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Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee jeong-Tae Koh Hong-In Shin je-Yong Choi Yun Hyun Huh je-hwang ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

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Analysis of the Sloshing Flows of a LNG Cargo Tank

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Journal of Thermal Science 2011年第5期20卷 442-448页

作者： Deog Hee Doh Hyo je Jo Byeong Rog Shin Min Cheol ryu Yoon Sik hwang Division of Mechanical and Information Eng. Korea Maritime University Division of Naval Architecture and Ocean Systems Eng. Korea Maritime University Department of Mechanical Engineering Changwon National University Fluid Dynamics R&D Team DSMEGeoje-siKorea

The sloshing flows in a LNG cargo tank model （1/50 scale） of a ship are measured by an embedded pano- ramicPIV system. The measurement system consists of a Nd-Yag laser（120mJ, 15Hz）, two cameras（lk x lk） and a host computer. Four experimental cases were tested for the tank model, in which swaying motions are made by a 6 DOF-motion platform. The amplitudes of swaying are 9.76mm and 29.29mm, and the swaying frequencies are 0.633Hz and 0.828Hz. The measurement regions are the vertical plane 50ram away from the front wall of the tank where a pump tower is installed. It was verified that the flow patterns of the sloshing are similar to each other when the swaying amplitudes are similar.

关键词： Sloshing Model Ship Cargo Tank Embedded Panoramic PIV Swaying Motion

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Applying machine learning techniques to predict detonation initiation fromhot spots

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Energy and AI 2022年第3期9卷 121-127页

作者： je Ir ryu Department of Mechanical Engineering University of California-BerkeleyBerkeleyCA 94720USA

As hot spots can be a source of detonation initiation by autoignition in a reactive mixture, understanding hotspot initiated detonation is significantly important for energy-related applications of detonation. Although theZel’dovich reactivity gradient theory is extremely useful to predict reaction propagation modes from hot spots,the prediction is limited due to the changes in the unburnt mixture during the induction time. In the currentstudy, machine learning based estimation methods by training the numerical simulation result data set aresuggested to avoid the extensive and empirical effort to find initial conditions of hot spot initiated detonationin inhomogeneous mixtures. The data set was obtained from the detailed numerical simulations with variousconditions of hot spots and divided into training and test data sets. Some variables were normalized withothers to avoid multicollinearity. Three different machine learning techniques, logistic regression, classificationand regression trees, and artificial neural network, were utilized to develop prediction models. Using thedeveloped models by machine learning approaches, the modes of hot spot initiated reaction front propagationcan be predicted without computationally expensive numerical simulations. The accuracies of the machinelearning based prediction models were significantly improved compared to the baseline model simply usingthe Zel’dovich reactivity gradient theory. These models can be utilized as preliminary prediction methods ofhot spot induced detonation initiation conditions for further detailed numerical simulations and dominantinput variables.

关键词： Detonation Deflagration Hydrogen Syngas Logistic regression CART Artificial neural network

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Artificial optoelectronic synapse based on spatiotemporal irradiation to source-sharing circuitry of synaptic phototransistors

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InfoMat 2024年第2期6卷 131-141页

作者： Seungho Song Changsoon Choi Jongtae Ahn je-Jun Lee Jisu Jang Byoung-Soo Yu Jung Pyo Hong Yong-Sang ryu Yong-Hoon Kim Do Kyung hwang Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Center for Spintronics Post-Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Division of Nanoscience&Technology KIST SchoolUniversity of Science and Technology(UST)SeoulRepublic of Korea School of Biomedical Engineering Korea UniversitySeoulRepublic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulRepublic of Korea

To overcome the intrinsic inefficiency of the von Neumann architecture,neuromorphic devices that perform analog vector–matrix multiplication have been highlighted for achieving power-and time-efficient data *** particular,artificial synapses,of which conductance should be programmed to represent the synaptic weights of the artificial neural network,have been intensively researched to realize neuromorphic ***,inspired by excitatory and inhibitory synapses,we develop an artificial optoelectronic synapse that shows both potentiation and depression characteristics triggered only by optical *** design of the artificial optoelectronic synapse,in which excitatory and inhibitory synaptic phototransistors are serially connected,enables these characteristics by spatiotemporally irradiating the phototransistor channels with optical ***,a negative synaptic weight can be realized without the need for electronic components such as *** such attributes,the artificial optoelectronic synapse is demonstrated to classify three digits with a high recognition rate(98.3%)and perform image preprocessing via analog vector-matrix multiplication.

关键词： amorphous oxide semiconductor analog processing artificial synapse neuromorphic optoelectronics

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Magnetic wallpaper Dirac fermions and topological magnetic Dirac insulators

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npj Computational Materials 2023年第1期9卷 1695-1702页

作者： Yoonseok hwang Yuting Qian Junha Kang jehyun Lee Dongchoon ryu Hong Chul Choi Bohm-Jung Yang Center for Correlated Electron Systems Institute for Basic Science(IBS)Seoul 08826Korea Department of Physics and Astronomy Seoul National UniversitySeoul 08826Korea Center for Theoretical Physics(CTP) Seoul National UniversitySeoul 08826Korea

Topological crystalline insulators(TCIs)can host anomalous surface states which inherits the characteristics of crystalline symmetry that protects the bulk ***,the diversity of magnetic crystalline symmetries indicates the potential for novel magnetic TCIs with distinct surface ***,we propose a topological magnetic Dirac insulator(TMDI),whose two-dimensional surface hosts fourfold-degenerate Dirac fermions protected by either the p'_(c)4mm or p40 g0 m magnetic wallpaper *** bulk topology of TMDIs is protected by diagonal mirror symmetries,which give chiral dispersion of surface Dirac fermions and mirror-protected hinge *** propose candidate materials for TMDIs including Nd_(4)Te_(8)Cl_(4)O_(2)0 and DyB_(4) based on first-principles calculations,and construct a general scheme for searching TMDIs using the space group of paramagnetic parent *** theoretical discovery of TMDIs will facilitate future research on magnetic TCIs and illustrate a distinct way to achieve anomalous surface states in magnetic crystals.

关键词： Dirac topological protected

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N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

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Journal of Central South University 2013年第8期20卷 2226-2232页

作者： SHON Ho Sun hwang Kyung Kuk BAE Jang Whan KIM Kyung Ah LEE Jong Yun ryu Keun Ho Database and Bioinformatics Laboratory School of Electrical & Computer Engineering also PSM of School of Medicine Chungbuk National University Department of Medicine School of Medicine Chungbuk National University Department of Biomedical Engineering School of Medicine Chungbuk National University Department of Informatics and Convergence Chungbuk National University Cheongju

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

关键词： non ST-segment elevation myocardial infarction NT-ProBNP cardiovascular disease

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Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma:A multicenter study

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1340-1353页

作者： Jongman Kim Dong-Jin Joo Shin hwang jeong-Moo Lee je-Ho ryu Yang-Won Nah Dong-Sik Kim Doo-Jin Kim Young-Kyoung You Hee-Chul Yu Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Surgery Yonsei University College of MedicineSeoul 03722South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Pusan National University College of MedicineBusan 50612South Korea Department of Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033South Korea Department of Surgery Korea University College of MedicineSeoul 02841South Korea Department of Surgery Gachon University Gil Medical CenterGachon University College of MedicineIncheon 21565South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Patients with combined hepatocellular carcinoma and cholangiocarcinoma(cHCC-CC)are not traditionally considered eligible for liver transplantation(LT)AIM To compare outcomes between living donor LT(LDLT)patients with hepatocellular carcinoma(HCC)and LT patients with cHCC-CC and to identify risk factors for tumor recurrence and death after LT in cHCC-CC *** Data for pathologically diagnosed cHCC-CC patients(n=111)who underwent LT from 2000 to 2018 were collected for a nine-center retrospective ***(n=141)who received LDLT for HCC at Samsung Medical Center from January 2013 to March 2017 were selected as the control *** patients in two groups,respectively,were selected by 1:1 *** Cumulative disease-free survival(DFS)and overall survival(OS)in the cHCC-CC group were significantly worse than in the HCC group both before and after *** recurrence incidence in the cHCC-CC group was higher than that in the HCC group(75.5%vs 33.3%,P3,tumor size>3 cm,and lymph node metastasis were predisposing factors for tumor recurrence in multivariate *** a maximum tumor size>3 cm was a predisposing factor for *** The poor prognosis of patients diagnosed with cHCC-CC after LT can be predicted based on the explanted *** regular surveillance for cHCC-CC patients should be required for early detection of tumor recurrence.

关键词： Liver transplantation Outcomes Intrahepatic cholangiocarcinoma Hepatocellular carcinoma Recurrence

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Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae ryu Da-Woon Lee je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun Choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

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Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord

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Neural Regeneration Research 2020年第11期15卷 2162-2168页

作者： Ju-Young Oh Tae-Yeon hwang Jae-Hwan Jang Ji-Yeun Park Yeonhee ryu HyeJung Lee Hi-Joon Park Acupuncture and Meridian Science Research Center Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoulRepublic of Korea Department of Korean Medical Science Graduate School of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea BK21 PLUS Korean Medicine Science Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea College of Korean Medicine Daejeon UniversityDaejeonRepublic of Korea Korean Institute of Oriental Medicine DaejeonRepublic of Korea

Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side *** is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect,but the efficacy of muscovite for neuropathic pain has not been ***,we assessed whether muscovite nanoparticles can reduce the symptoms of pain by controlling the inflammatory process observed in neuropathic *** analgesic effects of muscovite nanoparticles were explored using partial sciatic nerve ligation model of neuropathic pain,in which one-third to onehalf of the nerve trifurcation of the sciatic nerve was tightly tied to the dorsal *** nanoparticles(4 mg/100μL)was given intramuscularly to evaluate its effects on neuropathic pain(3 days per week for 4 weeks).The results showed that the muscovite nanoparticle injections significantly alleviated partial sciatic nerve ligation-induced mechanical and cold *** the spinal cord,the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-α,interleiukin-6 and monocyte chemoattractant protein-1,which were upregulated in the partial sciatic nerve ligation ***,the muscovite nanoparticle injections resulted in a decrease in activating transcription factor 3,a neuronal injury marker,in the sciatic *** results suggest that the analgesic effects of muscovite nanoparticle on partial sciatic nerve ligation-induced neuropathic pain may result from inhibiting activation of astrocytes and microglia as well as pro-inflammatory *** propose that muscovite nanoparticle is a potential anti-nociceptive candidate for neuropathic *** experimental protocols in this study were approved by the Institutional Animal Ethics Committee(IACUC)at Dongguk University,South Korea(approval No.2017-022-1)

关键词： astrocyte microglia muscovite nanoparticle neuropathic pain partial sciatic nerve ligation pharmacopuncture pro-inflammatory cytokine spinal cord

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Geometric-phase intraocular lenses with multifocality

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Light(Science & Applications) 2022年第11期11卷 2805-2816页

作者： Seungmin Lee Gayeon Park Senho Kim Yeonghwa ryu Jae Woong Yoon Ho Sk hwang In Seok Song Chang Sun Lee Seok Ho Song Department of Physics Hanyang UniversitySeoul 04763Republic of Korea Department of Ophthalmology Catholic University of KoreaSeoul 07345Republic of Korea Seoul Ophthalmic Clinic Goyang 10463Republic of Korea Koryoeyetech In.Seoul 06093Republic of Korea Tigernics IncSeoul 04763Republic of Korea

We demonstrate a new type of multifocal and extended depth of focus(EDOF)intraocular lenses(IOLs)embeddingμm-thin geometric phase(GP)lens *** an emerging approach for lens phase design,the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL *** number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each *** and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal *** characterizing the defocus image and modulation transfer function of the GP IOLs,it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs,blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.

关键词： layer phase alignment

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