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Relationship of preoperative androgen levels and metabolic syndrome with quality of life and erectile function in patients who are to undergo radical prostatectomy

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Asian Journal of Andrology 2021年第5期23卷 520-526页

作者： Yann Neuzillet jean-francois Dreyfus jean-Pierre Raynaud Mathieu Rouanne Marc Schneider Morgan Roupret Sarah Drouin Marc Galiano Xavier Cathelineau Thierry Lebret Henry Botto Department of Urology Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Department of Clinical Research and Innovation Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France Department of Urology Hfipital Louis PasteurColmar 68000France Department of Urology Hopital Pitie-SalpetriereAssistance Publique-Hopitaux de ParisSorbonne UniversityParis 75013France Department of Urology Institut Mutualiste MontsourisParis-Descartes UniversityParis 75014France

This study aims to investigate whether clinical and biological preoperative characteristics of patients who were to undergo radical prostatectomy were associated with impairment in patient-reported quality of life(QoL)and erectile dysfunction immediately before *** evaluated patient-reported outcomes among 1019 patients(out of 1343)of the AndroCan study,willing to score the Aging Male Symptom(AMS)and the International Index of Erectile Function 5-item(IIEF-5)*** linear regression and robust multiple regression were used to ascertain the relationship between demographic,clinical,and hormonal parameters and global AMS or IIEF-5 *** a result,most patients(85.1%)of the Androcan cohort agreed to complete *** higher IIEF-5 global scores were found in non-Caucasian and obese patients,with larger waist circumference,metabolic syndrome,diabetes mellitus,cardiovascular disease,hypertension,high blood sugar,concomitant medications,and hypogonadism,while the AMS global score was significantly higher in patients with larger waist circumference,metabolic syndrome,high blood pressure,raised glycemia,and concomitant *** IIEF-5 global score was correlated to age,dehydroepiandrosterone(DHEA),fat mass percentage,and androstenediol(D5).The AMS global score was significantly correlated to DHEA,D5,and DHEA ***,the multivariate models showed that QoL and erectile function were significantly affected,before surgery,by symptoms and signs that are usually considered as pertaining to the metabolic syndrome,while sexual hormones are essentially correlated to erectile dysfunction.

关键词： erectile function metabolic syndrome quality of life radical prostatectomy testosterone

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A Phelipanche ramosa KAI2 protein perceives strigolactones and isothiocyanates enzymatically

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Plant Communications 2021年第5期2卷 132-147页

作者： Alexandre de Saint Germain Anse Jacobs Guillaume Brun jean-Bernard Pouvreau Lukas Braem David Cornu Guillaume Clavé Emmanuelle Baudu Vincent Steinmetz Vincent Servajean Susann Wicke Kris Gevaert Philippe Simier Sofie Goormachtig Philippe Delavault françois-Didier Boyer Institut jean-Pierre Bourgin INRAEAgroParisTechUniversitéParis-Saclay78000 VersaillesFrance Department of Plant Biotechnology and Bioinformatics Ghent University9052 GentBelgium Center for Plant Systems Biology VIB9052 GentBelgium Department of Biomolecular Medicine Ghent University9000 GhentBelgium Center for Medical Biotechnology VIB9000 GhentBelgium Laboratoire de Biologie et Pathologie Végétales(LBPV) Equipe d’Accueil 1157Universitéde Nantes44000 NantesFrance Institute for Biology Humboldt-Universit€at zu Berlin10115 BerlinGermany UniversitéParis-Saclay CEACNRSInstitute for Integrative Biology of the Cell(I2BC)91198Gif-sur-YvetteFrance UniversitéParis-Saclay CNRSInstitut de Chimie des Substances NaturellesUPR 230191198Gif-sur-YvetteFrance

Phelipanche ramosa is an obligate root-parasitic weed that threatens major crops in central *** order to germinate,it must perceive various structurally divergent host-exuded signals,including isothiocyanates(ITCs)and strigolactones(SLs).However,the receptors involved are still ***,we identify five putative SL receptors in *** and show that PrKAI2d3 is involved in the stimulation of seed *** demonstrate the high plasticity of PrKAI2d3,which allows it to interact with different chemicals,including *** SL perception mechanism of PrKAI2d3 is similar to that of endogenous SLs in non-parasitic *** provide evidence that PrKAI2d3 enzymatic activity confers hypersensitivity to ***,we demonstrate that methylbutenolide-OH binds PrKAI2d3 and stimulates *** germination with bioactivity comparable to that of *** study demonstrates that *** has extended its signal perception system during evolution,a fact that should be considered for the development of specific and efficient biocontrol methods.

关键词： a/b-hydrolase receptor seed germination stimulant strigolactones isothiocyanates Phelipanche ramosa

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相信相信的力量

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汽车工艺师 2020年第1期 20-21页

作者： jean-fran?ois Martins 山高刀具大中华区

犹记得2019年一月份我入职山高中国的时候,频频听到“2019年将是最艰难的一年”这样的预测,我心存疑惑,毕竟对于一个奋斗者而言,每一步走得都不容易。来到12月份,各项总结与销售数字呈现在桌面之上,看到山高中国各个方面都收获满满,我... 详细信息

犹记得2019年一月份我入职山高中国的时候,频频听到“2019年将是最艰难的一年”这样的预测,我心存疑惑,毕竟对于一个奋斗者而言,每一步走得都不容易。来到12月份,各项总结与销售数字呈现在桌面之上,看到山高中国各个方面都收获满满,我必须说:相信中国的力量,相信山高的力量。2019年,山高中国在关键领域持续保持销售额大幅增长的势头——航空航天领域两位数增长,医疗行业增长超30%。

关键词：销售数字医疗行业关键领域奋斗者大幅增长山高两位数销售额

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Effects of Judo Strength-Velocity Training during Precompetition on Cardiorespiratory Responses in Congolese Judoists Aged 15 - 17 Years Old

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Journal of Biosciences and Medicines 2016年第10期4卷 50-64页

作者： jean Georges André Moulongo Alphonse Massamba jean marie Kayembe Ntumba françois Lepira Bompeka Félix Lotoko Lisule Bernard Packa-Tchissambou Laboratory for Exercise Physiology and Biomechanics Higher Institute of Physical Education and Sports (ISEPS) University Marien NGOUABI Brazzaville Congo Direction of Research Documentation and the Files National Institute of Youth and Sports (INJS) Brazzaville Congo Laboratory of Biomaterials Health and Simulation of the Processes Higher School of Technology of the Cataracts Brazzaville Congo Faculty of Medicine University of Kinshasa Kinshasa Congo Department of Physical Education National Teaching University Kinshasa Congo

Objective: To evaluate the effects of “strength-velocity” training on the evolution of some cardiorespiratory parameters in postpubertal judoists of the Congolese national elite. Methods: The survey, exploratory, experimental and longitudinal, was about 14 boys, belonging to seven categories of weight of the International Federation of Judo. These judoists, at the level belonged to stages 3, 4 and 5 of the classification to Tanner, of pubertal maturation. Their median age was 16 years (range: 15 - 17 years). All topics have been submitted to “strength-velocity” training, focused around exercises bound to the development of the power and automatisms, from plyometric and isometric training. Three assessments have been realized in the beginning, to mid-training (3 months) and at the end of the program (6 months). The measured values were cardiorespiratory parameters. Results: The heart rate to the doorstep was decreased significantly (p = 0.048), so VO2 max (p = 0.046), FVC (p = 0.0244) and ratio VEMS/FVC (p = 0.046) as function of pubertal stage. In contrast, increase was not significant for VEMS (p = 0.205) and absolute VO2 to doorstep (p = 0.097). No significant effect of pubertal state on respiratory frequency was found. On the other hand, strength-velocity training improved cardiorespiratory data. To the recovery of the “strength-velocity test”, the decrease of the VO2 took place more quickly that the one of the VE, the VCO2 and the HR, variations linked to the category of topic weight. Conclusion: Among high level Congolese postpubertal judoists, the cardiorespiratory modifications induce faculty to the realization of a good performance and pursue objectives of health. However, it is necessary to be heedful as for situations to put in place in sittings at the time of such of “strength-velocity” training.

关键词： Judo Postpuberty Strength-Velocity Training Cardiorespiratory Modifications

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Release of Cardiac Biomarkers during a Cycling Race

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World Journal of Cardiovascular Diseases 2016年第8期6卷 285-294页

作者： Caroline Le Goff jean-françois Kaux Stéphanie D’Otreppe Sébastien Goffaux marianne Fillet jean-Paul Chapelle Etienne Cavalier Department of Clinical Chemistry University of Liège Liège Belgium Department of Physical Medicine and Sport Traumatology SPORTS2 FIFA Medical Centre of Excellence University of Liège Liège Belgium Department of Analytical Pharmaceutical Chemistry University of Liège Liège Belgium

Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177 km). We studied different cardiac biomarkers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury.

关键词： Cycling Cardiac Biomarkers Stress Biomarkers Renal Function Markers

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Hierarchical networks of food exchange in the black garden ant Lasius niger

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Insect Science 2021年第3期28卷 825-838页

作者： Martin Quque Olivier Bles Annaelle Benard Amelie Heraud Bastien Meunier frangois Criscuolo jean-Louis Deneubourg Cedric Sueur CA/RS IPHCUniversite de StrasbourgStrasbourgUMR718France Centre for Nonlinear Phenomena and Complex Systems(Cenoli)-CP 231 Universite libre de Bruxelles(ULB)BruxellesBelgium Universite de Bourgogne franche-Comte DijonFrance Universite de Rennes 1 RennesFrance Institut Universitaire de france ParisFrance

In most eusocial insects,the division of labor results in relatively few individuals foraging for the entire ***,the survival of the colony depends on its efficiency in meeting the nutritional needs of all its ***,we characterize the network topology of a eusocial insect to understand the role and centrality of each caste in this network during the process of food *** constructed trophallaxis networks from 34 food-exchange experiments in black garden ants(Lasius niger).We tested the influence of brood and colony size on(i)global indices at the network level(i.e.,efficiency,resilience,centralization,and modularity)and(ii)individual values(i.e.,degree,strength,betweenness,and the clustering coefficient).Network resilience,the ratio between global efficiency and centralization,was stable with colony size but increased in the presence of broods,presumably in response to the nutritional needs of *** metrics highlighted the major role of foragers in food *** addition,a hierarchical clustering analysis suggested that some domestics acted as intermediaries between foragers and other *** appeared to be hierarchical rather than random or centralized exclusively around ***,our results suggested that networks emerging from social insect interactions can improve group performance and thus colony fitness.

关键词： insects network evolution self-organization social evolution social network analyses

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Evaluation of Intraoperative Iatrogenic Lesions and Postoperative Complications in 1140 Patients Treated for Carpal Tunnel Syndrome in the Orthopedic Surgery and Traumatology Department of the Moulins-Yzeure Hospital Center in france

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Surgical Science 2023年第12期14卷 705-711页

作者： Saint Luc Mungina Sedou Charlène Tshitala jean-françois Dumez Issifou Moumouni Kevin Ndangi Kibadi Kapay Department of Surgery of the University Clinics of Kinshasa Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Matete General Reference Hospital Kinshasa Democratic Republic of the Congo Department of Orthopedic Surgery and Traumatology Moulins-Yzeure Hospital Center Moulins France

Introduction: Carpal tunnel syndrome is a more common form of upper limb canal syndrome, resulting from compression of the median nerve in the carpal tunnel, but is particularly troublesome. Medical treatment is often unsuccessful, and surgical treatment usually involves transection of the annular ligament. The aim of this study was to assess iatrogenic intraoperative and postoperative complications, as well as patient outcomes following the use of conventional and endoscopic surgery in the surgical management of carpal tunnel syndrome. Hypothesis: Are nerve, vascular and tendon injuries of iatrogenic origin always present in the surgical management of carpal tunnel syndrome, even though this surgery is performed on an outpatient basis? Patients and methods: This retrospective series is composed of 1140 patients, 230 men and 910 women, mean age 58.6 ± 16.4 years, operated on between 2010 and 2020 for carpal tunnel syndrome by conventional surgery and under endoscopy. Medical records, operative reports and consultation letters were consulted. All patients were reviewed regularly at one month post-op until recovery. Results: No nerve, vascular or tendon damage was noted, and at a maximum follow-up of 2 years, 20 patients had recurred, i.e. a 2.51% failure rate. Scar disunion was observed in 0.9%, wound infection in 0.9% and scar fibrosis in 0.9%. 92.98% of patients underwent outpatient surgery, irrespective of the type of anesthesia or surgical technique used. Patients who stayed in hospital for a short time were suffering from carpal tunnel syndrome associated with compression of the ulnar nerve in Guyon’s canal, for which both the median and ulnar nerves were freed during the same operation, under general anaesthetic. All patients were able to return to their previous activity within 30 days of surgery. Conclusion: Intraoperative iatrogenic complications, notably nerve, vascular and tendon lesions, were not identified despite the large sample size. On the other hand

关键词： Carpal Tunnel Iatrogenic Complications Patient Outcome Surgical Treatment

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Effectiveness and safety of therapeutic plasma exchange to modify the functionality of heparin-induced thrombocytopenia antibodies and correct profound thrombocytopenia:A case report and literature review

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Journal of Intensive Medicine 2023年第4期3卷 373-375页

作者： Audrey Graser Anne Bauters jean-Luc Auffray Caroline Vayne françois Provot Merce Jourdain Laurent Robriquet Department of Intensive Care Medicine CHU LilleLille F-59000France Service d'Hémostase-Transfusion Institut d'HématologieCentre de Biologie Pathologie GénétiqueBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Service de Cardiologie Institut Coeur PoumonBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Service d'Hématologie-Hémostase Centre Hospitalier Universitaire de ToursUniversitéde ToursTours EA4245 T2IFrance Pôle de Néphrologie Hôpital Albert CalmetteBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Department of Intensive Care Medicine Univ LilleInsermCHU LilleLille F-59000France

Introduction Heparin-induced thrombocytopenia(HIT)is a rare but life-threatening complication of heparin *** IgG antibodies recognize heparin-modified platelet factor 4(PF4/H IgG)and activate the platelets,increasing ... 详细信息

关键词： heparin antibodies thrombocytopenia

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Prevalence and Risk Factors of Cardiovascular Diseases in the Congo-Brazzaville Pygmies

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World Journal of Cardiovascular Diseases 2016年第7期6卷 211-217页

作者： Simplice Innocent Moussouami Eddie Janvier Bouhika Florent Nsompi jean Michel Bazaba Kayilou françois Mbemba Alphonse Massamba The Effort Laboratory of Physiology Biomechanics and Nutrition Superior Institute of Physical Education Uni-versity Marien NGOUABI Brazzaville Congo Interdisciplinary Laboratory Companies Sport Health and Development National School of Administration and Magistracy University Marien NGOUABI Brazzaville Congo

Objective: To evaluate the prevalence and determinants of overall cardiovascular risk among the pygmies of Congo Brazzaville. Methods: Cross-analysis of anthropometric data, clinical and laboratory 273 indigenous subjects including 54 patients with cardiovascular disease (CVD) and 183 without CVD, aged 29 to 69 years. The cardiovascular risk stratification table WHO/ISH 2003 was used to assess overall cardiovascular risk level. Multiple logistic regression was used to assess the independent determinants of cardiovascular risk using the global left ventricular hypertrophy as a marker. Results: Fifty-four subjects had cardiovascular disease (CVD), including 31 women (36.7%). They were aged 51.9 ± 12.4 years (p < 0.05) and showed a high blood pressure in short-long (100 ± 77 vs 32 ± 48 months;p < 0.001). It was also found a pulse pressure, PPO (58 ± 8 vs 51 ± 4 mmHg). In multivariate analysis, HDL-C levels, fasting glucose, age greater than 50 years and the higher parity or equalizes to 5 among women have emerged as key determinants of CVD risk. Conclusion: Whatever the stage, arterial hypertension in this study is associated at the risk of cardiovascular diseases (CVD) high at the Pygmies of Congo, emphasizing the need for a more aggressive follow-up strategy.

关键词： Cardiovascular Risk Determinants Prevalence Pygmy Congo

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<i>Partenariat Santé</i>: Results of a Community Program to Improve the Cardiovascular Health among Adult Population

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Open Journal of Preventive Medicine 2021年第4期11卷 147-158页

作者： jean-françois Giguère Pauline Brayet Camille Genest Alexis Mercier William Leblanc maria-Cécilia Gallani Faculty of Nursing Université Laval Quebec Canada Québec Heart and Lung Institute Quebec Canada Faculty of Medicine Université Laval Quebec Canada

Partenariat Santé (PS) launched in Québec in 2016, is inspired from the Cardiovascular Health Awareness Program (CHAP) and consists of a free session held in the community by students coming from different health sciences programs. The program’s mission is to make available early detection of modifiable CVD risk factors, raise awareness of participants about their impact on CVDs, and promote healthy life changes. In order to gather information to optimize the implementation of this program and eventually to enlarge its implementation to other sites, the first objective of this study was to explore the characteristics of the adult population participating in the PS program and to identify the risk factors they want to modify. The second objective was to evaluate one month later the effective implementation of the action plan elaborated during the motivational interview. The third objective was to evaluate the satisfaction of the participants with the PS program. One hundred ten subjects who attended PS sessions during this period were enrolled in the study. About 30% of participants have blood pressure values ≥ 140/90 mmHg and 40% present a waist circumference associated with higher risk profile. The behaviors to be changed mostly targeted by the participants were physical inactivity and nutrition. A motivational interview was conducted with the elaboration of an action plan to support the behavioral/outcomes changes. Sixty participants (54.5%) completed the questionnaire in the one-month follow-up. Forty-one (68.3%) participants revealed that they had put their action plans into practice, while 63.3% claimed that they mostly reached their objectives. Motivation remains high after one month for participants who put their action plans in place (7.8 ± 1.9 versus 7.4 ± 1.6;p = 0.214), whereas it decreased significantly for those who did not (6.8 ± 2.1 versus 5.8 ± 2.0;p = 0.029). The majority of them agreed that PS program was useful (75%) and led them to change their l

关键词： Community Health Motivational Interview Lifestyle Management Health Promotion

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