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Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin

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Pharmacology & Pharmacy 2022年第10期13卷 355-367页

作者： Omédine Koukoui Santorin Seton Mansouratou Betira jean baptiste amagbegnon Fidèle Sonounameto Eudoxie Assou Alphonse Sezan Laboratory of Animal Physiology Cellular Signaling and Pharmacology ENSBBA/UNSTIM Dassa Zoumè Benin Laboratory of Pharmacology and Improved Traditional Medicines FAST/University of Abomey-Calavi Godomey Benin

Cardiovascular diseases (CVD) are nowadays real health problems in the world. High blood pressure is one of the most important risk factors for CVD and is affecting more and more people in Benin. The objective of our work is to evaluate the safety and the efficacy of the leaves of five plants used for the treatment of hypertension in Benin. Acute toxicity was evaluated on wistar rats which orally administered a single dose of 2000 mg/kg of body weight of hydro-ethanolic extract of the leaves of Phyllanthus amarus Schumach. & Thonn., Persea americana MILL., Ipomoaea fistulosa Mart. ex Choisy., Heliotropium indicum L., Schrankia leptocarpa DC., and were monitored over a period of 14 days. Subacute toxicity was evaluated on rats which received a daily dose of 200 mg/kg of body weight of the plant leaf extract over a period of 28 days. Plant efficacy was assessed by measuring potassium in plant leaves. Administration of the single dose of the extract did not cause any deaths in rats;the weight of the rats varied depending on the extracts administered. Concerning the subacute treatment, the levels of aspartate amino transaminases (AST) and Alanine amino transaminases (AST) did not vary significantly after the 28 days of treatment with the different extracts. On the other hand, a significant increase in serum creatinine was observed in rats treated with extracts of Phyllanthus amarus. The leaves of Heliotropium indicum, Ipomoaea fistulosa and Phyllanthus amarus contain the highest levels of potassium. Among the five plants studied, only the leaves of Phyllanthus amarus seem to induce renal toxicity. Extracts from the leaves of Heliotropium indicum, Ipomoaea fistulosa might be the most effective in inducing hypotensive activity and do not show toxicity.

关键词： Hypertension Plant Extracts Toxicity Efficacy Potassium

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Evaluation of the Preventive and Therapeutic Activities of <i>Tridax procumbens</i>against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats

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Pharmacology & Pharmacy 2021年第7期12卷 127-140页

作者： jean-baptiste amagbegnon Omédine Koukoui Pascal C. Agbangnan Santorin Seton Mansouratou Betira Sedami Medegan Laura Loko Victorin Dougnon Luc Djogbenou Alphonse Sezan Laboratory of Animal Physiology Cellular Signalisation and Pharmacology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Laboratory of Study and Research in Applied Chemistry Unity of Research and Molecular Interactions (URIM/LERCA/UAC) Cotonou Benin Medicinal and Organic Chemistry Laboratory Faculty of Health Sciences Cotonou Benin Laboratory of Applied Entomology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory for Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Infectious Vector Borne Diseases Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Biomembranes and Cellular Signalisation University of Abomey-Calavi Cotonou Benin

From the Asteraceaes family, Tridax procumbens is a wild species frequently found in fields, meadows and roadsides. It is traditionally used to treat yellow fever, typhoid fever, high blood pressure and diabetes. In this work we used the hydro-ethanolic extract of the leaves and stems of the plant and also the fractions of this extract to determine the preventive and therapeutic activities of the plant against obesity, hyperglycemia and hyperlipidemia. The yields of the fractions obtained by decantation of the hydro-ethanolic extract are respectively 0.160% with hexane, 0.073% with dichloromethane, 0.09% with diethyl ether and 0.150% with ethyl acetate. Hyperglycemia and hyperlipidemia were induced in the rats submitted to a fatty and sweet diet for 28 days. Our results showed a significant increase in glycemia, weight and triglyceride level in rats that were subjected to the diet. On the other hand, the rats treated with the dose of 500 mg/kg of body weight of Tridax procumbens extract during the induction showed a reduction in weight gain and an absence of increase in blood sugar and triglyceride levels. The ethyl acetate fraction of Tridax procumbens extract administered to fatty and hyperglycemic rats at 50 mg/kg of body weight for 14 days did not induce change in the blood sugar and triglycerides level of fatty and hyperglycemic rats. If it seems obvious that the extract of Tridax procumbens prevents hyperglycemia and hyperlipidemia, the ethyl acetate fraction does not seem to have a therapeutic effect.

关键词： Tridax procumbens Prevention Treatment Hyperglycemia Hyperlipidemia

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Analysis of Cardiovascular Risk Factors in Hypertensive Farmers and Non-Farmers in the Zou Region of Central Benin

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Journal of Biosciences and Medicines 2023年第12期11卷 362-375页

作者： Fidele Sonounameto Marcelin Agbo Colette Azandjeme Santorin Seton Mansouratou Betira jean-baptiste amagbegnon Fresnel Cachon Maximin Senou Casmir Akpovi Alphonse Sezan Camille Dossou Lamine Baba-Moussa Joachim Gbenou Omedine Koukoui Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Research Unit of Animal Physiology Cell Signaling and Pharmacology (U-PASCPharm) ENSBBA/UNSTIM Dassa-Zoumé Benin Department of Health Promotion IRSP/UAC Ouidah Benin Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Unit of Experimental and Clinical Biology (U-BEC) ENSBBA/UNSTIM Dassa-Zoumé Benin Laboratory of Applied Biology Research Research Unit on Non-Communicable Diseases and Cancer EPAC/UAC Cotonou Benin Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal Physiology FAST/UAC Cotonou Benin Laboratory of Molecular Biology and Typing in Microbiology Department of Biochemistry and Cell Biology FAST/UAC Abomey Calavi Benin Laboratory of Pharmacognosy and Essential Oils FAST/UAC Cotonou Benin

The heavy use of chemicals, pesticides, cosmetics and plastic packaging coincides with a resurgence of cardiovascular disease, in particular hypertension, which is affecting younger and younger populations. The aim of this study was to analyze the cardiovascular risk factors in hypertensive farmers compared with hypertensive non farmers. This was a prospective case-control study that included 239 hypertensive farmers and non farmers aged 25 to 65 with blood pressure ≥ 140 mmHg and 90 mmHg. Hypertensive farmers (101) represented 42.25% of the population versus hypertensive non farmers (138) 57.74%. The median ages were 47 ± 11.3 years for farmers and 51.45 ± 9.77 years for non farmers. Biochemical analysisand screening for major cardiovascular disease risk factors such as metabolic syndrome were performed. Metabolic syndrome was defined according to the new definition of the International Diabetes Federation. Our results revealed higher blood glucose levels in farmers (47.77%) than in non farmers (27.20%) (p = 0.0132). Dyslipidemia was more frequent in non farmerswith high level of LDL cholesterol and total cholesterol. Farmers presented a high level of tryglycerides. The prevalence of obesity was higher in non farmers 51 (36.96%) than farmers 18 (17.82%). The prevalence of metabolic syndrome was 106 (44.35%) in our study population. There was not an important difference between farmers (39.60%) and non farmers (47.82%). However, the variation of metabolic syndrome according to age and sex showed a higher prevalence in young male farmers aged 25 to 45 whereas non farmers presented an increasing prevalence of metabolic syndrome according to age and the absence of metabolic syndrome between age 25 and 35. Our results showed that the cardiovascular risk appeared early in young farmers compared with non farmers suggesting a possible role of pesticides in the onset of this risk.

关键词： Chemicals Farmers Metabolic Syndrome Hypertension

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Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin

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Pharmacology & Pharmacy（药理与制药） 2022年第10期

作者： omédine koukoui santorin seton mansouratou betira jean baptiste amagbegnon fidèle sonounameto eudoxie assou alphonse sezan

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Contribution of SAR Radar Imagery in the Detection of Suspicious Vessels in the Ivorian EEZ

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World Journal of Engineering and Technology 2024年第1期12卷 200-212页

作者： Koffi Cyprien Yoboue jean-baptiste Kassi Eric Valère Djagoua Tiemelé Jacque-André Laboratory of Remote Sensing and GIS University Center for Research and Application in Remote Sensing (CURAT) Félix Houphouet-Boigny University of Abidjan Cocody Ivory Coast

The present work proposed a method for match SAR and AIS data to detect vessels carrying out suspicious activity in the Ivorian EEZ. Two superposition methods, detected AIS and SAR data, based on point-to-point association on the one hand and point-to-line on the other hand, were used to detect suspicious vessels in Ivorian marine waters. The results showed that most vessels detected in the Ivorian EEZ do not declare their positions to avoid being spotted. These funds are likely to practice illegal, undeclared and unregulated fishing (INN fishing). This clandestine activity is very recurrent in Ivorian waters. This is illustrated by the number of suspicious vessels detected by SAR radar imagery which is greater compared to declared or authorized vessels.

关键词： INN Fishing CFAR Algorithm AIS Sentinel-1A Ivory Coast

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Efficiency of Legumes in Increasing Yam Yield under Sandy Ferrasol in the Forest Zone of Southwestern Côte d’Ivoire

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Open Journal of Soil Science 2024年第4期14卷 227-236页

作者： Germaine A. Tanoh Félix B. O. Bouadou jean baptiste D. Ettien Department of Soil Sciences Water and Geomaterials University of Felix Houphou&#235t Boigny Abidjan C&#244te d&#8217Ivoire Department of Food Security and Nutrition Swiss Center for Scientific Research in C&#244te d&#8217Ivoire Abidjan C&#244te d&#8217Ivoire

The cropping system is based on traditional farming in rural areas. In this way, yields of some food crops like yam are very low considering their high need for nutrients. The nutrient-rich land is under high land pressure as it is occupied by cash crops such as oil palm and rubber at the expense of food crops and soil fertility is declining. The study was conducted in Grand-Lahou to assess the effect of organic matter provided by legumes in increasing yam yield. The randomized complete block design included four (4) treatments: Arachis hypogaea + yam association (T1), Acacia mangium + yam association (T2), Arachis + Acacia mangium + yam association (T3) and pure yam crop (T0). The parameters measured were: the soil nutrients content, the rate of mineralization of organic matter through the C/N ratio as well as the yield of yam through different techniques that allowed the objective of the study to be achieved. It was noted a slight improvement of nitrogen and organic carbon in all treatments with a higher value recorded in the T2 treatment. The C/N ratio decreased to 12 in all treatments compared to the control, which reflects a normal decomposition of the organic matter. Treatment T1 increased yam yield (8.4 t/ha) in contrast to treatments T2 (4.1 t/ha) and T3 (2.8 t/ha). Legume-based treatments T2 and T3 were associated with a significant decrease in yam yield, resulting in losses of −46.34% to −25.09%, while treatment T1 resulted in a gain of 28.57%. As a result, the treatments involving legumes contributed to normalizing the organic matter content of the soil. The simultaneous association of these two legumes led to a decrease in yam production, contrary to the treatment associating only groundnut.

关键词： Legumes Organic Matter Yam Yield Côte d’Ivoire

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Morbidity and Mortality Related to Infectious Diseases in the Roi Boudouin Paediatric Ward in Senegal

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Open Journal of Pediatrics 2024年第4期14卷 727-737页

作者： Guillaye Diagne Aliou Abdoulaye Ndongo Djeneba Fafa Cissé Sidy Lamine Mbaye jean baptiste Niokhor Diouf Fatou Ly Pediatrics Ward of Pikine Hospital Pikine Sngal Pediatrics Ward of Roi Boudouin Hospital Dakar Sngal

Introduction: Infant and child morbidity and mortality linked to infections remain a major concern in both developed and developing countries. The general objective was to determine the characteristics of hospital morbidity and mortality linked to infectious pathologies in the pediatric department of the King Baudouin hospital center in Dakar. Methods: This was a retrospective, descriptive and analytical study focusing on children hospitalized from January 1, 2018 to December 31, 2021 in the pediatric department of the King Baudouin hospital center in Dakar. Results: During the study period, 1474 children were hospitalized for an infectious pathology in the pediatric department. The sex ratio was 1.48. Children aged between one and twelve months represented 34.12%. Morbidity due to respiratory and digestive infections was 42.33% and 33.45%, respectively. Pediatric hospital mortality was 0.75% with a predominance noted in infants between 1 and 12 months (55.86%). Respiratory, digestive infections, sepsis and neurological infections were the main causes of death. Factors associated with mortality were age (1 to 12 months) with p Conclusion: Reducing infant and child mortality linked to infectious diseases remains a crucial challenge to address for improving children’s health. Early detection of related signs, prevention of infections, and adequate care and monitoring of infants and children can contribute to this reduction.

关键词： Morbidity Mortality Infections Children

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Interest of Non-Invasive Markers (APRI, FIB-4) for Assessing Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B without Cytolysis and with Low Viral Replication

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Open Journal of Gastroenterology 2024年第5期14卷 192-201页

作者： Mamadou Diakité Kouassi Olivier Claver Koffi Amadou Koné Akoun Fabrice Aké Oury Diallo Ahmadou Stellart jean M. Brou Anassi jean-baptiste Okon Department of Medicine and Hepato-Gastroenterology Teaching Hospital of Bouak&#233 Bouak&#233 C&#244te d&#8217Ivoire Faculty of Medical Sciences Alassane Ouattara University Bouak&#233 C&#244te d&#8217Ivoire

Background and Objectives: The indication for treatment in HBsAg-positive patients with low viral load and normal transaminases requires an assessment of fibrosis. In resource-limited settings, free hepatic fibrosis evaluation tests can aid in therapeutic decision-making. Our study aims to demonstrate the utility of assessing hepatic fibrosis using non-invasive markers (APRI and FIB-4) in patients with chronic B viral hepatitis without cytolytic activity and low viral replication in our context. Patients and Methods: This is a retrospective cross-sectional study conducted between January 2018 and December 2021 at the University Hospital Center of Bouaké. Included were all patients aged ≥18 with normal transaminases (Results: Our study included 241 patients, with a mean age of 36.19 years (±10.52 years) and a male predominance of 52%. The mean FibroScan® value was 6.44 ± 2.3 kPa, and 68 patients (28.22%) had fibrosis >7 kPa. To exclude significant fibrosis (FS Conclusion: A significant proportion of HBV-infected patients with normal ALT and low viral load have active liver disease. Both FIB-4 and APRI biological scores are useful in identifying individuals without significant fibrosis with a good negative predictive value (>50%).

关键词： HBV Infection APRI FIB-4 Impulse Elastography BouakéUniversity Hospital

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废玻璃制备方沸石用于吸附废水中的重金属研究

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现代化工 2024年第S2期 134-139页

作者：柏静钟海滢郭建宁容俊琪 jean-baptiste MAWULE DASSEKPO 澳门科技大学可持续发展研究所深圳信息职业技术学院交通与环境学院哈尔滨工业大学(深圳)土木与环境工程学院深圳信息职业技术学院滨海土木工程技术研究所

以废玻璃为原材料，采用水热合成法制备方沸石，探究其对废水中Pb2+、Cd2+和Cu2+的吸附性能。通过批式实验系统考察了多种物理化学因素（pH、温度、接触时间等）对吸附量的影响。结果表明，初始pH对吸附量的影响较为显著，而温度变化对... 详细信息

以废玻璃为原材料，采用水热合成法制备方沸石，探究其对废水中Pb2+、Cd2+和Cu2+的吸附性能。通过批式实验系统考察了多种物理化学因素（pH、温度、接触时间等）对吸附量的影响。结果表明，初始pH对吸附量的影响较为显著，而温度变化对平衡吸附量的影响较小。确定了方沸石吸附Pb2+、Cd2+和Cu2+的最佳工艺参数。利用Langmuir等温线模型对方沸石吸附水中的Pb2+、Cd2+和Cu2+过程进行拟合，结果表明，该吸附过程是均质单分子层吸附，且吸附动力学特征更符合准二级动力学方程，证实了该吸附过程主要通过离子交换、化学吸附和表面络合作用实现。为废玻璃的资源化利用及废水中重金属的去除提供了一种低成本、高效率的方法。

关键词：废玻璃方沸石废水重金属吸附性能

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Nephroblastoma in Adults about a Clinical Case

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Surgical Science 2024年第2期15卷 81-88页

作者： Tounkara Cheickna Coulibaly Amara Malle Oumar Amadou Bréhima Bolo Coulibaly Bagoyoko Kaloga Daye Samake Hamidou Berthe Honoré jean-baptiste Gabriel Diakite Mamadou Lamine Department of General Surgery Hospital Center “Mother Child” Luxembourg Bamako Mali Directorate of Army Health Services Kati Mali Department of Urology and Andrology Point G University Hospital Bamako Mali

Nephroblastoma is the most common malignant renal tumor in children and is related to an abnormal proliferation of cells resembling those of the embryonic kidney (metanephroma), hence the terminology;embryonal tumor. These are tumors that remain and remain unstudied in Mali because they are common in adults in our context. Its annual incidence is estimated at approximately 1/10,000 births. Nephroblastoma is a rare or even exceptional tumor in adults. The clinical manifestation was a large swelling of the right hypochondrium;abdominal pain for a year;unquantified fever, hypertension, initial hematuria associated with burning during urination and anemia. The main clinical manifestation remained fever and abdominal pain. This renal tumor posed a diagnostic problem which was previously labeled as a mesenteric tumor in our general surgery department. The diagnosis was made by imaging: CT and magnetic resonance imaging. The treatment is multidisciplinary and combines chemotherapy, surgery with or without radiotherapy. The prognosis is poor due to late diagnosis and less effectiveness of chemotherapy compared to the child. Survival did not exceed a year and a half because the renal tumor in our patient was surgically overcome. We report a case of nephroblastoma in an 86-year-old patient with unfavorable histology (hematogenous metastases), operated on in the general surgery department and whose postoperative course was simple and who was referred to oncology for treatment.

关键词： Nephroblastoma Malignant Kidney Tumor Treatment Adult Mali

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