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Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： jean-françois bretagne Stéphanie Hamonic Christine Piette jean-françois Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp Detection rate Quality performance

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Reproducing indolent B-cell lymphoma transformation with T-cell immunosuppression in LMP1/CD40-expressing mice

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Cellular & Molecular Immunology 2019年第4期16卷 412-414页

作者： Christelle Vincent-Fabert Alexis Saintamand Amandine David Mehdi Alizadeh françois Boyer Nicolas Arnaud Ursula Zimber-Strobl jean Feuillard Nathalie Faumont CNRS-UMR 7276 INSERM U1262 CRIBL University of Limogesand Hematology Laboratory of Dupuytren Hospital University Center(CHU)of LimogesLimogesFrance INSERM U917 University of Rennes 1RennesFrance LNPRM EFS BretagneRennesFrance Research Unit Gene Vectors Helmholtz Center MunichGerman Research Center for Environmental Health GmbHMunichGermany

Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling *** transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor *** least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.

关键词： lymphoma Richter transformation

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A Potential Flow Based Flight Simulator for an Underwater Glider

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Journal of Marine Science and Application 2013年第1期12卷 112-121页

作者： Surasak Phoemsapthawee Marc Le Boulluec jean-Marc Laurens fran ois Deniset International Maritime College Kasetsart University-Si Racha Campus Si Racha 20230 Thailand Ifremer RDT/HOBP-70 Plouzané 29280 France Ensta-bretagne 2 rue Fran ois VernyBrest cedex9 29806France IRENav Ecole NavaleLanveoc CC-600Brest cedex9 29240France

Underwater gliders are recent innovative types of autonomous underwater vehicles （AUVs） used in ocean exploration and observation. They adjust their buoyancy to dive and to return to the ocean surface. During the change of altitude, they use the hydrodynamic forces developed by their wings to move forward. Their flights are controlled by changing the position of their centers of gravity and their buoyancy to adjust their trim and heel angles. For better flight control, the understanding of the hydrodynamic behavior and the flight mechanics of the underwater glider is necessary. A 6-DOF motion simulator is coupled with an unsteady potential flow model for this purpose. In some specific cases, the numerical study demonstrates that an inappropriate stabilizer dimension can cause counter-steering behavior. The simulator can be used to improve the automatic flight control. It can also be used for the hydrodynamic design optimization of the devices.

关键词： underwater glider potential flow Newton-Euler equation autonomous underwater vehicles (AUVs) flight simulator

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Foreword to the special section on synchronous programming

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Frontiers of Computer Science 2013年第5期7卷 595-597页

作者： jean-Pierre TALPIN INRIA Rennes-bretagne-Atlantique Rennes 35042 France

1 Introduction Embedded systems are ubiquitous. In applications ranging from avionics, automotive, and industrial process control all the way to the handheld personal digital assistants （PDAs）, cell phones, and bio-...

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Results of intrauterine inseminations with two pooled sequential ejaculates in cases of oligozoospermia

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Asian Journal of Andrology 2018年第5期20卷 523-524页

作者： Jessika Moreau Nicolas Gatimel jean Parinaud Roger Leandri Department of Reproductive Medicine Toulouse University Hospital 330 Avenue de Grande Bretagne (Great Britain Avenue) 31059 Toulouse France EA 3694 Human Fertility Research Group Toulouse University Hospital 330 Avenue de Grande Bretagne (Great Britain Avenue) 31059 Toulouse France

Dear Editor, Intrauterine insemination （IUI） is mainly indicated in cases of unexplained or mild male subfertility. In these cases, gonadotropin ovarian stimulation combined with gonadotropin-releasing hormone （GnRH） antagonist IUI leads to up to an 18% delivery rate per attempt.1 However, when the number of motile spermatozoa inseminated is lower than 1× 10^6, the success rate drops below 5%.1 Since semen quality varies intra-individually, this threshold may not be reached on the day of IUI. In such cases, some authors have suggested asking men to provide two consecutive ejaculates and to perform IUI with the pooled spermatozoa.2 However, the effectiveness of IUI with pooled ejaculates is not dear3.

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Formal verification of synchronous data-flow program transformations toward certified compilers

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Frontiers of Computer Science 2013年第5期7卷 598-616页

作者： Van Chan NGO jean-Pierre TALPIN Thierry GAUTIER Paul Le GUERNIC Loic BESNARD INRIA Rennes-bretagne Atlantique Rennes 35042 France IRISA/CNRS Rennes 35042 France

Translation validation was invented in the 90＇s by Pnueli et al. as a technique to formally verify the correctness of code generators. Rather than certifying the code generator or exhaustively qualifying it, translation validators attempt to verify that program transformations preserve semantics. In this work, we adopt this approach to formally verify that the clock semantics and data dependence are preserved during the compilation of the Signal compiler. Translation valida- tion is implemented for every compilation phase from the initial phase until the latest phase where the executable code is generated, by proving the transformation in each phase of the compiler preserves the semantics. We represent the clock semantics, the data dependence of a program and its trans- formed counterpart as first-order formulas which are called clock models and synchronous dependence graphs （SDGs）, respectively. We then introduce clock refinement and depen- dence refinement relations which express the preservations of clock semantics and dependence, as a relation on clock mod- els and SDGs, respectively. Our validator does not require any instrumentation or modification of the compiler, nor any rewriting of the source program.

关键词： formal verification translation validation certi-fied compiler multi-clocked synchronous programs embed-ded systems.

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Polychronous automata and their use for formal validation of AADL models

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Frontiers of Computer Science 2019年第4期13卷 677-697页

作者： Thierry GAUTIER Clement GUY Alexandre HONORAT Paul LE GUERNIC jean-Pierre TALPIN Loic BESNARD Univ. Rennes Inria Rennes-Bretagne-Atlantique Research Centre F-35000 Rennes France Univ. Rennes CNRS IRISA F-35000 Rennes France

This paper investigates how state diagrams can be best represented in the polychronous model of computation (MoC) and proposes to use this model for code validation of behavior specifications in architecture analysis & design language (AADL). In this relational MoC, the basic objects are signals, which are related through dataflow equations. Signals are associated with logical clocks, which provide the capability to describe systems in which components obey multiple clock rates. We propose a model of finite-state automata, called polychronous automata, which is based on clock relationships. A specificity of this model is that an automaton is submitted to clock constraints, which allows one to specify a wide range of control-related configurations, being either reactive or restrictive with respect to their control environment. A semantic model is defined for these polychronous automata, which relies on boolean algebra of clocks. Based on a previously defined modeling method for AADL software architectures using the polychronous MoC, the proposed model is used as a formal model for the AADL behavior annex. This is illustrated with a case study involving an adaptive cruise control system.

关键词： architecture modeling formal semantics finitestate automaton polychronous model synchronous concurrency code generation AADL

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The effect of landscape complexity and microclimate on the thermal tolerance of a pest insect

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Insect Science 2018年第5期25卷 905-915页

作者： Lucy Alford Kevin Tougeron jean-Sebastien Pierre francoise Burel Joan van Baaren UMR 6553 ECOBIO Centre National de la Recherche Scientitique Universite de Rennes I Rennes Cedex France Departement de Sciences Biologiques Insfitut de Recherche en Biologie Vegetale Universite de Montreal Montreal QC Canada Universite Europeenne de bretagne (UEB) Rennes France

Landscape changes are known to exacerbate the impacts of climate change. As such, understanding the combined effect of climate and landscape on agroecosystems is vital if we are to maintain the fimction of agroecosystems. This study aimed to elucidate the effects of agricultural landscape complexity on the microclimate and thermal tolerance of an aphid pest to better understand how landscape and climate may interact to affect the thermal tolerance of pest species within the context of global climate change. Meteo- rological data were measured at the landscape level, and cereal aphids （Sitobion avenae, Metopolophium dirhodum and Rhopalosiphum padi） sampled, from contrasting landscapes （simple and complex） in winter 2013/2014 and spring 2014 in cereal fields of Brittany, france. Aphids were returned to the laboratory and the effect of landscape of origin on aphid cold tolerance （as determined by CTmin） was investigated. Results revealed that local landscape complexity significantly affected microclimate, with simple homogenous landscapes being on average warmer, but with greater temperature variation. Landscape complexity was shown to impact aphid cold tolerance, with aphids from complex land- scapes being more cold tolerant than those from simple landscapes in both winter and spring, but with differences among species. This study highlights that future changes to land use could have implications for the thermal tolerance and adaptability of insects. Fur- thermore, not all insect species respond in a similar way to microhabitat and microclimate, which could disrupt important predator-prey relationships and the ecosystem service they provide.

关键词： agroecosystems biological control cereal aphids climate change coldtolerance landscape ecology

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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain jean-françois Ramée jean-Luc Raoul jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché françoise Grudé Observatoire dédié au Cancer des régions bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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Exploring system architectures in AADL via Polychrony and SynDEx

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Frontiers of Computer Science 2013年第5期7卷 627-649页

作者： Huafeng YU Yue MA Thierry GAUTIER Loc BESNARD jean-Pierre TALPIN Paul Le GUERNIC Yves SOREL INRIA Rennes-bretagne Atlantique 263 av. du Général LeclercRennes 35042 France IRISA/CNRS 263 av. du Général LeclercRennes 35042 France INRIA Paris-Rocquencourt Domaine de VoluceauBP 105Le Chesnay Cedex 78153 France

Architecture analysis&design language(AADL)has been increasingly adopted in the design of embedded systems,and corresponding scheduling and formal verification have been well ***,little work takes code distribution and architecture exploration into account,particularly considering clock constraints,for distributed multi-processor *** this paper,we present an overview of our approach to handle these concerns,together with the associated toolchain,***,in order to avoid semantic ambiguities of AADL,the polychronous/multiclock semantics of AADL,based on a polychronous model of computation,is *** synthesis is then carried out in Polychrony,which bridges the gap between the polychronous semantics and the synchronous semantics of *** same timing semantics is always preserved in order to ensure the correctness of the transformations between diferent *** distribution and corresponding scheduling is carried out on the obtained SynDEx model in the last step,which enables the exploration of architectures originally specified in *** contribution provides a fast yet efcient architecture exploration approach for the design of distributed real-time and embedded *** avionic case study is used here to illustrate our approach.

关键词： Polychrony Signal AADL SynDEx architecture exploration modeling timing analysis scheduling distribution

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