检索结果-南通市图书馆

计算机与应用化学 1999年第2期16卷 101-104,110页

作者：陈海峰姚建华袁身刚荔建锋杨铄郑崇直范波涛 A.PANAYE J.P.DOUCET 中国科学院上海有机化学研究所中国科学院计算机化学开放实验室法国巴黎第七大学拓扑及系统动力学研究所

介绍了ＭｏｎｔｅＣａｒｌｏ法和遗传算法两种柔性构象检索方法，并对４种药效团进行了柔性构象检索，经过对比发现遗传算法可以在比较合理的时间内得得到较多的命中结构，比ＭｏｎｔｅＣａｒｌｏ法更适用于柔性构象检索。

关键词：柔性构象检索三维分子结构分子结构检索

Sustainable strategies for Ebola virus disease outbreak preparedness in Africa:a case study on lessons learnt in countries neighbouring the Democratic Republic of the Congo

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Infectious Diseases of Poverty 2022年第6期11卷 60-69页

作者： Caroline S.Ryan Marie‑Roseline D.Belizaire Miriam Nanyunja Olushayo Oluseun Olu Yahaya Ali Ahmed Anderson Latt Matthew Tut Kol Bertrand Bamuleke Jayne Tusiime Nadia Nsabimbona Ishata Conteh Shamiso Nyashanu Patrick Otim Ramadan Solomon Fisseha Woldetsadik jean‑pierre Mulunda Nkata Jim T.Ntwari Senya D.Nzeyimana Leopold Ouedraogo Georges Batona Vedaste Ndahindwa Elizabeth A.Mgamb Magdalene Armah Joseph Francis Wamala Argata Guracha Guyo Alex Yao Sokemawu Freeman Alexander Chimbaru Innocent Komakech Muhau Kuku Walter M.Firmino Grace E.Saguti Faraja Msemwa Shikanga O‑Tipo Precious C.Kalubula Ngoy Nsenga Ambrose Otau Talisuna WHO Sub-Regional Ofce for Africa NairobiKenya WHO Country Ofce BanguiCentral African Republic WHO Country Ofce JubaSouth Sudan WHO Regional Ofce for Africa BrazzavilleCongo WHO Sub-Regional Ofce for Africa DakarSenegal Africa Centres for Disease Control and Prevention Addis AbabaEthiopia WHO Country Ofce BrazzavilleCongo WHO Coun‑try Ofce BujumburaBurundi WHO Country Ofce AsmaraEritrea WHO Country Ofce KigaliRwanda WHO Country Ofce KampalaUganda WHO Country Ofce LuandaAngola WHO Country Ofce Dar Es SalaamTanzania WHO Country Ofce LusakaZambia

Background: From May 2018 to September 2022, the Democratic Republic of Congo (DRC) experienced seven Ebola virus disease (EVD) outbreaks within its borders. During the 10th EVD outbreak (2018–2020), the largest experienced in the DRC and the second largest and most prolonged EVD outbreak recorded globally, a WHO risk assessment identified nine countries bordering the DRC as moderate to high risk from cross border importation. These countries implemented varying levels of Ebola virus disease preparedness interventions. This case study highlights the gains and shortfalls with the Ebola virus disease preparedness interventions within the various contexts of these countries against the background of a renewed and growing commitment for global epidemic preparedness highlighted during recent World Health Assembly *** text: Several positive impacts from preparedness support to countries bordering the affected provinces in the DRC were identified, including development of sustained capacities which were leveraged upon to respond to the subsequent coronavirus disease 2019 (COVID-19) pandemic. Shortfalls such as lost opportunities for operationalizing cross-border regional preparedness collaboration and better integration of multidisciplinary perspectives, vertical approaches to response pillars such as surveillance, over dependence on external support and duplication of efforts especially in areas of capacity building were also identified. A recurrent theme that emerged from this case study is the propensity towards implementing short-term interventions during active Ebola virus disease outbreaks for preparedness rather than sustainable investment into strengthening systems for improved health security in alignment with IHR obligations, the Sustainable Development Goals and advocating global policy for addressing the larger structural determinants underscoring these ***: Despite several international frameworks established at the global level for e

关键词： Ebola virus disease Emergency preparedness and response Lessons learned Case study International Health Regulations Democratic Republic of the Congo

重组人类活化蛋白C在严重全身性感染患者重要临床亚组中的应用

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世界医学杂志 2003年第7期7卷 1-7页

作者： E．Wesley MD,MPH MD,DerekC.Angus MD,MPH JeffreyD.Helterbrand,PhD HowardLevy MBBCH,PhD jean-FrancoisDhainaut,MD,PhD jean-Louis,MD,PhD WillianL.Macias,MD,PhD GordonR.Bernard,MD pierre-FrancoisLaterre 不详

目的：评价重组人类活化蛋白C[Drotrecogin alfa(activated)]在严重全身性感染患者中所进行的世界范围的、随机、3期、安慰剂对照研究(PROWESS)中，对临床亚组的治疗效果。设计：对PROWESS研究中预先定义的亚组进行单元和多元分析。设... 详细信息

目的：评价重组人类活化蛋白C[Drotrecogin alfa(activated)]在严重全身性感染患者中所进行的世界范围的、随机、3期、安慰剂对照研究(PROWESS)中，对临床亚组的治疗效果。设计：对PROWESS研究中预先定义的亚组进行单元和多元分析。设置：共11个国家的164个医疗中心。患者：共1690例严重全身性感染患者。方法和主要结果：我们报告了预先依据人口统计学资料、外科情况、感染的类型和部位，以及代表疾病严重程度的临床和生化指标定义的亚组中，应用Drotrecogin alfa(activated)和安慰剂后观察到的28天死亡率。随后进行了亚组分析，探讨了Drotrecogin alfa(activated)降低整体死亡率是否与降低亚组死亡率一致，并对定量和定性的交互作用进行了检验。我们对PR0WESS安慰剂组采用逐步逻辑回归法，得到一个预期死亡危险模型，这个模型包括了许多提示死亡危险的临床和生化指标，以检测Drotrecogin alfa(activated)治疗益处的大小和潜在预期死亡危险的范围。因为Drotrecogin alfa(activated)有抗凝血特性，我们也对出血和血栓形成事件进行了分析。在几乎所有预先定义的亚组中，与安慰剂组相比，应用Drotrecogin alfa(activated)的实际死亡率更低。单元和多元回归分析均一致显示了应用Drotrecogin alfa(activated)使28天死亡率的相对危险度降低。当患者有较高的基线预期死亡危险时，发现应用Drotrecogin alfa(activated)使绝对死亡危险度降低更大，而且在所有依据疾病严重程度测量定义的不同亚组中，也发现当安慰剂组死亡率≥20%时，应用Drotrecogin alfa(activated)的实际死亡率更低。虽然因为只观察到很少出血和血栓事件而使鉴别能力有限，但与基线预期死亡危险相比，因治疗导致严重出血事件的绝对危险度似乎并没有增加。结论：对严重全身性感染患者应用Drotrecogin alfa(activated)可以显著提高生存率，而又趋向于可以提高基线死亡可能性较高患者的生存率。现有的资料提示，该药物增加出血的危险性并不随死亡率的增加而改变。

关键词：重组人类活化蛋白C 全身性感染治疗安慰剂对照研究

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秘石议会 1版

神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐

丛书名：格朗热惊悚推理系列

2007年

作者：（法）让-克里斯朵夫·格朗热（jean-Christophe Grange）张颖绮译

黛安费尽千辛万苦，远赴泰国认养了一个苍白瘦弱的男孩。男孩的年龄和出生地是个谜，还时常喃喃说着大家听不懂的语言。但黛安一眼就喜欢上了他，她叫他露西安。回巴黎后不久，露西安在一场车祸中被弹出车外，生命垂危。黛安求助无门... 详细信息

ISBN: (纸本)7806896627

黛安费尽千辛万苦，远赴泰国认养了一个苍白瘦弱的男孩。男孩的年龄和出生地是个谜，还时常喃喃说着大家听不懂的语言。但黛安一眼就喜欢上了他，她叫他露西安。回巴黎后不久，露西安在一场车祸中被弹出车外，生命垂危。黛安求助无门，只能冀望奇迹，而奇迹，真的再现了。一位德国医生不请自来……露西安果真在几个小时后开始好转，但与此同时，德国医生却陈尸医院的厨房！露西安谜祥的身世，莫名的车祸，德国医生的惨死，这一加连串的事件使得黛安开始质疑那场车祸！是意外，还是蓄意谋杀！黛安抽丝剥茧逐步追查，却发现事情渐渐超出了常理，超出

关键词：推理小说法国现代

来源：汇雅图书（南通市图书馆... 评论

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国际脑血管病杂志 2019年第2期27卷 84-97页

作者： Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) Department of Medic al-Surgical Intensive Care Medicine Faculty of Biology and Medicine Centre Hospitalier Universitaire VauDOIs (CHUV) Lhiversity of Lausanne Rue du Bugnon 46 B4 08.623 1011 Lausanne Switzerland Department of Intensive Care Medicine St James's Lhiversity Hospital James's St Ushers P.O. Box 580 Dublin & Ireland Service de Reanimation Medic o-chirurgic ale Hopital Pasteur 2 UniversiteCote d'Azur CHU de Nice 06000 Nice France Unite CNRS 7275 Sophia-Antipolis France Department of Intensive Care Erasme Hospital University Libre de Bruxelles Brussels Belgium Neurosciences Critical Care Departments of Anesthesiology and Critical Care Medicine Neurology and Neurosurgery Johns Hopkins Lhiversity Baltimore MD USA Department of Neurology University of California San Francisco San Francisco CA LKA Service de Reanimation Polyvalente Hopital Pasteur 2 CHU de Nice 30 Voie Romaine CS 51069 06001 Nice Cedex 1 France Division of Anaesthesia University of Cambridge Addenbrooke's Ffospital Box 93 Hfills Road Cambridge Cambridgeshire CB2 2QQ UK Department of Intensive Care 4131 Copenhagen University Hospital- Rigshospitalet Copenhagen Denmark Department of Neuroanesthesia and Neurocritic al Care The National Ffospital for Neurosurgery and Neurology Lhiversity College London Hospitals London UK Anesthesia and Intensive Care Operative th it S. Martino Hospital Belluno Italy Hospital Nacional Professor Alejandro Posadas Buenos Aires Argentina Department of Neurosciences IRCCS-Istituto di Ricerche Farmacotogiche Mario Negri Milan Italy School of Medicine and Surgery University of Milan-Bicocca Milan Italy Neurointensive Care San Gerardo Hospital ASST-Monza 20900 Monza Italy 南方医科大学南方医院神经内科广州510515 Neurological Intensive Care Lhit Department of Neurology Medical University of Innsbruck Innsbruck Austria Department of Intensive Care Medicine University Hospitals Leuven Louvain Belgium Neuroscience Intensive Care Unit Department of Anesthesia and C

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会... 详细信息

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。

关键词：循证医学指南液体治疗创伤性脑损伤蛛网膜下腔出血脑出血卒中甘露醇高渗神经重症监护

时空针灸灵龟八法干预乳腺癌术后化疗疲劳国际临床试验预试验方案的可行性分析

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世界中医药 2019年第8期14卷 1950-1958页

作者：左政李文辉陈德滇刘德权聂建云朱勉生鞠丽雅 jean-pierre Armand Mahasti Saghatchian Caroline Barry Bernard Asselain 李云芬王炜宇刘亮先宋冉黄梅包雄英王玲玲王英浩严梅李春香王常安刘莉娟袁恺马琼马瑞敏陈春信 Mathieu Noel 云南中医药大学针灸推拿康复学院昆明650500 北京中医药大学北京102488 云南省肿瘤医院昆明650106 时空针灸研究院巴黎75013 欧洲精准医学平台巴黎75013 昆明市中医院昆明650051 昆明圣约翰康复医院昆明650033 北京博识科技有限公司北京100023

目的:乳腺癌癌因性疲乏(CRF)在乳腺癌中普遍存在,并且可以发生在乳腺癌治疗的各个阶段,对CRF进行有效干预已成为乳腺癌患者顺利进行术后化疗的重要条件。时空针灸是朱勉生教授在古代按时取穴方法基础上吸纳欧洲医学文化理念总结出来的... 详细信息

目的:乳腺癌癌因性疲乏(CRF)在乳腺癌中普遍存在,并且可以发生在乳腺癌治疗的各个阶段,对CRF进行有效干预已成为乳腺癌患者顺利进行术后化疗的重要条件。时空针灸是朱勉生教授在古代按时取穴方法基础上吸纳欧洲医学文化理念总结出来的一种新针法。本预试验旨在通过法国专家设计的严格的随机对照临床试验方案探讨时空针灸灵龟八法干预乳腺癌CRF的安全性及可行性。方法:按照纳排标准入组有效病例40例,按照2∶1∶1比例随机分成3组:时空针灸灵龟八法组20例、非经非穴针灸组10例、空白对照组(单纯辅助化疗治疗)10例。在辅助化疗全过程中,针灸组每周接受一次针刺治疗。40例入组患者在T1:基线、T2:表阿霉素+环磷酰胺(EC)4个周期后、T3:紫杉醇4个周期后、T4:化疗后1个月这4个时间点进行量表测评及外周血检测。本预试验40例已全部出组。本文从试验的可行性、安全性等方面对时空针灸灵龟八法试验方案进行评价,为下一步临床试验提供经验和依据。结论:本试验方案可操作性强、安全,患者依从性好。针灸方案贯穿了中医望闻问切的诊断方法、“辨证论治”的理念、“因时、因地、因人”及“治病求本”的治疗原则,实现了中医个体化治疗同临床试验规范化要求的紧密结合。

关键词：针灸时空针灸灵龟八法乳腺癌CRF 可行性分析

Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model

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World Journal of Hepatology 2016年第21期8卷 902-914页

作者： Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol Institut Pasteur INSERM Institut Cochin INSERM U1016CNRS UMR8104Universite Paris Descartes(UMR S1016) Genoscience Pharma KU Leuven Rega Institute Laboratoire Alphabio APHP Groupe Hospitalier La Pitie Salpe-triereService de Chirurgie digestive et Hepato bilio pancreatique APHP Groupe Hospitalier CochinService de Chirurgie digestiveHepato-biliaire et Endocrinienne Universite Paris Descartes APHP Groupe Hospitalier CochinUnite d’Hepatologie Institut Pasteur Departement de Recherche TranslationnelleINSERM

AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.

关键词： Host antiviral therapy Hepatitis C virus Tissue culture Autophagy Quinoline derivative

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丙型肝炎病毒感染者的冷纤维蛋白原

中国医学前沿杂志（电子版） 2008年第2期1卷 54-59页

作者： Aurélien Delluc David Saadoun Pascale Ghillani-Dalbin Damien Sene jean Charles Piette Patrice Cacoub 沈兰洁 From Service de Médecine Interne Université Pierre et Marie CurieParis 6France From Laboratoired'Immunochimie Hpital Pitié-SalpêtrièreParisFrance

慢性丙型肝炎病毒(hepatitis C virus,HCV)感染是发达国家慢性肝病的首要病因,可导致肝硬化和肝细胞癌.慢性HCV感染是混合型冷球蛋白血症(mixed cryoglobulinemia,MC)的主要病因.MC是一种全身性血管炎,以血清中存在冷球蛋白(cryoglobuli... 详细信息

慢性丙型肝炎病毒(hepatitis C virus,HCV)感染是发达国家慢性肝病的首要病因,可导致肝硬化和肝细胞癌.慢性HCV感染是混合型冷球蛋白血症(mixed cryoglobulinemia,MC)的主要病因.MC是一种全身性血管炎,以血清中存在冷球蛋白(cryoglobulin,CG)(即II型混合型CG)为主要特征,可累及皮肤、肾和神经系统[1-3].II型MC含有单克隆免疫球蛋白IgM.

关键词：丙型肝炎病毒 CF CG 患者血管炎丙肝病毒感染者纤维蛋白原球蛋白 HCV 病毒学应答病毒学反应冷沉淀蛋白冷球蛋白血症

SURVEY OF PLANTS USED IN TRADITIONAL MEDICINE AGAINST MALARIA IN BUKAVU AND UVIRA/DR CONGO

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 98-98页

作者： Henry Manya Mboni Valentin Bashige Chiribagula Salvius Bakari Amuri Dede Mbangu Munahu Joseph Kahumba Byanga Caroline Stévigny jean-Baptiste Lumbu Simbi pierre Duez Laboratoire de Pharmacognosie Faculté des Sciences Pharmaceutiques Université de Lubumbashi (UNILU) Laboratoire de Pharmacognosie Bromatologie et Nutrition humaine Université Libre de Bruxelles (ULB) Service de Chimie Organique Département de Chimie Faculté des Sciences/UNILU Institut National pour l'Etude et la Recherche Agronomique Station de Kipopo Laboratory of Therapeutic Chemistry & Pharmacognosy University of Mons (UMONS)

Malaria,for its high prevalence and morbidity,is one of the major tropical parasitic diseases,particularly in DR *** therapy not only uses modem antimalarials,for which many Resistance problems are encountered,but als... 详细信息

关键词： SURVEY OF PLANTS USED IN TRADITIONAL MEDICINE AGAINST MALARIA IN BUKAVU AND UVIRA/DR CONGO DR

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion