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APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus

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Protein & Cell 2018年第8期9卷 733-737页

作者： Timur Mavylutov Xi Chen Lianwang Guo jay yang Department of Anesthesiology University of Wisconsin SMPH Madison Wl 53705 USA Department of Surgery and Physiology & Cell Biology Ohio State University Columbus OH 43210 USA

Dear Editor, Deciphering the role of any protein in a cell requires knowl- edge of the structure, subcellular localization, and the topological orientation of the protein within the relevant cells. The Sigma-1 receptor （S1R） largely localized to the endo- plasmic reticulum （ER） serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation （reviewed in Suet al., 2016）, however, the basic topology of this protein within a cell remains controversial.

关键词： ENDOPLASMIC-RETICULUM RECEPTOR SITES

Forecasting cyberattacks with incomplete,imbalanced,and insignificant data

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Cybersecurity 2018年第1期1卷 263-278页

作者： Ahmet Okutan Gordon Werner Shanchieh jay yang Katie McConky Computer Engineering Rochester Institute of TechnologyRochesterNYUSA Industrial&Systems Engineering Rochester Institute of TechnologyRochesterNYUSA

Having the ability to forecast cyberattacks before they happen will unquestionably change the landscape of cyber warfare and cyber *** work predicts specific types of attacks on a potential victim network before the actual malicious actions take *** challenge to forecasting cyberattacks is to extract relevant and reliable signals to treat sporadic and seemingly random acts of *** paper builds on multi-faceted machine learning solutions and develops an integrated system to transform large volumes of public data to aggregate signals with imputation that are relevant and predictive of cyber incidents.A comprehensive analysis of the individual parts and the integrated whole demonstrates the effectiveness and trade-offs of the proposed *** 16-months of reported cyber incidents by an anonymized victim organization,the integrated approach achieves up to 87%,90%,and 96% AUC for forecasting endpoint-malware,malicious-destination,and malicious-email attacks,*** assessed month-by-month,the proposed approach shows robustness to perform consistently well,achieving F-Measure between 0.6 and *** framework also enables an examination of which unconventional signals are meaningful for cyberattack forecasting.

关键词： Cyber security Forecasting Unconventional signals

Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege jay yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

Genome-wide high-throughput screening in yeast for functional analysis and drug target discovery

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Genome-wide high-throughput screening in yeast for functiona...

OptoGPT: A foundation model for inverse design in optical multilayer thin film structures

2014年第七届中国模式真菌研讨会

作者： jay yang Singer Instrument Co Ltd

Yeast is an ideal model organism for high-throughput phenotypic screening because of its experimental tractability and the availability of Yeast Knockout Collection and other powerful genetic *** such as synthetic genetic array analysis(SGA),yeast two-hybrid screening(Y2H),haploid insufficiency profiling/homozygous deletion profiling(HIP/HOP),and multicopy suppression profiling(MSP)have been developed for the systematic and unbiased mapping of genetic and physical interactions and drug-target ***,I will present

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Opto-Electronic Advances 2024年第7期7卷 4-16页

作者： Taigao Ma Haozhu Wang L.jay Guo Department of Physics University of MichiganAnn ArborMichigan 48109USA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMichigan 48109USA

Optical multilayer thin film structures have been widely used in numerous photonic ***,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each *** methods also cannot accommodate versatile design situations under different angles and *** addition,how to benefit practical fabrications and manufacturing has not been extensively considered *** this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.

关键词： multilayer thin film structure inverse design foundation models deep learning structural color

Detection of internal crack growth in polyethylene pipe using guided wave ultrasonic testing

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 319-329页

作者： jay Kumar Shah Hao Wang Said El-Hawwat Centre of Advanced Infrastructure and Transportation RutgersThe State University of New JerseyNJ 08854USA Department of Civil and Environmental Engineering RutgersThe State University of New JerseyNJ 08854USA

Despite the success of guided wave ultrasonic inspection for internal defect detection in steel pipes,its application on polyethylene(PE)pipe remains relatively *** growth of internal cracks in PE pipe severely affects its pressure-holding capacity,hence the early detection of internal cracks is crucial for effective pipeline maintenance *** study extends the scope of guided wave-based ultrasonic testing to detect the growth of internal cracks in a natural gas distribution PE *** experiments and a finite element model were planned to study the wave-crack interaction at different stages of axially oriented internal crack growth with a piezoceramic transducer-based setup arranged in a pitch-catch *** dispersion analysis supplemented with preliminary experiments was performed to isolate the optimal inspection frequency,leading to the selection of the T(0,1)mode at 50-kHz for the investigation.A transmission index based on the energy of the T(0,1)mode was developed to trace the extent of simulated crack *** findings revealed an inverse linear correlation between the transmission index and the crack depth for crack growth beyond 20%crack depth.

关键词： polyethylene pipes internal cracks guided wave ultrasonic testing torsional modes finite element modeling

Carbene chemistry for unnatural biosynthesis

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Science China(Life Sciences) 2024年第1期67卷 204-207页

作者： Jing Huang jay D.Keasling Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeley 94720USA Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryville 94608USA Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeley 94720USA Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby 2800Denmark Department of Bioengineering University of CaliforniaBerkeley 94720USA Synthetic Biochemistry Center Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhen 518055China

Previously,chemists working in synthesis were jealous of biologists since the enzymes found in nature usually exhibited great catalytic properties(e.g.,high catalytic efficiency,excellent selectivity such as substrate selectivity,regioselectivity and stereoselectivity).However,biological systems lack many counterparts of reactions widely used in chemical synthesis.

关键词： synthesis selectivity catalytic

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra S.MacDonald jay Penney Department of Biomedical Sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

《第28届急性疾病质量倡议工作组共识报告:脓毒症相关急性肾损伤》解读

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中华肾脏病杂志 2024年第3期40卷 237-244页

作者：刘彩虹 jay Koyner 赵宇亮付平四川大学华西医院肾脏内科、四川大学华西医院肾脏病研究所成都610041 芝加哥大学内科学系芝加哥60607

脓毒症相关急性肾损伤(sepsis associated acute kidney injury,SA-AKI)被定义为脓毒症背景下急性肾损伤(acute kidney injury,AKI)的存在。在遗传易感性的背景下,脓毒症可通过多种机制导致SA-AKI的发生,基于病理生理机制的差异,SA-AKI... 详细信息

脓毒症相关急性肾损伤(sepsis associated acute kidney injury,SA-AKI)被定义为脓毒症背景下急性肾损伤(acute kidney injury,AKI)的存在。在遗传易感性的背景下,脓毒症可通过多种机制导致SA-AKI的发生,基于病理生理机制的差异,SA-AKI归属于不同的“内型”,且表现为不同的“亚表型”。生物标志物和预测模型的结合具备早期识别AKI高风险患者和明确SA-AKI“内型”的潜力。容量复苏及血液净化是SA-AKI治疗的优化策略。此外,基于儿童的SA-AKI临床研究值得期待。

关键词：脓毒症急性肾损伤诊断急性疾病质量倡议专家共识