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Efficacy of combined cataract extraction and endoscopic cyclophotocoagulation for the reduction of intraocular pressure and medication burden

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International journal of Ophthalmology(English edition) 2016年第5期9卷 693-698页

作者： Sammie j.Roberts Matthew Mulvahill jeffrey R.SooHoo Mina B.Pantcheva Malik Y.Kahook Leonard K.Seibold Department of Ophthalmology University of Colorado School of MedicineAnschutz Medical Campus Department of Biostatistics University of ColoradoAnschutz Medical Campus

AIM： To report on the efficacy of combined endoscopic cyclophotocoagulation（ECP） and phacoemulsification cataract extraction（PCE） with intraocular lens placement for reduction of intraocular pressure（IOP） and medication burden in glaucoma.·METHODS： A retrospective case review of 91 eyes（73patients） with glaucoma and cataract that underwent combined PCE/ECP surgery was performed. Baseline demographic and ocular characteristics were recorded,as well as intraocular pressure, number of glaucoma medications, and visual acuity postoperatively with 12-month follow-up. Treatment failure was defined as less than 20% reduction in IOP from baseline on two consecutive visits（at 1, 3, 6, or 12 mo postoperatively）,IOP ≥21 mm Hg or ≤5 mm Hg on two consecutive visits, or additional glaucoma surgery performed within12 mo after PCE/ECP.·RESULTS： Overall, mean medicated IOP was reduced from 16.65 mm Hg at baseline to 13.38 mm Hg at 12mo（P 0.0001）. Mean number of glaucoma medications was reduced from 1.88 medications at baseline to 1.48 medications at 12mo（P =0.0003）. At 3mo postoperatively,the success rate was 73.6%（95%CI： 63.3, 81.5）, 57.1% at6mo（95% CI： 46.3, 66.6）, and 49.7% at 12mo（95% CI：38.9, 59.6）. Patient demographic characteristics were not associated with treatment success. The only ocular characteristic associated with treatment success was a higher baseline IOP.· CONCLUSION： Combined PCE/ECP surgery is an effective surgical option for the reduction of IOP and medication burden in glaucoma patients. Patients withhigher baseline IOP levels are most likely to benefit from this procedure.

关键词： endoscopic cyclophotocoagulation glaucoma cataract extraction

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Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine

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Cellular & Molecular Immunology 2015年第6期12卷 719-728页

作者： Li-Zhen He jeffrey Weidlick Crystal Sisson Henry C Marsh Tibor Keler Celldex Therapeutics Inc. Hampton N J USA and Celldex Therapeutics Inc. Needham MA USA

Previous studies have documented that selective delivery of protein antigens to cells expressing mannose receptor （MR） can lead to enhanced immune responses. We postulated that agents that influenced the MR expression level, and the activation and migration status of MR-expressing antigen presenting cells, would modulate immune responses to MR-targeted vaccines. To address this question, we investigated the effect of clinically used adjuvants in human MR transgenic （hMR-Tg） mice immunized with an MR-targeting cancer vaccine composed of the human anti-MR monoclonal antibody B 11 fused with the oncofetal protein, human chorionic gonadotropin beta chain （hCGβ）, and referred to as B 11-hCGβ. We found that humoral responses to low doses of B11-hCGβ could be enhanced by prior administration of GM-CSF, which upregulated MR expression in vivo. However, co-administration of the Toll-like receptor （TLR） agonists, poly-ICLC and/or CpG with B11-hCGβ was required to elicit Thl immunity, as measured by antigen-specific T-cell production of IFN-γ. The TLR agonists were shown to increase the number of vaccine-containing cells in the draining lymph nodes of immunized hMR-Tg mice. In particular, with B11-hCGβand poly-ICLC, a dramatic increase in vaccine-positive cells was observed in the T-ceU areas of the lymph nodes, compared to the vaccine alone or combined with GM-CSF. Importantly, the absence of the TLR agonists during the priming immunization led to antigen-specific tolerance. Therefore, this study provides insight into the mechanisms by which adjuvants can augment immune responses to B11-hCGβ and have implications for the rationale design of clinical studies combining MR-targeted vaccination with TLR agonists.

关键词： GM-CSF hCGβ mannose receptor Toll-like receptor agonists

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CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma

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Cancer Communications 2021年第9期41卷 925-929页

作者： Wenhai Deng Panpan Chen Wen Lei Yang Xu Nengwen Xu jeffrey j.Pu Aibin Liang Wenbin Qian Key Laboratory of Laboratory Medicine Ministry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouZhejiang 325000P.R.China Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310009P.R.China University of Arizona NCI designated Comprehensive Cancer Center TucsonArizona 85719USA Department of Hematology Tongji Hospital of Tongji UniversityShanghai 200065P.R.China Institute of Hematology Zhejiang UniversityHangzhouZhejiang 310003P.R.China National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006P.R.China

To the Editor:CD19-targeting chimeric antigen receptor T(CAR-T)cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage ***,relapse with CD19-negative tumor after treatment with anti-CD19 CAR-T cells has been reported in different types of B-cell lymphoid malignancies,with a percentage exceeding 10% in patients with acute lymphoblastic leukemia[1]and up to 38% in patients with non-Hodgkin lymphoma(NHL)[2].

关键词： CD19 CAR acute

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Developmental and Feedforward Control of the Expression of Folate Biosynthesis Genes in Tomato Fruit

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Molecular Plant 2010年第1期3卷 66-77页

作者： jeffrey C. Wallera Tariq A. Akhtar Aurora Lara-Nunez jesse F. Gregory lli Ryan R McQuinn james j. Giovannoni Andrew D. Hanson Horticultural Sciences Department University of Florida Gainesville FL 32611 USA Food Science and Human Nutrition Department University of Florida Gainesville FL 32611 USA United States Department of Agriculture-Agricultural Research Service and Boyce Thompson Institute for Plant Research Ithaca NY 14853 USA

Little is known about how plants regulate their folate content, including whether the expression of folate biosynthesis genes is orchestrated during development or modulated by folate levels. Nor is much known about how folate levels impact the expression of other genes. These points were addressed using wild-type tomato fruit and fruit engineered for high folate content. In wild-type fruit, the expression of genes specifying early steps in folate biosynthesis declined during development but that of other genes did not. In engineered fruit overexpressing foreign GTP cyclohy- drolase I and aminodeoxychorismate synthase genes, the expression of the respective endogenous genes did not change, but that of three downstream pathway genes--aminodeoxychorismate lyase, dihydroneopterin aldolase, and mitochondrial folylpolyglutamate synthase--respectively increased by up to 7.8-, 2.8-, and 1.7-fold, apparently in response to the build-up of specific folate pathway metabolites. These results indicate that, in fruit, certain folate pathway genes are developmentally regulated and that certain others are subject to feedforward control by pathway intermediates. Micro- array analysis showed that only 14 other transcripts （of 11 000 surveyed） increased in abundance by two-fold or more in high-folate fruit, demonstrating that the induction of folate pathway genes is relatively specific.

关键词： Folate biosynthesis fruit development metabolic engineering transcript profiling.

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Volumetric measurement of rock movement using photogrammetry

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International journal of Mining Science and Technology 2016年第1期26卷 123-130页

作者： Benton Donovan j. Iverson Stephen R. Martin Lewis A. johnson jeffrey C. Raffaldi Michael j. National Institute for Occupational Safety and Health. Spokane 99207 USA

NIOSH ground control safety research program at Spokane,Washington,is exploring applications of photogrammetry to rock mass and support monitoring. This paper describes two ways photogrammetric techniques are being used. First,photogrammetric data of laboratory testing is being used to correlate energy input and support deformation. This information can be used to infer remaining support toughness after ground deformation events. This technique is also demonstrated in a field ***,field photogrammetric data is compared to crackmeter data from a deep underground *** were found to average 8 mm,but have produced results within 0.2 mm of true displacement,as measured by crackmeters. Application of these techniques consists of monitoring overall fault activity by monitoring multiple points around the crackmeter. A case study is provided in which a crackmeter is clearly shown to have provided insufficient information regarding overall fault ground *** is proving to be a useful ground monitoring tool due to its unobtrusiveness and ease of use.

关键词： PhotogrammetryGround controlMonitoringDeep vein miningVolume calculationCrackmeter

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Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

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Asian journal of Andrology 2023年第1期25卷 43-49页

作者： jeffrey j Leow Soon Hock Koh Marcus WL Chow Wayren Loke Rolando Salada Seok Kwan Hong Yuyi Yeow Chau Hung Lee Cher Heng Tan Teck Wei Tan Department of Urology Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore

Magnetic resonance imaging(MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s)on *** role of concurrent systematic in addition to targeted biopsies is currently *** our prospectively maintained database,we identified men with at least one Prostate Imaging-Reporting and Data System(PI-RADS)≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May *** significant prostate cancer(csPCa)was defined as any Gleason grade group≥2 *** 545 patients who underwent MRI fusion-targeted biopsy,222(40.7%)were biopsy naïve,247(45.3%)had previous prostate biopsy(s),and 76(13.9%)had known prostate cancer undergoing active *** cancer was more commonly found in biopsy-naïve men(63.5%)and those on active surveillance(68.4%)compared to those who had previous biopsies(35.2%;both P<0.001).Systematic biopsies provided an incremental 10.4%detection of csPCa among biopsy-naïve patients,versus an incremental 2.4%among those who had prior negative *** regression found age(odds ratio[OR]=1.03,P=0.03),prostate-specific antigen(PSA)density≥0.15 ng ml^(−2)(OR=3.24,P<0.001),prostate health index(PHI)≥35(OR=2.43,P=0.006),higher PI-RADS score(vs PI-RADS 3;OR=4.59 for PI-RADS 4,and OR=9.91 for PI-RADS 5;both P<0.001)and target lesion volume-to-prostate volume ratio≥0.10(OR=5.26,P=0.013)were significantly associated with csPCa detection on targeted *** conclusion,for men undergoing MRI fusion-targeted prostate biopsies,systematic biopsies should not be omitted given its incremental value to targeted biopsies *** factors such as PSA density≥0.15 ng ml^(−2),PHI≥35,higher PI-RADS score,and target lesion volume-to-prostate volume ratio≥0.10 can help identify men at higher risk of csPCa.

关键词： prostate biopsy prostate cancer prostate health index prostate-specific antigen software fusion Uronav

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Predicting Ground Effects of Omnidirectional Antennas in Wireless Sensor Networks

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Wireless Sensor Network 2010年第12期2卷 879-890页

作者： john F. janek jeffrey j. Evans 不详

Omnidirectional antennas are often used for radio frequency (RF) communication in wireless sensor networks (WSNs). Outside noise, electromagnetic interference (EMI), overloaded network traffic, large obstacles (vegetation and buildings), terrain and atmospheric composition, along with climate patterns can degrade signal quality in the form of data packet loss or reduced RF communication range. This paper explores the RF range reduction properties of a particular WSN designed to operate in agricultural crop fields to collect aggregate data composed of subsurface soil moisture and soil temperature. Our study, using simulation, anechoic and field measurements shows that the effect of antenna placement close to the ground (within 10 cm) signi?cantly changes the omnidirectional transmission pattern. We then develop and propose a prediction method that is more precise than current practices of using the Friis and Fresnel equations. Our prediction method takes into account environmental properties for RF communication range based on the height of nodes and gateways.

关键词： Omnidirectional Antenna Ground Effects Wireless Densor Networks

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Permutation and Complementary Algorithm to Generate Random Sequences for Binary Logic

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International journal of Communications, Network and System Sciences 2011年第5期4卷 345-350页

作者： jie Wan jeffrey Z. j. Zheng School of Software Yunnan University Kunming China

Randomness number generation plays a key role in network, information security and IT applications. In this paper, a permutation and complementary algorithm is proposed to use vector complementary and permuta-tion operations to extend n-variable Logic function space from 22n functions to 22n * 2n! configurations for variant logic framework. Each configuration contains 2n functions can be shown in a 22n-1*22n-1 matrix. A set of visual results can be represented by their symmetric properties in W, F and C codes respec-tively to provide the essential support on the variant logic framework.

关键词： Logic Function Permutation and Complementary Variant Logic Symmetric Distribution Random Sequence

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In-situ stress measurements and stress change monitoring to monitor overburden caving behaviour and hydraulic fracture pre-conditioning

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International journal of Mining Science and Technology 2016年第1期26卷 103-110页

作者： Puller jesse W. Mills Ken W. jeffrey Rob G. Walker Rick j. Strata Control Technology Wollongong NSW 2500 Australia CSIRO Energy Melbourne. Vic 3000 Australia

A coal mine in New South Wales is longwall mining 300 m wide panels at a depth of 160–180 m directly below a 16–20 m thick conglomerate strata. As part of a strategy to use hydraulic fracturing to manage potential windblast and periodic caving hazards associated with these conglomerate strata,the in-situ stresses in the conglomerate were measured using ANZI strain cells and the overcoring method of stress relief. Changes in stress associated with abutment loading and placement of hydraulic fractures were also measured using ANZI strain cells installed from the surface and from underground. Overcore stress measurements have indicated that the vertical stress is the lowest principal stress so that hydraulic fractures placed ahead of mining form horizontally and so provide effective pre-conditioning to promote caving of the conglomerate strata. Monitoring of stress changes in the overburden strata during longwall retreat was undertaken at two different locations at the mine. The monitoring indicated stress changes were evident 150 m ahead of the longwall face and abutment loading reached a maximum increase of about7.5 MPa. The stresses ahead of mining change gradually with distance to the approaching longwall and in a direction consistent with the horizontal in-situ stresses. There was no evidence in the stress change monitoring results to indicate significant cyclical forward abutment loading ahead of the face. The forward abutment load determined from the stress change monitoring is consistent with the weight of overburden strata overhanging the goaf indicated by subsidence monitoring.

关键词： Stress measurementOverburdenHydraulic fracturing Longwall

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Scatterhoarding rodents favor higher predation risks for cache sites:The potential for predators to influence the seed dispersal process

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Integrative Zoology 2015年第3期10卷 257-266页

作者： Michael A.STEELE Ghislain ROMPRÉ jeffrey A.STRATFORD Hongmao ZHANG Matthew SUCHOCKI Shealyn MARINO Department of Biology Wilkes UniversityWilkes-BarrePAUSA The Scotts Company MarysvilleOHUSA School of Life Science Central China Normal UniversityWuhanChina

Scatterhoarding rodents often place caches in the open where pilferage rates are reduced,suggesting that they tradeoff higher risks of predation for more secure cache *** tested this hypothesis in two study systems by measuring predation risks inferred from measures of giving-up densities(GUDs)at known cache sites and other sites for *** GUDs were measured with small trays containing 3 L of fine sand mixed with sunflower *** the first experiment,we relied on a 2-year seed dispersal study in a natural forest to identify caches of eastern gray squirrels(Sciurus carolinensis)and then measured GUDs at:(i)these caches;(ii)comparable points along logs and rocks where rodent activity was assumed highest;and(iii)a set of random *** found that GUDs and,presumably,predation risks,were higher at both cache and random points than those with *** the second site,we measured GUDs of eastern gray squirrels in an open park system and found that GUDs were consistently lowest at the base of the tree compared to more open sites,where previous studies show caching by squirrels to be highest and pilferage rates by naïve competitors to be *** results confirm that predation risks can influence scatterhoarding decisions but that they are also highly context dependent,and that the landscape of fear,now so well documented in the literature,could potentially shape the temporal and spatial patterns of seedling establishment and forest regeneration in systems where scatterhoarding is common.

关键词： giving-up densities predation risk scatterhoarding Sciurus seed dispersal

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