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An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol

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Journal of Traditional Chinese Medicine 2022年第2期42卷 289-295页

作者： Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui jean-pierre armand ZHU Miansheng JU Liya Institute Gustave Roussy ParisFrance Research Center of Epidemiology and public health ParisFrance Institute Curie of Paris ParisFrance Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical UniversityKunmingChina PreciMed Platform Europe ParisFrance MD Anderson Cancer Hospital MadridSpain ARIATAS Association pour la Recherche et l’Information de l’Acupuncture Time-Acupoints-Space ParisFrance Yunnan Zhu's expert workstation National famous traditional Chinese medicine expert of Mian-Sheng ZHUKunmingChina

OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and ***:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data *** with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant *** will be delivered once a week during chemotherapy with VAS-F *** order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this ***:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer *** induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life ***,we do not have effective pharmacological interventions *** clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been ***:The findings of the trial will allow us to determine the effects of acupuncture treatment *** will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.

关键词： breast neoplasms chemotherapy adjuvant fatigue immunity clinical protocols time-acupoints-space acupuncture

Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

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Chinese Journal of Cancer 2014年第12期33卷 620-624页

作者： Feng Roger Luo Jian Ding Helen X. Chen Hao Liu Man-Cheong Fung Maria Koehler jean pierre armand Lei Jiang Xiao Xu Ge Zhang Li Xu Pascal Qian Li Yan The US Chinese Anti-Cancer Association MartinezCA 94553 USA Department of Oncology Janssen Research & Development LLC RaritanNJ 08869 USA Shanghai Institute of Materia Medica Chinese Academy of Sciences Cancer Therapy Evaluation Program National Cancer Institute Novartis Pharmaceuticals (China) Oncology Pfizer Oncology New YorkNY 10017 USA Institut Gustave Roussy Cancer Campus Grand Paris ACEA Biosciences Inc. Jiangsu Hengrui Medicine Co. Ltd. Beijing Cancer Hospital and Institute Peking University School of Oncology

The US Chinese Anti-Cancer Association(USCACA)teamed up with Chinese Society of Clinical Oncology(CSCO)to host a joint session at the17th CSCO Annual Meeting on September 20th,2014in Xiamen,*** a focus on breakthrough cancer medicines,the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and *** goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China.A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China.

关键词：抗癌药物中国临床美国学会肿瘤协会新药

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现代免疫学是打开中医药生物机制的钥匙

Journal of Traditional Chinese Medical Sciences 2023年第4期10卷 383-394,518页

作者：鞠利雅蒋剑金晔 armand jean-pierre Charron Dominique PreciMed Europe Platform PreciMed Asia Laboratoire“jean Dausset” AP-HPINSERN U976Saint-Louis Hospital Institut Gustave Roussy 上海交通大学医学院附属瑞金医院

中医以整体观来认识人的健康与疾病防治,在中国的应用已有数千年历史,传向国际亦有百余年。但是中医与现代医学在疾病理论机理上有很多差别。在现代医学中,免疫学是最复杂的系统之一,是针对病原体的整体防御系统,通过系统平衡调节参与... 详细信息

中医以整体观来认识人的健康与疾病防治,在中国的应用已有数千年历史,传向国际亦有百余年。但是中医与现代医学在疾病理论机理上有很多差别。在现代医学中,免疫学是最复杂的系统之一,是针对病原体的整体防御系统,通过系统平衡调节参与疾病的发生与进展。特别值得一提的是,中医与免疫学在整体观、防御机制、平衡调节,昼夜时辰等方面有着共通之处。本综述重点关注中医和免疫学之间的相同与不同,用现代免疫学的数据阐明传统中医理论的生物学机理。我们相信不断进步的多组学技术,可以深入诠释中医理论机理,用现代免疫学数据为中医的治疗原理和应用疗效提供更多的生物学证据。

关键词：中医免疫学整体观平衡个性化医疗

Use of traditional Chinese medicine in the treatment of immune-related adverse events of cancer immunotherapy

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Journal of Traditional Chinese Medical Sciences 2018年第4期5卷 323-327页

作者： Li Hou Liya Ju Jing Wang Tian Zhou Yang Shen Jiaqi Chi jean-pierre armand Anlong Xu Kaiwen Hu Department of Hematology and Oncology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China HLA et Medicine Batiment BazinSaint-Louis HospitalParis 75010France Department of Oncology Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Gustave Roussy Villejuif 94805France School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China

Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of ***,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ *** this represents a new challenge in the field of cancer treatment,traditional Chinese medicine(TCM)provides benefits in the treatment of *** article reviews the studies of the treatment of immune-related gastrointestinal diseases and dermatosis with TCM and introduces the collaborative efforts between China and France in the implementation of TCM for the treatment of irAEs.

关键词： Immune-related adverse events Traditional Chinese medicine Cancer immunotherapy Immune checkpoint inhibitors

时空针灸灵龟八法干预乳腺癌术后化疗疲劳国际临床试验预试验方案的可行性分析

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世界中医药 2019年第8期14卷 1950-1958页

作者：左政李文辉陈德滇刘德权聂建云朱勉生鞠丽雅 jean-pierre armand Mahasti Saghatchian Caroline Barry Bernard Asselain 李云芬王炜宇刘亮先宋冉黄梅包雄英王玲玲王英浩严梅李春香王常安刘莉娟袁恺马琼马瑞敏陈春信 Mathieu Noel 云南中医药大学针灸推拿康复学院昆明650500 北京中医药大学北京102488 云南省肿瘤医院昆明650106 时空针灸研究院巴黎75013 欧洲精准医学平台巴黎75013 昆明市中医院昆明650051 昆明圣约翰康复医院昆明650033 北京博识科技有限公司北京100023

目的:乳腺癌癌因性疲乏(CRF)在乳腺癌中普遍存在,并且可以发生在乳腺癌治疗的各个阶段,对CRF进行有效干预已成为乳腺癌患者顺利进行术后化疗的重要条件。时空针灸是朱勉生教授在古代按时取穴方法基础上吸纳欧洲医学文化理念总结出来的... 详细信息

目的:乳腺癌癌因性疲乏(CRF)在乳腺癌中普遍存在,并且可以发生在乳腺癌治疗的各个阶段,对CRF进行有效干预已成为乳腺癌患者顺利进行术后化疗的重要条件。时空针灸是朱勉生教授在古代按时取穴方法基础上吸纳欧洲医学文化理念总结出来的一种新针法。本预试验旨在通过法国专家设计的严格的随机对照临床试验方案探讨时空针灸灵龟八法干预乳腺癌CRF的安全性及可行性。方法:按照纳排标准入组有效病例40例,按照2∶1∶1比例随机分成3组:时空针灸灵龟八法组20例、非经非穴针灸组10例、空白对照组(单纯辅助化疗治疗)10例。在辅助化疗全过程中,针灸组每周接受一次针刺治疗。40例入组患者在T1:基线、T2:表阿霉素+环磷酰胺(EC)4个周期后、T3:紫杉醇4个周期后、T4:化疗后1个月这4个时间点进行量表测评及外周血检测。本预试验40例已全部出组。本文从试验的可行性、安全性等方面对时空针灸灵龟八法试验方案进行评价,为下一步临床试验提供经验和依据。结论:本试验方案可操作性强、安全,患者依从性好。针灸方案贯穿了中医望闻问切的诊断方法、“辨证论治”的理念、“因时、因地、因人”及“治病求本”的治疗原则,实现了中医个体化治疗同临床试验规范化要求的紧密结合。

关键词：针灸时空针灸灵龟八法乳腺癌CRF 可行性分析

Foreword to the special section on synchronous programming

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Frontiers of Computer Science 2013年第5期7卷 595-597页

作者： jean-pierre TALPIN INRIA Rennes-Bretagne-Atlantique Rennes 35042 France

1 Introduction Embedded systems are ubiquitous. In applications ranging from avionics, automotive, and industrial process control all the way to the handheld personal digital assistants （PDAs）, cell phones, and bio-...

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Evidence of a Light-Sensing Role for Folate in Arabidopsis Cryptochrome Blue-Light Receptors

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Molecular Plant 2008年第1期1卷 68-74页

作者： Nathalie Hoang jean-pierre Bouly Margaret Ahmad Universite Paris Vl Casier 156 4 Place Jussieu 75005 Paris France Penn State University 25 Yearsley Mill Road Media PA 19063 USA

Arabidopsis cryptochromes cry1 and cry2 are blue-light signalling molecules with significant structural similarity to photolyases-a class of blue-light-sensing DNA repair enzymes. Like photolyases, purified plant cryptochromes have been shown to bind both flavin and pterin chromophores. The flavin functions as a light sensor and undergoes reduction in response to blue light that initiates the signalling cascade. However, the role of the pterin in plant cryptochromes has until now been unknown. Here, we show that the action spectrum for light-dependent degradation of cry2 has a significant peak of activity at 380 nm, consistent with absorption by a pterin cofactor. We further show that cry1 protein expressed in living insect ceils responds with greater sensitivity to 380 nm light than to 450 nm, consistent with a light-harvesting antenna pigment that transfers excitation energy to the oxidized flavin of cry1. The pterin biosynthesis inhibitor DHAP selectively reduces cryptochrome responsivity at 380 nm but not 450 nm blue light in these cell cultures, indicating that the antenna pigment is a folate cofactor similar to that of photolyases.

关键词： a Light-Sensing Role for Folate Arabidopsis Cryptochrome Blue-Light Receptors

Useful zero friction simulations for assessing MBS codes Pascal’s formula giving wheelsets frequency for zero wheel-rail friction

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Theoretical & Applied Mechanics Letters 2022年第3期12卷 145-155页

作者： jean pierre Pascal Pascal Coding Rue d’ErquyPleneuf-Val-Andre F-22370France

Present study provides a simple analytical formula,the“Klingel-like formula”or“Pascal’s Formula”that can be used as a reference to test some results of existing railway codes and specifically those using rigid *** develops properly the 3D Newton-Euler equations governing the 6 degrees of freedom(DoF)of unsuspended loaded wheelsets in case of zero wheel-rail friction and constant ***,by solving numerically these equations,we got pendulum like harmonic oscillations of which the calculated angular frequency is used for assessing the accuracy of the proposed formula so that it can in turn be used as a fast practical target for testing multi-body system(MBS)railway *** to the harmonic property of these pendulum-like oscillations,the squareω2 of their angular frequency can be made in the form of a ratio K/M where K depends on the wheelset geometry and load and M on its *** on K and M are useful to understand wheelsets *** analytical formula is derived from the first order writing of full trigonometric Newton-Euler equations by setting zero elastic wheel-rail penetration and by assuming small *** trigonometric equations are numerically solved to assess that the formula providesω2 inside a 1%accuracy for usual wheelsets *** decreasing the conicity down to 1×10^(−4) rad,the relative formula accuracy is under 3×10^(−5).In order to test the formula reliability for rigid contact formulations,the stiffness of elastic contacts can be increased up to practical rigidity(Hertz stiffness×1000).

关键词： Unsuspended wheelsets Klingel formula Rigid contact Harmonic oscillation Multi body system railway codes Code validation

Pozzolanic reactivity of silico-aluminous fly ash

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Particuology 2008年第2期6卷 93-98页

作者： pierre Adamiec jean-Charles Benezet Ali Benhassaine Ecole des Mines d'Alès 6 Avenue de Clavières30319 ALES CedexFrance

For some years it has been possible to control the particle size of fly ashes, by-products of thermal power stations. Incorporating these very fine particles （obtained by grinding and/or pneumatic selection） improves the physical-mechanical characteristics of mortars and concretes. In this study, we measured the lime consumption of the various fractions （granulometric and densimetric） and identified by X-ray diffraction the neoformed phases by the pozzolanic reaction, to show that it is not sufficient to simply define the pozzolanicity of products based on lime consumption since it does not take into account the nature of the phases formed. The size of the particles used in the test samples also has a determining effect on the quantity of lime consumed. Before comparing results, it is necessary to ensure that the size of the particles （of the global ash and its constituents） be the same. Two distinct neoformed ohases appear： CSH in the largest granular fractions （d〉 40 μm） and C3AH6 in the smaller fractions.

关键词： Fly ash Pozzolanic reaction Particle size