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Novel virulence factor dupA of Helicobacter pylori as an important risk determinant for disease manifestation:An overview

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World Journal of Gastroenterology 2020年第32期26卷 4739-4752页

作者： jawed alam Avijit Sarkar Bipul Chandra Karmakar Mou Ganguly Sangita Paul Asish K Mukhopadhyay Division of Infectious Diseases Institute of Life ScienceBhubaneswar 751023India Division of Bacteriology ICMR-National Institute of Cholera and Enteric DiseasesKolkata 700010India

Helicobacter pylori(***)is a microaerophilic,Gram-negative,human gastric pathogen found usually in the mucous lining of *** infects more than 50%of the world’s population and leads to gastroduodenal *** outcome of disease depends on mainly three factors:Host genetics,environment and bacterial *** these,bacterial virulence factors such as cagA,vacA are well known for their role in disease ***,based on the global epidemiological results,none of the bacterial virulence(gene)factors was found to be associated with particular diseases like duodenal ulcer(DU)in all ***,substantial importance has been provided for research in strain-specific genes outside the cag pathogenicity island,especially genes located within the plasticity *** found within the plasticity regions was first demonstrated in 2005 and was proposed for duodenal ulcer development and reduced risk of gastric cancer in certain geographical *** to the discrepancies in report from different parts of the world in DU development related to *** virulence factor,dupA became an interesting area of research in elucidating the role of this gene in the disease *** this review,we shed light on the detailed information available on the polymorphisms in dupA and their clinical *** have critically appraised several pertinent studies on dupA and discussed their merits and *** review also highlights dupA gene as an important biomarker for DU in certain populations.

关键词： Helicobacter pylori Plasticity region Duodenal ulcer Gastric cancer dupA gene

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