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Scaffold protein MAPK8IP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity

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Asian Journal of Andrology 2023年第2期25卷 198-207页

作者： Jian Huang Wang liu Bi-Yun lin jean c li Jane Lu Ben-Yi li center for Pathological Diagnosis and Research The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001China Department of Urology The University of Kansas Medical CenterKansas CityKS 66160USA

Mitogen-activated protein kinase-8-interacting protein 2(MAPK8IP2)is a scaffold protein that modulates MAPK signal *** MAPK pathways were heavily implicated in prostate cancer progression,the regulation of MAPK8IP2 expression in prostate cancer is not yet *** assessed MAPK8IP2 gene expression in prostate cancer related to disease progression and patient survival ***8IP2 expression was analyzed using multiple genome-wide gene expression datasets derived from The cancer Genome Atlas(TcGA)RNA-sequence project and complementary DNA(cDNA)*** cox regressions and log-rank tests were used to analyze the overall survival outcome and progression-free ***8IP2 protein expression was evaluated using the immunohistochemistry *** quantitative PcR and Western blot methods analyzed androgen-stimulated MAPK8IP2 expression in LNcaP *** primary prostate cancer tissues,MAPK8IP2 mRNA expression levels were significantly higher than those in the case-matched benign prostatic *** MAPK8IP2 expression was strongly correlated with late tumor stages,lymph node invasion,residual tumors after surgery,higher Gleason scores,and preoperational serum prostate-specific antigen(PSA)***8IP2 upregulation was significantly associated with worse overall survival outcomes and progression-free *** castration-resistant prostate cancers,MAPK8IP2 expression strongly correlated with androgen receptor(AR)signaling *** cell culture-based experiments,MAPK8IP2 expression was stimulated by androgens in AR-positive prostate cancer ***,MAPK8IP2 expression was blocked by AR antagonists only in androgen-sensitive LNcaP but not castration-resistant c4-2B and 22RV1 *** results indicate that MAPK8IP2 is a robust prognostic factor and therapeutic biomarker for prostate *** potential role of MAPK8IP2 in the castration-resistant progression is under further investigation.

关键词： cell cycle regulation disease progression mitogen-activated protein kinase-8-interacting protein 2 patient survival prostate cancer

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Multi-source information fusion:Progress and future

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chinese Journal of Aeronautics 2024年第7期37卷 24-58页

作者： Xinde li Fir DUNKIN jean DEZERT School of Automation Southeast UniversityNanjing 210008China Nanjing center for Applied Mathematics Nanjing 211135China Key Laboratory of Measurement and control of cSE Ministry of EducationNanjing 210096China Southeast University Shenzhen Research Institute Shenzhen 518063China Information Modeling and Processing Department ONERAPalaiseau 92320France

Multi-Source Information Fusion(MSIF),as a comprehensive interdisciplinary field based on modern information technology,has gained significant research value and extensive application prospects in various domains,attracting high attention and interest from scholars,engineering experts,and practitioners *** achieving fruitful results in both theoretical and applied aspects over the past five decades,there remains a lack of comprehensive and systematic review articles that provide an overview of recent development in *** light of this,this paper aims to assist researchers and individuals interested in gaining a quick understanding of the relevant theoretical techniques and development trends in MSIF,which conducts a statistical analysis of academic reports and related application achievements in the field of MSIF over the past two decades,and provides a brief overview of the relevant theories,methodologies,and application domains,as well as key issues and challenges currently ***,an analysis and outlook on the future development directions of MSIF are presented.

关键词： Multi-sensor system Information fusion Artificial intelligence Pattern recognition Human-machine integration

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NRF2 signaling cascade in amyotrophic lateral sclerosis:bridging the gap between promise and reality

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Neural Regeneration Research 2024年第5期19卷 1006-1012页

作者： Pauline Tarot christelle Lasbleiz jean-charles liévens MMDN Univ MontpellierEPHEINSERMMontpellierFrance cNRS ParisFranceEPHEINSERMMontpellierFrance

Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor *** include muscle weakness and atrophy,spasticity,and progressive ***,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral *** only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial *** difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis *** mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious *** the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and *** here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis c9orf72 NRF2 oxidative defense oxidative stress sulforaphane superoxide dismutase 1 TDP43

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Monitoring absolute vertical land motions and absolute sea-level changes from GPS and tide gauges data over French Polynesia

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Geodesy and Geodynamics 2024年第1期15卷 13-26页

作者： Xianjie li jean-Pierre Barriot Bernard Ducarme Marania Hopuare Yidong Lou Geodesy Observatory of Tahiti University of French PolynesiaFaa'a 98702French Polynesia catholic University of Louvain Georges Lemaître Centre for Earth and Climate Research(ELI)1348 Louvain-la-NeuveBelgium GNSS Research center Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

In this study,we estimate the absolute vertical land motions at three tidal stations with collocated Global Navigation Satellite System(GNSS)receivers over French Polynesia during the period 2007-2020,and obtain,as ancillary results,estimates of the absolute changes in sea level at the same *** verify our processing approach to determining vertical motion,we first modeled vertical motion at the International GNSS Service(IGS)THTI station located in the capital island of Tahiti and compared our estimate with previous independent determinations,with a good *** obtained the following estimates for the vertical land motions at the tide gauges:Tubuai island,Austral Archipelago-0.92±0.17 mm/yr,Vairao village,Tahiti Iti:-0.49±0.39 mm/yr,Rikitea,Gambier Archipelago-0.43±0.17 mm/*** absolute variations of the sea level are:Tubuai island,Austral Archipelago 5.25±0.60 mm/yr,Vairao village,Tahiti Iti:3.62±0.52 mm/yr,Rikitea,Gambier Archipelago 1.52±0.23 mm/*** discuss these absolute values in light of the values obtained from altimetric measurements and other means in French Polynesia.

关键词： GPS Tide gauges Sea level changes Vertical land motion

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Deep eutectic solvent-driven self-assembly of metal mercaptide complexes with enzyme-mimicking activities for detection of uric acid through one-step cascade catalytic reaction

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Green chemical Engineering 2024年第1期5卷 75-84页

作者： jean claude Munyemana Jia chen Xin li Yangxia Han Hao Tang Hongdeng Qiu cAS Key Laboratory of chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China University of chinese Academy of Sciences Chinese Academy of SciencesBeijing100039China Department of Pharmacy Gansu Provincial HospitalLanzhou730000China

This work presents a generic strategy to create a series of metal mercaptides complexes via coordination selfassembly between transition metals(Mn,cu,co,Fe,and Ni)and cysteine(cys)by forming the sulfur-metal *** strategy involves dissolving metal chlorides and cys into deep eutectic solvents(DES),followed by the precipitation of metal mercaptides complexes(such as cys-Mn)by adding water as an antisolvent,where DES serves as the solvent,shape directing,and capping agent,thereby preventing the formation of other metal ***,the prepared complexes possess both laccase and peroxidase-like properties,allowing the design of a technique for the detection of L-3,4-dihydroxyphenylalanine(L-DOPA)and uric acid,*** prepared cys-Mn can linearly oxidize L-DOPA with its concentrations from 0.1 to 130μM and the detection limit was calculated to be 75.5 n ***,the cys-Mn can mimic the activity of peroxidase towards oxidization of o-phenylenediamine at neutral p H,allowing single-step and one-pot cascade reactions for visual and fluorometric measurements of uric acid(UA)that could work in the range of 0.2-500μM UA with a detection limit of 0.06μM and 0.054μМ,*** assay was successful in detecting UA in serum and urine samples with relative standard deviation(RSD)ranging from 7.3%to 10.2%and 3.0%-8.5%respectively,suggesting that it may prove useful in medical diagnostic testing.

关键词： Metal-mercaptides Deep eutectic solvents Self-assembly Peroxidase-mimic catalyst Uric acid detection

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Multichannel coupling induced topological insulating phases with full multimerization

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Photonics Research 2024年第3期12卷 491-498页

作者： JUN li YAPING YANG c-M.HU MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics and Astronomy University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose and experimentally realize a class of quasi-one-dimensional topological lattices whose unit cells are constructed by coupled multiple identical resonators,with uniform hopping and inversion *** the presence of coupling-path-induced effective zero hopping within the unit cells,the systems are characterized by complete multimerization with degenerate-1 energy edge states for open boundary condition.

关键词： symmetry topological coupling

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Dynamic Event-Triggered consensus control for Input constrained Multi-Agent Systems With a Designable Minimum Inter-Event Time

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IEEE/cAA Journal of Automatica Sinica 2024年第3期11卷 649-660页

作者： Meilin li Yue Long Tieshan li Hongjing liang c.L.Philip chen the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE the Yangtze Delta Region Institute University of Electronic Science and Technology of ChinaHuzhou 313000 the Laboratory of Electromagnetic Space cognition and Intelligent control Beijing 100089China the School of computer Science and Engineering South China University of TechnologyGuangzhou 510006

This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first ***,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale *** is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event *** addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable ***,the results are extended to regional consensus of the MASs with the bounded control *** simulations show the effectiveness of the proposed approach.

关键词： constrained input designable minimum inter-event time directed communication topology dynamic event-triggered mechanism MASs consensus control

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Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli cHEN c.T.MUTASA Dong li School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of practical importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. The oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. The effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. The growth rates of two most unstable modes when δ ckness and the half height of the channel, respectively. However, their vorticities are different. The vorticity of the most unstable mode is symmetric, while the other is asymmetric. The Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ lizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. The effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. The energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. The effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

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Virtual Transmission Solution Based on Battery Energy Storage Systems to Boost Transmission capacity

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Journal of Modern Power Systems and clean Energy 2024年第2期12卷 466-474页

作者： Matías Agüero Jaime Peralta Eugenio Quintana Victor Velar Anton Stepanov Hossein Ashourian jean Mahseredjian Roberto cárdenas coordinador Eléctrico Nacional SantiagoChile PGSTech Montreal Canada Ecole Polytechnique de Montréal Montréal Canada University of chile Santiago Chile IEEE

The increasing penetration of variable renewable energy(VRE)generation along with the decommissioning of conventional power plants in chile,has raised several operational challenges in the chilean National Power Grid(NPG),including transmission congestion and VRE *** mitigate these limitations,an innovative virtual transmission solution based on battery energy storage systems(BESSs),known as grid booster(GB),has been proposed to increase the capacity of the main 500 kV corridor of the *** paper analyzes the dynamic performance of the GB using a wide-area electromagnetic transient(EMT)model of the *** GB project,composed of two 500 MVA BESS units at each extreme of the 500 kV corridor,allows increasing the transmission capacity for 15 min during N-1 contingencies,overcoming transmission limitations under normal operation conditions while maintaining system stability during *** dynamic behavior of the GB is also analyzed to control power flow as well as voltage *** results show that the GB is an effective solution to allow greater penetration of VRE generation while maintaining system stability in the NPG.

关键词： Battery energy storage system(BESS) grid booster transient stability voltage stability electromagnetic transient(EMT)

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Key Technologies and Prospects for Electric Vehicles Within Emerging Power Systems: Insights from Five Aspects

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cSEE Journal of Power and Energy Systems 2024年第2期10卷 439-447页

作者： Yalun li Minggao Ouyang c.c.chan Xueliang Sun Yonghua Song Wei cai Yilin Xie Yuqiong Mao Department of Electrical Engineering and School of Vehicle and MobilityTsinghua UniversityBeijing 100084China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China Department of Mechanical and Materials Engineering University of Western OntarioLondonON N6A 3K7Canada State Key Laboratory of Internet of Things for Smart city University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

The energy revolution requires coordination in energy consumption, supply, storage and institutional *** energy generation technologies, along with their associated costs, are already fully equipped for large-scale ***, energy storage remains a bottleneck, and solutions areneeded through the use of electric vehicles, which traditionallyplay the role of energy consumption in power systems. Toclarify the key technologies and institutions that support EVsas terminals for energy use, storage, and feedback, the cSEEJPES forum assembled renowned experts and scholars in relevantfields to deliver keynote reports and engage in discussions ontopics such as vehicle–grid integration technology, advancedsolid-state battery technology, high-performance electric motortechnology, and institutional innovation in the industry *** experts also provided prospects for energy storage andutilization technologies capable of decarbonizing new powersystems.

关键词： Electric vehicles engineering philosophy highpower density motor new power system solid state batteries vehicle grid integration.

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