantation

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2020年第1期22卷 34-38页

作者： jeffrey L Ellis Andrew m Higgins Jay Simhan Department of Urology Einstein Healthcare NetworkDivision of Urologic OncologyDepartment of Surgical OncologyFox Chase Cancer CenterPhiladelphiaPA 19141 USA

The opioid epidemic continues to be a serious public health *** have pointed to prescription drug misuse as a nidus for patients to become addicted to opioids and as such,urologists and other surgical subspecialists must critically define optimal pain management for the various procedures performed within their respective *** pain following penile prosthesis implantation remains a unique challenge for urologists,given the increased pain patients commonly experience in the postoperative *** most of the existing urological literature focuses on interventions performed in the operating room,there are many studies that examine the role of preoperative adjunctive pain medicine in diminishing postoperative narcotic *** are relatively few studies looking at postoperative strategies for managing pain in prosthetic surgery with follow-up past the immediate *** review assess the various strategies employed for managing pain following penile implantation through the lens of the current state of the opioid crisis,thus examining how urologists can responsibly treat pain without contributing to the growing threat of opioid addiction.

关键词： analgesia epidemic opioid pain prosthetic

临床试验数据共享声明国际医学期刊编辑委员会统一要求

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2017年第16期20卷 365-366页

作者： Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano jeffrey m drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛不详中华医学杂志英文版编辑部

国际医学期刊编辑委员会（ICmJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICmJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数... 详细信息

国际医学期刊编辑委员会（ICmJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICmJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。迄今，应我们的反馈要求，ICmJE收到了很多来自个人和团体的意见。

关键词：临床试验数据数据共享期刊编辑工作

Salinization:the ultimate threat to temperate lakes,with particular reference to Southeastern Wisconsin(USA)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1461-1475页

作者： jeffrey A.THORNTON Thomas m.SLAWSKI Hebin LIN International Environmental management Services Ltd. Watershed Services Coordinator The Meadows Center for Water and the EnvironmentTexas State University601 University DriveSan MarcosTX 78666United States of America Graduate School of Human Development and Environment Kobe University3-11 TsurukabutoNada-kuKobeHyogo 657 8501Japan Southeastern Wisconsin Regional Planning Commission W239 N1812 Rockwood DriveP.O.Box 1607WaukeshaWI 53187-1607United States of America

many lakes in Southeastern Wisconsin(the metropolitan-milwaukee area) are gradually becoming increasingly "salty".While these waterbodies would not be considered presently to be saline lakes,there has been a rapid increase in the chloride concentrations in most of these lakes over the last 30 years,with the lakes increasing from a mean chloride concentration of about 19 mg/L to over 100 mg/L in some *** ecological impacts can be expected when chloride values exceed 250 mg/L,the rate of increase presents a basis for concern,especially since the underlying geology of the region is based on limestone/dolomite which is deficient in ***,the origin of the chlorides is anthropogenic:human and industrial wastewaters(treatment of which has effected improvements in trophic status but has not affected other water-borne contaminants) and winter de-icing practices based upon large quantities of sodium chloride are major contributors to the increasing concentrations of chloride in the region's *** taking remedial measures,the rate of salinization is expected to continue to increase,resulting,ultimately,in the alteration of the freshwater systems in the region.

关键词： salinization temperate lakes chloride concentrations salt management

这项临床试验完成注册了吗?——国际医学杂志编辑委员会声明

在线全文

学校读者我要写书评

暂无评论

中国循证医学杂志 2006年第4期6卷 310-312页

作者： Catherine De Angelis jeffrey m. drazen Frank A. Frizelle Charlotte Haug John Hoey Richard Horton Sheldon Kotzin Christine Laine Ana marusic A. John P.m. Overbeke Torben V.Schroeder Harold C. Sox martin B. Van Der Weyden 刁骧（译）孙丁（审校）秦莉（审校）《美国医学会杂志》主编《新英格兰医学杂志》主编《新西兰医学杂志》编辑《挪威医学杂志》主编《加拿大医学会杂志》编辑《柳叶刀杂志》编辑美国国立医学图书馆《内科学年鉴》副编审《克罗地亚医学杂志》编辑《荷兰医学杂志》执行编辑《丹麦医学会杂志》编辑《内科学年鉴》编辑《澳大利亚医学杂志》编辑不详

2004年9月，国际医学杂志编辑委员会（ICmJE）成员联合发表述评，旨在推动所有临床试验进行注册。我们声明，只有当某项试验在征集首位患者之前就进行了注册，才会考虑发表其研究结果。该政策适用于在2005年7月1日及以后开始征募患者的... 详细信息

2004年9月，国际医学杂志编辑委员会（ICmJE）成员联合发表述评，旨在推动所有临床试验进行注册。我们声明，只有当某项试验在征集首位患者之前就进行了注册，才会考虑发表其研究结果。该政策适用于在2005年7月1日及以后开始征募患者的试验。由于许多目前正在进行中的试验开始时都没有注册，对于这些试验我们将注册截止时间延长到2005年9月13日以前。我们当前和今后的目标是推动建立一个全面的、公众可及的临床试验数据库。对于那些承受风险参与临床试验的众多志愿者来说，完全注册是一种恰当的回报方式。他们有权知道通过他们的无私奉献换来的研究信息是否成为可能指导患者诊疗决策的公共记录的一部分；也有权知道对他们的诊疗决策是基于所有的试验证据，而非仅依据作者决定报道的和杂志编辑决定发表的部分试验。

关键词：临床试验数据库编辑委员会医学杂志国际诊疗决策时间延长无私奉献志愿者