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Prevalence of Dyslipidemia among Patients Received at the Biochemistry Unit of the Charles de Gaulle Pediatric University Hospital in Ouagadougou

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Advances in Biological Chemistry 2024年第1期14卷 16-26页

作者： Fabienne Marie Soudre Arnaud Kouraogo Alice Kiba Ollo Da Mahutin Benoîte Hounhoui Diema Nadia Karama Seraphine Mano denis Claude Drabo Augustin Kyetega Raoul Karfo Elie Kabre jean Sakande Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Charles de Gaulle Pediatric University Hospital Ouagadougou Burkina Faso Health Sciences Institute Nazi BONI University Bobo Dioulasso Burkina Faso Biochemistry Unit Sourou Sanou University Hospital Bobo Dioulasso Burkina Faso Tengandogo University Hospital Ouagadougou Burkina Faso Faculty of Health Sciences Saint Thomas d’Aquin University Ouagadougou Burkina Faso Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso National Agency for Environmental Food Labor and Health Product Safety Ouagadougou Burkina Faso

Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.

关键词： Dyslipidemia Lipid Profile Lipid Abnormalities Prevalence Burkina Faso

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Epidemiology, Clinical Features and Antifungal Resistance Profile of Candida auris in Africa: Systematic Review

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Journal of Biosciences and Medicines 2024年第1期12卷 126-149页

作者： Isidore Wendkièta Yerbanga Seydou Nakanabo Diallo Toussaint Rouamba Delwendé Florence Ouedraogo Katrien Lagrou Rita Oladele jean-Pierre Gangneux Olivier denis Hector Rodriguez-Villalobos Isabel Montesinos Sanata Bamba Centre Hospitalier Universitaire Régional de Ouahigouya Ouahigouya Burkina Faso Ecole Doctorale des Sciences De la Santé Université Nazi Boni Bobo-Dioulasso Burkina Faso Centre Muraz/Institut National de Santé Publique Bobo-Dioulasso Burkina Faso Clinical Research Unit of Nanoro Institute for Research in Health Sciences National Center for Scientific and Technological Research Ouagadougou Burkina Faso Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium and Department of Laboratory Medicine and National Reference Center for Mycosis Excellence Center for Medical Mycology (ECMM) University Hospitals Leuven Leuven Belgium College of Medicine University of Lagos Lagos Nigeria Univ Rennes CHU Rennes Inserm Irset (Institut de recherche en santé environnement et travail) European ECMM Excellence Center in Medical Mycology Université de Rennes Rennes France Department of Microbiology CHU Namur site-Godinne Université Catholique de Louvain Yvoir Belgium Ecole de Santé Publique Université Libre de Bruxelles Brussels Belgium Department of Microbiology Cliniques Universitaires Saint-Luc—Université Catholique de Louvain Bruxelles Belgium Centre Hospitalier Universitaire Sour? Sanou Bobo-Dioulasso Burkina Faso

Candida auris since it discovery in 2009 is becoming a severe threat to human health due to its very quickly spread, its worldwide high resistance to systemic antifungal drugs. In resource-constrained settings where several conditions are met for its emergence and spread, this worrisome fungus could cause large hospital and/or community-based outbreaks. This review aimed to summarize the available data on C. auris in Africa focusing on its epidemiology and antifungal resistance profile. Major databases were searched for articles on the epidemiology and antifungal resistance profile of C. auris in Africa. Out of 2,521 articles identified 22 met the inclusion criteria. In Africa, nearly 89% of African countries have no published data on C. auris. The prevalence of C. auris in Africa was 8.74%. The case fatality rate of C. auris infection in Africa was 39.46%. The main C. auris risk factors reported in Africa were cardiovascular disease, renal failure, diabetes, HIV, recent intake of antimicrobial drugs, ICU admissions, surgery, hemodialysis, parenteral nutrition and indwelling devices. Four phylogenetic clades were reported in Africa, namely clades I, II, III and IV. Candida auris showed a pan-African very high resistance rate to fluconazole, moderate resistance to amphotericin B, and high susceptibility to echinocandins. Finally, C. auris clade-specific mutations were observed within the ERG2, ERG3, ERG9, ERG11, FKS1, TAC1b and MRR1 genes in Africa. This systematic review showed the presence of C. auris in the African continent and a worrying unavailability of data on this resilient fungus in most African countries.

关键词： Africa Antifungal Resistance Candida auris Clinical Features Phylogenetic Clades

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法国精神卫生的分区化服务模式

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临床精神医学杂志 2000年第4期10卷 247-248页

作者：邹义壮 Jacques Dubuis denis Leguray Eric Malapert jean Dalery 北京回龙观医院 100096 里昂第一大学医学院里昂维纳蒂斯中心医院巴黎Perray Vaucluse中心医院昂热Cesema中心医院

从本世纪60年代开始,法国在全国逐步建立和完善了在世界上独具特色的精神卫生服务体系,即以精神病院为中心,分片覆盖到社区的精神卫生服务模式,被称作'分区化'模式(sectorization).

关键词：法国精神卫生分区化服务模式

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Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging

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World Journal of Clinical Oncology 2016年第3期7卷 293-301页

作者： Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet UMR1071 Inserm/Université d’Auvergne and INRA USC2018 Clermont Université Service de Chirurgie Digestive Centre Hospitalier Universitaire UMR990 Inserm/Université d’Auvergne Clermont Université Service de Médecine Nucléaire Centre Jean Perrin

AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical ***: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided

关键词： Colorectal carcinoma Escherichia coli Colibactin Myeloperoxidase In vivo optical imaging

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新植蔗施肥模式与宿根蔗产量及糖分关系的研究

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甘蔗（福建） 1999年第1期6卷 13-21页

作者：梁计南谭中文 Mouele jean denis 罗明珠李玉潜陈培寿华南农业大学甘蔗研究室

本文研究了新植蔗不同施肥模式对宿根蔗的后续效应，旨在探讨新植蔗不同施肥模式下，宿根蔗产量和蔗糖分差异及其原因，为进一步优化甘蔗三高施肥模式提供理论依据。试验结果表明，在新植蔗不同施肥模式下，就模式间进行比较，宿根蔗蔗... 详细信息

本文研究了新植蔗不同施肥模式对宿根蔗的后续效应，旨在探讨新植蔗不同施肥模式下，宿根蔗产量和蔗糖分差异及其原因，为进一步优化甘蔗三高施肥模式提供理论依据。试验结果表明，在新植蔗不同施肥模式下，就模式间进行比较，宿根蔗蔗茎产量和收获株数存在显著差异，其规律与新植蔗的结果相一致；宿根蔗的株高在施肥情况下存在显著差异；宿根蔗茎径差异不显著；株高的变异系数存在明显差异，且施肥与否规律相同；生长中后期的叶片Ｎ含量存在明显差异，在施肥情况下差异更加明显；蔗汁锤度无显著差异；叶片Ｐ和Ｋ含量无明显差异。试验结果也表明，在新植蔗不同施肥模式下，宿根蔗施肥比不施肥，蔗茎产量和株数显著增加；叶片含Ｎ、Ｐ、Ｋ量明显增加；株高的变异系数明显较低；而其他性状则无明显的差异。分析试验结果可以看出，新植蔗不同施肥模式下宿根蔗产量的差异主要是由于株数、株高、叶片含氮量、株高整齐度的差异所致，宿根蔗的株数。

关键词：甘蔗施肥宿根蔗新植蔗

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说服关于雄辩的对话

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2000年

作者： (法)让-德尼·布勒丹(jean-denis Bredin) (法)蒂埃里·雷维(Thierry L

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Characterization and Quantification of Phenolic Compounds of Hydroethanolic Extracts and Fractions of Leaves Gnetum africanum (Welv.) and Gnetum buchholzianum (Engl.) (Gnetaceae)

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Open Journal of Applied Sciences 2022年第7期12卷 1304-1318页

作者： Bertin Sone Enone Gisèle Marie-Marguerite Etame-Loe Charles Christian Ngoule jean-Pierre Ngene Juliette Koube Lahngong Methodius Shinyuy Simone Véronique Fannang Moïse Henri Julien Nko’o jean Baptiste Hzounda Fokou Hans denis Bamal Celestine Magne Valdi Steve Djova Wilfred Ndogmo Tekapi Sandrine Sikadeu Josiane Etang Albert Mouelle Sone Laboratory of Microbiology Immunology-Hematology and Morphological Sciences Doctoral Training Unit in Health Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Microbiology University of Yaounde I Yaounde Cameroon Chemistry Laboratory Faculty of Sciences University of Douala Douala Cameroon Department of Biology and plant Organisms Faculty of Science Douala Cameroon

Research for bioactive molecules and not resistant to infectious agents remains topical for science. The total polyphenols (TPP) and total flavonoids (TFv) of the hydroethanolic extracts and fractions obtained were quantified according to the spectrophotometric method described in the literature using the Folin-Ciocalteu reagent and the colorless solutions of sodium nitrite 2.5% and aluminum chloride 10% respectively. The characterization of chemical compounds was made by coupling liquid chromatography (LC) and mass spectroscopy (MS). Thus, 15 chemical compounds were characterized, seven from Gnetum africanum (EBa) and eight from Gnetum buchholzianum (EBb). The majority of which were stilbens, such as Gnetupendin D, Dimethoxygnetulin, Methoxyparvifolol D, Isorhaponcitin from Eba and Gnetuhaidin P, Gnetupendin D, Gnetuhainin C, phenols (Alcohol Homovanillyl, Alcohol Erythro guaiacylglycerol-β-O-4'-coniferyl, and Alcohol Homovanillyl from EBb. The minority were flavonoids such as Dimethoxydihydropyraneriodictyol, Dimethoxyeriodictyol (EBa) and Dimethoxydihydropyraneriodictyol, Trimethoxyluteolin (EBb). The levels of total polyphenolics and total flavonoids content were respectively 14.520 ± 0.557 mg EAA/g Extract and 29.870 ± 2.485 mg EQ/g Extract for EBa. The levels of total polyphenolics and total flavonoids content for EBb were respectively 4.560 ± 0.010 mg EAA/g Extract and 2.233 ± 0.251 mg EQ/g Extract. The high levels of flavonoids content respectively 220.200 ± 35.500 and 335.300 ± 57.810 mg EQ/g Extract were shown in Dichlorometan fraction from EBa and EBb. These bioactive compounds identified and total phenolics compounds quantified can be exploited in pharmacological and pharmacokinetical activities to fight against multi-resistant infectious agents and as well as oxidative stress and antiinflammatory diseases.

关键词： Gnetum africanum Gnetum buchholzianum Phenolic Compounds Liquid Chromatography Mass Spectroscopy

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A new hemostatic agent composed of Zn^(2+)-enriched Ca^(2+)alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo

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Bioactive Materials 2022年第12期7卷 368-382页

作者： Anne-Charlotte Ponsen Richard Proust Sabrina Soave Françoise Mercier-Nom´e Isabelle Garcin Laurent Combettes jean-Jacques Lataillade Georges Uzan INSERM UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plateforme d’Histologie Immunopathologie de Clamart(PHIC) Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Universit´e Paris-Saclay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSERM UMRS 1174 Universit´e Paris-SaclayOrsayFrance Centre de Transfusion Sanguine des Arm´ees ClamartFrance

To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a negative impact on tissue repair in the resected organ. To avoid complications and obtain a hemostatic agent that promotes tissue repair, a zinc-supplemented calcium alginate compress was developed: HEMO-IONIC®. This compress is non-absorbable and is therefore removed once hemostasis has been achieved. After demonstrating the hemostatic efficacy and stability of the blood clot obtained with HEMO-IONIC, the impact of Surgicel, TachoSil, and HEMO-IONIC on cell activation and tissue repair were compared (i) in vitro on endothelial cells, which are essential to tissue repair, and (ii) in vivo in a mouse skin excision model. In vitro, only HEMO-IONIC maintained the phenotypic and functional properties of endothelial cells and induced their migration. In comparison, Surgicel was found to be highly cytotoxic, and TachoSil inhibited endothelial cell migration. In vivo, only HEMO-IONIC increased angiogenesis, the recruitment of cells essential to tissue repair (macrophages, fibroblasts, and epithelial cells), and accelerated maturation of the extracellular matrix. These results demonstrate that a zinc-supplemented calcium alginate, HEMO-IONIC, applied for 10 min at the end of surgery and then removed has a long-term positive effect on all phases of tissue repair.

关键词： Hemostatic agent Alginate Surgery Hemostasis Endothelial cells Tissue repair

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Self-medication of achalasia with cannabis, complicated by a cannabis use disorder

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World Journal of Gastroenterology 2015年第20期21卷 6381-6383页

作者： Amandine Luquiens Nelson Lourenco Amine Benyamina Henri-jean Aubin Hopital Paul Brousse-Addictologie 94804 Villejuif cedex France Service d'hepatogastroenterologie Hopital Saint Louisuniversite Denis Diderot Paris Ⅶ 75010 ParisFrance

Achalasia is a rare esophagus motility disorder. Medical, endoscopic and surgical treatments are available, but all endorse high relapse rates. No data has been published to date reporting a therapeutic effect of cannabis use neither in achalasia nor on its influence on manometric measurements. We report the case of a patient diagnosed with achalasia. He could benefit from a large panel of therapeutic interventions, but none of them was effective over the time. He first used cannabis at age 20 and identified benefits regarding achalasia symptoms. He maintained regular moderate cannabis use for 9 years, with minimal digestive inconvenience. A manometry performed without cannabis premedication was realized at age 26 and still found a cardiospasm. Cannabis use could explain the gap between functional symptoms assessment and manometry measurement. Further investigations are warranted to explore a therapeutic effect of cannabis in achalasia and possible influence on outcome measurements.

关键词： Achalasia Cannabis Treatment Manometry Addiction

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卵化的自然起源

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环球科学 2023年第17期 34-39页

作者：让-丹尼·维涅戚译引(翻译) 法国国家科学研究中心(CNRS) 法国国家自然博物馆不详

驯化到底是什么?这篇来自《科学美国人》法国版的文章介绍了近三十年来,考古学如何重新勾勒人类与动植物之间关系演变的历史,展现了关于驯化的全新图景。

关键词：《科学美国人》关系演变考古学驯化动植物卵化

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