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Distinctive and complementary roles of E2F transcription factors during plant replication stress responses

Molecular Plant 2023年第8期16卷 1269-1282页

作者： Maherun Nisa Thomas Eekhout Clara Bergis Jose-Antonio Pedroza-Garcia Xiaoning He Christelle Mazubert Ilse Vercauteren Toon Cools Rim Brik-Chaouche jeannine drouin-wahbi Layla Chmaiss David Latrasse Catherine Bergounioux Klaas Vandepoele Moussa Benhamed Lieven De Veylder Cécile Raynaud Universite Paris-Saclay CNRSINRAEUniversite EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Universite de Paris Cite CNRSINRAEInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium Center for Plant Systems Biology VIB9052 GhentBelgium Present address:Plant Molecular and Cellular Biology Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA

Survival of living organisms is fully dependent on their maintenance of genome integrity,being permanently threatened by replication stress in proliferating *** the plant DNA damage response(DDR)regulator SOG1 has been demonstrated to cope with replication defects,accumulating evidence points to other pathways functioning independent of ***,we report the roles of the Arabidopsis E2FA and EF2B transcription factors,two well-characterized regulators of DNA replication,in plant response to replication *** a combination of reverse genetics and chromatin immunoprecipitation approaches,we show that E2FA and E2FB share many target genes with SOG1,providing evidence for their involvement in the *** of double-and triple-mutant combinations revealed that E2FB,rather than E2FA,plays the most prominent role in sustaining plant growth in the presence of replication defects,either operating antagonistically or synergistically with ***,SOG1 aids in overcoming the replication defects of E2FA/E2FB-deficient ***,our data reveal a complex transcriptional network controlling the replication stress response in which E2Fs and SOG1 act as key regulatory factors.

关键词： replication stress E2F SOG1 cell cycle Arabidopsis

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A population study of fasting time and serum prostate-specific antigen （PSA） level

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Asian Journal of Andrology 2014年第5期16卷 740-744,I0009,I0010页

作者： Cheryl K Lau Maggie Guo jeannine A Viczko Christopher T Naugler Calgary Laboratory Services Calgary Department of Family Medicine University of Calgary Calgary Canada Department of Pathology and Laboratory Medicine Department of Family Medicine University of Calgary Calgary Canada

Prostate cancer is one of the most common cancers in men. Traditional screening and diagnostic methods include digital rectal examinations （DREs）, biopsies and serum prostate-specific antigen （PSA） tests, with the latter being the more popular. PSA is a biomarker for prostate cancer; however, it is highly sensitive to external factors as well as other prostate diseases. As such, the reliability of of the serum PSA level as a sole screening and diagnostic tool for prostate cancer is controversial. Recently, it has been shown that fasting extremes can affect concentrations of serum chemistry analytes, thus raising the question of whether or not fasting has an effect on the highly sensitive PSA biomarker. Patients testing for serum PSA levels are often concomitantly submitting to other tests that require fasting, subjecting certain patients to a fasting PSA level while others not. The objective of this study was to investigate whether this discrepancy in fasting state translates into an effect on serum PSA levels. Serum PSA levels and fasting time records for 157 276 men who underwent testing at Calgary Laboratory Services （CLS; Calgary, Alberta, Canada） between 01 January 2010 and 31 March 2013 were accessed. Linear regression models of mean PSA levels and fasting times revealed a statistically important relationship at certain fasting times. Applying a dynamic mathematical model to explore the clinical effect of fasting suggests minimal impact on serum PSA result interpretation. Thus, patients can be tested for serum PSA levels regardless of their fasting state.

关键词： diagnostic test fasting prostate-specific antigen (PSA)

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Cachexia and pancreatic cancer: Are there treatment options?

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World Journal of Gastroenterology 2014年第28期20卷 9361-9373页

作者： Tara C Mueller Marc A Burmeister jeannine Bachmann Marc E Martignoni Department of Surgery University Hospital Rechts der IsarTechnical University of Munich Braun Melsungen AG/Department of Anesthesiology University Hospital Hamburg Eppendorf

Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma (PDAC) and is associated with reduced survival and quality of life. Unfortunately, the therapeutic options of this multi-factorial and complex syndrome are limited. This is due to the fact that, despite extensive preclinical and clinical research, the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood. Furthermore, there is still a lack of consensus on the definition of cachexia, which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature. In order to provide an efficient therapy for cachexia, an early and reliable diagnosis and consistent monitoring is required, which can be challenging especially in obese patients. Although many substances have been tested in clinical and preclinical settings, so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia. However, recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancer-associated cachexia and ultimately improve patients’ outcome. In this current review, we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients. This strategy consists of nutritional, dietary, pharmacological, physical and psychological methods.

关键词： Cachexia Pancreatic neoplasms Nutritional support Gastrointestinal neoplasms

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Scalable nanolaminated SERS multiwell cell culture assay

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Microsystems & Nanoengineering 2020年第1期6卷 916-926页

作者： Xiang Ren Wonil Nam Parham Ghassemi jeannine S.Strobl Inyoung Kim Wei Zhou Masoud Agah Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Department of Statistics Virginia TechBlacksburgVA 24061USA

This paper presents a new cell culture platform enabling label-free surface-enhanced Raman spectroscopy(SERS)analysis of biological *** platform integrates a multilayered metal-insulator-metal nanolaminated SERS substrate and polydimethylsiloxane(PDMS)multiwells for the simultaneous analysis of cultured *** cell lines,including breast normal and cancer cells and prostate cancer cells,were used to validate the applicability of this unique *** cell lines were cultured in different *** Raman spectra of over 100 cells from each cell line were collected and analyzed after 12h of introducing the cells to the *** unique Raman spectra of each cell line yielded biomarkers for identifying cancerous and normal cells.A kernel-based machine learning algorithm was used to extract the high-dimensional variables from the Raman ***,the nonnegative garrote on a kernel machine classifier is a hybrid approach with a mixed nonparametric model that considers the nonlinear relationships between the higher-dimension *** breast cancer cell lines and normal breast epithelial cells were distinguished with an accuracy close to 90%.The prediction rate between breast cancer cells and prostate cancer cells reached 94%.Four blind test groups were used to evaluate the prediction power of the SERS *** peak intensities at the selected Raman shifts of the testing groups were selected and compared with the training groups used in the machine learning *** blind testing groups were correctly predicted 100% of the time,demonstrating the applicability of the multiwell SERS array for analyzing cell populations for cancer research.

关键词： laminated culture prediction

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Over-the-scope-grasper: A new tool for pancreatic necrosectomy and beyond-first multicenter experience

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 799-808页

作者： Markus Brand jeannine Bachmann Christoph Schlag Ulrich Huegle Imdadur Rahman Edris Wedi Benjamin Walter Oliver Moschler Lukas Sturm Alexander Meining Department of Internal Medicine II University of WürzburgWürzburg 97080Germany Department of Surgery Klinikum rechts der IsarUniversity of MünchenMünchen 81675Germany Department of Gastroenterology and Hepatology University of ZürichZürich 8091Switzerland Department of Gastroenterology and Hepatology Klinikum Koln-HolweideKoln 50968Germany Department of Gastroenterology University Hospital SouthamptonSouthampton SO166YDUnited Kingdom Department of Gastroenterology Gastrointestinal Oncology and Interventionell EndoscopySana Klinikum OffenbachOffenbach 63069Germany Department of Internal Medicine I University of UlmUlm 89070Germany Department of Gastroenterology Marienhospital OsnabrückOsnabrück 49074Germany Department of Internal Medicine II University of FreiburgFreiburg 79106Germany

BACKGROUND Endoscopic treatment of pancreatic necrosis can be challenging and timeconsuming because sticky necrotic debris is sometimes difficult to remove. The over-the-scope-grasper, a new tool that has recently become available for this purpose, might also be useful for other indications. However, clinical data on the efficacy and safety of this new device are *** To evaluate the technical success and safety of the device in a multicenter *** The over-the-scope-grasper was used in nine selected endoscopic centers between November 2020and October 2021 for appropriate indications. Overall, 56 procedures were included in the *** retrospectively evaluated procedural parameters of all endoscopic interventions using a predefined questionnaire, with special respect to technical success, indications, duration of intervention, type of sedation, and complications. In the case of pancreatic necrosectomy, the access route, stent type, number of necrosis pieces removed, and clinical handling were also *** A total of 56 procedures were performed, with an overall technical success rate of 98%. Most of the procedures were endoscopic pancreatic necrosectomies(33 transgastric, 4 transduodenal). In 70%of the procedures, access to the necrotic cavity was established with a lumen apposing metal *** technical success of pancreatic necrosectomy was 97%, with a mean of 8 pieces(range, 2-25pieces) of necrosis removed in a mean procedure time of 59 min(range, 15-120 min). In addition,the device has been used to remove blood clots(n = 6), to clear insufficiency cavities before endoluminal vacuum therapy(n = 5), and to remove foreign bodies from the upper gastrointestinal tract(n = 8). In these cases, the technical success rate was 100%. No moderate or severe/fatal complications were reported in any of the 56 *** These first multicenter data demonstrate that the over-the-scope-grasper is a promising device for endoscopic pancreat

关键词： Over-the-scope-grasper Endoscopic pancreatic necrosectomy Grasper Direct endoscopic necrosectomy Pancreatic necrosis Endoscopic tool

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Seasonal variation in native hydraulic conductivity between two deciduous oak species

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Journal of Plant Ecology 2020年第1期13卷 78-86页

作者： Dilia Mota-Gutiérrez Guadalupe Arreola-González Rafael Aguilar-Romero Horacio Paz jeannine Cavender-Bares Ken Oyama Antonio Gonzalez-Rodriguez Fernando Pineda-García Facultad de Biología Universidad Michoacana de San Nicolás de Hidalgo.Edificio RCiudad UniversitariaGral.Francisco J.Múgica S/N A-1Felicitas de Río58030 MoreliaMichoacánMexico Escuela Nacional de Estudios Superiores Unidad MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Instituto de Investigaciones en Ecosistemas y Sustentabilidad Campus MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Deparment of Ecology Evolution and BehaviorUniversity of MinnesotaSaint PaulMN 55108USA

Aims Mechanisms of plant drought resistance include both tolerance and *** vulnerability to embolism and turgor loss point are considered traits that confer tolerance,while leaf abscission and deciduousness characterizes the avoidance *** these mechanisms are thought to trade-off expressing a continuum among species,little is known on how variation in the timing and duration of leaf shedding in response to drought affect the relationship between xylem and leaf *** the present study,we explored the extent to which drought tolerance differs between two oak(Quercus)species that exhibit different leaf shedding ***,we predicted that *** Trel.,which loses leaves at the end of the dry season(late-deciduous)and is thus exposed to a greater risk of cavitation,would be more drought tolerant and more conservative in its water use than *** Liebm.,which loses its leaves for only a short period of time in the middle of the dry season(brevideciduous).Methods The study was conducted in central Mexico in a single population of each of the two oak species,separated from each other by a distance of 1.58 km,and by an altitudinal difference of 191 *** deserticola(late deciduous)is more frequent down slope,while ***(brevideciduous)tends to occur at higher elevations along the *** assessed seasonal differences(rainy versus dry season)in native stem hydraulic conductivity,and tested for variation in xylem vulnerability to cavitation,leaf water use and leaf turgor loss point between the two *** Findings The two oak species did not differ in traits conferring drought tolerance,including xylem vulnerability to embolism,leaf turgor loss point,or stomatal ***,both species had different performance during the dry season;the brevideciduous species had lower negative impact in the xylem function than the late-deciduous ***,seasonal changes in plant physiological performance

关键词： Quercus hydraulic conductivity embolisms leaf phenology

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Sleep Characteristics in Mice with Targeted Disruptions of Neuronal or Inducible Nitric Oxide Synthase Genes

Sleep Characteristics in Mice with Targeted Disruptions of N...

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The4thASRSCongress

作者： jeannine A.Majde James M.Krueger Department of Veterinary and Comparative Anatomy Pharmacology and PhysiologyWashington State UniversityPullmanWAUSA 99164-6520 Department of Veterinary and Comparative Anatomy Pharmacology and PhysiologyWashington State UniversityPullmanWAUSA 99164-6520

＜正＞Nitric oxide has many biological activities, including the regulation of sleep. NO is derived from arginine via the action of nitric oxide synthase （NOS）. There are three types of NOSs: neuronal （nNOS）, inducible （iNOS）, and endothelial （eNOS）. Several lines of evidence indicate that NO plays an important role in rapid eye movement sleep （REMS） regulation. To further

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Exploring HONO formation and its role in driving secondary pollutants formation during winter in the North China Plain

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环境科学学报:英文版 2023年第10期132卷 83-97页

作者： Shaobin Zhang Guo Li Nan Ma Yao He Shaowen Zhu Xihao Pan Wenlin Dong Yanyan Zhang Qingwei Luo jeannine Ditas Uwe Kuhn Yuxuan Zhang Bin Yuan Zelong Wang Peng Cheng Juan Hong Jiangchuan Tao Wanyun Xu Ye Kuang Qiaoqiao Wang Yele Sun Guangsheng Zhou Yafang Cheng Hang Su Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 511443China Max Planck Institute for Chemistry Mainz 55128Germany School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Institute of Mass Spectrometry and Atmospheric Environment Jinan UniversityGuangzhou 510632China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Institute of Atmospheric CompositionChinese Academy of Meteorological SciencesBeijing 100081China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Gucheng Experimental Station of Ecological and Agricultural Meteorology Chinese Academy of Meteorological SciencesBeijing 100081China

Daytime HONO photolysis is an important source of atmospheric hydroxyl radicals(OH).Knowledge of HONO formation chemistry under typical haze conditions,however,is still *** the Multiphase chemistry experiment in Fogs and Aerosols in the North China Plain in 2018,we investigated the wintertime HONO formation and its atmospheric implications at a rural site *** different episodes based on atmospheric aerosol loading levels were classified:clean periods(CPs),moderately polluted periods(MPPs)and severely polluted periods(SPPs).Correlation analysis revealed that HONO formation via *** conversion of NO_(2)was more efficient on aerosol surfaces than on ground,highlighting the important role of aerosols in promoting HONO *** HONO budget analysis indicated a large missing source(with an average production rate of 0.66±0.26,0.97±0.47 and 1.45±0.55 ppbV/hr for CPs,MPPs and SPPs,respectively),which strongly correlated with photo-enhanced reactions(NO_(2)heterogeneous reaction and particulate nitrate photolysis).Average OH formation derived from HONO photolysis reached up to(0.92±0.71),(1.75±1.26)and(1.82±1.47)ppbV/hr in CPs,MPPs and SPPs respectively,much higher than that from O3 photolysis(i.e.,(0.004±0.004),(0.006±0.007)and(0.0035±0.0034)ppbV/hr).Such high OH production rates could markedly regulate the atmospheric oxidation capacity and hence promote the formation of secondary aerosols and pollutants.

关键词： HONO North China Plain Budget analysis OH radicals

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使用Web Services Enhancements发送带有附件的SOAP消息

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中文信息（程序春秋） 2003年第8期 35-38页

作者： jeannine Hall Gailey 鬼稻子

WS-Attachments 是一种推荐的 Web 服务标准,它能利用 DIME 消息封装协议来帮助在 SOAP 消息中发送附件。本文得介绍 Web Services Enhancements(WSE)1.0 fof *** 支持使用 DIME 和 WS-Attachments 规范来发送附件的方法。

关键词： Web Services Enhancements SOAP 附件发送方法 DIME消息封装协议

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舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者安全性的评价:随机双盲临床研究

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中华麻醉学杂志 2022年第1期42卷 16-23页

作者： W.Joseph Herring Yuki Mukai Aobo Wang jeannine Lutkiewicz John F.Lombard Li Lin Molly Watkins David M.Broussard Manfred Blobner 美国默克集团临床研究部肯纳尔沃斯堡新泽西州07033美国奥克斯纳诊所基金会新奥尔良市洛杉矶70121美国慕尼黑工业大学医学院麻醉科与重症监护医学科慕尼黑80333德国乌尔姆大学医学院麻醉科与重症监护医学科乌尔姆89081德国

目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库... 详细信息

目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库溴铵或维库溴铵)进行随机分组,新斯的明/格隆溴铵组:中度神经肌肉阻滞;舒更葡糖钠2 mg/kg组,中度神经肌肉阻滞;舒更葡糖钠4 mg/kg组,深度神经肌肉阻滞;舒更葡糖钠16 mg/kg组,深度神经肌肉阻滞(仅罗库溴铵)。主要研究终点包括治疗期间窦性心动过缓、窦性心动过速和其他心律失常的发生情况。结果344例患者进入随机化分配,331例患者接受了治疗[61%为男性,BMI(28.5±5.3)kg/m^(2),年龄(69±11)岁]。舒更葡糖钠2 mg/kg组治疗期间窦性心动过缓发生率显著降低,舒更葡糖钠2 mg/kg组和4 mg/kg组治疗期间窦性心动过速发生率显著降低(P0.05)。结论ASA分级Ⅲ或Ⅳ级高风险手术患者使用舒更葡糖钠拮抗罗库溴铵或维库溴铵诱导的中度和深度神经肌肉阻滞的安全性良好。

关键词：舒更葡糖钠安全性 ASA分级Ⅲ或Ⅳ级

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