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Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats

World Journal of Gastroenterology 2008年第45期14卷 6943-6947页

作者： jean-marc Regimbeau David Fuks Niaz Kohneh-Shahri Benot Terris Olivier Soubrane Laboratory of Innovative treatment of Liver Diseases (EA 1833) Université René Descartes Federation of Digestive Diseases Amiens North Hospital University of Picardy place Victor Pauchet Department of Pathology Hpital Cochin Port Royal

AIM： To develop a simplified and quick protocol to induce cirrhosis and standardize models of partial liver resection in rats. METHODS： In Fischer F344 rats two modified protocols of phenobarbital-carbon tetrachloride （CCl4）（dilution 50%） gavage to induce cirrhosis （frequency adjusted according to weight, but each subsequent dose was systematically administered） were tested, i.e. the rapid and slow protocols. Prothrombin time （PT） and total bilirubin （TB） were also evaluated. Animals from the rapid group underwent 15% hepatectomy and animals from the slow group underwent 70% hepatectomy. RESULTS： Rapid protocol： This corresponded to 1 gavage/4 d over 6 wk （mortality 30%）. Mean PT was 35.2 ±2.8 s （normal： ld.5 s）, and mean TB was 1.8 ± 0.2 mg/dL （normal： 0.1 mg/dL）. Slow protocol： This cop responded to 1 gavage/6 d over 9 wk （mortality 10%）. Mean PT was 11.8 ± 0.2 s （normal： 14.5 s）, and mean TB was 0.4 ± 0.04 mg/dL （normal： 0.1 mg/dL）. Pathological analyses were performed in both protocols which showed persistent cirrhosis at 3 mo. Rat mortality in the rapid garage group who underwent 15% hepatectomy and in the slow garage group who underwent 70% hepatectomy was 50% and 70%, respectively, CONCLUSION： Our modified model is a simplified method to induce cirrhosis which is rapid （6 to 9 wk）, efficient and stable up to 3 mo. Using this method, ＂Child Pugh A＂ or ＂Child Pugh BC＂ cirrhotic rats were obtained. Our models of cirrhosis and hepatectomy can be used in various situations focusing on postoperative survival.

关键词： Carbon tetrachloride Cell therapy Hepatectomy Liver cirrhosis Liver failure acute Mortality Surgery

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Holography in the invisible. From the thermal infrared to the terahertz waves: outstanding applications and fundamental limits

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Light(Advanced Manufacturing) 2022年第2期3卷 157-170页

作者： marc Georges Yuchen Zhao jean-François Vandenrijt Centre Spatial de Liège STAR Research InstituteLiège UniversitéLiege Science Park4031 Angleur(Liège)Belgium

Since its invention,holography has been mostly applied at visible wavelengths in a variety of ***,non-destructive testing of manufactured objects was a driver for developing holographic methods and all related ones based on the speckle pattern *** substantial limitation of holographic non-destructive testing is the setup stability requirements directly related to the laser *** observation has driven some works for 15 years:developing holography at wavelengths much longer than visible *** this paper,we will first review researches carried out in the infrared,mostly digital holography at thermal infrared wavelengths around 10 *** will discuss the advantages of using such wavelengths and show different examples of *** nondestructive testing,large wavelengths allow using digital holography in perturbed environments on large objects and measure large deformations,typical of the aerospace *** astonishing applications such as reconstructing scenes through smoke and flames were *** moving further in the spectrum,digital holography with so-called Terahertz waves(up to 3 millimeters wavelength)has also been *** main advantage here is that these waves easily penetrate some ***,one can envisage Terahertz digital holography to reconstruct the amplitude and phase of visually opaque *** review some cases in which Terahertz digital holography has shown potential in biomedical and industrial *** will also address some fundamental bottlenecks that prevent fully benefiting from the advantages of digital holography when increasing the wavelength.

关键词： Long wave infrared Terahertz waves Digital holography Speckle interferometry

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Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm

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World Journal of Gastroenterology 2010年第5期16卷 588-595页

作者： Philippe Ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux jean-Charles Grimaud marc Barthet Department of Gastroenterology Hpital NordChemin des Bourrely13915 Marseille cedex 20France

AIM:To evaluate the feasibility and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our *** these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal *** mean age of the patients was 71 *** mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,*** were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb and 4%typeⅡ*** examination showed tubulous adenoma in 31%,tubulo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the *** two cases(7.7%)of procedural bleeding that occurred were managed endoscopically and one small perforation was treated with *** follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic submucosal dissection,despite providing incomplete histological assessment.

关键词： Endoscopic mucosal resection Perforation Colorectal carcinoma Large polyps

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Frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 637-644页

作者： Lionel Rebibo Thierry Yzet Cyril Cosse Richard Delcenserie Eric Bartoli jean-marc Regimbeau Department of Digestive Surgery Amiens University Medical Center the Jules Verne University of Picardie Department of Radiology Amiens University Medical Center and the Jules Verne University of Picardie Department of Digestive SurgeryAmiens University Medical Center and the Jules Verne University of Picardie Department of Gastroenterology Amiens University Medical Center and the Jules Verne University of Picardie

BACKGROUND:The Frey procedure(FP)is the treatment of choice for symptomatic chronic pancreatitis(CP).In cases of biliary stricture,biliary derivation can be performed by choledochoduodenostomy,Roux-en-Y choledochojejunostomy or,more recently,reinsertion of the common bile duct(CBD)into the resection *** objective of the present study was to evaluate the outcomes associated with each of these three types of biliary ***:We retrospectively analyzed demographic,CPrelated,surgical and follow-up data for patients having undergone FP for CP with biliary derivation between 2004and 2012 in our university medical *** primary efficacy endpoint was the rate of CBD stricture *** secondary endpoints were surgical parameters,postoperative complications,postoperative follow-up and the presence of risk factors for secondary CBD ***:Eighty patients underwent surgery for CP during the study *** these,15 patients received biliary derivation with the *** of the FPs(53.3%)were combined with choledochoduodenostomy,4(26.7%)with choledochojejunostomy and 3(20.0%)with reinsertion of the CBD into the resection *** mean operating time was *** complications(73.3%)were recorded,including one major complication(6.7%)that necessitated radiologicallyguided drainage of an abdominal *** mean(range)length of stay was 17 days(8-28)and the median(range)follow-up time was 35.2 months(7.2-95.4).Two patients presented stricture after CBD reinsertion into the resection cavity;one was treated with radiologically-guided dilatation and the other underwent revisional Roux-en-Y *** patients presented alkaline reflux gastritis(37.5%),one(12.5%)cholangitis and one CBD stricture after FP with *** risk factors for secondary CBD stricture were ***:As part of a biliary derivation,the FP gave good *** did not observe any complications specifically relat

关键词： common bile duct stricture chronic pancreatitis Frey procedure pancreatectomy

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Masquelet technique in military practice:specificities and future directions for combat-related bone defect reconstruction

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Military Medical Research 2023年第3期10卷 369-382页

作者： Laurent Mathieu Romain Mourtialon Marjorie Durand Arnaud de Rousiers Nicolas de l’Escalopier jean‑marc Collombet Department of Orthopedic Trauma and Reconstructive SurgeryPercy Military Hospital101 avenue Henri Barbusse92140 ClamartFrance Department of Surgery Ecole du Val‑de‑GrâceFrench Military Health Service Academy1place Alphonse Laveran75005 ParisFrance Military Biomedical Research Institute(IRBA) 1 place Général Valérie André91220 Brétigny‑sur‑OrgeFrance

Because of its simplicity,reliability,and replicability,the Masquelet induced membrane technique(IMT)has become one of the preferred methods for critical bone defect reconstruction in *** it is now used worldwide,few studies have been published about IMT in military *** reconstruction is particularly challenging in this context of care due to extensive soft-tissue injury,early wound infection,and even delayed management in austere *** on our clinical expertise,recent research,and a literature analysis,this narrative review provides an overview of the IMT application to combat-related bone *** presents technical specificities and future developments aiming to optimize IMT outcomes,including for the management of massive multi-tissue defects or bone reconstruction performed in the field with limited resources.

关键词： Bone defect Induced membrane technique Gunshot wound Low resources Masquelet technique Military War surgery

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Portopulmonary hypertension and hepatopulmonary syndrome

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World Journal of Gastroenterology 2014年第25期20卷 8072-8081页

作者： Florence Aldenkortt marc Aldenkortt Laurence Caviezel jean Luc Waeber Anne Weber Eduardo Schiffer Division of Anesthesiology Department of AnesthesiologyClinical Pharmacology and Intensive CareGeneva University Hospitals1211 GenevaSwitzerland

Portopulmonary hypertension (POPH) and hepatopulmonary syndrome (HPS) are two frequent complications of liver disease, with prevalence among liver transplant candidates of 6% and 10%, respectively. Both conditions result from a lack of hepatic clearance of vasoactive substances produced in the splanchnic territory. Subsequently, these substances cause mainly pulmonary vascular remodeling and some degree of vasoconstriction in POPH with resulting elevated pulmonary pressure and right ventricular dysfunction. In HPS the vasoactive mediators cause intrapulmonary shunts with hypoxemia. Medical treatment is disappointing overall. Whereas liver transplantation (LT) results in the disappearance of HPS within six to twelve months, its effect on POPH is highly unpredictable. Modern strategies in managing HPS and POPH rely on a thorough screening and grading of the disease’s severity, in order to tailor the appropriate therapy and select only the patients who will benefit from LT. The anesthesiologist plays a central role in managing these high-risk patients. Indeed, the important hemodynamic and respiratory modifications of the perioperative period must be avoided through continuation of the preoperatively initiated drugs, appropriate intraoperative monitoring and proper hemodynamic and respiratory therapies.

关键词： End stage liver disease Hepatopulmonary syndrome Portopulmonary Hypertension Anesthesia

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Combined radiologic and endoscopic treatment(using the “rendezvous technique”) of a biliary fistula following left hepatectomy

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World Journal of Gastroenterology 2016年第30期22卷 6955-6959页

作者： Aurélien Gracient Lionel Rebibo Richard Delcenserie Thierry Yzet jean-marc Regimbeau Service de Chirurgie Digestive H?pital Sud CHU d'Amiens Avenue René LaennecF-80054 Amiens cedex 01 France Department of Gastroenterology Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France Department of Radiology Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France EA4294 Jules Verne University of Picardie F-80054 Amiens cedex 01 France Clinical Research Center Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France

Despite the ongoing decrease in the frequency of complications after hepatectomy, biliary fistulas still occur and are associated with high morbidity and mortality rates. Here, we report on an unusual technique for managing biliary fistula following left hepatectomy in a patient in whom the right posterior segmental duct joined the left hepatic duct. The biliary fistula was treated with a combined radiologic and endoscopic procedure based on the "rendezvous technique". The clinical outcome was good, and reoperation was not required.

关键词： Left hepatectomy Rendezvous technique biliary stent biliary fistula Anatomic variation

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Bartonella species in small mammals and their potential vectors in Asia

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Asian Pacific Journal of Tropical Biomedicine 2014年第10期4卷 757-767页

作者： Tawisa Jiyipong Sathaporn Jittapalapong Serge Morand jean-marc Rolain Research Unit on Infectious and Emerging Tropical Diseases(URMITE).CNRS-IRD-INSERM UMR 7278 IHU Mediterranee InfectionFulty of Medicine and PharmacyAix-Marseille-UniversityMarseilleFrance Center for Agricultural Biotechnology(AG-BIO/PEDRO-CHE) Kasetsart UniversityKamphaeng Saen CampusNakhon Pathom.73140Thailand Center of Excellence ongricultural Biotechnology(AG-BIO/PERDO-CHE) Bangkok 10900Thailand Center of Advanced Studies for Agriculture and Food KU Institute for Advanced Studieskasetsart UniversityBangkok 10900Thailand(CASAFNRU-KUThailand) Department of Parasitology Faculty of Veterinary MedicineKasetsart UniversityBangkokThailand Institut Sciences of Evolution UMR 5554 CNRS-IRD-UM2CC65University de Montpellier 2F-34095MontpellierFrance Walai Rukhavej Btanical Research Institute Mahasarakham UniversityMahasrakhamThailand

In this article,authors review the current knowledge of Bartonella infection in small mammals including rodents,insectivores,bats and exotic small mammal pets and their vectors in *** of Bartonella are Gram-negative intracellular bacteria that infect erythrocytes of various mammalian and non-mammalian animals and mainly transmitted by blood sucking arthropod *** genus Bartonella includes several species of important human diseases with severe clinical *** new Bartonella species were isolated from rodents and other small mammals,and from human patients in *** species are identified using standard polymerase chain reaction amplification and a sequencing targeting two housekeeping genes(glt.A and rpoB) and the internal transcribed spacer *** also discuss the implications in term of potential emerging zoonotic diseases.

关键词： Bartonella Small mammals Rodents Shrews Asia

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Fast genre classification of web images using global and local features

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CAAI Transactions on Intelligence Technology 2018年第3期3卷 161-168页

作者： Guo-Shuai Liu Rui-Qi Wang Fei Yin jean-marc Ogier Cheng-Lin Liu National Laboratory of Pattern Recognition Institute of Automation of Chinese Academy of Sciences 95 Zhongguancun East Road Beijing 100190 People's Republic of China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 People's Republic of China L3i Laboratory Faculty of Science and Technology University of La Rochelle 17042 La Rochelle Cedex 1 France Center for Excellence of Brain Science and Intelligence Technology Beijing 100190 People's Republic of China

To effectively mine the contents embedded in web images, it is useful to classify the images into different types so that they can be fed to different procedures for detailed analysis. The authors herein propose a hierarchical algorithm for efficiently classifying web images into four classes. Their algorithm consists of two stages： the first stage extracts global features reflecting the distributions of color, edge and gradient, and uses a support vector machine （SVM） classifier for preliminary classification. Images assigned low confidence by the first stage classifier are processed by the second stage, which further extracts local texture features represented in the bag-of-words framework and uses another SVM classifier for final classification. In addition, they design two fusion strategies to train the second-stage classifier and generate the final prediction depending on the usage of local features in the second stage. To validate the effectiveness of proposed method, they built a database containing more than 55,000 images from various sources. On their test image set, they obtained an overall classification accuracy of 98.4% and the processing speed is over 27 fps on an Intel（R） Xeon（R） central processing unit （2.90 GHz）.

关键词：网络图像计算机技术发展现状智能技术

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Molecular dynamics simulations of initial Pd and PdO nanocluster growth in a magnetron gas aggregation source

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 324-329页

作者： Pascal Brault William Chamorro-Coral Sotheara Chuon Amael Caillard jean-marc Bauchire Stevè Baranton Christophe Coutanceau Erik Neyts GREMI UMR 7344 CNRS Universite d'Orleans45067 Orleans Cedex 2France IC2MP UMR 7285 CNRS Universite de Poitiers86073 Poitiers Cedex 9France Department of Chemistry University of Antwerp2610 AntwerpBelgium

Molecular dynamics simulations are carried out for describing growth of Pd and PdO nanoclusters using the ReaxFF force field. The resulting nanocluster structures are successfully compared to those of nanoclusters experimentally grown in a gas aggregation source. The PdO structure is quasi-crystalline as revealed by high resolution transmission microscope analysis for experimental PdO nanoclusters. The role of the nanocluster temperature in the molecular dynamics simulated growth is highlighted.

关键词： molecular dynamics cluster growth plasma sputtering nanocatalyst

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