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乳铁传递蛋白:功能卓越的乳生物活性蛋白(英文)

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中国食品添加剂 2009年第S1期20卷 285-293页

作者： jean -paul Perraudin 北京新百利恒康源国际贸易有限公司

乳铁蛋白是一种铁结合的糖蛋白,是具有多种生物功能的乳生物活性蛋白,具有非常重要的科学研究价值。在过去的二十年中,乳铁蛋白的各种生物功能已被深入研究和报道。从最初发现的抗微生物活性,到调节铁的吸收与代谢、免疫调节、促进细胞... 详细信息

乳铁蛋白是一种铁结合的糖蛋白,是具有多种生物功能的乳生物活性蛋白,具有非常重要的科学研究价值。在过去的二十年中,乳铁蛋白的各种生物功能已被深入研究和报道。从最初发现的抗微生物活性,到调节铁的吸收与代谢、免疫调节、促进细胞增长等其他功能,增强宿主的防御能力。乳铁蛋白可以作为预防和治疗人类多种疾病的药物在防止感染和抵抗病毒,抑制肿瘤发生与转移等方面发挥作用。本文概括了乳铁蛋白在抗菌、抗氧化,免疫调节,抗癌等方面的生物功能以及作用机理。

关键词：乳铁蛋白铁代谢免疫功能抗微生物

Expected outcomes and patients’selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict”scores may help clinicians:Real-life French cohorts results

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World Journal of Clinical Cases 2021年第18期9卷 4559-4572页

作者： Xavier Adhoute Edouard Larrey Rodolphe Anty Patrick Chevallier Guillaume Penaranda Albert Tran jean-Pierre Bronowicki jean-Luc Raoul paul Castellani HervéPerrier Olivier Bayle Olivier Monnet Bernard Pol Marc Bourliere Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseille 13008France Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Radiology Hôpital Universitaire de l’ArchetNice 06000France Statistics Department AlphaBio LaboratoryMarseille 13003France Department of Gastroenterology and Hepatology Centre Hospitalo-Universitaire de NancyVandoeuvre les Nancy 54511France Department of Medical Oncology Institut de Cancérologie de l’OuestSite de NantesNantes 44805France Department of Radiology Hôpital Saint-JosephMarseille 13008France Department of Hepatobiliary Surgery Hôpital Saint-JosephMarseille 13008France

BACKGROUND Careful selection of hepatocellular carcinoma(HCC)patients prior to chemoembolization treatment is a daily reality,and is even more necessary with new available therapeutic options in *** propose two new models to better stratify patients and maximize clinical benefit:“6 and 12”and“pre/post-TACE-predict”(TACE,transarterial chemoembolization).METHODS We evaluated and compared their performance in predicting overall survival with other systems{Barcelona Clinic Liver Cancer(BCLC),Albumin-Bilirubin(ALBI)and NIACE[Number of tumor(s),Infiltrative HCC,alpha-fetoprotein,Child-Pugh(CP),and performance status]}in two HCC French cohorts of different stages enrolled between 2010 and *** The cohorts included 324 patients classified as BCLC stages A/B(cohort 1)and 137 patients classified as BCLC stages B/C(cohort 2).The majority of the patients had cirrhosis with preserved liver function.“Pre-TACE-predict”and“6 and 12”models identified three distinct categories of patients exhibiting different prognosis in cohort ***,their prognostic value was no better than the BCLC system or NIACE *** function based on CP and ALBI grades significantly impacted patient ***,the“post-TACE-predict”model had a higher predictive value than other *** stratification ability as well as predictive performance of these new models in an intermediate/advanced stage population was less efficient(cohort 2).CONCLUSION The newly proposed“Pre-TACE-predict”and“6 and 12”models offer an interesting stratification into three categories in a recommended TACE population,as they identify poor candidates,those with partial control and durable *** models'contribution was reduced in a population with advanced stage HCCs.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Pre-TACEpredict Six-and-twelve Barcelona Clinic Liver Cancer Prognosis

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基于时间抽象状态机的AADL模型验证

软件学报 2015年第2期26卷 202-222页

作者：杨志斌胡凯赵永望马殿富 jean-paul BODEVEIX Institut de Recherche en Informatique de Toulouse Université de Toulouse 北京航空航天大学计算机学院北京100191

提出了一种基于时间抽象状态机(timed abstract state machine,简称TASM)的AADL(architecture analysis and design language)模型验证方法.分别给出了AADL子集和TASM的抽象语法,并基于语义函数和类ML的元语言形式定义转换规则.在此基础... 详细信息

提出了一种基于时间抽象状态机(timed abstract state machine,简称TASM)的AADL(architecture analysis and design language)模型验证方法.分别给出了AADL子集和TASM的抽象语法,并基于语义函数和类ML的元语言形式定义转换规则.在此基础上,基于AADL开源建模环境OSATE(open source AADL tool environment)设计并实现了AADL模型验证与分析工具AADL2TASM,并基于航天器导航、制导与控制系统(guidance,navigation and control)进行了实例性验证.

关键词： AADL(architecture analysis and design language) TASM(timed abstract state machine) 模型转换形式验证

Characterization of Micro and Nano-Scaled Co/Ni Bi-Layered Films Electrodeposited Under Influence of Magnetic Field:Effects on Structure and Morphology

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Journal of Iron and Steel Research International 2012年第S2期19卷 1145-1148页

作者： LEVESQUE Alexandra LI Donggang FRANCZAK Agneszka WANG Qiang CHOPART jean-paul LISM BP 103951687 REIMS Cedex 2France Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern University

In this study,the possibility of obtaining micro and nano-scaled Co/Ni bi-layered films by use of the electrochemical method was *** electrodeposition process was performed with presence and absence of a uniform external magnetic field up to 1T to examine its influence on structure and morphology of the obtained thin films. Afterwards,each sample was annealed under high magnetic field with strength up to 12 T at 623 K,what allowed compare and determine the changes in morphology and structure,before and after heat *** Co/Ni bi-layered thin films were deposited onto an indium-doped tin oxide(ITO)-coated conducting glass substrate from sulfate baths with boric acid as an *** results show drastic changes in the morphology between macro and nano-scaled films which were strongly affected by an introduction of the magnetic field to the electrodeposition *** annealing process allowed to determine the nucleus transition and showed that under the high temperature treatment it is possible to control the growth mode as well as the phase composition changes.

关键词： Co/Ni bi-layered films electrodeposition onto ITO micro and nano-structure magnetic field annealing process

Carbon dioxide:A new material for energy storage

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Progress in Natural Science:Materials International 2014年第4期24卷 295-304页

作者： Jacques Amouroux paul Siffert jean Pierre Massué Simeon Cavadias Béatriz Trujillo Koji Hashimoto Phillip Rutberg Sergey Dresvin Xianhong Wang Ecole Nationale Supérieure de Chimie de Paris (ENSCP) Université Pierre et Marie Curie ParisFrance 2. European Material Research Society(EMRS)StrasbourgFrance 3. Laboratoire de Génie des Procédés Plasmas et Traitement de Surface(LGPPTS)Université Pierre et Marie Curie ParisFrance 4. Institute Polytechnic National de MéxicoMexico 5. Lab Electrotechnic and Electrophysic State Polytechnical University of St.PetersbourgRussia 6. Tohoku UniversityJapan Tohoku Institute of Technology Japan Plasma Laboratory State Polytechnical University of St.Petersbourg Russia 9. Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryCASChina

Though carbon dioxide is the main green house gas due to burning of fossil resource or miscellaneous chemical processes,we propose here that carbon dioxide be a new material for energy *** it can be the key to find the solution for three critical issues facing the world:food ecosystems,the greenhouse issue and energy *** propose to identify the carbon recovery through a circular industrial revolution in the first part,and in the second part we present the starting way of three business plants to do that from industrial *** pointing out all the economic constraints and the hidden competitions between energy,water and food,we try to qualify the phrase "sustainable development" and open the way of a huge circular economy.

关键词： Carbon dioxide Energy storage material Carbon dioxide recovery Chemical utilization Circular economy Sustainable development

丙型肝炎病毒与HIV混合感染者肝移植术后丙型肝炎病毒准种变化

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中华肝脏病杂志 2007年第2期15卷 141-142页

作者：徐兵江家骥潘晨 jean-paul Thiery 福州市传染病医院肝病研究所 350025 福建医科大学附一医院肝病中心 Center of Hepato-Biliary Hospital of Paul Brousse at Villejuif Paris France

2003年法国巴黎paulBrousse医院肝胆中心收治2例HCV与HIV混合感染并行肝移植术的患者。我们研究了这2例患者血中HCV准种的变化，应用单链构形多态性分析（SSCP），检测HCV基因的高变异区（HVR区）和包膜区（C区）。

关键词：肝炎病毒丙型 HIV 肝移植准种

Extreme multiexciton emission from deterministically assembled single-emitter subwavelength plasmonic patch antennas

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Light(Science & Applications) 2020年第1期9卷 1697-1705页

作者： Amit Raj Dhawan Cherif Belacel Juan Uriel Esparza-Villa Michel Nasilowski Zhiming Wang Catherine Schwob jean-paul Hugonin Laurent Coolen Benoit Dubertret Pascale Senellart Agnes Maitre Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054People’s Republic of China Sorbonne Universite CNRSInstitut des Nanosciences de ParisUMR 758875005 ParisFrance Centre de Nanosciences et de Nanotechnologies et de Nanostructures CNRS UMR9001Universite Paris-Saclay10 boulevard Thomas Gobert91120 MarcoussisFrance Laboratoire de Physique et d’Etude des Materiaux ESPCI-ParisTechPSL Research UniversitySorbonne UniversiteCNRS UMR 821310 rue VauquelinParis 75005France Laboratoire Charles Fabry Institut d’Optique Graduate SchoolCNRS UMR 8501Universite Paris Saclay2 avenue Augustin Fresnel91127 Palaiseau CedexFrance

Coupling nano-emitters to plasmonic antennas is a key milestone for the development of nanoscale quantum light *** challenge,however,is the precise nanoscale positioning of the emitter in the ***,we present a laser etching protocol that deterministically positions a single colloidal CdSe/CdS core/shell quantum dot emitter inside a subwavelength plasmonic patch antenna with three-dimensional nanoscale *** exploiting the properties of metal–insulator–metal structures at the nanoscale,the fabricated single-emitter antenna exhibits a very high-Purcell factor(>72)and a brightness enhancement of a factor of *** to the unprecedented quenching of Auger processes and the strong acceleration of the multiexciton emission,more than 4 photons per pulse can be emitted by a single quantum dot,thus increasing the device *** technology can be applied to a wide range of photonic nanostructures and emitters,paving the way for scalable and reliable fabrication of ultracompact light sources.

关键词： patch precise acceleration

Hatha yoga training improves standing balance but not gait in Parkinson's disease

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Sports Medicine and Health Science 2020年第2期2卷 80-88页

作者： Naveen Elangovan Corjena Cheung Arash Mahnan jean F.Wyman paul Tuite Jürgen Konczak Human Sensorimotor Control Laboratory School of KinesiologyUniversity of MinnesotaMinneapolisMNUSA Center for Clinical Movement Science University of MinnesotaMinneapolisMNUSA School of Nursing University of MinnesotaMinneapolisMNUSA Department of Neurology University of Minnesota HealthMinneapolisMNUSA Department of Health Hong Kong Adventist CollegeHong KongChina

Background and purpose:Complementary therapies,such as yoga,have been proposed to address gait and balance problems in Parkinson's disease(PD).However,the effects of yoga on gait and static balance have not been studied systematically in people with PD(PWP).Here we evaluated the effects of a 12-week long Hatha yoga intervention on biomechanical parameters of gait and posture in ***:We employed a pilot randomized controlled trial design with two groups of mild-to-moderate PWP(immediate treatment,waitlist control;N?10 each;Mean Hoehn and Yahr score=2 for each group).Baseline Unified Parkinson's Disease Rating Scale(UPDRS)motor scores,and gait and postural kinematics including postural sway path length,cadence,walking speed,and turning time were *** immediate treatment group received a 60-min Hatha yoga training twice a week for 12 weeks,while the waitlisted control group received no *** 12 weeks,gait and postural kinematics were assessed(post-test for treatment group and second-baseline for waitlist group).Then,the waitlist group received the same yoga training and was evaluated ***:After Hatha yoga training,UPDRS motor scores improved with an 8-point mean decrease which is considered as a moderate clinically important change for mild-moderate *** path length during stance decreased significantly(mean reduction:-34.4%).No significant between-group differences or improvements in gait kinematics were ***:This study showed that a 12-week Hatha yoga training can improve static balance in *** found no evidence that it systematically improves gait performance in PWP.

关键词： Hatha yoga Parkinson's disease Posture Gait

18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma:A case report

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World Journal of Hepatology 2017年第11期9卷 562-566页

作者： Willy Liu jean Delwaide Noella Bletard Philippe Delvenne paul Meunier Roland Hustinx Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege (CHU-ULg) Department of Hepato-gastroenterology CHU Liege (CHU-ULg) Department of Pathology CHU Liege(CHU-ULg) Department of Pathology CHU Liege (CHU-ULg) Department of Radiology CHU Liege (CHUULg) Department of Nuclear Imaging CHU Liege (CHU-ULg)

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take.

关键词： Liver surgery Liver tumor Liver cancer Benign tumor Laparoscopy Prognosis