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Follow Up of Hypertensive Patients at Regional Hospital of Bafoussam, West Cameroon: Biochemical Profiles in Naive and Hypotensive Drug Treated Patients

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World Journal of Cardiovascular Surgery 2020年第9期10卷 167-185页

作者： Vanessa Linda Nzesseu Charles Kouam Kouam jean-de-dieu tamokou Jules-Roger Kuiate department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon department of Internal Medicine Bafoussam Regional Hospital Bafoussam Cameroon

Objective: The aim of this work was to study the effects of antihypertensive therapies on certain metabolic parameters in hypertensive patients. Methods: A cross-sectional and analytical study conducted within the Bafoussam Re-gional Hospital on 343 patients including 99 normotensives and 244 hyperten-sives distributed in 71 patients naive to treatment and 173 patients under treatment (84 under monotherapy, 67 under bitherapy and 21 under trithera-py). The antihypertensive medications were recorded from the medical records. A questionnaire survey was administered to study participants and potential risk factors for hypertension sought. Blood and urine samples were collected for lipid, renal and hepatic disorder analysis. Two blood pressure measure-ments enabled us to diagnose hypertensive patients. Measurements of bio-chemical parameters such as total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, creatinine, glucose, aspartate aminotransferase (ASAT), alanine aminotransferase (ALT), potassium, chloride and calcium were done in serum by methods resulting from commercial kits. Results: Cal-cium Channel Blockers were significantly associated with increases in blood potassium (odd-ratios (OR) = 8.63, p = 0.036) and sodium (OR = 0.20, p = 0.037). Angiotensin-converting enzyme/Angiotensin II receptor blockers were significantly associated with an increase in plasma activity of ASAT (OR = 0.12, p = 0.03) whereas Diuretics were significantly associated with an increase in ALAT plasma activity (OR = 0.003, p = 0.012). Dual therapies were associ-ated with highest frequencies of hypercreatininemia (41.8%) and hyperglyce-mia (44.8%) whereas hypocholesterolemia HDL (38.1%) was most observed in hypertensive patients on triple therapy. The different therapies resulted in very low frequencies of abnormal liver profiles (in general almost all below 10%). Tritherapy h

关键词： Antihypertensives Therapy Metabolic Abnormalities

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New Hemisynthetic Oleanane Saponin with Antimicrobial Activities

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Advances in Biological Chemistry 2021年第1期11卷 1-11页

作者： Cyrille Ngoufack Tagousop jean-de-dieu tamokou Leonel Donald Tsamo Feugap Dominique Harakat Laurence Voutquenne-Nazabadioko David Ngnokam department of Basic Scientific Studies University Institute of Technology University of Ngaoundere Ngaoundere Cameroon Research Unit of Environmental and Applied Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Service Commun d’Analyses Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France Groupe Isolement et Structure Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France

A new hemisynthetic oleanane saponin: 4',2",3",4",6"-penta-O-acetyl-6'-O- methyl-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl oleanolic acid (2) was obtained after acetylation and methylation reaction on 3-O... 详细信息

关键词： Saponin Acetylation Methylation Antimicrobial Activities

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Triterpenoids and Semisynthetic derivatives with Antimicrobial Activities from the Leaves of <i>Caloncoba glauca</i>(Flacourtiaceae)

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Advances in Biological Chemistry 2021年第4期11卷 149-164页

作者： James D. Simo Mpetga Arno R. Nanfack Donfack jean-de-dieu tamokou Irene Chinda Kengne Pierre Tane Xiao-Jiang Hao Mathieu Tene Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming China

Chemical investigation of the MeOH extract from the leaves of C. glauca yielded nine known triterpenoids (1-9) belonging to the cycloartane and friedelane series. Two of these compounds namely glaucartanoic acid A (1) and 3β,21β-dihydroxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (5) were subjected to chemical derivatizations and afforded five new derivatives: diacetylglaucartanoic acid A (1a), 24-acetylglaucartanoic acid A (1b), glaucartanoic acid A methyl ester (1c), 24-methoxyglaucartanoic acid A methyl ester (1d), and 3β,21β-diacetoxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (5a

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Antioxidant Xanthones,Anthraquinones and Semi-synthetic derivatives from Vismia rubescens and ***

Antioxidant Xanthones,Anthraquinones and Semi-synthetic Deri...

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多学科交叉，产学研联合，实现西部药用植物资源的可持续利用——第十届全国药用植物及植物药学术研讨会

作者： Michel F.Tala Hippolyte K.Wabo Pierre Tane jean D.D.tamokou Patricia D. Tchakam Jules R.Kuiate department of Chemistry Faculty of ScienceUniversity of Dschang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Science department of Biochemistry Faculty of ScienceUniversity of Dschang

Chemical investigation of the methanol extract from *** yielded seven known compounds:friedelin, friedelanol,lupeol,1,7-dihydroxyxanthone(1),1,4,8-trihydroxyxanthone(2),1,2,8-trihydroxyxanthone(3)and physcion(4);that of the extract of *** also gave seven known compounds:laurenquinone A(5), laurenquinone B(6),xanthone V(7),laurentixanthone C(8),bivismiaquinone(9),vismiaquinone(10)and vismiaquinone B(11).Laurenquinone B(6)and xanthone V(7)were subjected to acetylation to afford two new acetylated derivatives:methyl 5,7-diacetoxy-6,11-dihydro-2,2,9-trimethyl-6,11-dioxo-2H-naphto[2,3-g]chromene-

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