检索结果-南通市图书馆

Double Blinded,Randomized and Controlled Comparative Study Evaluating the Cleaning Activity of Two Ear Cleaners in Client-Owned Dogs with Spontaneous Otitis Externa

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2019年第6期9卷 67-78页

作者： Geneviève Marignac jean Yanique Petit jean Francois Jamet Loic Desquilbet jean luc Petit Frédérique Woehrlé Tessa Trouchon Oscar Fantini Sébastien perrot Dermatology Derpartment Ecole Nationale Vétérinaire d’AlfortMaisons-AlfortFrance Institut of Alfort’s Clinical Research IRCAEcole Nationale Vétérinaire d’AlfortMaisons-AlfortFrance Veterinary Clinic Choisy le RoiFrance Global Medical Marketing&CommunicationVetoquinol SAMagny-VernoisLureFrance Preclinical&Clinical Development Global Drug Development DivisionVétoquinol SAMagny-VernoisLureFrance

Ear cleaning is a therapeutic component in the management of otitis externa in dogs. The objectives of this study were to evaluate the in vivo efficacy and safety of a new ear cleanser, Sonotix? against EpiOtic? Advanced for the management of canine otitis externa. Eighteen clients owned dogs with a diagnosis of erythemato-ceruminous or purulent otitis externa were prospectively included and randomized to two treatment group: EpiOtic? Advanced and Sonotix?. Cytology and video-otoscopic examination (erythema, amount of cerumen and thickness and surface of ear canal covered by cerumen) of all affected ears were done at D0, both before (T0) and 30 minutes (T0 + 30 min) after ear cleaning. Then an ear medication was applied (Aurizon?, Vetoquinol). Owners were instructed to clean affected ears daily and apply the ear medication 30 minutes later for 5 days (D1-D5). Dogs were seen again at D6 for cytology and video-otoscopic examination. At T0, no significant differences were found between both ear cleansers groups regarding macroscopic and microscopic scorings. At T0 + 30 min and D6 cytological and video-otoscopic scores were significantly decreased (Wilcoxon test;p < 0.01) compared to baseline in both groups. However, the cleaning activity of Sonotix? was statistically superior to Epiotic? as evidenced by the median global scores of video-otoscopic examination at T0 + 30 min (Mann Whitney Test, p < 0.01). Effective ear cleaning is an essential part of any treatment scheme because it favours the contact between the ointment and the lining ear epidermis and speeds resolution by the removal of cerumen, microbial organisms and cellular debris. In our study, the important reductions in yeast, cocci, and rod-shaped organism counts were demonstrated in smears at T0 + 30 min and D6 in both groups. Video-otoscopic examination performed 30 minutes after ear cleaning suggests that Sonotix? seems to be more effective in removing cerumen than EpiOtic? Advanced.

关键词： Ear Cleaning Canine Ear Cleanser Otitis Externa

Gaining access to acetyl-CoA by peroxisomal surface display

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2023年第2期8卷 224-226页

作者： Thomas perrot Sebastien Besseau Nicolas Papon Vincent Courdavault Biomolecules et Biotechnologies Vegetales BBVEA2106Universite de ToursToursFrance Univ Angers Univ BrestIRFSFR ICATF-49000AngersFrance

Synthetic biology is constantly making progress for producing compounds on ***,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal *** allow... 详细信息

关键词： Synthetic biology Enzymes colocalization Peroxisomal membrane Acetyl-CoA Polyketides

Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第40期11卷 6312-6321页

作者： Carine Strup-perrot Marie-Catherine Vozenin-Brotons Marie Vandamme Christine Linard Denis Mathé Laboratoire d'étude des pathologies Radio-induites Laboratoire UPRES EA 27-10 'Radiosensibilité des tumeurs et tissus sains'

AIM： To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS： Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, such as zymography, immunohistochemistry and real time reverse transcriptase-polymerase chain reaction, were used to localize and quantify MMPs and the molecules involved in MMP activating and inhibitory pathways （plasmin/ plasminogen, TIMPs）, CD^8＋, as well as inflammatory （interleukin （IL）-1β, IL-8, tumor necrosis factor-s, TNF-α） and fibrogenic mediators （transforming growth factor- β1-3） within ileal tissue at 1, 3, and 7 d after irradiation. RESULTS： A marked increase in MMP-2 and -14 mRNA and protein levels associated with an increased activity of MMP-2 was observed in irradiated ileal tissue. MMP-2 and -14 expression was mainly observed in inflammatory, epithelial, and mesenchymal cells, whereas a slight increase in MMP-3 expression was detected in the few infiltrating macrophages at d i after irradiation. Conversely, MMP-1, -7, and -9 mRNA levels were not found to be affected by abdominal irradiation. Irradiation was found to induce disappearance of CD^8＋ cells. Furthermore, we have observed that TNF-α and IL-1β protein levels increased 6 h after irradiation, whereas those of IL-8 only increased after 3 d and was concomitant with neutrophil infiltration. In addition, the expressions of molecules involved in MMP activating and inhibitory pathways （urokinase-type plasminogen activator andtissue-type plasminogen activator; TIMP-1, TIMP-2, and plasminogen activator-inhibitor-i） were found to be increased after abdominal irradiation. CONCLUSION： This study showed that abdominal irradiation induces an acute remodeling of the ileum associated with an increased expression of MMPs and TIMPs that do not involve CD^8＋ T cells but involve mesenchymal and epi

关键词： Matrix metalloproteinases Irradiation Ileum T cells Cytokines

Neuroendocrine Differentiation in the Progression of Prostate Cancer: An Update on Recent Developments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2012年第3期2卷 173-182页

作者： Valérie perrot Laboratory M.E.R.C.I.-EA 3829 Institute of Research and Biomedical Innovation (IRIB) University of Rouen Rouen France

Neuroendocrine (NE) differentiation, either benign or malignant, is the hallmark of prostate cancer (PCa). Clusters of malignant NE cells are found in most prostate cancer cases. NE differentiation is among the non-mutually exclusive theories proposed to explain the progression to androgen independence of PCa. NE differentiation is usually associated with an increased aggressivity and invasiveness of prostate tumors and a poor prognosis. This review aims to present an overview of current knowledge on neuroendocrine differentiation in PCa to improve our understanding of tumour progression and androgen independence. The NE component represents an important therapeutic axis. Development of new generation of drugs that selectively target NE-like cells may lead to the development of new therapeutic modalities for advanced and hormone-refractory PCa.

关键词： Prostate Cancer Hormonal Therapy Neuroendocrine Neuroendocrine Differentiation Neuropeptides Chromogranin A Tumorigenesis Adenocarcinoma

First Report of a Successful Development of Yam Hybrids(Dioscorea alata L.)from Lyophilized and Long-Term Stored Pollens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际实验植物学杂志(英文) 2023年第10期92卷 2861-2874页

作者： Erick Malédon Elie Nudol Christophe perrot Marie-Claire Gravillon Ronan Rivallan Denis Cornet Hâna Chair Komivi Dossa CIRAD UMR AGAP InstitutPetit BourgGuadeloupe97170France UMR AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierF-34398France CIRAD UMR AGAP InstitutMontpellierF-34398France

Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding ***,pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic *** 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam *** pollens were collected from two Dioscorea alata males,then lyophilized(two lyophilization treatments were applied),followed by storage at room temperature(24℃–25℃)for 12 ***,the lyophilized and stored pollens were tested for viability by crossing with four female *** results showed that lyophilization is effective for achieving viable pollens after 12 months of *** 1(48 h drying)showed higher pollen germination and fertility rates than Treatment 2(72 h drying).Although we observed a reduction in viability of lyophilized pollens after 12 months of storage,we generated hybrid seedlings with success rates from 12%to 21%compared to 21%–31%when using fresh *** testing based on molecular genotyping confirmed the hybrid status of the obtained seedlings,which grew well in a *** is a practical approach for a long-term storage of greater yam pollen *** protocol will positively impact yam breeding programs particularly in developing countries.

关键词： Yam freeze-drying pollen conservation genetic gain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

整车轮胎噪声转换系数试验与优化

噪声与振动控制 2020年第6期40卷 153-158页

作者：王启翔葛剑敏王童 perrot jean-Dominique 同济大学声学研究所上海200092 米其林集团法国63000

为确保基于室内转鼓法所得单条轮胎噪声转换至整车轮胎噪声时结果准确合理,采用室内转鼓法和惯性滑行法对不同类型轮胎进行噪声测试,并对相同工况下不同的转鼓室和室外实验场的测试结果进行分析处理。结果表明:通过在转鼓室内布置声阵... 详细信息

为确保基于室内转鼓法所得单条轮胎噪声转换至整车轮胎噪声时结果准确合理,采用室内转鼓法和惯性滑行法对不同类型轮胎进行噪声测试,并对相同工况下不同的转鼓室和室外实验场的测试结果进行分析处理。结果表明:通过在转鼓室内布置声阵列对单条轮胎进行噪声测试,并结合文中确定的最优转换系数,最终预测的整车轮胎噪声准确可信。最终确定通过单条轮胎预测整车轮胎噪声的转换系数,这对轮胎的开发与研究具有重要意义。

关键词：声学轮胎噪声惯性滑行法声阵列室内转鼓法

Meckel Diverticulum Carcinoid Tumor Complicated by Ileal Invagination. About One Case at Vichy Hospital

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2022年第4期11卷 133-137页

作者： Omar Sow Nicolas Sorbane Fetche Alice Anusca Lionel perrot Service de Chirurgie Viscérale et Digestive Centre Hospitalier de Vichy Vichy France Service de Chirurgie H&ocirc pital de la Paix Université Assane Seck de Ziguinchor Ziguinchor Senegal

Meckel’s diverticulum is a common pathology in children and rare in adults. We present a case of a 79-year-old patient in which a significant gastrointestinal bleeding, whose paraclinical explorations confirmed a fatty tumor of the terminal ileum. The exploratory coelioscopy revealed a tumor of the Meckel diverticulum complicated of intestinal invagination, resected at the same time with resection and extracorporeal anastomosis by mini coelio-guided laparotomy. Histology confirmed the presence of heterotopical tissue of the duodenal mucosa with Brunner cells and a carcinoid tumor. In conclusion, this clinical case shows that coelioscopy can be considered a very important diagnostic and therapeutic tool in this pathology especially in the elderly.

关键词： Meckel’s Diverticulum Carcinoid Tumor Invagination Cœliosurgery

Results of the Management of Gastrointestinal Stromal Tumors (GIST): About 6 Cases at the Vichy Hospital Center (France)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2022年第7期13卷 397-404页

作者： Omar Sow Nicolas Sorbane Fetche Vermare Clarisse Annabel Bautrand Alice Anusca Lionel perrot Department of Visceral and Digestive Surgery Vichy Hospital Center Vichy France Department of Surgery H&ocirc pital de la Paix Assane Seck University Ziguinchor Senegal

The aim of our study was to analyze the results of surgical management of gastrointestinal stromal tumors (GIST) at the Vichy Hospital Center. Methodology: Between 2010 and 2020, the data of 6 patients operated at the Vichy Hospital Center for GIST were analyzed. The parameters studied were: age, sex, antecedents, discovery circumstances, imagery, surgical procedure, anatomopathological data, the follow-up and the morbidity-mortality. Results: There were 5 men and one woman with an average age of 72.16 years [58 - 80 years]. The average time of evolution was 8 months (0 - 14 months). The diagnosis was fortuitous in 2 cases. Atypical abdominal pain was the main symptom in 3 cases. One case was received in a clinical picture of peritoneal irritation syndrome. Echo-endoscopy with biopsy specimen histology made it possible to make the diagnosis in 5 cases and the surgical specimen in 1 case. The fusiform type was the predominant histological form. The stomach was the most common location. The average size of GISTs was 7.3 × 4 cm with a positive C Kit in all patients. Neoadjuvant chemotherapy was performed on one patient. Surgery was curative and was done laparoscopically on 4 patients. Adjuvant chemotherapy based on Imatinib at a rate of 400 mg/d in 3 patients was initiated. One patient presented a fistula of the esophagus-jejunal anastomosis on D6 post operation controlled by a drainage and an antibiotic therapy. Mortality was zero. During the surgery, all of the patients were followed up with surgeon, oncologist. Conclusion: GISTs are the most common mesenchymal tumors of the digestive tract with a preferential gastric location. Laparoscopic surgery, with advances in molecular biology and the introduction of targeted therapy has improved the management of these tumors in terms of morbidity and mortality.

关键词： Gastrointestinal Stromal Tumor Laparoscopic Surgery Targeted Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

皮肤卟啉病的治疗

国外医学.皮肤病学分册 1983年第4期9卷 205-207页

作者： perrot H 冯信忠

近年来的许多生化研究已证实各种型别的卟啉病均存在酶的缺陷,但是卟啉病,尤其是皮肤卟啉病的治疗并无大的改观.肝性卟啉病的主要治疗方法往往是经验疗法,或是根据实验研究而提出的,红细胞生成性卟啉病的最有效治疗方法是抑制皮肤的光... 详细信息

近年来的许多生化研究已证实各种型别的卟啉病均存在酶的缺陷,但是卟啉病,尤其是皮肤卟啉病的治疗并无大的改观.肝性卟啉病的主要治疗方法往往是经验疗法,或是根据实验研究而提出的,红细胞生成性卟啉病的最有效治疗方法是抑制皮肤的光毒性反应.

关键词：剂量叶琳用药量放血疗法血液疗法类胡萝卜素胡萝卜素叶红素治疗方法疗效皮肤解剖部位