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Migration of bone marrow progenitor cells in the adult brain of rats and rabbits

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World Journal of Stem Cells 2016年第4期8卷 136-157页

作者： Donnahue Dennie jean-pierre Louboutin David S Strayer Section of Anatomy Department of Basic Medical SciencesUniversity of the West IndiesMona Campus Department of Cell Biology Anatomy and PathologyThomas Jefferson University

Neurogenesis takes place in the adult mammalian brain in three areas:Subgranular zone of the dentate gyrus(DG);subventricular zone of the lateral ventricle;olfactory *** molecular markers can be used to characterizethe cells involved in adult *** has been recently suggested that a population of bone marrow(BM)progenitor cells may migrate to the brain and differentiate into neuronal *** explore this hypothesis,we injected recombinant SV40-derived vectors into the BM and followed the potential migration of the transduced ***-term BM-directed gene transfer using recombinant SV40-derived vectors leads to expression of the genes delivered to the BM firstly in circulating cells,then after several months in mature neurons and microglial cells,and thus without central nervous system(CNS)*** of transgene-expressing cells expressed NeuN,a marker of mature ***,BM-derived cells may function as progenitors of CNS cells in adult *** mechanism by which the cells from the BM come to be neurons remains to be *** the observed gradual increase in transgene-expressing neurons over 16mo suggests that the pathway involved differentiation of BM-resident cells into neurons,cell fusion as the principal route cannot be totally ruled *** studies using similar viral vectors showed that BM-derived progenitor cells migrating in the CNS express markers of neuronal precursors or immature ***-positive cells were found in the subgranular zone of the DG of the hippocampus 16 mo after intramarrow injection of the *** addition to cells expressing markers of mature neurons,transgene-positive cells were also positive for nestin and doublecortin,molecules expressed by developing neuronal *** cells were actively proliferating,as shown by short term BrdU incorporation *** seizures by using kainic acid increased the number of BM progenitor cells transduced by SV40vectors migrating

关键词： Stem cells Bone marrow Hippocampus Cell therapy SV40 Brain Nestin Doublecortin Neurons Development Epilepsy Seizures

Predictors of long-term clinical outcome of patients with acute massive pulmonary embolism after thrombolytic therapy

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Chinese Medical Journal 2003年第4期116卷 503-509页

作者：刘品明 Nicolas Meneveau Francois Schiele jean pierre Bassand Department of Cardiology Second Affiliated HospitalZhongshan University Service de Cardiologie Centre Hospitalier Universitare

To assess the in-hospital clinical course and the long-term evolution of acute massive pulmonary embolism after thrombolytic therapy and to identify predictors of adverse clinical outcome Methods A total of 260 patients hospitalized from January 1989 to October 1998 were retrospectively reviewed and followed up for 3 9 to 8 4 years Baseline characteristics and variables pre- and post-thrombolysis were identified Particular attention was paid to the clinical events, including death, recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, and major bleeding attributable to the use of anticoagulants Kaplan-Meier event-free survival curves were generated Univariate analysis by means of the log-rank test was used to test each candidate variable for association with clinical outcome Multivariate analysis with the Cox proportional hazard model was used to determine independent predictors of the long-term outcome Results The in-hospital mortality rate was 8 5%, with 68 2% due to pulmonary embolism itself, and the follow-up mortality rate was 31 7%, with 29 2% due to recurrent embolism Factors associated with an adverse outcome in univariate analysis were: (1) prior thromboembolic diseases; (2) duration of anticoagulant therapy 50 mmHg after thrombolysis; and (6) greater than 30% obstruction of pulmonary vasculature identified by pulmonary ventilation/perfusion scintigraphy before hospital discharge Multivariate analysis identified three independent predictors of poor long-term outcome for patients with acute massive pulmonary embolism after thrombolysis; which were: (1) Doppler recording of pulmonary artery systolic pressure >50 mm Hg, with relative risk of 3 78 and a 95% confidence interval of 2 70 to 4 86; (2)

关键词： pulmonary embolism · deep venous thrombosis · thrombolytic therapy

Global dynamics of a model of hepatitis B virus infection in a sub-Saharan African rural area

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International Journal of Biomathematics 2020年第6期13卷 257-298页

作者： jean pierre II Kouenkam Joseph Mbang Yves Emvudu Department of Mathematics Faculty of Science University of Yaounde I P.O.Box 812 YaoundeCameroon UMI 209 IRD/UPMC UMMISCO Bondy Projet MASAIE INRIA Grand Est France and Projet GRIMCAPEL1RIMACameroun

We formulate and systematically study a deterministic compartmental model of Hepatitis *** model has some important and novel features compared with the well-known basic model in the ***,it takes into account the differential susceptibility that follows the vaccine formulation employing three-doses *** points up the HbeAg status of carriers,their levels of viral replication,the fact that treatment being not curative is recommended only to a small proportion of chronic carriers,and finally the fact that only inactive carriers are able to recover from *** model has simple dynamical behavior which has a globally asymptotically stable disease-free equilibrium when the basic reproduction number R0≤1 and an endemic equilibrium when R0>*** the use of Lyapunov functions,when it exists,we prove the global asymptotic stability of the endemic equilibrium under some *** data from Tokombere,a rural area in Cameroon,numerical simulations are *** numerical simulations first confirm analytical results,second they suggest that a policy based on treatment could not significantly impact the course of the ***,they show as it is well known that vaccination is a very effective measure to control the ***,they show that neonatal vaccination influences more the course of infection than mass vaccination ***,they picture how much loss between consecutive doses of vaccine could be ***,it is suggested that for a Sub-saharan African rural area,two-thirds of expected incidence of Hepatitis B virus infection and one third of expected prevalence of chronic carriers could be averted by 2030 if the birth dose vaccination becomes systematic and if mass vaccination rate increases to up 10%.

关键词： Nonlinear dynamical systems Lyapunov methods inactive carriers differential susceptibility differential infectivity

Carbon dioxide for gut distension during digestive endoscopy:Technique and practice survey

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World Journal of Gastroenterology 2009年第12期15卷 1475-1479页

作者： Filip Janssens Jacques Deviere pierre Eisendrath jean-Marc Dumonceau Division of Gastroenterology and Hepatology Geneva University HospitalsMicheli-du-Crest street241205 GenevaSwitzerland Medical-Surgical Department of Gastroenterology and Hepato-Pancreatology Erasme HospitalUniversité Libre de BruxellesBrusselsBelgium

AIM:To assess the adoption of Carbon dioxide(CO2)insufflation by endoscopists from various European countries,and its ***:A survey was distributed to 580 endoscopists attending a live course on digestive ***:The response rate was 24.5%.Fewer than half the respondents(66/142,46.5%)were aware of the fact that room air can be replaced by CO2 for gut distension during endoscopy,and 4.2%of respondents were actually using CO2 as the insufflation *** aware of the possibility of CO2 insufflation mentioned technical difficulties in implementing the system and the absence of significant advantages of CO2 in comparison with room air as barriers to adoption in daily practice(84%and 49%of answers,respectively;two answers were permitted for this item).CONCLUSION:Based on this survey,adoption of CO2 insufflation during endoscopy seems to remain relatively exceptional.A majority of endoscopists were not aware of this possibility,while others were not aware of recent technical developments that facilitate CO2 implementation in an endoscopy suite.

关键词： Colonoscopy Practice survey Carbondioxide Digestive endoscopy

Actigraphy: A new diagnostic tool for hepatic encephaiopathy

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World Journal of Gastroenterology 2006年第14期12卷 2243-2244页

作者： Isabelle Hourmand-Ollivier Marie-Astrid Piquet jean pierre Toudic pierre Denise Thng Dao Department of Nutrition and Hepatogastroenterology CHU Cte de Nacre-14033 cedex Caen France Physiology Laboratory CHU Cte de Nacre-14033 cedex Caen France

AIM： To assess the actigraphy, an ambulatory and continuous monitoring of wrist motor activity fitted to study sleep/wake patterns in hepatic encephalopathy （HE）. METHODS： Twenty-five cirrhotic patients （17 M, 8 F, mean age 56± 11 years, 24/25 alcoholic, Child-Pugh A, B, C： 2, 6, 17） were included. The patients were classified into 3 groups： stage 0 group （n = 12）, stage 1-2 group （n = 6）, and stage 3-4 group （n = 7） of encephalopathy. Over three consecutive days, patients had clinical evaluation 3 times a day with psychometric test, venous ammoniemia, flash visually evoked potentials （VEP）, electroencephalogram and continuous actigraphic monitoring for 3 d, providing 5 parameters： mesor, amplitude, acrophase, mean duration of activity （MDAI） and inactivity （MDII） intervals. RESULTS： Serum ammonia and VEP did not differ among the 3 groups. Electroencephalography mean dominant frequency （MDF） correlated significantly with clinical stages of HE （r=0.65, P=0.003）. The best correlation with HE stage was provided by actigraphy especially with MDAI （r= 0.7, P〈10^-4） and mesor （r= 0.65, P〈 10^-4）. MDAI correlated significantly with MDF （r= 0.62, 0.004） and was significantly shorter in case of HE compared to patients without HE （stage 0： 5.33± 1.6 min; stage 1-2：3.28±1.4 min; stage 3-4：2.52±1.1 min; P〈0.05）. Using a threshold of MDAI of less than 4.9 min, sensitivity, specificity, positive predictive value, negative predictive value for HE diagnosis were 85%, 67%, 73% and 80%, respectively. CONCLUSION： Actigraphy may be an objective method to identify HE, especially for early HE detection. Motor activity at the wrist correlates well with clinical stages of HE. MDAI and mesor are the most relevant parameters.

关键词： Hepatic encephalopathy Cirrhosis Actigraphy

Complete Isolation System for Laboratory Infectious Animal

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中国实验动物学报 2005年第S1期13卷 31-32页

作者： jean pierre

Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

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Cellular & Molecular Immunology 2022年第5期19卷 561-576页

作者： Felicitas E.Hengel jean-pierre Benitah Ulrich O.Wenzel Ⅲ.Department of Medicine University Hospital Hamburg-EppendorfHamburgGermany Inserm UMR-S 1180 Faculty of PharmacyUniversity Paris SaclayGif-sur-YvetteFrance

The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different *** evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic *** plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial *** intake is indispensable for normal body function but can be detrimental when it exceeds dietary *** data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell *** of these effects are mediated by changes in the microbiome and metabolome due to high-salt *** purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension *** and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

关键词： Arterial hypertension salt innate and adaptive immunity renin angiotensin aldosterone system mineralocorticoid receptor angiotensinⅡreceptor

Strong Spatial Aggregation of Martian Surface Temperature Shaped by Spatial and Seasonal Variations in Meteorological and Environmental Factors

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Research in Astronomy and Astrophysics 2022年第1期22卷 156-173页

作者： Yao-Wen Luo Fei Li Jian-Guo Yan jean-pierre Barriot Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan430070China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan430070China Observatoire Geodesique de Tahiti University of French PolynesiaBP 6570F-98702 Faa'aTahitiFrench Polynesia

Spatio-temporal variation in the Martian surface temperature(MST)is an indicator of ground level thermal processes and hence a building block for climate ***,the distribution of MST exhibits different levels of spatial aggregation or heterogeneity,and varies in space and ***,the effect of regional differences in meteorological or environmental factors on the MST is not well ***,we investigated the degree of spatial autocorrelation of MST across the surface of Mars globally by Moran’s I,and identified the hot spots by GetisOrd G;*.We also estimated the regional differences in the influence of seasonally dominant factors including thermal inertia(TI),albedo,surface pressure,latitude,dust and slope on MST by a geographically weighted regression *** results indicate(1)that MST is spatially aggregated and hot and cold spots varied over time and space.(2)Hemispheric differences in topography,surface TI and albedo were primarily responsible for the hemispheric asymmetry of hot spots.(3)The dominant factors varied by geographical locations and *** example,the seasonal Hadley circulation dominates at the low-latitudes and CO;circulation at the high-latitudes.(4)Regions with extreme variations in topography and low TI were sensitive to meteorological and environmental factors such as dust and CO_(2)*** conclude that the spatial autocorrelation of MST and the spatial and seasonal heterogeneity of influencing factors must be considered when simulating Martian climate *** work provides a reference for further exploration of Martian climatic processes.

关键词： methods:analytical planets and satellites:surfaces methods:statistical planets and satellites:fundamental parameters

Mapping data gaps to estimate biomass across Brazilian Amazon forests

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Forest Ecosystems 2020年第3期7卷 334-348页

作者： Graciela Tejada Eric Bastos Görgens Alex Ovando jean pierre Ometto Earth System Science Center(CCST) National Institute for Space Research(INPE)Av dos Astronautas 1758São Josédos CamposSP12227-010Brazil Department of Forestry Engineering Universidade Federal dos Vales do Jequitinhonha e MucuriCampus JKRod.MGT 367km 5835000Alto do JacubaDiamantinaMG39100-000Brazil National Center for Monitoring and Early Warning of Natural Disasters(CEMADEN) Estrada Doutor Alino Bondesani 500São Josédos CamposSP12247-016Brazil

Background: Tropical forests play a fundamental role in the provision of diverse ecosystem services, such as biodiversity,climate and air quality regulation, freshwater provision, carbon cycling, agricultural support and culture. To understand the role of forests in the carbon balance, aboveground biomass(AGB) estimates are needed. Given the importance of Brazilian tropical forests, there is an urgent need to improve AGB estimates to support the Brazilian commitments under the United Nations Framework Convention on Climate Change(UNFCCC). Many AGB maps and datasets exist, varying in availability, scale and coverage. Thus, stakeholders, policy makers and scientists must decide which AGB product, dataset or combination of data to use for their particular goals. In this study, we assessed the gaps in the spatial AGB data across the Brazilian Amazon forests not only to orient the decision makers about the data that are currently available but also to provide a guide for future ***: We obtained a map of the gaps in the forest AGB spatial data for the Brazilian Amazon using statistics and differences between AGB maps and a spatial multicriteria evaluation that considered the current AGB datasets. The AGB spatial data gap map represents areas with good coverage of AGB data and, consequently, the main gaps or priority areas where further biomass assessments should focus, including the northeast of Amazon State, Amapá and northeast of Pará. Additional y, by quantifying the variability in both the AGB maps and field data on multiple environmental factors,we provide valuable elements for understanding the current AGB data as a function of climate, soil, vegetation and ***: The map of AGB data gaps could become a useful tool for policy makers and different stakeholders working on National Communications, Reducing Emissions from Deforestation and Degradation(REDD+), or carbon emissions modeling to prioritize places to implement further AGB a

关键词： Amazon Tropical forest Carbon Aboveground biomass Data gaps REDD+ Environmental factors