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Future for inertial-fusion energy in Europe:a roadmap

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High Power Laser Science and Engineering 2023年第6期11卷 162-192页

作者： Dimitri Batani Arnaud Colaitis Fabrizio Consoli Colin N.Danson Leonida Antonio Gizzi Javier Honrubia Thomas Kühl Sebastien Le Pape jean-luc miquel Jose Manuel Perlado R.H.H.Scott Michael Tatarakis Vladimir Tikhonchuk luca Volpe Centre Lasers Intenses et Applications(CELIA) Universitéde Bordeaux±CNRS±CEATalence cedexFrance ENEA Fusion and Technology for Nuclear Safety and Security DepartmentC.R.FrascatiFrascatiItaly AWE AldermastonReadingUK Centre for Inertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)PisaItaly ETSIAE Universidad Politecnica de Madrid MadridSpain GSI-Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses(LULI) CNRS±Ecole PolytechniquePalaiseau cedexFrance ALP Le BarpFrance and CEA/DAMÎle de FranceBruyères le ChâtelArpajon cedexFrance Instituto Fusión NuclearªGuillermo Velardeº(IFN-GV) Universidad Politecnica de MadridMadridSpain Central Laser Facility STFC Rutherford Appleton LaboratoryHarwell OxfordOxfordshireUK Institute of Plasma Physics and Lasers University Research and Innovation CentreHellenic Mediterranean UniversityRethymnoCreteGreece Department of Electronic Engineering School of EngineeringHellenic Mediterranean UniversityChaniaCreteGreece Extreme Light Infrastructure ERIC ELI-Beamlines FacilityDolníBÏrežanyCzech Republic Centro de Laseres Pulsados(CLPU) Parque CientificoVillamayorSalamancaSpain

The recent achievement of fusion ignition with laser-driven technologies at the National Ignition Facility sets a historic accomplishment in fusion energy *** accomplishment paves the way for using laser inertial fusion as a viable approach for future energy *** has a unique opportunity to empower research in this field internationally,and the scientific community is eager to engage in this *** propose establishing a European programme on inertial-fusion energy with the mission to demonstrate laser-driven ignition in the direct-drive scheme and to develop pathway technologies for the commercial fusion *** proposed roadmap is based on four complementary axes:(ⅰ)the physics of laser-plasma interaction and burning plasmas;(ⅱ)high-energy high repetition rate laser technology;(ⅲ)fusion reactor technology and materials;and(ⅳ)reinforcement of the laser fusion community by international education and training *** foresee collaboration with universities,research centres and industry and establishing joint activities with the private sector involved in laser *** project aims to stimulate a broad range of high-profile industrial developments in laser,plasma and radiation technologies along with the expected high-level socio-economic impact.

关键词： education and training fusion reactor technology high-energy laser high repetition rate laser inertial confinement fusion laser-plasma interaction public-private partnership radiation resistant materials

Metamorphoses of the University and the Pathways of Indigenous Students in Quebec:Issues of Accessibility to Studies and Academic Persistence from a Perspective of the Decolonization of Education-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第4期8卷 304-315页

作者： jean-luc Ratel Annie Pilote Faculty of Education Universitédu QuébecàMontréalCanada Faculty of Education UniversitéLavalCanada

In connection with the historical context of social segregation and the assimilative aim of formal education imposed on them,the Indigenous Peoples of Québec have long been excluded from higher ***,even if their graduation rates are increasing,a persistent gap with the non-Indigenous population is *** data in this article are drawn from 23 interviews with students and university graduates of the First Nations of Québec,as part of a thesis in educational *** paper analyzes how these students manage to combine the contributions of Indigenous education with those of Western education by developing paths that are part of the decolonization movement of *** relationship to Indigenous identity and cultures clearly influences their educational background and is analyzed taking into account power relations with the dominant *** paper emphasizes more particularly the relationship to studies,the adaptation to the student profession,and the balance between studies,work,and family among Indigenous students,in a context of transition from university to multiversity which contributed to the increase of Indigenous university attendance.

关键词： Educational inclusion and exclusion Higher and university education Educational inequalities Canada

Protein glycation:a wolf in sweet sheep’s clothing behind neurodegeneration

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Neural Regeneration Research 2024年第5期19卷 975-976页

作者： Ana B.Uceda Francisco Leal-Pérez miquel Adrover Institut Universitari d’Investigacióen Ciències de la Salut(IUNICS) Institut d’InvestigacióSanitària Illes Balears(IdISBa) Departament de Química Universitat de les Illes BalearsCtraPalma de MallorcaSpain

At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and *** brain and its glial and neuronal cells are ... 详细信息

关键词： organs sheep sweet

New Insights in the Biodegradability and the Ecotoxicological Effects of Solar Products Containing Mineral and Chemical UV-Filters on Marine Zoo- and Phytoplanktons: An in silico and in vitro Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 98-111页

作者： jean-Claude Hubaud Karim Mekideche jean-Eric Branka luc Lefeuvre HELIOSCIENCE Cité de la cosmétique 2 rue Odette Jasse Marseille France EPHYSCIENCE 498ter route de Saint Joseph de Porterie Nantes France Laboratoires Dermatologiques d’Uriage Neuilly-sur-Seine France

Background: Cosmetic formulations, and particularly solar products which contain mineral and chemical UV-filters, are often suspected of causing harmful effects on marine fauna and flora. After the publication of our work in 2019 concerning the ecotoxicological effects of such formulations on corals (Seriatopora hystrix), we here provide some new information about the biodegradability and the ecotoxicological effects of these products on marine zoo- and phytoplankton. Therefore, we choose to realize in silico and in vitro studies of the biodegradability of several solar products but also to evaluate the ecotoxicological effects of these products on one phytoplankton, i.e. Phaeodactylum tricornutum, and one zooplankton, i.e. Acartia tonsa, of a great importance for sea species survival (notably as sources of food). Materials and methods: Two different approaches were used to study the biodegradability of the tested products: One in silico method and an in vitro one. 2 solar products were involved in the in silico study which consisted in the determination of the degradation factor (DF) of each ingredient of the tested formulas in order to finally obtain their estimated biodegradability percentage. Already available data concerning each ingredient coupled to a computer model developed with one of our partners were used to achieve this study. The in vitro study involved 8 formulas containing UV-filters and was led by following the OECD 301 F guidelines. Ecotoxicological studies of 7 of the formulas containing UV-filters were for their part realized by following the ISO 10253 guidelines for the experiments led with Phaeodactylum tricornutum, and the ISO 14669 guidelines for the experiments led with Acartia tonsa. In these studies, the effect of each tested product on crustaceans’ mortality and algal growth inhibition was assessed. Results: The in silico study predicted that formulas containing chemical UV-filters display a high biodegradability (superior to the threshol

关键词： UV-Filters Chemical UV-Filter Biodegradability Ecotoxicology in silico in vitro Zooplankton Phytoplankton Phaeodactylum tricornutum Acartia tonsa

Drosophila X virus-like particles as delivery carriers for improved oral insecticidal efficacy of scorpion Androctonus australis peptide against the invasive fruit fly,Drosophila suzukii

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Insect Science 2024年第3期31卷 847-858页

作者： Qi Xue luc Swevers Clauvis Nji Tizi Taning Faculty of Bioscience Engineering Department of Plants and CropsGhent UniversityGhentBelgium Insect Molecular Genetics and Biotechnology Institute of Biosciences and ApplicationsNational Centre for Scientific Research"Demokritos"AthensGreece

Insect-specific neurotoxic peptides derived from the venoms of scorpions and spiders can cause acute paralysis and death when injected into insects,offering a promising insecticidal component for insect pest ***,effective delivery systems are required to help neurotoxic peptides pass through the gut barrier into the hemolymph,where they can ***,we investigated the potential of a novel nanocarrier,Drosophila X virus-like particle(DXV-VLP),for delivering a neurotoxin from the scorpion Androctonus australis Hector(AaIT)against the invasive pest fruit fly,Drosophila *** results show that the fusion proteins of DXV polyproteins with AalT peptide at their Ctermini could be sufficiently produced in Lepidoptera Hi5 cells in a soluble form using the recombinant baculovirus expression system,and could self-assemble into VLPs with similar particle morphology and size to authentic DXV *** addition,the AalT peptides displayed on DXV-VLPs retained their toxicity,as demonstrated in injection bioassays that resulted in severe mortality(72%)in adults after 72 *** fed to adults,mild mortality was observed in the group treated with DXV-AalT(38%),while no mortality occurred in the group treated with AaIT peptide,thus indicating the significant role of DXV-VLPs in delivering AalT ***,this proof-of-concept study demonstrates for the first time that VLPs can be exploited to enhance oral delivery of insect-specific neurotoxic peptides in the context of pest ***,it provides insights for further improvements and potentially the development of neurotoxin-based bioinsecticides and/or transgenic crops for insect pest control.

关键词： AalT Drosophila suzuki nanocarrier neurotoxic peptides pest control virus-like particle(VLP)

Detection of Burned Areas through Spectral Indices Analysis of Sentinel-2A Satellite Images in the Abokouamékro Wildlife Reserve (Central, Côte D’Ivoire)

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Open Journal of Applied Sciences 2024年第1期14卷 205-222页

作者： Bob Kouakou Kouadio Sié Ouattara Alain Clément jean-Marc Gala Bi Zaouri jean-luc Kouadio Kouassi jean-luc Edouard Kouakou N’guessan Laboratoire des Sciences et Technologies de la Communication et de l’Information (LSTCI) Institut National Polytechnique Houphou&#235t Boigny (INP-HB) Yamoussoukro C&#244te d’Ivoire Laboratoire des Sciences Agronomiques et Génie Rural Institut National Polytechnique Houphou&#235t Boigny (INPHB) Yamoussoukro C&#244te d’Ivoire Ecole de Géomatique et du Territoire (EGT) Abidjan C&#244te d’Ivoire LARIS SFR MATHSTIC Université d’Angers Angers France Centre Universitaire de Recherche et d’application en Télédétection (CURAT) UFR des Sciences de la Terre et des Ressources Minières Abidjan C&#244te d’Ivoire Laboratoire de Botanique UFR Biosciences Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

In Côte d’Ivoire, the recurring and unregulated use of bushfires, which cause ecological damage, presents a pressing concern for the custodians of protected areas. This study aims to enhance our comprehension of the dynamics of burnt areas within the Abokouamékro Wildlife Reserve (AWR) by employing the analysis of spectral indices derived from satellite imagery. The research methodology began with the calculation of mean indices and their corresponding spectral sub-indices, including NDVI, SAVI, NDWI, NDMI, BAI, NBR, TCW, TCG, and TCB, utilizing data from the Sentinel-2A satellite image dated January 17, 2022. Subsequently, a fuzzy classification model was applied to these various indices and sub-indices, guided by the degree of membership α, with the goal of effectively distinguishing between burned and unburned areas. Following the classification, the accuracies of the classified indices and sub-indices were validated using the coordinates of 100 data points collected within the AWR through GPS technology. The results revealed that the overall accuracy of all indices and sub-indices declines as the degree of membership α decreases from 1 to 0. Among the mean spectral indices, NDVI-mean, SAVI-mean, NDMI-mean exhibited the highest overall accuracies, achieving 97%, 95%, and 90%, respectively. These results closely mirrored those obtained by sub-indices using band 8 (NDVI-B8, SAVI-B8, and NDMI-B8), which yield respective overall accuracies of 93%, 92%, and 89%. At a degree of membership α = 1, the estimated burned areas for the most effective indices encompassed 2144.38 hectares for NDVI-mean, 1932.14 hectares for mean SAVI-mean, and 4947.13 hectares for mean NDMI-mean. A prospective approach involving the amalgamation of these three indices could have the potential to yield improved outcomes. This study could be a substantial contribution to the discrimination of bushfires in Côte d’Ivoire.

关键词： Spectral Indices Wildfire Burned Areas Abokouamékro Wildlife Reserve Côte D’Ivoire

Comparative study of univariate and multivariate strategy for short-term forecasting of heat demand density:Exploring single and hybrid deep learning models

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Energy and AI 2024年第2期16卷 53-68页

作者： Sajad Salehi Miroslava Kavgic Hossein Bonakdari luc Begnoche Civil Engineering Department University of Ottawa161 Louis PasteurOttawaON K1N 6N5Canada Advisors Inc 525-38 Place du CommerceMontrealQC H3E 1TBCanada

Accurate short-term forecasting of heating energy demand is needed for achieving optimal building energy management,cost savings,environmental sustainability,and responsible energy ***,short-term heating energy prediction contributes to zero-energy building performance in cold *** the critical importance of short-term forecasting in heating energy management,this study evaluated six prevalent deep-learning algorithms to predict energy load,including single and hybrid *** overall best-performing predictors were hybrid models using Convolutional Neural Networks,regardless of whether they were multivariate or ***,while the multivariate models performed better in the first hour,the univariate models often were more accurate in the final 24 ***,the best-performing predictor of the first timestep was a multivariate hybrid Convolutional Neural Network–Recurrent Neural Network model with a coefficient of determination(R^(2))of 0.98 and the lowest mean absolute ***,the best-performing predictor of the final timestep was the univariate hybrid model Convolutional Neural Network–Long Short-Term Memory with an R^(2)of ***,the prediction accuracy of the best-performing multivariate hybrid models reduced faster per hour compared to the univariate *** findings suggest that multivariate models may be better suited for early timestep predictions,while univariate models may be better suited for later time ***,combining the models can enhance accuracy at various timesteps for achieving high fidelity in forecasting and offering a comprehensive tool for energy management.

关键词： Short-term heat demand forecasting Multiple-step output strategy Deep learning Cold climates Commercial buildings

Bound and Resonating Multiquark Configurations

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Chinese Physics Letters 2024年第8期41卷 8-12页

作者： jean-Marc Richard Institut de Physique des 2 Infinis de Lyon Université Claude Bernard(Lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

tRNA^(Glu)-derived fragments from embryonic extracellular vesicles modulate bovine embryo hatching

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1559-1566页

作者： Yuan Fan Krishna Chaitanya Pavani Katrien Smits Ann Van Soom luc Peelman Department of Veterinary and Biosciences Faculty of Veterinary MedicineGhent UniversityHeidestraat 199820 MerelbekeBelgium Department of Internal Medicine Reproduction and Population MedicineFaculty of Veterinary MedicineGhent UniversitySalisburylaan 1339820 MerelbekeBelgium Department for Reproductive Medicine Ghent University HospitalCorneel Heymanslaan 109000 GhentBelgium

Transfer RNA-derived small RNAs(tsRNAs)have been shown to be involved in early embryo development and repression of endogenous retroelements in embryos and stem ***,it is unknown whether tsRNAs also regulate embryo *** this study,we mined the sequencing data of a previous experiment in which we demonstrated that the microRNA(miRNA)cargo of preimplantation embryonic extracellular vesicles(EVs)influences embryo *** thus profiled the tsRNA cargo of EVs secreted by blastocysts and *** majority of tsRNAs was identified as tRNA halves originating from the 5'ends of *** the 148 differentially expressed tsRNAs,the 19 nt tRNA fragment(tRF)tDR-14:32-Glu-CTC-1 was found to be significantly up-regulated in EVs derived from ***-qPCR assays confirmed its significant up-regulation in non-blastocyst embryos and their conditioned medium compared to the blastocyst group(P<0.05).Inhibition of tDR-14:32-Glu-CTC-1 by supplementing antagomirs to the conditioned medium improved embryo hatching(P<0.05).Transcriptomic analysis of embryos treated with tDR-14:32-Glu-CTC-1 antagomirs further showed differential expression of genes that are associated with embryo hatching and *** summary,tDR-14:32-Glu-CTC-1 is up-regulated in non-blastocyst embryos and their secretions,and inhibition of tDR-14:32-Glu-CTC-1 promotes embryo hatching,while influencing embryo implantation-related genes and *** results indicate that embryonic EVs containing specific tRFs may regulate preimplantation embryo development.

关键词： Embryo Extracellular vesicles Hatching tRNA fragments ts RNAs