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Mitigation of municipal solid waste leachate contamination at Payatas, Metro Manila, Philippines: A technical proposal

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Chinese Journal Of Geochemistry 2006年第B8期25卷 122-122页

作者： Marvin Joseph Montefrio Kai Scene Ng Lee Yih Koh Erwin Torio Mark Hansley Chua Louernie de Sales-Papa jeffrey Philip Obbard National University of Singapore Division of Environmental Science and Engineering Singapore University of the Philippines Environmental Engineering Graduate Program Quezon City Philippines

Intravascular ultrasound assessment of the incidence and predictors of edge dissections and intramural hematomas after drug-eluting stent implantation

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上海医学 2007年第S1期30卷 32-32页

作者： Gary S.Mintz Stéphane G.Carlier Jose de Ribamar Costa Jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone jeffrey W.Moses GE Junbo Martin B.Leon Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Columbia University Medical Center and Cardiovascular Research Foundation New York USA.

Objective We used intravascular ultrasound (IVUS) to assess incidence, predictors, morphology, and angiographic findings of edge dissections and intramural hematomas after drug-eluting stent (DES) implantation. Methods We studied 887 patients with 1 045 non-in-stent restenosis lesions in 977 native arteries undergoing DES implantation with IVUS imaging, and compared the dissected stent end to the non-dissected stent end. Results Eighty-two dissections were detected; 51.2% (42/82) involved the proximal and 48.8% (40/82) the distal stent edge. When compared to the non-dissected stent end, residual plaque area [(8.0±4.3) mm2 vs (5.2±3.0) mm2, P<0.01], plaque burden [(52±12)% vs (36±15)%, P<0.01], plaque eccentricity (8.4±5.5 vs 4.0±3.4, P<0.01), and stent edge symmetry (1.17±0.11 vs 1.14±0.08, P=0.02) were larger; plaque burden≥50% was more frequent (62% vs 17%, P<0.01) and calcium deposits (52.5% vs 35.6%, P=0.03) more common; and the lumen/stent area (0.86±0.16 vs 1.02±0.18, P<0.01) was smaller in the stent dissected end. Independent predictors of stent edge dissection were residual plaque eccentricity (OR=1.3, P<0.01) and residual plaque burden≥50% (OR=7.3, P<0.01). Intramural hematomas occurred in 34.1% (28/82) of *** predictors of intramural hematomas were plaque eccentricity (OR=1.4, P=0.005), plaque burden≥50% (OR=7.1, P=0.02), and mean lumen diameter to stent diameter ratio (OR=0.37, P=0.04).Concluslon IVUS identified edge dissections after 9.4% of DES implantations. Residual plaque eccentricity and significant plaque burden predicted coronary stent edge dissections. Dissections in less diseased reference segments with an arc of normal vessel wall (greater plaque eccentricity) more often evolved into an intramural hematoma.

关键词： stent eluting plaque implantation burden restenosis intravascular incidence lumen dissection

Assessment of inconclusive left main coronary lesions: lessons from an intravascular ultrasound study

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上海医学 2007年第S1期30卷 109-109页

作者： Gary S.Mintz Stéphane G.Carlier Jose de Ribamar Costa Jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone jeffrey W.Moses Junbo Ge Martin B.Leon Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Columbia University Medical Center and Cardiovascular Research Foundation New YorkUSA

Objective Angiographic assessment of a left main coronary artery (LMCA) stenosis is often difficult and unreliable. Intravascular ultrasound (IVUS) assessment of absolute lumen dimensions has been shown to correlate with fractional flow reserve (FFR) and to predict clinical outcome in patients with a LMCA stenosis. Methods During 21 months period (October, 2004 to July, 2006), 153 patients (Ostial lesions, n=47; Non-ostial lesion, n=106) underwent IVUS evaluation specifically to assess the severity of an angiographically inconclusive LMCA narrowing. IVUS analysis included plaque morphology; external elastic membrane (EEM), lumen, plaque cross-sectional areas (CSA), plaque burden (plaque CSA/ EEM) and remodeling index (lesion EEM CSA/reference EEM CSA). Results Overall, minimum lumen area (MLA) and diameter (MLD) and plaque burden measured 8.2 mm2, 2.6 mm, and 59.3 %, respectively. An MLA<6.0 mm2 (which has been shown to correlate with a FFR <0.75) was seen 41.5% in ostial lesions and 44.5% in non-ostial lesions. In particular, ostial LMCA lesions had a larger MLA and a smaller plaque burden than non-ostial lesions (Table). Conclusions Patients referred for LMCA evaluation commonly have insignificant narrowing. Negative remodeling was prominent at the LMCA ostium. These patients deserve IVUS assessment before revascularization.

关键词： intravascular plaque remodeling stenosis burden severity lumen absolute dimensions correlate

Volumetric intravascular ultrasound comparisons of drug-eluting stent thrombosis and in-stent restenosis

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上海医学 2007年第S1期30卷 207-207页

Objectives We compared intravascular ultrasound (IVUS) findings of drug-eluting stent (DES)-treated lesions that developed stent thrombosis versus in-stent restenosis (ISR) to identify underlying mechanical differences. Methods IVUS findings in 15 post-DES thrombosis patients were compared with 45 matched ISR patients who had no evidence of stent thrombosis. Results Minimum stent area [MSA, (3.7±0.8) mm2 vs (4.9±1.8) mm2, P=0.01], minimum stent diameter [(1.9±0.3) mm vs (2.3±0.4) mm, P=0.005], mean stent area [(5.2±0.8) mm2 vs (7.2±2.1) mm2, P<0.01], and both focal [MSA/reference lumen area, (54.7±15.9)% vs (75.0±20.1)%, P=0.001] and diffuse stent expansion [mean stent area/reference lumen area, (76.6±23.0)% vs (110.3±23.3)%, P<0.01] were significantly smaller in the stent thrombosis group (vs the ISR group). An MSA <4.0 mm2 (73.3% vs 35.6%, P=0.01) or <5.0 mm2 (86.7% vs 53.3%, P=0.02) was more often found in the stent thrombosis group (vs the ISR group). The MSA site occurred more frequently in the proximal stent segment within the stent thrombosis group compared to the ISR group (60% vs 24.4%, P=0.01). There were no differences in edge dissection, stent fracture, or stent-vessel wall malapposition between the two groups. Independent predictors of stent thrombosis were diffuse stent expansion (OR=1.5, P=0.03) and proximal location of the MSA site (OR=12.7, P=0.04). Conclusion DES-treated lesions that develop thrombosis or restenosis are often underexpanded. Underexpansion appears to be more severe in DES-thrombosis lesions. Lesions with diffuse underexpansion and a proximal (vs distal) underexpanded MSA site are more predisposed to thrombus formation than ISR.

关键词： stent restenosis intravascular eluting proximal diffuse lumen thrombus dissection versus

面向21世纪的高等教育:实现卓越的六项考验

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上海教育 2013年第3期 47-47页

作者： jeffrey S.Lehman 王政吉孟旭初上海纽约大学

要成为上海纽约大学的一员,学生必须闪耀智慧的火花,具备高尚的品格,并且拥有能够与同学相互激发各自最大潜力的特质和个性。今年秋天,中国最年轻的大学——上海纽约大学,将敞开大门迎来第一批学生。上海纽约大学是高等教育界的一次大... 详细信息

要成为上海纽约大学的一员,学生必须闪耀智慧的火花,具备高尚的品格,并且拥有能够与同学相互激发各自最大潜力的特质和个性。今年秋天,中国最年轻的大学——上海纽约大学,将敞开大门迎来第一批学生。上海纽约大学是高等教育界的一次大胆尝试,很多人会问,是什么促使我们进行这样的尝试。在这里,我想为大家介绍一下这所大学的办学理念。

关键词：纽约大学

体重调整固定剂量普通肝素与低分子肝素治疗急性静脉血栓栓塞的比较

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美国医学会杂志（中文版） 2007年第5期26卷 259-264页

作者： Clive Kearon jeffrey S. Ginsberg Jim A. Julian James Douketis Susan Solymoss Paul Ockelford Sharon Jackson Alexander G. Turpie Betsy MacKinnon Jack Hirsh Michael Gent 王春玲（译）孙艺红（译）胡大一（校） McMaster University and the Henderson Research Centre Hamilton Ontario McGill University Montreal Quebec McGill University and University of Auckland Auckland New Zealand

背景：普通肝素用于治疗急性静脉血栓栓塞时，通常在监测血凝下静脉输注给药，患者需要住院治疗。然而，体重调整后皮下注射固定剂量普通肝素可能既适用于住院也适用于门诊静脉血栓栓塞患者的治疗。目的：确定皮下注射体重调整固定剂量... 详细信息

背景：普通肝素用于治疗急性静脉血栓栓塞时，通常在监测血凝下静脉输注给药，患者需要住院治疗。然而，体重调整后皮下注射固定剂量普通肝素可能既适用于住院也适用于门诊静脉血栓栓塞患者的治疗。目的：确定皮下注射体重调整固定剂量普通肝素治疗静脉血栓栓塞是否与低分子肝素同样安全有效。设计、地点及患者：随机、开标、裁定者盲法、非劣效试验。708例急性静脉血栓栓塞患者来自加拿大和新西兰6所大学附属临床中心，年龄≥18岁。试验于1998年9月至2004年2月进行。在随机分组的患者中，11例从疗效分析中排除，8例从安全性分析中排除。干预：普通肝素皮下注射初始剂量为333U／kg，以后给予固定剂量250U／kg，每12小时1次（n=345）。低分子肝素（依诺肝素或达肝素）按100IU／kg剂量皮下注射，每12小时1次（n=352）。两种治疗均可院外进行，配合华法林治疗3个月。主要观测指标：随机分组后3个月内复发性静脉血栓栓塞事件及10天内严重出血情况。结果：普通肝素组有13例患者（3．8％）发生静脉血栓栓塞复发，而低分子肝素组有12例患者复发（3．4％；绝对差值，0．4％；95％可信区间，-2．6％～3．3％）。开始治疗后10天内普通肝素组有4例患者（1．1％）发生严重出血，而低分子肝素组有5例（1．4％；绝对差值，-0．3％；95％可信区间，-2．3％～1．7％）。院外治疗患者在普通肝素组占72％，低分子肝素组占68％。结论：对于急性静脉血栓栓塞患者而言，皮下注射固定剂量普通肝素与低分子肝素一样安全有效，适于门诊治疗。

关键词：低分子肝素治疗静脉血栓栓塞普通肝素固定剂量急性体重安全性分析皮下注射

糖尿病视网膜病变和黄斑囊样水肿患者曲安奈德眼内注射前、后玻璃体内血管内皮生长因子和基质衍生因子-1的水平

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美国医学会眼科杂志（中文版） 2005年第2期17卷 93-99,106页

作者： H. Logan Brooks Sergio Caballero Charles K. Newell Robert L. Steinmetz Debbie Watson Mark S. Segal jeffrey K. Harrison Edward W. Scott Maria B. Grant 孙文赏(译) 申敏如(校) Southern Vitreoretinal Association. Tallahassee. Fla University of Florida Gainesville. the Departments of Pharmacology and Therapeutics University of Florida Gainesville. the Departmentsof Pharmacology and Medicine University of Florida Gainesville. the Departmentsof Pharmacology and Molecular Biology University of Florida Gainesville. 不详

背景：能导致糖尿病视网膜病变（DR）视力丧失的弥漫性黄斑囊样水肿（DME）和（或）异常新生血管（NV）可能受生长因子和化学激活剂的调节。化学激活素基质衍生因子-1（SDF-1）是一种血管内皮生长因子（VEGF）表达的有效刺激剂，是NV的... 详细信息

背景：能导致糖尿病视网膜病变（DR）视力丧失的弥漫性黄斑囊样水肿（DME）和（或）异常新生血管（NV）可能受生长因子和化学激活剂的调节。化学激活素基质衍生因子-1（SDF-1）是一种血管内皮生长因子（VEGF）表达的有效刺激剂，是NV的重要效应物。并且是与发生DME有关血管通透性的关键诱导物。循环中的内皮前体细胞对SDF-1应答迁徙参与NV。目的：调查不同程度的的DR和DME患者。在眼内注射曲安奈德（triamcinolone acetonide）前后，玻璃体中SDF-1和VEGF之间的关系。用于治疗难治的DME。方法：在这一前瞻性的研究中。包括36例患者并观察了6个月。在紧接着注射曲安奈德前和注射1个月后获得的标本，用酶联免疫吸附试验检测玻璃体中VEGF和SDF-1的水平。结果：增生性DR患者的VEGF和SDF-1与非增生DR患者相比显著高（P〈0．01）。DME患者与非DME患者相比较。SDF-1水平显著增加。VEGF与SDF-1的水平和疾病的严重程度相关（r^2=0．88）。结论：应用曲安奈德出现了激动人心的结果，VEGF和SDF-1降到了几乎检测不出来的水平。消除了DME并使活动性的NV退化。我们的结果支持SDF-1和VEGF在DR有害视力后果的发病机制中的作用，并提示注射曲安奈德后，可能由于抑制了VEGF和SDF-1，使得DME消退和（或）NV开始纤维化的退化。

关键词：血管内皮生长因子(VEGF) 糖尿病视网膜病变(DR) 黄斑囊样水肿水肿患者眼内注射曲安奈德玻璃体内衍生基质 SDF-1

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异常心理学

膝状神经节周围蛛网膜囊肿与面神经管脑脊液漏:一种罕见临床疾病的组织病理学联系

作者： (美)杰弗里·S. 尼维德(jeffrey S. Nevid) (美)斯潘塞·A. 拉瑟斯(Spencer A. Rathus) (美)贝弗里·A. 格林(Beverly A. Greene)

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中华耳鼻咽喉头颈外科杂志 2021年第9期56卷 1007-1007页

作者： Emerson E.Lee Nicholas S.Andresen Bryan McKenzie jeffrey D.Sharon Howard W.Francis Daniel Q.Sun 王鹏军(译) 殷善开(审校) 美国约翰斯·霍普金斯大学耳鼻咽喉头颈外科美国伊诺瓦费尔法克斯医院国加州大学旧金山分校耳鼻咽喉头颈外科美国杜克大学头颈外科和交流科学系上海市第六人民医院耳鼻咽喉头颈外科

目的起源于面神经管的脑脊液漏被认为是由于蛛网膜下腔沿面神经颞骨内段向膝状神经节或更远端区域异常延伸所致,但其病因尚不明确。尽管该病是颞骨脑脊液漏的一种罕见病因,但由于存在脑膜炎反复发作的风险、脑脊液漏的解剖位置难以确定... 详细信息

目的起源于面神经管的脑脊液漏被认为是由于蛛网膜下腔沿面神经颞骨内段向膝状神经节或更远端区域异常延伸所致,但其病因尚不明确。尽管该病是颞骨脑脊液漏的一种罕见病因,但由于存在脑膜炎反复发作的风险、脑脊液漏的解剖位置难以确定以及与手术修补困难,临床上仍可出现严重的后果。本文报道了3例面神经管膝状窝蛛网膜囊肿伴或不伴脑脊液漏的临床病例,并从1组人颞骨标本中发现了这种罕见临床现象的组织病理学联系。儿童与成人患者的脑脊液漏表现出不同的病理生理机制。颞骨组织学显示蛛网膜下腔在面神经管异常延伸,这可能是蛛网膜囊肿形成和膝状窝区出现脑脊液漏的原因。

关键词：面神经管蛛网膜囊肿脑脊液漏膝状神经节病理生理机制临床现象组织病理学蛛网膜下腔