检索结果-南通市图书馆

Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

Journal of Pharmaceutical Analysis 2021年第1期11卷 77-87页

作者： Christelle Machon Frederic Catez Nicole Dalla Venezia Floriane Vanhalle Laetitia Guyot Anne Vincent Maxime Garcia Beatrice Roy jean-jacques Diaz Jerome Guitton Laboratoire de Chimie Analytique Faculte de Pharmacie de LyonUniversite Lyon 18 Avenue RockefellerLyon69373France Laboratoire de Biochimie et de Pharmaco-toxicologie Centre Hospitalier Lyon-SudeHCLPierre Benite69495France Inserm U1052 CNRS UMR5286 Centre de Recherche en Cancerologie de LyonF-69000 LyonFrance.Centre Leon BerardF-69008 LyonFranceUniversite de Lyon 1F-69000 LyonFrance Institut des Biomolecules Max Mousseron(IBMM) UMR 5247 CNRSUniversite de MontpellierENSCMCampus TrioletMontpellierFrance Laboratoire de toxicologie Faculte de pharmacie de Lyon8 avenue RockefellerF-69373 LyonFrance

5-Fluorouracil(5-FU)is an anticancer drug extensively used for different *** metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes,DNA and *** this paper,we describe the development of a method based on liquid chromatography coupled with high resolution mass spectrometry suitable for the simultaneous determination of the ten anabolic metabolites(nucleoside,nucleotide and sugar nucleotide)of *** chromatographic separationwas optimized on a porous graphitic carbon column allowing the analysis of the metabolites of 5-FU as well as endogenous *** detection was performed on an Orbitrap■tandem mass *** of the method was verified in intracellular content and in RNA *** limit of detection was equal to 12 pg injected on column for nucleoside metabolites of 5-FU and 150 pg injected on column for mono-and tri-phosphate nucleotide *** effect was evaluated in cellular contents,DNA and RNA extracts for nucleoside and nucleotides *** method was successfully applied to i)measure the proportion of each anabolic metabolite of 5-FU in cellular contents,ii)follow the consequence of inhibition of enzymes on the endogenous nucleotide pools,iii)study the incorporation of metabolites of 5-FU into RNA and DNA,and iv)to determine the incorporation rate of 5-FUrd into 18 S and 28 S sub-units of rRNA.

关键词： 5-Fluorouracil LC-MS-HRMS Nucleotide RNA DNA Incorporation rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RELATIONSHIP BASED ON FIRSTS

引用

Beijing Review 2017年第2期60卷 16-17页

作者： jean-jacques de Dardel

Beijing Review： In recent years, China and Switzerland have maintained intensive high-level exchanges, as frequent bilateral meetings between senior officials demonstrate. What do you think are the major reasons for ... 详细信息

关键词：英语阅读理解人物

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heap-Leaching of Low-Grade Uranium Ore at SOMAIR： From Laboratory Tests to Production of 700 Tonnes U Per Year

引用

Journal of Chemistry and Chemical Engineering 2011年第6期5卷 549-557页

作者： Nicolas Durupt jean jacques Blanvillain ARE＇A NC Service d＇Etudes de Proeddds et d ＇Analyses （SEPA） BP 71 87250 Bessines sur Gartempe France

In 2006, SOMAIR decided to increase the uranium production by 50% using heap leaching for the treatment of low grade ores. These ores, which come from different lodes with various properties, have been studied in four steps：（ 1 ） Lab tests： to compare the ores （characterization, acid consumptions, recovery...）; （2） Column tests on an average sample： to define significant parameters for a feasibility study; （3） Column tests on specific samples： to optimize recovery for each ore and identify problems of percolation due to the clays; （4） Pilot tests in large boxes （stalls）： to validate process parameters. Uranium production by heap leaching started in July 2009.

关键词： Uranium heap-leaching low grade ores clays column tests acid consumption.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

社会契约论

引用

作者： (法)让－雅克·卢梭(jean-jacques Rousseau)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Carbon dioxide:A new material for energy storage

引用

Progress in Natural Science:Materials International 2014年第4期24卷 295-304页

作者： jacques Amouroux Paul Siffert jean Pierre Massué Simeon Cavadias Béatriz Trujillo Koji Hashimoto Phillip Rutberg Sergey Dresvin Xianhong Wang Ecole Nationale Supérieure de Chimie de Paris (ENSCP) Université Pierre et Marie Curie ParisFrance 2. European Material Research Society(EMRS)StrasbourgFrance 3. Laboratoire de Génie des Procédés Plasmas et Traitement de Surface(LGPPTS)Université Pierre et Marie Curie ParisFrance 4. Institute Polytechnic National de MéxicoMexico 5. Lab Electrotechnic and Electrophysic State Polytechnical University of St.PetersbourgRussia 6. Tohoku UniversityJapan Tohoku Institute of Technology Japan Plasma Laboratory State Polytechnical University of St.Petersbourg Russia 9. Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryCASChina

Though carbon dioxide is the main green house gas due to burning of fossil resource or miscellaneous chemical processes,we propose here that carbon dioxide be a new material for energy *** it can be the key to find the solution for three critical issues facing the world:food ecosystems,the greenhouse issue and energy *** propose to identify the carbon recovery through a circular industrial revolution in the first part,and in the second part we present the starting way of three business plants to do that from industrial *** pointing out all the economic constraints and the hidden competitions between energy,water and food,we try to qualify the phrase "sustainable development" and open the way of a huge circular economy.

关键词： Carbon dioxide Energy storage material Carbon dioxide recovery Chemical utilization Circular economy Sustainable development

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ESR-铀系联合分析与等时线法结合在考古遗址化石测年中的应用探索

引用

核技术 2012年第12期35卷 923-928页

作者：韩非 jean-jacques Bahain 尹功明刘春茹中国地震局地质研究所地震动力学国家重点实验室北京100029 法国国家自然历史博物馆史前部

在ESR考古测年中,外部剂量率通常是年代结果的一个主要误差来源,其在历史过程中不断变化,所以很难通过现今的野外测量准确测定。等时线技术可解决化石样品测年中外部剂量率的不确定性问题。本研究尝试将ESR-铀系联合化石分析结合等时线... 详细信息

在ESR考古测年中,外部剂量率通常是年代结果的一个主要误差来源,其在历史过程中不断变化,所以很难通过现今的野外测量准确测定。等时线技术可解决化石样品测年中外部剂量率的不确定性问题。本研究尝试将ESR-铀系联合化石分析结合等时线技术应用于重庆龙骨坡遗址CⅢ’6层相邻探方中采集的5颗牙齿。ESR-铀系联合分析显示全部样品均经历了铀的近期吸收过程。平均外部剂量率通过等时线方法分步迭代计算,得到样品等时线年龄为1.77±0.09 Ma。本研究表明,将ESR-铀系联合分析与等时线技术相结合可同时解决牙齿化石样品ESR测年中内部剂量率和外部剂量率的问题。

关键词： ESR-铀系联合测年外部剂量率等时线法牙齿化石龙骨坡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

社会契约论

社会契约论

引用

作者： (法)让·卢梭(jean-jacques Rousseau)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Changes in smoking patterns after HIV diagnosis or antiretroviral treatment initiation: a global systematic review and meta-analysis

引用

Infectious Diseases of Poverty 2020年第2期9卷 14-22页

作者： Jobert Richie Nansseu Dalhia Noelle Tounouga jean jacques Noubiap jean Joel Bigna Department of Public Health Faculty of Medicine and Biomedical Sciences of the University of YaoundéIYaoundéCameroon Department for the Control of Disease Epidemics and PandemicsMinistry of Public HealthYaoundéCameroon Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide HospitalAdelaideAustralia Department of Epidemiology and Public Health Centre Pasteur of CameroonPO Box 1274YaoundéCameroon School of Public Health Faculty of MedicineUniversity of Paris Sud XILe Kremlin BicêtreFrance

Background:Tobacco consumption is more life-threatening in people living with human immunodeficiency virus(HIV)than within the general population;therefore,people living with HIV(PLWH)should be highly motivated to take action towards quitting smoking at or after HIV *** aim of this systematic review with meta-analysis was to investigate changes in smoking habits among PLWH over *** text:We considered prospective and retrospective cohort studies including PLWH aged 15 years and above,which have measured the prevalence of tobacco smoking(current,former or never)at study initiation and completion,and published between January 1,2000 and April 15,2018 without language or geographical *** searched PubMed,EMBASE,Web of Science,Africa Journal Online,and Global Index *** used a random-effects model to pool *** studies were *** proportion of current and former smokers decreased slightly over time,around 2.5 and 3.8%,***,the proportion of never smokers decreased sharply by 22.5%,and there were 2.1 and 1.5%PLWH who shifted from never and former smoking to current smoking,*** the other hand,10.5%PLWH shifted from current to former smoking,7.1%tried to quit tobacco consumption but failed,and 10.1%stayed in the"never smoking"category over ***:PLWH seem not to change positively their smoking habits towards quitting tobacco *** is urgent need to increase actions aimed at helping this vulnerable population to quit tobacco consumption,including individually tailored therapeutic education,psychosocial and pharmacologic supports.

关键词： Smoking HIV AIDS Tobacco Global health

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exercise-induced albuminuria vs circadian variations in blood pressure in type 1 diabetes

引用

World Journal of Diabetes 2017年第2期8卷 74-79页

作者： Isabelle Hota Tadida Meli Aurel T Tankeu Mesmin Y Dehayem David Chelo jean jacques N Noubiap Eugene Sobngwi Institut Supérieur des Sciences de la Santé Université des Montagnes Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences National Obesity Center Yaoundé Central Hospital Mother and Child Center of the Chantal Biya Foundation Department of Medicine Groote Schuur Hospital and University of Cape Town

AIM To investigated the relationship between exerciseinduced ambulatory blood pressure measurement(ABPM) abnormalities in type 1 diabetes mellitus(T1DM) adolescents. METHODS We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio(ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1 DM patients and 20 matched controls. T1 DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure(BP) and renal function according to the general referencepopulation. Non-diabetic controls were adolescents of general population matched for sex, age and *** Mean duration of diabetes was 4.2 ± 2.8 years. The mean 24 h systolic blood pressure(SBP) and diastolic blood pressure(DBP) were respectively 116 ± 9 mm Hg in the diabetic group vs 111 ± 8 mm Hg in the nondiabetic(P = 0.06), and 69 ± 7 mm Hg vs 66 ± 5 mm Hg(P = 0.19). There was no difference in the diurnal pattern of BP in diabetes patients and non-diabetic controls(SBP: 118 ± 10 mm Hg vs 114 ± 10 mm Hg, P = 0.11; DBP: 71 ± 7 mm Hg vs 68 ± 6 mm Hg, P = 0.22). Nighttime BP was higher in the diabetic group with respect to SBP(112 ± 11 mm Hg vs 106 ± 7 mm Hg, P = 0.06) and to the mean arterial pressure(MAP)(89 ± 9 mm Hg vs 81 ± 6 mm Hg, P = 0.06). ACR at rest was similar in both groups(5.5 mg/g vs 5.5 mg/g, P = 0.74), but significantly higher in diabetes patients after exercise(10.5 mg/g vs 5.5 mg/g, P = 0.03). SBP was higher in patients having exercise-induced albuminuria(116 ± 10 mm Hg vs 108 ± 10 mm Hg, P = 0.09). CONCLUSION Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1 DM.

关键词： Albuminuria Blood pressure Ambulatory blood pressure measurement Exercise Type 1 diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

社会契约论

引用

作者： (法)让-雅克·卢梭(jean-jacques Rousseau)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：