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Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways

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Cancer Biology & Medicine 2017年第2期14卷 129-141页

作者： Armel Herve Nwabo Kamdje paul Takam Kamga Richard Tagne Simo Lorella Vecchio paul Faustin Seke Etet jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera Department of Biomedical Sciences University of Ngaoundere Laboratory University of Verona Department of Basic Health SciencesCollege of Applied Medical SciencesQassim University Faculty of Science University of Poitiers Department of Biochemistry College of MedicineUniversity of Saskatchewan

Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like "wounds that do not heal." In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.

关键词： Mesenchymal stromal cells systemic circulation migration homing tumor modulation signaling pathways chemoresistance

Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda jean Luc Raoul Julien Edeline jean-Frédéric Blanc Bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller paul Castellani Yves Patrice Le Treut jean Pierre Bronowicki Marc Bourlière Department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille Department of Hepato-Gastroenterology and Digestive Oncology Institut Paoli-Calmette Marseille Department of Hepato-Gastroenterology and Digestive Oncology Centre Eugène Marquis Rennes Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux Department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille Department of Radiology Hopital Saint-Joseph Marseille Department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French *** Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and D(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P < 0.0001). The nomogram had the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CLIP Hepatocellular carcinoma

Characterization of dynamic distortion in LED light output for optical wireless communications

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Photonics Research 2021年第6期9卷 916-928页

作者： ANTON ALEXEEV jean-paul M.G.LINNARTZ KUMAR ARULANDU XIONG DENG Department of Electrical Engineering Eindhoven University of Technology5600 MB EindhovenThe Netherlands Signify(Philips Lighting)Research HTC 34(WB)5656 AE EindhovenThe Netherlands

Light-emitting diodes(LEDs)are widely used for data transmission in emerging optical wireless communications(OWC)*** paper analyzes the physical processes that limit the bandwidth and cause nonlinearities in the light output of modern,high-efficiency *** processes of carrier transport,as well as carrier storage,recombination,and leakage in the active region appear to affect the communications performance,but such purely physics-based models are not yet commonly considered in the algorithms to optimize OWC *** a dynamic modeling of these phenomena,we compile a(invertable)signal processing model that describes the signal distortion and a parameter estimation procedure that is feasible in an operational communications *** combine multiple approaches for steady-state and dynamic characterization to estimate such LED *** verify that,for a high-efficiency blue GaN LED,the models become sufficiently accurate to allow digital *** compare the simulation results using the model against optical measurements of harmonic distortion and against measurements of the LED response to a deep rectangular current *** show how the topology of the model can be simplified,address the self-calibration techniques,and discuss the limits of the presented *** model is suitable for the creation of improved nonlinear equalizers to enhance the achievable bit rate in LED-based OWC systems and we believe it is significantly more realistic than LED models commonly used in communications systems.

关键词： optical distortion dynamic

Lightweighting: Impact on Grade Development and Market Strategy

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Lightweighting: Impact on Grade Development and Market Strat...

Anti-ischemic efficacy of the cardiac pacemaker channel inhibitor ivabradine

第十届中国钢铁年会暨第六届宝钢学术年会

作者： Nauzin jean-paul FIVES KEODS

Lightweighting implies to take into account needs of the carmaker such as crash behavior and stiffness. These two main functions lead to conclude that developing grades for structural part（with higher Tensile strength） is not the only way. The replacement of steel used for the big inner and outer panels is mandatory if steelmakers don not want to lose this market because of the efficiency of aluminium.

关键词： lightweighting flat carbon steel car design market strategy

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Anti-ischemic efficacy of the cardiac pacemaker channel inhi...

Two new approaches for the treatment of vitiligo and melasma

第十五届国际药理学大会

作者： jean-paul Vilaine Institut de Recherches Servier （Suresnes France）

＜正＞ Ivabradine induces a selective heart rate reduction by inhibiting the cardiac pacemaker current If. Ivabradine and propranolol were compared in an experimental model of exercise-induced regional myocardial ischemia in Yucatan micropigs. Both compounds, administered orally at 5 mg/kg. induced a similar heart rate reduction at rest and during exercise. Ivabradine. unlike propranolol. did not de- crease myocardial contractility at rest and during exercise. Ivabradine reduced by 80% the exercise-induced ST segment shift of ECG in the ischemic area as pro-pranolol, but better improved the myocardial contractile dysfunction. The anti-ischemic efficacy of ivabradine was tested in approximately 5000 patients with stable angina. In a double-blinded trial, including 939 patients with stable angina, ivabradine （5 mg bid for 4 weeks followed by either 7.5 or 10 mg bid for 12 weeks） was at least as effective as atenolol （50 mg od for 4 weeks and 100 mg od for 12 weeks） in improving all criteria of exercise tolerance tests and in decreasing the number of angina *** is at least as potent as a β-blocker in limiting exercise-induced myocardial ischemia

关键词： Heart rate ivabradine myocardial ischemia exercise

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Two new approaches for the treatment of vitiligo and melasma

Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities

中华医学会第16次全国皮肤性病学术年会

作者： jean-paul Ortonne University of Nice-Sophia Antipolis FranceProfessor of Dermatology and Chairman Department of Dermatology University of Nice-Sophia Antipolisand scientific director of the Clinical Pharmacology Centre Applied to Dermatology

The 308 nm excimer laser and the 308 nm excimer lamp are equivalent for inducing repigmentation of vitiligo The 308nm excimer lasers and 308nm excimer lamps have both been shown to be effective in treating vitiligo but a direct comparison has never been *** objective of the study was to test the equivalence of those two devices for treating non segmental vitiligo.

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World Journal of Hepatology 2013年第4期5卷 196-205页

作者： Nouhoum Bouare Andre Gothot jean Delwaide Sebastien Bontems Dolores Vaira Laurence Seidel paul Gerard Christiane Gerard Department of Clinical Biology Laboratory HematologyImmuno-Hematology and AIDS Reference Laboratory B35Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Hepatology and Gastroenterology Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Public Health(Biostatistics) Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Institute of Mathematics Université de Liège4000 LiègeBelgium

AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both ***:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two *** tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both *** data were collected from patients recruited through a *** risk factors of both diseases were identified by univariate and multivariate ***:HCV seroprevalence was 0.2% for young and 6.5% for older *** prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our ***:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases.

关键词： Hepatitis C virus Human immunodeficiency virus Epidemiology Risk factors Women Mali Bamako

Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances

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World Journal of Hepatology 2012年第12期4卷 365-373页

作者： Nouhoum Bouare Dolores Vaira Andre Gothot jean Delwaide Sebastien Bontems Laurence Seidel paul Gerard Christiane Gerard Department of Hematobiology Immuno-Hematology and AIDS Reference Laboratory B35CHU-ULg4000 LiegeBelgium Department of Hepatology and Gastroenterology CHU-ULg4000 LiegeBelgium Department of Public Health(Biostatistics) CHU-ULg4000 LiegeBelgium Institute of Mathematics ULg4000 LiegeBelgium

AIM: To estimate the prevalence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections in women in Mali and to evaluate the performance of serological assays.

关键词： Human immunodeficiency virus Hepatitis C virus Serology Molecular diagnostics Women West Africa Bamako

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安全关键异构软件混合建模及代码生成方法

软件学报 2021年第4期32卷 904-933页

作者：宗喆杨志斌袁胜浩周勇 jean-paul BODELEIX Mamoun FILALI 南京航空航天大学计算机科学与技术学院江苏南京211106 高安全系统的软件开发与验证技术工信部重点实验室(南京航空航天大学) 江苏南京211106 IRIT-University of Toulouse Toulouse 31062France

随着系统复杂性的急剧增加,未来安全关键软件越来越多地采用异构构件组合架构,各种构件可能使用不同的计算模型或实现语言,使得整个软件系统呈现异构性.因此,设计此类系统需要使用复杂的建模方法.AADL(architecture analysis and design... 详细信息

随着系统复杂性的急剧增加,未来安全关键软件越来越多地采用异构构件组合架构,各种构件可能使用不同的计算模型或实现语言,使得整个软件系统呈现异构性.因此,设计此类系统需要使用复杂的建模方法.AADL(architecture analysis and design language)是一种安全关键系统体系结构多范式建模语言,丰富的可表达方式和可扩展性使其成为安全关键异构软件设计的重要选择.提出一种AADL和SDL(specification and description language)混合建模方法,支持以自底向上的方式对安全关键软件系统进行混合建模,并给出面向多核处理器平台的代码自动生成方法.首先,通过扩展AADL属性集,以支持使用SDL建模语言表达软件构件的功能行为.其次,以Ada作为目标语言,给出AADL-SDL混合模型的多任务代码生成方法.最后,实现了原型工具支持AADL和SDL混合建模及多任务Ada代码生成,并基于导航、制导与控制系统案例对所提方法的有效性进行分析.

关键词：安全关键异构软件混合建模 AADL SDL 多核代码自动生成