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Livedoid vasculopathy improved by intravenous immunoglobulin

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Livedoid vasculopathy improved by intravenous immunoglobulin

Xanthoma disseminatum with intracranial involvement

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Tai Kyung Noh Chong Hyun Won Sung Eun Chang Mi Woo Lee jee ho choi Kee Chan Moon Department of Dermatology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

＜正＞Livedoid vasculopathy（LV） usually presents with painful,slowly healing ulcerations of the lower *** precise pathophysiology of this relatively rare disease remains *** strategies usually include rheologic, ant...

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Xanthoma disseminatum with intracranial involvement

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Tai Kyung Noh Hye Rim Moon Chong Hyun Won Sung Eun Chang Mi Woo Lee jee ho choi Kee Chan Moon Department of Dermatology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

＜正＞Xanthoma disseminatum（XD） is a rare normolipidemic mucocutaneous xanthomatosis classified as a benign non-Langerhans cell *** is characterized by mucocutaneous xanthomas symmetrically distributed,typically inv...

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Comparative Study of Transfer Learning Models for Retinal Disease Diagnosis from Fundus Images

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Computers, Materials & Continua 2022年第3期70卷 5821-5834页

作者： Kuntha Pin jee ho Chang Yunyoung Nam Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Ophthalmology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon420-767Korea Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea

While the usage of digital ocular fundus image has been widespread in ophthalmology practice,the interpretation of the image has been still on the hands of the ophthalmologists which are quite *** explored a robust deep learning system that detects three major ocular diseases:diabetic retinopathy(DR),glaucoma(GLC),and age-related macular degeneration(AMD).The proposed method is composed of two ***,an initial quality evaluation in the classification system is proposed to filter out poorquality images to enhance its performance,a technique that has not been explored ***,the transfer learning technique is used with various convolutional neural networks(CNN)models that automatically learn a thousand features in the digital retinal image,and are based on those features for diagnosing eye *** performance of many models is conducted to find the optimal model which fits with fundus *** the different CNN models,DenseNet-201 outperforms others with an area under the receiver operating characteristic curve of ***,the corresponding specificities for healthy,DR,GLC,andAMDpatients are found to be 89.52%,96.69%,89.58%,and 100%,*** results demonstrate that the proposed method can reduce the time-consumption by automatically diagnosing multiple eye diseases using computer-aided assistance tools.

关键词： Multiclass classification deep neural networks glaucoma agerelated macular degeneration diabetic retinopathy transfer learning quality evaluation

Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： jee-Yeon Ryu You Jung choi Eun-Jeong Won Emmanuel Hui ho-Shik Kim Young-Seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： Seongsoo Kim Seohyeon jee Kyung Min choi Dong-Sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

What physicians should know about the management of chronic hepatitis B in children: East side story

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World Journal of Gastroenterology 2014年第13期20卷 3582-3589页

作者： Hun-jee Choe Byung-ho Choe Seoul National University College of Medicine Seoul 110-799South Korea Department of Pediatrics Kyungpook National University School of MedicineDaegu 700-721South Korea

Understanding the natural course of chronic hepatitis B virus(HBV)infection is very important for the management and treatment of chronic hepatitis B in *** on treatment guidelines,the management of HBV carriers and treatment of active hepatitis have been advancing and resulted in increased survival,as well as decreased risks of complications such as liver cirrhosis and hepatocellular *** of a continuing medical education(CME)program for primary physicians becomes an important responsibility of pediatric *** could prevent misdiagnosis and unnecessary treatment that could lead to liver complications or antiviral *** addition,education of patients and their parents is necessary to achieve better therapeutic outcomes.

关键词： Hepatitis B virus Natural course Diagnosis Treatment Lamivudine Resistance

Study of Partial Coefficients for Design of Semicircular Breakwaters

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China Ocean Engineering 2010年第1期24卷 29-40页

作者：郄禄文 Byung ho choi College of Civil Engineering Hebei University Department of Civil and Environmental Engineering Sungkyunkwan University300 Chunchun-dongJangan-GuSuwon

In the present study, the reliability design of semicircular breakwater is based on the verification of the rules defined by standard specifications, where partial coefficients are introduced to ensure safety. The reliability of the semicircular breakwaters has been analyzed by using the Hasofer-Lind method to determine the reliability index of structure that has correlated loads, utilizing the long-term observed wave data at a given place. The relation curve between reliability index and safety factor in the traditional design method, as well as the relationships between reliability index and partial coefficients, have been obtained. This paper proposes values of partial coefficients for the design expression of semicircular breakwaters in the cases of anti-sliding and anti-overturning.

关键词： partial coefftcient reliability index correlated variables semicircular breakwater

Comparative Study of Visual and Instrumental Analyses of Shade Selection

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Journal of Wuhan University of Technology(Materials Science) 2010年第1期25卷 62-67页

作者： jee-Ha choi Ju-Mi Park Seung-Geun Ahn Kwang-Yeob Song Min-ho Lee Jae-Youn Jung Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The difference between visual and instrumental analyses of a shade selection on natural teeth was investigated. With visual analysis, five prosthodontist examined the middle third of the unrestored maxillary right central incisor of a patient using VITAPEN classical and Vita Toothguide 3D-MASTER tooth shade guide. In instrumental analysis, one prosthodontist examined the same teeth using a spectrophotometer （ShadepilotTM, Degudent, Hanau-Wolfgang, Germany, software 2.40）. Overall, instrumental analysis is more accurate and reproducible than a visual assessment. however, the difference is clinically acceptable.

关键词： shade selection visual analysis instrumental analysis spectrophotometer