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Antibacterial, Anti-Inflammatory and Antioxidant Activities of an ACAZY Herbal Formula Used in Traditional Medicine to Treat Respiratory Infections

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Natural Science 2024年第9期16卷 131-145页

作者： Mohamed Bonewendé Belemlilga Bagora Bayala Abdoul Gilchrist Laurent Boly Madinatou Annick Ouédraogo Alida Raissa Boina Boubacar Yaro Florentina Badea Camélia Diguti Moumouni Koala Denise P. Ilboudo Charles Bavouma Sombié Pascal Nadembega jean-Marie Compaoré paul Darga Mahoukèdè Théodora Zohoncon Moussa Ouédraogo Aristide Traore Noufou Ouédraogo Florentina Matei Rasmane Semdé Sylvin Ouédraogo Jacques Simporé Innocent Pierre Guissou Laboratoire de Recherche-Dveloppement de Phytomdicaments et Mdicaments (LR-D/PM) Institut de Recherche en Sciences de la Sant (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Centre de Recherche Biomolculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Normale Suprieure Koudougou Burkina Faso Laboratoire de Dveloppement du Mdicament (LADME) Centre de Formation de Recherche et dExpertises en Sciences du Mdicament (CEA-CFOREM) cole Doctorale Sciences de la Sant (ED2S) Universit Joseph KI-ZERBO Burkina Faso Laboratoire de Microbiologie Applique Universit des Sciences Agronomiques et de Mdecine Vtrinaire (UASMV) de Bucarest en Roumanie Bucharest Romania Dpartement de la mdecine traditionnelle Ministre de la Sant et de lHygine Publique Ouagadougou Burkina Faso Universit Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso

ACAZY is a plant formula used in traditional medicine in Burkina Faso to treat respiratory infections. After phytochemical analysis, this study evaluated extracts’ anti-inflammatory, antioxidant and antibacterial properties from the ACAZY recipe. Three extractions, an aqueous macerate (AM), an aqueous decoction (AD) and an hydroethanolic macerate (HEM) of the ACAZY recipe powder were carried out. Phytochemical screening of the extracts was carried out using high-performance thin-layer chromatography (HPTLC) and the determination of phenolic compounds. The anti-inflammatory potential was assessed in vitro using pro-inflammatory enzyme inhibition tests. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric-reducing antioxidant power (FRAP) antioxidant properties were also determined. The antibacterial activity was evaluated on Staphylococcus aureus and Streptococcus pneumoniae strains. Phytochemical analysis revealed the presence of flavonoids, saponins, tannins, anthracenosids, sterols and triterpenes in the extracts. The extracts inhibited pro-inflammatory enzymes by more than 40% at only 100 µg/mL. The extracts also showed potent antibacterial activity with a minimum inhibitory concentration 1 mg/mL on Staphylococcus aureus and 2 mg/mL on Streptococcus pneumoniae. The extracts in the ACAZY formula have shown anti-inflammatory and antioxidant properties in vitro. The AD also showed an antibacterial activity. This justifies its use in traditional medicine to treat acute respiratory infections.

关键词： ACAZY Anti-Inflammatory Antioxidant Antibacterial In Vitro

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Geochemical constraints on the origin and tectonic setting of the serpentinized peridotites from the Paleoproterozoic Nyong series,Eseka area,SW Cameroon

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Acta Geochimica 2020年第3期39卷 404-422页

作者： Philomene Nga Essomba Tsoungui Sylvestre Ganno Evine Laure Tanko Njiosseu jean Lavenir Ndema Mbongue Brice Kamguia Woguia Landry Soh Tamehe Jonas Didero Takodjou Wambo jean paul Nzenti Department of Earth Sciences University of Yaounde IP.O.Box 3412MessaYaoundeCameroon Department of Earth Sciences University of DschangP.O.Box.67DschangCameroon Key Laboratory of CBM Resources and Reservoir Formation Process Chinese Ministry of EducationChina University of Mining and TechnologyXuzhou 221116JiangsuChina

Serpentinized rocks closely associated with Paleoproterozoic eclogitic metabasites were recently discovered at Eseka area in the northwestern edge of the Congo craton in southern ***,we present new field data,petrography,and first comprehensible wholerock geochemistry data and discuss the protolith and tectonic significance of these serpentinites in the *** studied rock samples are characterized by pseudomorphic textures,including mesh microstructure formed by serpentine intergrowths with cores of olivine,bastites after *** constitutes almost the whole bulk of the rocks and is associated(to the less amount)with tremolite,talc,spinel,and ***-rock chemistry of the Eseka serpentinites led to the distinction of two *** 1 has high MgO(>40 wt%)content and high Mg#values(88.80)whereas Type 2 serpentinite samples display relatively low MgO concentration and Mg#values(50 ppm).This similarity,associated with the high Cr contents,spinel-peridotite protolith compositions and Mg/Si and Al/Si ratios imply that the studied serpentinites were formed in a subductionrelated *** U-shaped chondrite normalizedREE patterns of serpentinized peridotites,coupled with similar enrichments in LREE and HFSE,suggest the refertilized nature due to melt/rock interaction prior to *** on the results,we suggest that the Eseka serpentinized peridotites are mantle residues that suffered a high degree of partial melting in a subductionrelated environment,especially in Supra Subduction Zone *** new findings suggest that the Nyong series in Cameroon rep

关键词： Serpentinites Mantle peridotites Melt/rock interaction Paleoproterozoic suture zone Eseka area Nyong series Congo/Sao Francisco cratons

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The Origin,Causes and Impacts of the 2013 Political Crisis in Central African Republic

The Origin,Causes and Impacts of the 2013 Political Crisis i...

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作者： jean-paul STEVE DARRYL KIRIMAT YAKOUROU GBEGBIYA 华中师范大学

学位级别：硕士

中非共和国(以下简称“中非”)的平民不断受到暴力犯罪的威胁。在除首都班吉以外的几乎所有地区,武装组织之间的战斗仍在继续。自2016年5月以来,武装组织发动的袭击,包括以前几乎没有发生过武装冲突的地区在内,已经造成数百人死亡,上万... 详细信息

中非共和国(以下简称“中非”)的平民不断受到暴力犯罪的威胁。在除首都班吉以外的几乎所有地区,武装组织之间的战斗仍在继续。自2016年5月以来,武装组织发动的袭击,包括以前几乎没有发生过武装冲突的地区在内,已经造成数百人死亡,上万人流离失所。中非当前的政治危机可以追溯到2013年3月24日,穆斯林团体塞雷卡叛军联盟推翻总统弗朗索瓦·博齐泽。塞雷卡的暴政导致了反巴拉卡组织的形成。目前中非国内局势暴力升级的根源不仅在于穆斯林和基督教社区之间的分歧,而且还在于各个武装组织之间经济利益和政治利益的变化。2017年5月,联合国维和特派团(MISCA)和联合国人权事务高级专员办事处调查发现,反巴拉卡和塞雷卡部队可能在2013-2016年间犯下战争罪和反人类罪。自2013年初以来,反巴拉卡组织和塞雷卡部队都针对平民使用了性暴力。

关键词：联合国维和武装组织中非危机任务

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Uncertainty Reduction Through Data Management in the Development, Validation, Calibration, and Operation of a Hurricane Vulnerability Model

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International Journal of Disaster Risk Science 2020年第6期11卷 790-806页

作者： jean-paul Pinelli Josemar Da Cruz Kurtis Gurley Andres Santiago Paleo-Torres Mohammad Baradaranshoraka Steven Cocke Dongwook Shin College of Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Civil and Coastal Engineering University of FloridaGainesvilleFL 32611USA Center for Ocean-Atmospheric Prediction Studies(COAPS) Florida State UniversityTallahasseeFL 32306USA

Catastrophe models estimate risk at the intersection of hazard,exposure,and *** of these areas requires diverse sources of data,which are very often incomplete,inconsistent,or missing *** poor quality of the data is a source of epistemic uncertainty,which affects the vulnerability models as well as the output of the catastrophe *** article identifies the different sources of epistemic uncertainty in the data,and elaborates on strategies to reduce this uncertainty,in particular through identification,augmentation,and integration of the different types of *** challenges are illustrated through the Florida Public Hurricane Loss Model(FPHLM),which estimates insured losses on residential buildings caused by hurricane events in *** define the input exposure,and for model development,calibration,and validation purposes,the FPHLM teams accessed three main sources of data:county tax appraiser databases,National Flood Insurance Protection(NFIP)portfolios,and wind insurance *** data from these different sources were reformatted and processed,and the insurance databases were separately cross-referenced at the county level with tax appraiser *** FPHLM hazard teams assigned estimates of natural hazard intensity measure to each insurance *** efforts produced an integrated and more complete set of building descriptors for each policy in the NFIP and wind *** article describes the impact of these uncertainty reductions on the development and validation of the vulnerability models,and suggests avenues for data *** learned should be of interest to professionals involved in disaster risk assessment and management.

关键词： Catastrophe modeling Data augmentation and integration Florida Public Hurricane Loss Model(FPHLM) Uncertainty reduction Vulnerability model

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Why Does Newton’s Apple Fall Vertically to the Ground: The Gravitation Code

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Journal of Modern Physics 2016年第13期7卷 1702-1711页

作者： jean-paul Auffray Ex: Courant Institute of Mathematical Sciences New York University New York NY USA

No, Isaac Newton did not “explain” gravitation. What he did, and this certainly constituted all and by itself a great achievement, was to recognize (to “assert”) the universal character of gravitation: all material objects (bodies) attract each other by gravitation. But how does gravitation perform its deeds? This remained a mystery to Newton. In a “desperate move” at the end of his life, he introduced the concept of “Particles which are moved by certain active Principles [our emphasis]—such as is that of Gravity” he said. We resurrect this scheme, we provide it with a quantum structure—a stunning new insight into the workings of gravitation obtains.

关键词： Gravitation Newton Fatio de Duillier Ethereal Particles I-Meteons

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The Absolute Certainty Principle (ACP) Revolutionizes Quantum Physics

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Journal of Modern Physics 2016年第16期7卷 2341-2346页

作者： jean-paul Auffray Ex Courant Institute of Mathematical Sciences New York University New York NY USA

When the ubiquitous quantum, acting as an active principle, generates meteons in the System of the World, the Absolute Certainty Principle (ACP) regulates the characteristics of their motion. This newly uncovered law of Nature suggests that the cosmos is filled with an “aether”, as Newton and others—even Einstein!—called it in their days, and explains quite simply why we stand erect vertically on the surface of the Earth and why the universe is in expansion.

关键词： Heisenberg Uncertainty Principle Quantum Meteorites Absolute Certainty Principle Energy Gravitation Newton Einstein Universe Expansion

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Archaea and the human gut:New beginning of an old story

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World Journal of Gastroenterology 2014年第43期20卷 16062-16078页

作者： Nadia Gaci Guillaume Borrel William Tottey paul William O’Toole jean-Fran?ois Brugère EA-4678 CIDAM Clermont UniversitéUniversité d’AuvergneF-63000 Clermont-FerrandFrance School of Microbiology and Alimentary Pharmabiotic Centre University College CorkCorkIreland

Methanogenic archaea are known as human gut inhabitants since more than 30 years ago through the detection of methane in the breath and isolation of two methanogenic species belonging to the order Methanobacteriales, Methanobrevibacter smithii and Methanosphaera stadtmanae. During the last decade, diversity of archaea encountered in the human gastrointestinal tract (GIT) has been extended by sequence identification and culturing of new strains. Here we provide an updated census of the archaeal diversity associated with the human GIT and their possible role in the gut physiology and health. We particularly focus on the still poorly characterized 7th order of methanogens, the Methanomassiliicoccales, associated to aged population. While also largely distributed in non-GIT environments, our actual knowledge on this novel order of methanogens has been mainly revealed through GIT inhabitants. They enlarge the number of final electron acceptors of the gut metabolites to mono- di- and trimethylamine. Trimethylamine is exclusively a microbiota-derived product of nutrients (lecithin, choline, TMAO, L-carnitine) from normal diet, from which seems originate two diseases, trimethylaminuria (or Fish-Odor Syndrome) and cardiovascular disease through the proatherogenic property of its oxidized liver-derived form. This therefore supports interest on these methanogenic species and its use as archaebiotics, a term coined from the notion of archaea-derived probiotics.

关键词： Human gut microbiota Methanogens Methanomassiliicoccus Methanomethylophilus Trimethylaminuria Trimethylamine Methane Cardiovascular disease Archaebiotics Probiotics

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Reducing loss of significance in the computation of Earth-based two-way Doppler observables for small body missions

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Research in Astronomy and Astrophysics 2021年第8期21卷 75-90页

作者： Wei-Tong Jin Fei Li Jian-Guo Yan Xuan Yang Mao Ye Wei-Feng Hao Thomas paul Andert jean-Pierre Barriot State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China State Key Laboratory of Satellite Navigation System and Equipment Technology Shijiazhuang 050200China Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China Universitat der Bundeswehr München NeubibergBayern85579Germany University of French Polynesia BP 6570F-98702 Faa'aTahitiFrench Polynesia

Two-way Doppler measurement is a typical Earth-based radiometric technique for interplanetary spacecraft navigation and gravity science *** most widely used model for the computation of two-way Doppler observables is Moyer’s differenced-range Doppler(DRD) formula,which is based on a Schwarzschild approximation of the Solar-System ***,the computation of range difference in DRD formula is sensitive to round-off errors due to approximate numbers defined by the norm IEEE754 in all *** paper presented two updated models and their corresponding detailed instructions for the computation of the two-way Doppler observables so as to impair the effects of this type of numerical *** two models were validated by two case studies related to the Rosetta mission—asteroid Lutetia flyby and comet 67 P/Churyumov-Gerasimenko orbiting *** these two cases,the numerical noise from the updated models can be reduced by two orders-of-magnitude in the computed two-way Doppler *** results showed an accuracy from better than 6 × 10^(-3) mm s^(-1) at 1 s counting time interval to better than 3 × 10^(-5) mm s^(-1) at 60 s counting time interval.

关键词： methods:numerical space vehicles planets and satellites:general

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Association between the Different Phenotypes of Polycystic Ovary Syndrome and the Outcome in in Vitro Fertilization at Human Reproductive Center paul et Chantal Biya-Yaoundé

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 18-28页

作者： Ngono Akam Vanina Ngah Minala Belinga Etienne Belinga Etienne Mpono Pascale Nyada Serges Onana Y. Kasia Cho Joselyne Kasia Florence Adjessa Abega Kasia jean Marie Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital Yaoundé Cameroon Department of Gynecology and Obstetrics Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

Background: In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) represents the final step in the management of Polycystic Ovarian Syndrome (PCOS). Our objective was to study the association between PCOS phenotypes and IVF/ICSI results in women admitted to Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (CHRACERH). Material and Method: We carried out a cohort study with historical-prospective data collection over a period of seven years (January 2016 to March 2023) at Chracerh. PCOS patients were subdivided into 4 subgroups A, B, C and D. Results: We recruited 128 patients including 64 PCOS patients divided into four phenotypes and 64 non-PCOS patients constituting the control group. Phenotype D without hyperandrogenism had used the lowest dose of gonadotropins, i.e. 1939.7 ± 454.3 IU, and had produced a greater quantity of estradiol on the day ovulation was triggered (6529.8 ± 4324.8 ng/ml). The average number of punctured follicles and mature oocytes were higher in the phenotype D group. Ovarian hyperstimulation syndrome (OHSS) occurred mainly in phenotype D (3/35), with an estimated prevalence of 2.3%. The fertilization rate seemed lower in the hyperandrogenic phenotypes A, B, C compared to the group without hyperandrogenism without significant difference (p = 0.461). The biological pregnancy rate and live birth rate were comparable between the different groups. Conclusion: Phenotype D used less dose of gonadotropins. Biological pregnancy and live birth rates were comparable between the different phenotypes.

关键词： Phenotype Polycystic Ovarian Syndrome IVF/ICSI Prognosis CHRACERH

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Depositional age and tectonic environment of the Gouap banded iron formations from the Nyong group,SW Cameroon:Insights from isotopic,geochemical and geochronological studies of drillcore samples

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Geoscience Frontiers 2021年第2期12卷 549-572页

作者： Landry Soh Tamehe Chongtao Wei Sylvestre Ganno Carlos Alberto Rosiere jean paul Nzenti Chesther Gatse Ebotehouna Guanwen Lu Key Laboratory of CBM Resources and Reservoir Formation Process Chinese Ministry of EducationChina University of Mining and TechnologyXuzhouJiangsu221116China Department of Earth Sciences University of Yaounde IP.O.Box 812YaoundeCameroon Department of Geology Universidade Federal de Minas Gerais31270-901Belo HorizonteMinas GeraisBrazil School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

The discovery of the Gouap banded iron formations(BIFs)-hosted iron mineralization in the northwestern of the Nyong Group(Ntem Complex)in southwestern Cameroon provides unique insights into the geology of this *** this contribution,we firstly report detailed study of geochemistry,isotopic and geochronology of well preserved samples of the Gouap BIFs collected from diamond *** Gouap BIFs consist mainly of amphibole BIFs and amphibole-pyrite BIFs characterized by dominant Fe_(2)O_(3)+SiO_(2)contents and variable contents of CaO,MgO and SO_(3),consistent with the presence of amphibole,chlorite,epidote and pyrite,formed during amphibolite facies metamorphism and overprinted hydrothermal *** amphibole–pyrite BIFs are typically enriched in trace and rare earth elements(REE)compared to the amphibole BIFs,suggesting the influence of detrital materials as well as secondary hydrothermal *** Post Archean Australian Shale(PAAS)-normalized REE–Y profiles of the Gouap BIFs display positive La,Eu anomalies,weak negative Ce anomalies,indicating a mixture of low-temperature hydrothermal fluids and relatively oxic conditions probably under relative shallow *** present here the first isotopic data of BIFs within the Ntem ***δ^(30)Si_(NBS28)values of the quartz from the Gouap BIFs vary from-1.5‰to-0.3‰and from-0.8‰to-0.9‰for the amphibole BIFs and amphibole–pyrite BIFs,*** quartz hasδ^(18)OV-SMOW values of 6.8‰–9.5‰(amphibole BIFs)and 9.2‰–10.6‰(amphibole–pyrite BIFs).The magnetite from the Gouap BIFs showsδ^(18)O values ranging from-3.5‰to-1.8‰and from-3‰to-1.7‰for the amphibole BIFs and amphibole–pyrite BIFs,***,the pyrite grains in the amphibole–pyrite BIFs displayδ34S values of 1.1‰–1.8‰.All isotopic data of the Gouap BIFs confirm that they might have precipitated from low-temperature hydrothermal fluids with detrital input distant from the volcanic *** to their geochemical and isotop

关键词： Gouap Banded iron formations Isotope geochemistry Zircon geochronology Ryacian period Brasiliano-Congo orogeny

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