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Study of the Osmosis Phenomenon to Predict the Stiffness of the Arterial Wall

材料科学与工程（中英文B版） 2020年第2期10卷 64-73页

作者： jeanne sandrine mabekou takam Jean Romaric Tsafack Nzifack Medar Fogue Pierre Kisito Talla Unitéde Recherche de Mécanique et de Modélisation des Systèmes Physiques(UR2MSP) Universitéde DschangDschang 237Cameroun Unitéde Recherche d’ingénierie des systèmes industriels et de l’Environnement(LISIE) IUT Fotso Victor de BandjounBandjoun 237Cameroun

In the present work we describe a new expression of total stress taking into account the passive and active contributions but especially the pore level *** attention is paid to the effective stress and osmotic pressure gradient in numerical simulation to understand the mechanical behavior of the human arterial *** new model aims to predict the rigidity of the artery,by using the theoretical model of hyper-elastic,anisotropic and dynamical behavior of human common carotid *** principal obtained result showed that:the osmosis phenomenon is the best parameter to explain the loss water in arterial *** loss of water causes the rigidity of the artery which thus can be controlled by the osmosis *** the results are in good agreement with the expected results of the literature and could play the important role in the diagnosis of the patients with the CVD(Cardiovascular Disease).

关键词： Hyper-elastic anisotropic effective stress osmosis phenomenon

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Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing

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Cellular & Molecular Immunology 2020年第4期17卷 418-420页

作者： Hussein Issaoui Mélissa Ferrad Nour Ghazzaui sandrine Lecardeur jeanne Cook-Moreau François Boyer Yves Denizot UMR CNRS 7276 INSERM U1262Equipe Labellisée LIGUE 2018University of LimogesCBRSrue Pr.Descottes87025 LimogesFrance

Activation-induced deaminase(AID)is required for immunoglobulin(Ig)class switch recombination(CSR),in which the constant(C)μgene of IgM is substituted with C_(γ),C_(ε),or C_(α),thereby generating IgG,IgE,and IgA antibodies,respectively,with new effector functions but the same antigenic specificity.1 AID targets specific DNA switch(S)regions preceding C regions except for Cδ.2 Sμis usually the donor region,while Sγ,ε,αare the acceptor *** deaminates C into U on single-stranded DNA by targeting the WRCY(W=A/T,R=A/G,and Y=C/T)hot motif and,to a lesser extent,the SYC(S=G/C,Y=C/T)cold motif.3,4 AID is a member of the apolipoprotein B editing complex(APOBEC)*** APOBEC genes,a family of evolutionarily conserved cytidine deaminases,APOBEC3 is implicated in diverse cell functions including innate immunity against retroviruses.4 The DNA-editing APOBEC3 enzymes have recently attracted attention due to their involvement in cancer and potential applications in gene editing.5–7 While a single copy of each APOBEC3 gene is present in rodents,seven copies of each APOBEC3 gene are found in humans.

关键词： immunity involvement thereby

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Mediator contributes to IgH locus VDJ rearrangements by promoting usage of most distal V segments

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Cellular & Molecular Immunology 2020年第4期17卷 407-409页

作者： Iman Dalloul Zeinab Dalloul sandrine Le Noir François Boyer Bernardo Reina-San-Martin jeanne Cook-Moreau Michel Cogné UMR CNRS 7276 INSERM U1262Universite de LimogesLimoges 87025France INSERM U1258 UMR CNRS 7104Institut de Genetique et de Biologie Moleculaire et CellulaireUniversitéde StrasbourgIllkirch 67400France

INTRODUCTION The immunoglobulin heavy(IgH)chain locus includes a large cluster of V,D and J segments spanning thousands of kilobases in mammals and its expression implies long-range 3D-regulation of various gene modifications.1 V(D)J recombination occurs during early B-cell ontogeny.2 It is regulated by multiple transcription factors and cis-regulatory elements,and most notably by the intronic 5′Eμelement located in the JH to Cμintron.3 The intergenic control region 1(IGCR1)located between the VH and D gene clusters inhibits rearrangement of the most DH-proximal VH gene segments,while promoting usage of distal VH gene segments.4 Other downstream elements of the locus,flanking its 3′end might have more subtle roles:while the large 3′regulatory region(3′RR)shows strong internal synergies2 and behaves as a superenhancer in mature B *** deletion showed no influence on the VDJ repertoire and rather increased transcription of unrearranged V segments.3–5 Insulators binding CTCF farther downstream of the 3′RR were shown,however,to promote usage of distal VH segments.6 Altogether,there are strong indications that elements involved in long-distance regulation of transcription might also influence VDJ ***-frame splicing of VDJ exons is also needed for full Ig expression.7 Given the functional importance of gene architecture and long-range interactions for the IgH locus physiology,we explored the dependence of the VDJ repertoire on Med1,a known actor of long-range enhancer interactions.

关键词： B cells mediator VDJ repertoire

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RIP140 regulates POLK gene expression and the response to alkylating drugs in colon cancer cells

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Cancer Drug Resistance 2022年第2期5卷 401-414页

作者： Pascale Palassin Marion Lapierre sandrine Bonnet Marie-jeanne Pillaire Balázs Győrffy Catherine Teyssier Stéphan Jalaguier Jean-Sébastien Hoffmann Vincent Cavaillès Audrey Castet-Nicolas IRCM Institut de Recherche en Cancérologie de MontpellierINSERMU1194Institut Régional du Cancer de MontpellierUniversitéde MontpellierMontpellier 34298France Institut de Pharmacologie et de Biologie Structurale IPBSUniversitéde ToulouseCNRSUPSToulouse 31077France. Department of Bioinformatics Semmelweis University and TTK Lendület Cancer Biomarker Research GroupBudapest H-1117Hungary Laboratoire de pathologie Laboratoire d’excellence Toulouse CancerInstitut Universitaire du Cancer-ToulouseOncopoleToulouse 31059France Département de Pharmacie Clinique Centre Hospitalo-Universitaire MontpellierMontpellier 34295France. Unitéde Formation et de Recherche des Sciences Pharmaceutiques et Biologiques Montpellier 34090France.

Aim:The transcription factor RIP140(receptor interacting protein of 140 kDa)is involved in intestinal *** plays a role in the control of microsatellite instability(MSI),through the regulation of MSH2 and MSH6 gene *** aim of this study was to explore its effect on the expression of POLK,the gene encoding the specialized translesion synthesis(TLS)DNA polymeraseκknown to perform accurate DNA synthesis at ***:Different mouse models and engineered human colorectal cancer(CRC)cell lines were used to analyze by RT-qPCR,while Western blotting and luciferase assays were used to elucidate the role of RIP140 on POLK gene *** DNA microarray datasets were *** in vitro sensitivity of CRC cells to methyl methane sulfonate and cisplatin was ***:RIP140 positively regulates,at the transcriptional level,the expression of the POLK gene,and this effect involves,at least partly,the p53 tumor *** different cohorts of CRC biopsies(with or without MSI),a strong positive correlation was observed between RIP140 and POLK gene *** connection with its effect on POLK levels and the TLS function of this polymerase,the cellular response to methyl methane sulfonate was increased in cells lacking the Rip140 ***,the association of RIP140 expression with better overall survival of CRC patients was observed only when the corresponding tumors exhibited low levels of POLK,thus strengthening the functional link between the two genes in human ***:The regulation of POLK gene expression by RIP140 could thus contribute to the maintenance of microsatellite stability,and more generally to the control of genome integrity.

关键词： Colorectal cancer genome stability translesion DNA synthesis polymerase Pol Kappa RIP140

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