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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1624-1628页

作者： Milena Pahlitzsch jeanette brünner Johannes Gonnermann Anna-Karina B.Maier Necip Torun Eckart Bertelmann Matthias KJ.Klamann Glaucoma and Retinal Degeneration Research Group UCLInstitute of Ophthalmology Department of Ophthalmology Campus Virchow ClinicCharite University MedicineAugustenburger Platz 1

AIM： To compare IOPen and ICare rebound tonometry to Goldmann applanation tonometry（GAT） according to International Standards Organization（ISO） 8612 ***： Totally 191 eyes（n =107 individuals） were included. Criteria of ISO 8612 were fulfilled： 3 clusters of IOP, measured by GAT, were formed. The GAT results were given as mean±standard ***： GAT（19.7±0.5 mm Hg） showed a significant correlation to ICare（19.8±0.5 mm Hg）（r =0.547, P 〈0.001）and IOPen（19.5 ±0.5 mm Hg）（r =0.526, P 〈0.001）.According to ISO 8612 criteria in all 3 IOP groups the number of outliers（of the 95% limits of agreement）exceeded 5% for ICare and IOPen vs GAT： No.1（n =68）29.4% and 22.1%, No.2（n =62） 35.5% and 37.1%, No.3（n =61） 26.2% and 42.6%, ***： The strict requirements of the ISO 8612 are not fulfilled in a glaucoma collective by ICare and IOPen at present. As long as the Goldmann tonometry is applicable it should be used first of all for reproducible IOP readings. ICare and IOPen tonometry should be considered as an alternative tool, if application of Goldmann tonometry is not possible.

关键词： ICare tonometry IOPen tonometry Goldmann applanation tonometry glaucoma intraocularpressure

Photocatalytic OH radical formation and quantification over TiO_2 P25:Producing a robust and optimised screening method

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Chinese Chemical Letters 2018年第6期29卷 773-777页

作者： Caitlin Buck Nathan Skillen jeanette Robertson Peter K.J.Robertson School of Chemistry and Chemical Engineering Queen's University Belfast School of Biological Sciences Queen's University Belfast Medical Biology Centre

The development of photocatalytic technology has grown significantly since its initial report and as such,a number of screening methods have been developed to assess activity. In the field of environmental remediation, a crucial factor is the formation of highly oxidising species such as OH radicals. These radicals are often the primary driving force for the removal and breakdown of organic and inorganic contaminants. The quantification of such compounds is challenging due to the nature of the radical,however indirect methods which deploy a chemical probe to essentially capture the radical have been shown to be effective. As discussed in the work presented here, optimisation of such a method is fundamental to the efficiency of the method. A starting concentration range of coumarin from 50 mmol/L to 1000 mmol/L was used along with a catalyst loading of 0.01 g/L to 1 g/L Ti TiO2 to identify that 250 mmol/L and 0.5 g/L Ti TiO2 were the optimum conditions for production. Under these parameters a maximum production rate of 35.91 mmol/L（Rmax= 0.4 mmol/L OH＊ min-1） was achieved which yielded at photonic efficiency of 4.88 OH＊moles photon-1 under UV irradiation. The data set presented also highlighted the limitations which are associated with the method which included; rapid exhaustion of the probe molecule and process inhibition through UV light saturation. Identifying both the optimum conditions and the potential limitations of the process were concluded to be key for the efficient deployment of the photocatalytic screening method.

关键词： Photocatalytic screening OH radical quantification Coumarin Environmental remediation Method optimisation

An assessment of direct and indirect effects of climate change for populations of the Rocky Mountain Apollo butterfly （ Parnassius smintheus Doubleday）

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Insect Science 2011年第4期18卷 385-392页

作者： Stephen F. Matter Amanda Doyle Kurt Illerbrun jeanette Wheeler Jens Roland Department of Biological Sciences University of Cincinnati Cincinnati Ohio USA Department of Biological Sciences University of Alberta Edmonton Alberta Canada Department of Mathematical and Statistical Sciences University of Alberta Edmonton Alberta Canada

Climate change is occurring and insects are responding. Current challenges for ecologists and managers are predicting how organisms will respond to continuing climate change and determining how to mitigate potential negative effects. In contrast to broad scale predictions for climate change involving the distribution of species, in this article we highlight the many ways in which local populations of the Rocky Mountain Apollo butterfly （Parnassius smintheus Doubleday） are predicted to respond to climate change. Using experimental and observational data collected over the past 15 years, we detail both direct and indirect effects. In addition, we identify limitations in our knowledge restricting the ability to predict how populations will respond to climate change. Some changes, such as warmer winter temperatures, may have beneficial effects; however, most of the effects of climate change will be detrimental. Variability in snow cover during the overwintering period and habitat loss due to forest encroachment have the largest potential negative effects.

关键词： alpine host plants population growth tree-line weather

Ophthalmic community perception of new medication needs

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 848-851页

作者： William C.Stewart jeanette A.Stewart Lindsay A.Nelson PRN PharmaFarm LLC

AIM：To survey ophthalmologists（who have participated previously in clinical research） and ophthalmic industry professionals（who have been involved in ocular research and development） to indicate perceived needs for new pharmaceuticals in various ophthalmic ***：A prospective,industry-based survey was sent to ophthalmologists and ophthalmic industry professionals about the perceived needs for new pharmaceutical ***：This survey was sent to 559 ophthalmic pharma professionals and *** received 82（15%） *** results showed that the most commonly perceived need for new pharmaceuticals were dry and wet age-related macular degeneration,glaucoma,diabetic macular edema and dry *** was a statistical difference found between response groups（P〈0.0001）.Respondents indicated they would express their commitment to a new product they perceived as needed by recommending to colleagues（63%）,prescribing（60%）,participating as principle investigator in a related clinical trial（52%）,advising the company（52%）,lecturing on behalf of the product（43%）,investing in the product（38%）,taking no action（7%） or obtain a position in the company（1%）.CONCLUSION：Ophthalmic pharma professionals and ophthalmologists perceive the greatest need for new medicines in ophthalmology to be in dry and wet agerelated macular degeneration,glaucoma,diabetic macular edema and dry eye.

关键词： ophthalmic ophthalmology ocular eye disease pharmaceuticals start-up development needs medication therapies future new treatments

New and Unusual Cat's Eyes and Asteriated Gems

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宝石和宝石学杂志（中英文） 2022年第1期24卷 1-11页

作者： Martin P.Steinbach Lore Kiefert jeanette Fiedler STEINBACH-Gems with a Star Idar-Oberstein 55743Germany Dr.Lore Kiefert Gemmology Consulting Heidelberg 69115Germany DDI-Foundation German Diamond Institute Pforzheim 75172Germany

The article describes 6 types of gemstones which show phenomena such as chatoyancy and *** gemstones have not been described before,either because they come from new sources,or because the phenomenon has not been seen before in the type of gemstone *** from the new sources are star garnet from the Karelia Province in Russia,and star garnet from the Jiangsu Province in *** usually does not show a cat’s eye effect,but the two described samples display a weak cat’s *** unusual white quartz from brazil with a sharp cat’s eye is described,as well as a star sapphire with two differently coloured stars on each side of the cabochon,as well as a trapiche-type *** stones were tested with gemmological,microscopic,and advanced techniques and the results are presented.

关键词： cat’s eye star asterism chatoyancy quartz grandidierite sapphire garnet

FIVE RED TIDE SPECIES IN GENUS PROROCENTRUM INCLUDING THE DESCRIPTION OF PROROCENTRUM DONGHAIENSE LU SP. *** THE EAST CHINA SEA

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Chinese Journal of Oceanology and Limnology 2001年第4期19卷 337-344页

作者：陆斗定 jeanette Goebel Submarine Geoscience of SOA Second Institute of Oceanography Landesamt für Natur und Umwelt des Landes Schleswig-Holstein Hamburger Chaussee 25

A new planktonic dinoflagellate, Prorocentrum donghaiense Lu sp. nov., is described in the present paper. The water sample was collected from the Changjiang Estuary, the East China Sea. The species identification is based on shape, size, surface micro morphology, ornamentation of thecal plates and the architecture of the periflagellar area and the intercalary bands as seen by light and scanning electron microscope. Prorocentrum donghaiense Lu sp. nov. is compared with other prorocentrum species with respect to morphological characteristics and bloom behavior. It is not known whether Prorocentrum donghaiense Lu sp. nov produces phycotoxins like some other Prorocentrum species. Four other red tide species in the family Prorocentraceae (Dinophyceae), namely P. balticum , P. minimum, P. micans, P. triestinum , were examined and identified by light and scanning electron microscope. They have been recorded as bloom forming species. Some aggregates of Prorocentrum are observed at the end of blooms. An event of strong discoloration caused by P. donghaiense could be detected by satellite sensor in the East China Sea in the late spring of 1995.

关键词： Prorocentrum micro morphology East China Sea red tide

Prophylaxis with intraocular pressure lowering medication and glaucomatous progression in patients receiving intravitreal anti-VEGF therapy

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1611-1618页

作者： jeanette Du James T Patrie Xiao-Yu Cai bruce E Prum Yevgeniy Shildkrot New York Eye and Ear Infirmary of Mount Sinai 310 East 14 StreetNew YorkNY 10003USA Department of Public Health Sciences University of VirginiaP.0.Box 800717CharlottesvilleVirginia 22908USA Department of Ophthalmology University of Virginia School of Medicine1300 Jefferson Park AveCharlottesvilleVirginia 22908USA

AIM: To investigate whether pretreatment with pressurelowering medication prior to anti-vascular endothelial factor(VEGF) injections had an effect on glaucomatous progression in patients with preexisting glaucoma or ocular hypertension(OHT).METHODS: A total of 66 eyes from 54 patients with a preexisting diagnosis of glaucoma or OHT, treated with six or more anti-VEGF injections were selected for chart review. Primary outcome measures were rate of visual field loss in d B/year, rate of change in retinal nerve fiber layer(RNFL) thickness in microns/year, and need for additional glaucoma ***: The number of eyes requiring additional glaucoma medication was 5 of 20(25.0%) and 14 of 46(30.4%) for the pretreated and non-pretreated groups, respectively. The number of eyes requiring glaucoma laser or surgery was 4 of 20(20.0%) and 13 of 46(28.3%) for the pretreated and non-pretreated groups, respectively. Estimated mean rate of pattern standard deviation decline was not significant in either group(P>0.073), with no difference between groups(P=0.332). Although both groups showed significant RNFL change from baseline(P<0.011), no difference was detected between groups(P=0.467).CONCLUSION: Pretreatment has no detectable effect on structural or functional glaucomatous progression. Patients receiving repeated injections may be at risk for glaucomatous complications requiring invasive intervention.

关键词： anti-vascular endothelial growth factor therapy pretreatment glaucomatous progression

TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants

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Molecular Plant 2020年第5期13卷 717-731页

作者： jeanette Moulinier-Anzola Maximilian Schwihla Lucinda De-Araujo Christina Artner Lisa Jorg Nataliia Konstantinova Christian Luschnig Barbara Korbei Institute of Molecular Plant Biology Department of Applied Genetics and Cell BiologyUniversity of Natural Resources and Life SciencesVienna(BOKU)Muthgasse 181190 ViennaAustria Department of Molecular Toxicology and Environment Biotechnology Center-Eduardo Mondlane UniversityAv.de MocambiqueKm 1.5.MaputoMozambique Institute of Science and Technology Austria(1ST Austria) Am Campus 13400 KlosterneuburgAustria

Protein abundance and localization at the plasma membrane(PM)shapes plant development and mediates adaptation to changing environmental *** is regulated by ubiquitination,a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent *** understand the significance and the variety of roles played by this reversible modification,the function of ubiquitin receptors,which translate the ubiquitin signature into a cellular response,needs to be *** this study,we show that TOL(TOM1-like)proteins function in plants as multivalent ubiquitin receptors,governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport(ESCRT)***2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding *** of these domains results not only in a loss of ubiquitin binding but also altered localization,abolishing TOL6 ubiquitin receptor *** and localization of TOL6 is itself regulated by ubiquitination,whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes,assisting in the fine-tuning of the delicate interplay between protein recycling and *** together,our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants.

关键词： ubiquitination ESCRT pathway ubiquitin receptor plasma membrane protein degradation

Morphological and genetic comparison of two strains of a Prorocentrum species isolated from Zhejiang coastal water of China and Masan Bay of Korea

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Chinese Journal of Oceanology and Limnology 2011年第4期29卷 832-839页

作者：陆斗定王红霞黄海燕夏平戴鑫烽 GBEL jeanette JEONG Hae Jin State Key Laboratory of Satellite Ocean Environment Dynamics Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of Oceanography State Oceanic Administration Landesamt für Landwirtschaft Umwelt und lndliche Rume Hamburger Chaussee 25 Flintbek 24220 Germany School of Earth and Environmental Science College of Natural Sciences Seoul National University Korea

In this paper, we examined the detailed morphology of two strains of Prorocentrum isolated from the coastal waters of Zhejiang (Wenling area), China, and Masan Bay of Korea. A taxonomic comparison was made among strains on the basis of morphological and molecular data. The cellular dimensions of the Chinese Wenling strain (LAMB090508) and Korean strain (PDKS0206) were similar and the cells of both strains were of asymmetric and elongated shape. The posterior end of most cells was rounded. Megacytic zones of aged cells were broader with dense tiny knobs. The roundish nucleus was located in the posterior part of the cell. A few irregular shaped chloroplasts were distributed within the cell. The nucleotide similarity of the two strains, determined from the 5.8S rDNA-ITS sequences, was 99.83%. The comparative results of morphology and molecular analysis suggest that both strains isolated from China and Korea were the identical species, Prorocentrum donghaiense Lu.

关键词： Prorocentrum morphology 5.8S rDNA-ITS coastal waters of China Korea

Clearcuts and related secondary dieback undermine the ecological effectiveness of FSC certification in a boreal forest

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Ecological Processes 2020年第1期9卷 108-116页

作者： jeanette Silvin Blumröder Monika T.Hoffmann Olga Ilina Susanne Winter Peter R.Hobson Pierre L.Ibisch Centre for Econics and Ecosystem Management Eberswalde University for Sustainable DevelopmentAlfred-Moeller-Str.116225 EberswaldeGermany Petrozavodsk State University Lenina st.33185000 PetrozavodskRussia Karelian Nature Conservancy(SPOK) PetrozavodskRussia WWF Germany Reinhardtstr1810117 BerlinGermany Centre for Econics and Ecosystem Management Writtle University CollegeLordship RoadWrittle Chelmsford Essex CM13RRUK

Background:Over the last 25 years,the prominent forest certification system established by the Forest Stewardship Council(FSC)has used by many companies worldwide for claiming responsible forest *** objectives of the Russian National FSC standard to decrease the size of clearcuts and the retention of forest elements such as residual seed trees need on-site validation to proof the effectiveness of *** assess the ecological impacts of harvesting practices and benefits of FSC certification,we geospatially compared logging activities with and without FSC *** a sample area covering approximately 3,000 km^(2) in the east of the Russian Arkhangelsk Region,we used available data on tree cover loss and satellite images to assess secondary impacts of clearcuttings on adjacent remnant forests and to quantify the logging ***,the size and structure as well as the density of skidding trails of ten specific clearcuttings located within the sample area were surveyed using satellite images and in the field observation to delineate the boundaries of clearcuts and forested remnants within the ***:We found a significant increase of small-scale tree cover loss in the proximity of the *** dieback is possibly linked to the scale and intensity of logging in the *** the investigated clearcuts,FSC failed to reduce the size,to increase the retention of forest remnants including seed trees on logged areas,and to maintain larger tracts of undisturbed ground and soil compared to clearcuts that were logged before they received ***:Trees and forest remnants remaining inside an increasingly stressed forest ecosystem matrix may not resist further harvesting-related and climate change-induced stresses and ***-scale clearcuttings seem to have negative impacts even in adjacent forests and undermine the ecological effectiveness of FSC certification in the study *** Russi

关键词： Ecological effectiveness Impact assessment Forest certification Sustainable forestry